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List of works by Ronald Duman

A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis

scientific journal article

Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects ⬇️

scientific article published on February 17, 2012

Antidepressant Effects of Fibroblast Growth Factor-2 in Behavioral and Cellular Models of Depression ⬇️

scientific article published on April 17, 2012

Antidepressant effect of the calcium-activated tyrosine kinase Pyk2 in the lateral septum

scientific journal article

Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection

scientific article

Antipsychotic-induced gene regulation in multiple brain regions

scientific article

Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex ⬇️

scientific article published on October 29, 2011

Cell atrophy and loss in depression: reversal by antidepressant treatment ⬇️

scientific article published on October 11, 2011

Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment

scientific article

Cell-type specific modulation of NMDA receptors triggers antidepressant actions

scientific article published on 02 June 2020

Chromatin remodeling: a novel mechanism of psychotropic drug action

scientific article

Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat.

scientific article

Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress

scientific article

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

scientific journal article

Depression: a case of neuronal life and death?

scientific article

Differential expression and regulation of the cAMP-selective phosphodiesterase type 4A splice variants in rat brain by chronic antidepressant administration

scientific journal article

Effects of estradiol on learned helplessness and associated remodeling of hippocampal spine synapses in female rats.

scientific article published on January 2010

Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder

scientific article

Electroconvulsive seizure-induced gene expression profile of the hippocampus dentate gyrus granule cell layer

scientific article published in November 2006

Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity

scientific article

Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans

scientific article published on 17 February 2022

GABA interneurons mediate the rapid antidepressant-like effects of scopolamine

scientific article

GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine.

scientific article published on 16 September 2016

GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine

scientific article published on 17 May 2013

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure ⬇️

scientific article published on February 3, 2011

Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment

scientific article

How do antidepressants work? New perspectives for refining future treatment approaches.

scientific article

Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses

scientific article published on 17 October 2020

Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect.

scientific article

Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation

scientific article published on 11 March 2020

It is time to take a stand for medical research and against terrorism targeting medical scientists

scientific article

Ketamine Strengthens CRF-Activated Amygdala Inputs to Basal Dendrites in mPFC Layer V Pyramidal Cells in the Prelimbic but not Infralimbic Subregion, A Key Suppressor of Stress Responses

scientific article

Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide.

scientific article published on 24 May 2018

Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics

scientific article

Ketamine: A Paradigm Shift for Depression Research and Treatment

scientific article published on 01 March 2019

Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT1A receptor stimulation

scientific article published on 12 May 2020

Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin

scientific article published on 24 February 2020

Molecular and cellular studies of PTSD: Postmortem transcriptome analysis and novel therapeutic targets

scientific article published on 23 August 2018

Neurobiology of rapid acting antidepressants: role of BDNF and GSK-3β.

scientific article published on January 2014

Neurogenic actions of atypical antipsychotic drugs and therapeutic implications

scientific article

Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior

scientific article

Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions.

scientific article

Overexpression of human GATA-1 and GATA-2 interferes with spine formation and produces depressive behavior in rats

scientific article

PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies

scientific article published on 12 May 2020

Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections

scientific article

Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models

scientific article

Positive modulation of NMDA receptors by AGN-241751 exerts rapid antidepressant-like effects via excitatory neurons

scientific article published on 15 October 2020

Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats

scientific article

Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions

scientific article published on 21 February 2020

REDD1 is essential for stress-induced synaptic loss and depressive behavior

scientific article

Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors

scientific article

Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond

scientific article published on June 2013

Regulation of neurogenesis and angiogenesis in depression

scientific article

Remodeling of hippocampal spine synapses in the rat learned helplessness model of depression

scientific article

Repeated unpredictable stress and antidepressants differentially regulate expression of the bcl-2 family of apoptotic genes in rat cortical, hippocampal, and limbic brain structures

scientific journal article

Role of BDNF in the pathophysiology and treatment of depression: Activity-dependent effects distinguish rapid-acting antidepressants

scientific article published on 06 December 2019

Role of neurotrophic factors in the etiology and treatment of mood disorders

scientific article

Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses.

scientific article

Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications

scientific article

Signaling pathways underlying the rapid antidepressant actions of ketamine ⬇️

scientific article published on September 2, 2011

Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects

scientific article

Stress induces equivalent remodeling of hippocampal spine synapses in a simulated postpartum environment and in a female rat model of major depression

scientific article published on 21 December 2016

Synaptic Dysfunction in Depression: Potential Therapeutic Targets ⬇️

scientific article published on October 5, 2012

Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic.

scientific article published on 26 August 2017

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

scientific article

Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome

scientific article

The Connecticut Mental Health Center: Celebrating 50 Years of a Successful Partnership Between the State and Yale University

scientific article

The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?

scientific article published on 25 May 2018

The stress-induced transcription factor NR4A1 adjusts mitochondrial function and synapse number in prefrontal cortex.

scientific article published on 2 January 2018

Transcriptomic organization of the human brain in post-traumatic stress disorder

scientific article published on 21 December 2020

VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants

scientific journal article

Wnt2 expression and signaling is increased by different classes of antidepressant treatments

scientific article

mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure

scientific article

mTOR activation is required for the antidepressant effects of mGluR2/3 blockade ⬇️

scientific article published on November 24, 2011

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

scientific article

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