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List of works by Remco H. Westerink

A comparison of the in vitro cyto- and neurotoxicity of brominated and halogen-free flame retardants: prioritization in search for safe(r) alternatives.

scientific article published on 7 January 2014

Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics

scientific article published on 10 October 2020

Activation and potentiation of human GABAA receptors by non-dioxin-like PCBs depends on chlorination pattern.

scientific article published on 6 September 2010

Acute disturbance of calcium homeostasis in PC12 cells as a novel mechanism of action for (sub)micromolar concentrations of organophosphate insecticides.

scientific article published on February 2014

Application of in vitro neurotoxicity testing for regulatory purposes: Symposium III summary and research needs.

scientific article

Are high-throughput measurements of intracellular calcium using plate-readers sufficiently accurate and reliable? ⬇️

scientific article published on September 24, 2010

Azole Fungicides Disturb Intracellular Ca2+ in an Additive Manner in Dopaminergic PC12 Cells ⬇️

scientific article published on May 24, 2013

Bromination pattern of hydroxylated metabolites of BDE-47 affects their potency to release calcium from intracellular stores in PC12 cells.

scientific article published on April 2010

CGRP1 receptor activation induces piecemeal release of protease-1 from mouse bone marrow-derived mucosal mast cells

scientific article published on 21 October 2010

Ca(2+) -independent vesicular catecholamine release in PC12 cells by nanomolar concentrations of Pb(2+).

scientific article

Calcium-related processes involved in the inhibition of depolarization-evoked calcium increase by hydroxylated PBDEs in PC12 cells.

scientific article

Caveats and limitations of plate reader-based high-throughput kinetic measurements of intracellular calcium levels.

scientific article published on 12 June 2011

Characterization of calcium responses and electrical activity in differentiating mouse neural progenitor cells in vitro.

scientific article published on 16 November 2013

Corrigendum to Recommendation on test readiness criteria for new approach methods in toxicology: exemplified for developmental neurotoxicity

scientific article published on 01 January 2019

Differential alterations of synaptic plasticity in dentate gyrus and CA1 hippocampal area of Calbindin-D28K knockout mice.

scientific article published on 22 February 2012

Differential effects of 20 non-dioxin-like PCBs on basal and depolarization-evoked intracellular calcium levels in PC12 cells.

scientific article

Do we really want to REACH out to in vitro?

scientific article

Don't judge a neuron only by its cover: neuronal function in in vitro developmental neurotoxicity testing.

scientific article published on 7 September 2012

Dual actions of lindane (γ-hexachlorocyclohexane) on calcium homeostasis and exocytosis in rat PC12 cells.

scientific article published on 21 June 2010

Dual role of calbindin-D28K in vesicular catecholamine release from mouse chromaffin cells.

scientific article

Estradiol inhibits depolarization-evoked exocytosis in PC12 cells via N-type voltage-gated calcium channels.

scientific article published on 19 November 2010

Exocytosis: using amperometry to study presynaptic mechanisms of neurotoxicity.

scientific article published on March 2004

Heterogeneity of catecholamine-containing vesicles in PC12 cells

scientific article published on 01 April 2000

High concentrations of MDMA ('ecstasy') and its metabolite MDA inhibit calcium influx and depolarization-evoked vesicular dopamine release in PC12 cells.

scientific article published on 7 April 2011

Immunoglobulinfree light chains reduce in an antigen-specific manner the rate of rise of action potentials of mouse non-nociceptive dorsal root ganglion neurons

scientific article published on 31 August 2013

In vitro neuroendocrine effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the AhR-expressing hypothalamic rat GnV-3 cell line.

scientific article published on 16 July 2013

Introduction to special issue: Neurotoxicity of brominated flame retardants and the quest for safer alternatives

scientific article published on 10 September 2015

Modulation of cell viability, oxidative stress, calcium homeostasis, and voltage- and ligand-gated ion channels as common mechanisms of action of (mixtures of) non-dioxin-like polychlorinated biphenyls and polybrominated diphenyl ethers.

scientific article published on 18 May 2013

Modulation of human GABAA receptor function: a novel mode of action of drugs of abuse.

scientific article published on 25 June 2011

Modulation of human α4β2 nicotinic acetylcholine receptors by brominated and halogen-free flame retardants as a measure for in vitro neurotoxicity ⬇️

scientific article published on June 28, 2012

Multiple novel modes of action involved in the in vitro neurotoxic effects of tetrabromobisphenol-A.

scientific article published on 30 April 2012

Neonatal exposure to brominated flame retardant BDE-47 reduces long-term potentiation and postsynaptic protein levels in mouse hippocampus

scientific article published on 5 February 2007

Neurotoxicity of PBDEs: Dingemans et al. Respond.

scientific article published in August 2011

Neurotoxicity of brominated flame retardants: (in)direct effects of parent and hydroxylated polybrominated diphenyl ethers on the (developing) nervous system

scientific article

Organochlorine Insecticides Lindane and Dieldrin and Their Binary Mixture Disturb Calcium Homeostasis in Dopaminergic PC12 Cells ⬇️

scientific article published on January 11, 2012

PCB-47, PBDE-47, and 6-OH-PBDE-47 differentially modulate human GABAA and alpha4beta2 nicotinic acetylcholine receptors.

scientific article published on 22 September 2010

Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug-drug interactions.

scientific article published on 03 October 2012

Potentiation of the human GABA(A) receptor as a novel mode of action of lower-chlorinated non-dioxin-like PCBs.

scientific article published in April 2010

Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C

scientific article published on 06 November 2020

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

scientific article published on 23 February 2018

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use.

scientific article

Selective inhibition of human heteromeric alpha9alpha10 nicotinic acetylcholine receptors at a low agonist concentration by low concentrations of ototoxic organic solvents.

scientific article published on 18 June 2008

Sense in Pb2+ sensing

scientific article published on 12 July 2012

The PC12 cell as model for neurosecretion

scientific article

The plastic brain: neurotoxicity of micro- and nanoplastics

scientific article published on 08 June 2020

Three Distinct Modes of Exocytosis Revealed by Amperometry in Neuroendocrine Cells ⬇️

scientific article published on February 16, 2011

Vesicular catecholamine release from rat PC12 cells on acute and subchronic exposure to polychlorinated biphenyls.

scientific article

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