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List of works by Ronald A. DePinho

A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis ⬇️

scientific article published on December 6, 2010

A Biochemical and Biological Analysis of Myc Superfamily Interactions ⬇️

scientific article published on January 1, 1997

A genetic screen for candidate tumor suppressors identifies REST

scientific article

A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma

scientific article published on 6 November 2006

A mouse plasma peptide atlas as a resource for disease proteomics

scientific article published on 3 June 2008

A mouse to human search for plasma proteome changes associated with pancreatic tumor development

scientific article

A tumor vessel-targeting fusion protein elicits a chemotherapeutic bystander effect in pancreatic ductal adenocarcinoma

scientific article published on March 2017

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

scientific article

ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence

scientific journal article

Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes

scientific article

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

scientific article

Alu elements mediate MYB gene tandem duplication in human T-ALL

scientific article published on 10 December 2007

An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer

scientific article published on 16 May 2018

An enolase inhibitor for the targeted treatment of ENO1-deleted cancers

scientific article published on 23 November 2020

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

scientific article published on 11 June 2018

Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer

scientific article published on February 2012

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

scientific article published on April 2006

Author Correction: An enolase inhibitor for the targeted treatment of ENO1-deleted cancers

scientific article published on 18 December 2020

Axis of ageing: telomeres, p53 and mitochondria

scientific article

Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma

scientific article

Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma

scholarly article

Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma

scientific article

Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations

scientific article published on February 2006

Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

scholarly article

Braf(V600E) cooperates with Pten loss to induce metastatic melanoma

scientific article published on 12 March 2009

Brain metastasis: opportunities in basic and translational research

scientific article published on 28 July 2009

Cancer Stemness Meets Immunity: From Mechanism to Therapy

scientific article published on 01 January 2021

Cancer signaling: when phosphorylation meets methylation

scientific article

Cancer: crime and punishment.

scientific article

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4 ⬇️

scientific article published on September 14, 1995

Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor

scientific article

Characterization of melanocyte-specific inducible Cre recombinase transgenic mice

scientific article published on 01 May 2006

Chromatin Regulator, CHD1, Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer

scientific article published on 08 May 2020

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

scientific article published on 21 May 2007

Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment

scientific article published on 09 January 2020

Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy

scientific article

Collateral Lethality: A new therapeutic strategy in oncology

scientific article

Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types

scientific article published on November 2007

Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure

scientific article published on July 2014

Connecting chromosomes, crisis, and cancer

scientific article

Constitutive telomerase expression promotes mammary carcinomas in aging mice

scientific article

Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras

scientific article

Contrasting roles for Myc and Mad proteins in cellular growth and differentiation ⬇️

scientific article published on August 29, 1995

Cooperative effects of INK4a and ras in melanoma susceptibility in vivo ⬇️

scientific article published on November 1, 1997

Correction: Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy.

scientific article

Corrigendum: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

scholarly article published in Genes & Development

Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development

scientific article (publication date: June 2005)

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification ⬇️

scientific article

DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse

scientific journal article

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

scientific article published on 14 October 2010

Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma.

scientific article published in August 2003

Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells

scientific article published in December 2007

Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia ⬇️

scientific article published on October 17, 2012

Effective combinatorial immunotherapy for castration-resistant prostate cancer

scientific article published on 20 March 2017

Effective combinatorial immunotherapy for penile squamous cell carcinoma

scientific article published on 01 May 2020

Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells ⬇️

scientific article published on July 1, 1995

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

scientific article

Emerging insights into the molecular and cellular basis of glioblastoma

scientific article published in April 2012

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

scientific article

Epidermal growth factor receptor and Ink4a/Arf

article

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

scientific article

Erratum: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

scientific article published on 12 June 2013

Erratum: Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer

scientific article published in Nature

Erratum: Effective combinatorial immunotherapy for castration-resistant prostate cancer.

scientific article

Erratum: FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

scientific article published on 24 July 2015

Erratum: Telomere dysfunction induces metabolic and mitochondrial compromise

scholarly article published in Nature

Essential role of mouse telomerase in highly proliferative organs ⬇️

scientific article (publication date: 9 April 1998)

FOXO1 in the ventromedial hypothalamus regulates energy balance

scientific article

FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin ⬇️

scientific article published on September 4, 2012

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

scientific article published on 06 September 2018

FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress

scientific article

FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase

scientific article

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

scientific article published on 12 May 2015

FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase

scientific article published on 27 November 2018

FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation

scientific article published on 26 June 2009

FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription

scientific article

FoxOs Integrate Pleiotropic Actions of Insulin in Vascular Endothelium to Protect Mice from Atherosclerosis ⬇️

scientific article published on March 7, 2012

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

scientific article (publication date: 26 January 2007)

