List of works - Stephan Köhler

A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth

scientific article published on 30 December 2010

Analysis of the behavior of eryC mutants of Brucella suis attenuated in macrophages.

scientific article

Anti-virulence strategy against Brucella suis: synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors

scientific article published on 01 April 2011

Antimicrobials: targeting virulence genes necessary for intracellular multiplication

scientific article published on 15 February 2006

Brucella spp. of amphibians comprise genomically diverse motile strains competent for replication in macrophages and survival in mammalian hosts

scientific article published on 16 March 2017

Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?

scientific article published on December 2017

Brucella suis histidinol dehydrogenase: synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide

scientific article published on 01 June 2008

Characterization of Brucella suis clpB and clpAB mutants and participation of the genes in stress responses

scientific article

Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.

scientific article published in March 2010

Differential use of the two high-oxygen-affinity terminal oxidases of Brucella suis for in vitro and intramacrophagic multiplication.

scientific article

From the discovery of the Malta fever's agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis.

scientific article

Global Rsh-dependent transcription profile of Brucella suis during stringent response unravels adaptation to nutrient starvation and cross-talk with other stress responses.

scientific article published on 08 July 2013

Glutamate decarboxylase-dependent acid resistance in Brucella spp.: distribution and contribution to fitness under extremely acidic conditions.

scientific article

Identification and isolation of Brucella suis virulence genes involved in resistance to the human innate immune system.

scientific article

Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions

scientific article published on 24 February 2012

Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety

scientific article published on 13 February 2015

Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.

scientific article published on 21 February 2010

Lethality of Brucella microti in a murine model of infection depends on the wbkE gene involved in O-polysaccharide synthesis

scientific article published on 01 December 2019

Montpellier infectious diseases (MID): 1st annual meeting (2011).

scientific article published on 13 July 2011

N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases

scientific article published on 20 March 2015

Oxo- and thiooxo-imidazo[1,5-c]pyrimidine molecule library: beyond their interest in inhibition of Brucella suis histidinol dehydrogenase, a powerful protection tool in the synthesis of histidine analogues.

scientific article

Quantitative analysis of the Brucella suis proteome reveals metabolic adaptation to long-term nutrient starvation

scientific article

RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity.

scientific article

Requirement of norD for Brucella suis virulence in a murine model of in vitro and in vivo infection.

scientific article

Secretion of listeriolysin by Brucella suis inhibits its intramacrophagic replication.

scientific article

Structural basis for the rational design of new anti-Brucella agents: the crystal structure of the C366S mutant of L-histidinol dehydrogenase from Brucella suis

scientific article

Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.

scientific article published on 13 August 2007

The Glutaminase-Dependent System Confers Extreme Acid Resistance to New Species and Atypical Strains of Brucella.

scientific article

The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell

scientific article

The glutamic acid decarboxylase system of the new species Brucella microti contributes to its acid resistance and to oral infection of mice.

scientific article

The homologous and heterologous regions within the iap gene allow genus- and species-specific identification of Listeria spp. by polymerase chain reaction ⬇️

scientific article published on August 1, 1992

The intramacrophagic environment of Brucella suis and bacterial response.

scientific article

The stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virB

article

The virB operon is essential for lethality of Brucella microti in the Balb/c murine model of infection

scientific article published on 01 April 2011

Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production.

scientific article

Zinc metalloenzymes as new targets against the bacterial pathogen Brucella ⬇️

scientific article published on December 1, 2011

List of works by Stephan Köhler

A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth

Analysis of the behavior of eryC mutants of Brucella suis attenuated in macrophages.

Anti-virulence strategy against Brucella suis: synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors

Antimicrobials: targeting virulence genes necessary for intracellular multiplication

Brucella spp. of amphibians comprise genomically diverse motile strains competent for replication in macrophages and survival in mammalian hosts

Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?

Brucella suis histidinol dehydrogenase: synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide

Characterization of Brucella suis clpB and clpAB mutants and participation of the genes in stress responses

Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.

Differential use of the two high-oxygen-affinity terminal oxidases of Brucella suis for in vitro and intramacrophagic multiplication.

From the discovery of the Malta fever's agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis.

Global Rsh-dependent transcription profile of Brucella suis during stringent response unravels adaptation to nutrient starvation and cross-talk with other stress responses.

Glutamate decarboxylase-dependent acid resistance in Brucella spp.: distribution and contribution to fitness under extremely acidic conditions.

Identification and isolation of Brucella suis virulence genes involved in resistance to the human innate immune system.

Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions

Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety

Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.

Lethality of Brucella microti in a murine model of infection depends on the wbkE gene involved in O-polysaccharide synthesis

Montpellier infectious diseases (MID): 1st annual meeting (2011).

N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases

Oxo- and thiooxo-imidazo[1,5-c]pyrimidine molecule library: beyond their interest in inhibition of Brucella suis histidinol dehydrogenase, a powerful protection tool in the synthesis of histidine analogues.

Quantitative analysis of the Brucella suis proteome reveals metabolic adaptation to long-term nutrient starvation

RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity.

Requirement of norD for Brucella suis virulence in a murine model of in vitro and in vivo infection.

Secretion of listeriolysin by Brucella suis inhibits its intramacrophagic replication.

Structural basis for the rational design of new anti-Brucella agents: the crystal structure of the C366S mutant of L-histidinol dehydrogenase from Brucella suis

Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.

The Glutaminase-Dependent System Confers Extreme Acid Resistance to New Species and Atypical Strains of Brucella.

The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell

The glutamic acid decarboxylase system of the new species Brucella microti contributes to its acid resistance and to oral infection of mice.

The homologous and heterologous regions within the iap gene allow genus- and species-specific identification of Listeria spp. by polymerase chain reaction ⬇️

The intramacrophagic environment of Brucella suis and bacterial response.

The stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virB

The virB operon is essential for lethality of Brucella microti in the Balb/c murine model of infection

Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production.

Zinc metalloenzymes as new targets against the bacterial pathogen Brucella ⬇️