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

scientific article

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

scientific article

FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis

scientific article

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

scientific article published on 13 May 2010

From the Cover: Neutralization of terminal differentiation in gliomagenesis

scientific article published on 05 August 2013

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

scientific article published on 01 January 2019

Functional interactions among members of the Myc superfamily and potential relevance to cutaneous growth and development

scientific article published on April 1, 1996

Future cancer research priorities in the USA: a Lancet Oncology Commission

scientific article published on 31 October 2017

Generation of functional insulin-producing cells in the gut by Foxo1 ablation ⬇️

scientific article published on March 11, 2012

Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice

scientific article

Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer

scientific article published on 3 March 2015

Genetics and biology of pancreatic ductal adenocarcinoma

scientific article

Genetics and biology of pancreatic ductal adenocarcinoma.

scientific article

Genetics and biology of prostate cancer

article

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

scholarly article

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

scientific article

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

scientific article published on 04 September 2011

Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor

scientific article

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

scientific article published on 27 March 2013

Gone but not forgotten

scientific article published in Nature

Hepatic FoxOs Regulate Lipid Metabolism via Modulation of Expression of the Nicotinamide Phosphoribosyltransferase Gene ⬇️

scientific article published on March 8, 2011

Hepatic Suppression of Foxo1 and Foxo3 Causes Hypoglycemia and Hyperlipidemia in Mice ⬇️

scientific article published on December 6, 2011

High-resolution characterization of the pancreatic adenocarcinoma genome

scholarly article

High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients

article

High-resolution genomic profiles of human lung cancer

scientific article

Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein ⬇️

scientific article published on May 14, 1998

How disruption of cell cycle regulating genes might predispose to sun-induced skin cancer

scientific article

How stem cells age and why this makes us grow old.

scientific article

Human CPR (Cell Cycle Progression Restoration) Genes Impart a Far– Phenotype on Yeast Cells ⬇️

scientific article published on November 1, 1997

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

scientific article published on 03 February 2011

ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma

scientific article published on 9 June 2017

IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action ⬇️

scientific article published on May 2, 2012

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

scientific article

Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer

scientific article published on January 2009

Impaired Processing of DNA Photoproducts and Ultraviolet Hypermutability With Loss of p16INK4a or p19ARF

scientific article published on 01 December 2004

Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling

scientific article published on August 2008

Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse

scholarly article

Ink4a/arf deficiency promotes ultraviolet radiation-induced melanomagenesis.

scientific article

International network of cancer genome projects

scientific article

KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer

scientific article published on 21 March 2019

Keeping telomerase in its place

scientific article published on 01 September 2002

LKB1 (XEEK1) regulates Wnt signalling in vertebrate development

scientific article

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

scientific article

Linking functional decline of telomeres, mitochondria and stem cells during ageing

scientific article

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

scientific article

Loss of FOXO1 Cooperates with TMPRSS2-ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion

scientific article

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

scientific article

Lung cancer signatures in plasma based on proteome profiling of mouse tumor models

scientific article

MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas

scientific article

Malignant astrocytic glioma: genetics, biology, and paths to treatment

scientific article (publication date: November 2007)

Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities.

scientific article published on 17 November 2006

Mig-6 controls EGFR trafficking and suppresses gliomagenesis

scientific article

Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase

scientific article

Molecular Basis of Heavy-Chain Class Switching and Switch Region Deletion in an Abelson Virus-Transformed Cell Line ⬇️

scientific article published on December 1, 1984

Molecular diversity of astrocytes with implications for neurological disorders

scholarly article

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

scholarly article

Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction

scientific article published on 26 February 2013

Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

scientific article published on 24 February 2017

Myc and Max: a putative transcriptional complex in search of a cellular target

scientific article published on June 1, 1992

Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants ⬇️

scientific article published on 01 August 1992

Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma.

scientific article published on 21 January 2014

Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia

scientific article

Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma

scientific article

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

scientific article

Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment

scientific article published on 11 February 2020

Oncogenic Kras drives invasion and maintains metastases in colorectal cancer.

scientific article published on 13 March 2017

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

scientific article

Opposing roles of TGFβ and BMP signaling in prostate cancer development

scientific article published in December 2017

Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators

scientific article published on 30 August 2012

PAF promotes stemness and radioresistance of glioma stem cells.

scientific article published on 9 October 2017

PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis.

scientific article

PCAF modulates PTEN activity

scientific article

PI3 kinase signals BCR-dependent mature B cell survival

scientific article published on October 2009

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

scientific article

PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas

scientific article

PRKCI promotes immune suppression in ovarian cancer

scientific article published on 11 July 2017

PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network

scientific article published on 23 May 2011

PTEN: a novel anti-oncogenic function independent of phosphatase activity

scientific article

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms

scientific article published on 28 January 2008

Pancreatic cancer biology and genetics

scientific article

Passenger deletions generate therapeutic vulnerabilities in cancer

scientific article

Prognostic determinants in prostate cancer

scientific article

Proinvasion metastasis drivers in early-stage melanoma are oncogenes

scientific article

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

scientific article

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas

scientific article published in September 2005

Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy

scientific article

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

scientific article published on July 2004

Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.

scientific article

Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth ⬇️

scientific article published on June 4, 1998

Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy

scientific article

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

scientific article

SF2312 is a natural phosphonate inhibitor of enolase

scientific article

SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway.

scientific article published in June 2008

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

scientific article published on 02 February 2011

STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA

scientific article

STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers

scientific article published on 18 October 2018

SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities

scientific article published on 17 April 2002

Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

scientific article published on November 2006

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

scientific article

Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation

scholarly article

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

scientific article published in Nature

Stromal biology of pancreatic cancer

scientific article published on July 2007

Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57 KIP2 requires binding to proliferating cell nuclear antigen ⬇️

scientific article published on February 17, 1998

Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a

scientific article

Survival factor NFIL3 restricts FOXO-induced gene expression in cancer

scientific article published on April 2013

Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma

scientific article published on 01 June 2019

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

scientific article published on 27 March 2019

Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis

scientific article published on 7 October 2002

Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer

scientific article published on 6 February 2017

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.

scientific article published on 8 February 2017

TMIC-14. AUTO-/PARACRINE SIGNALING OF PI3K/AKT/YKL-40 IN MESENCHYMAL GLIOBLASTOMA PROGRESSION

scientific article published on 5 November 2018

TMIC-22. DECIPHERING GLIOMA INTRINSIC TRANSCRIPTIONAL SUBTYPES IDENTIFIES TUMOR EVOLUTION ASSOCIATES WITH CHANGES IN IMMUNE-MICROENVIRONMENT

scientific article published on 6 November 2017

Take care of your chromosomes lest cancer take care of you.

scientific article

Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma

scientific article

Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy

scientific article

Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

scientific article

Targeting YAP-dependent MDSC infiltration impairs tumor progression.

scientific article

Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection

scientific article published on July 2013

Telomerase extracurricular activities

scientific article

Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases

scientific article published on 16 February 2012

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

scientific article

Telomere dysfunction activates YAP1 to drive tissue inflammation

scientific article published on 21 September 2020

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

scientific article published in Nature

Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome

scientific article published on May 2015

Telomere dysfunction induces metabolic and mitochondrial compromise.

scientific article

Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer

scientific article published on 17 February 2008

Telomere dysfunction provokes regional amplification and deletion in cancer genomes.

scientific article

Telomere dysfunction suppresses multiple endocrine neoplasia in mice

scientific article

Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression

scientific article

Telomeres and mitochondria in the aging heart

scientific article published on April 2012

Telomeres and telomerase in cancer

scientific article

The Autophagy-related Gene 14 (Atg14) Is Regulated by Forkhead Box O Transcription Factors and Circadian Rhythms and Plays a Critical Role in Hepatic Autophagy and Lipid Metabolism ⬇️

scientific article published on September 19, 2012

The INK4a/ARF tumor suppressor: one gene—two products—two pathways ⬇️

scientific article published on 01 August 1998

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53 ⬇️

scientific article published on March 20, 1998

The LKB1 tumor suppressor negatively regulates mTOR signaling

scientific article

The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans

article

The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.

scientific article published in January 2004

The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis

scientific article published in April 2007

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

scientific article

The mighty mouse: genetically engineered mouse models in cancer drug development

scientific article published on 18 August 2006

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

scientific article

Towards patient-based cancer therapeutics

scientific article

Transcription factor FoxO1 is essential for enamel biomineralization

scientific article

Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

scientific article

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.

scientific article published in July 2017

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.

scientific article

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

scientific article

Tumor microenvironment remodeling enables bypass of oncogenic KRAS dependency in pancreatic cancer

scientific article published on 27 April 2020

Tumorigenic and Developmental Effects of Combined Germ-line Mutations in Rb and p53 ⬇️

scientific article published on January 1, 1994

USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation

scientific article published on 05 September 2019

Unique challenges for glioblastoma immunotherapy - Discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology ⬇️

scientific article published on 24 December 2020

Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma.

scientific article published in February 2007

Walking the telomere plank into cancer.

scientific article

What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator

scientific article published on 11 September 2008

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

scientific article published on 01 November 2019

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

scientific article

ZNF365 promotes stability of fragile sites and telomeres.

scientific article published on 17 June 2013

mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells

scientific article

mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival

scientific journal article

mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases

scientific article published on 25 February 2014

mTORC1 signaling governs hematopoietic stem cell quiescence

scientific article published on 02 April 2009

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

scholarly article

p16(INK4a) and p53 deficiency cooperate in tumorigenesis.

scientific article

p16(Ink4a) in melanocyte senescence and differentiation

scientific article published in March 2002

p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis

scientific article published on April 2004

p19 Arf induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation ⬇️

scientific article published on October 27, 1998

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

scientific article

p53: good cop/bad cop.

scientific article

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