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List of works by Pedro Miguel Lacal

A proangiogenic peptide derived from vascular endothelial growth factor receptor-1 acts through alpha5beta1 integrin.

scientific article

Antitumor activity of a novel anti-vascular endothelial growth factor receptor-1 monoclonal antibody that does not interfere with ligand binding

scientific article published on 19 September 2016

Challenging resistance mechanisms to therapies for metastatic melanoma.

scientific article

Cilengitide downmodulates invasiveness and vasculogenic mimicry of neuropilin 1 expressing melanoma cells through the inhibition of αvβ5 integrin.

scientific article published on 28 November 2014

Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes

scientific article

Ellagic Acid Inhibits Bladder Cancer Invasiveness and In Vivo Tumor Growth

scientific article

Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid

scientific article published on 14 November 2018

Expression of the soluble vascular endothelial growth factor receptor-1 in cutaneous melanoma: role in tumour progression.

scientific article published on May 2011

Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth

scientific journal article

Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion

scientific article

Increased melanoma growth and metastasis spreading in mice overexpressing placenta growth factor.

scientific article published on August 2006

Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan.

scientific article published on 8 May 2013

Inhibition of O6-alkylguanine DNA-alkyltransferase or poly(ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide

scientific article published on 01 August 1997

Inhibition of endothelial cell migration and angiogenesis by a vascular endothelial growth factor receptor-1 derived peptide.

scientific article published on 3 August 2008

MSH3 expression does not influence the sensitivity of colon cancer HCT116 cell line to oxaliplatin and poly(ADP-ribose) polymerase (PARP) inhibitor as monotherapy or in combination.

scientific article published on May 2013

Multiple Sclerosis Treatment and Melanoma Development

scientific article published on 22 April 2020

Neuropilin-1 as Therapeutic Target for Malignant Melanoma.

scientific article published on 03 June 2015

Neuropilin-1 expressing melanoma cells as a model to study the aggressiveness of metastatic melanoma.

scientific article published on 15 January 2015

Neuropilin-1 expression promotes invasiveness of melanoma cells through vascular endothelial growth factor receptor-2-dependent and -independent mechanisms.

scientific article published on 20 May 2013

On the Horizon: Targeting Next-Generation Immune Checkpoints for Cancer Treatment

scientific article published on 06 August 2019

PDIA3 Expression in Glioblastoma Modulates Macrophage/Microglia Pro-Tumor Activation

scientific article published on 03 November 2020

Pharmacological inhibition of poly(ADP-ribose) polymerase activity down-regulates the expression of syndecan-4 and Id-1 in endothelial cells.

scientific article

Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1.

scientific article published on 18 June 2013

Placenta growth factor and neuropilin-1 collaborate in promoting melanoma aggressiveness.

scientific article published on 29 January 2016

Platelet-derived growth factor C and calpain-3 are modulators of human melanoma cell invasiveness.

scientific article published on 10 October 2013

Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide

scientific article published on 8 November 2005

Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis

article

Poly(ADP-ribose) polymerase inhibitor olaparib hampers placental growth factor-driven activation of myelomonocytic cells.

scientific article published on 5 March 2018

Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo.

scientific article published on 3 April 2017

Targeting Tumor-Associated Macrophages to Increase the Efficacy of Immune Checkpoint Inhibitors: A Glimpse into Novel Therapeutic Approaches for Metastatic Melanoma

scientific article published on 17 November 2020

Targeting the PI3K/AKT/mTOR pathway overcomes the stimulating effect of dabrafenib on the invasive behavior of melanoma cells with acquired resistance to the BRAF inhibitor

scientific article published on 30 June 2016

Targeting the PTTG1 oncogene impairs proliferation and invasiveness of melanoma cells sensitive or with acquired resistance to the BRAF inhibitor dabrafenib.

scientific article published on 9 December 2017

Telomerase activity is sufficient to bypass replicative senescence in human limbal and conjunctival but not corneal keratinocytes.

scientific article published on December 2004

The Anti-Vascular Endothelial Growth Factor Receptor-1 Monoclonal Antibody D16F7 Inhibits Glioma Growth and Angiogenesis In Vivo.

scientific article

The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells

scientific article published on 10 August 2017

The sVEGFR1-i13 splice variant regulates a β1 integrin/VEGFR autocrine loop involved in the progression and the response to anti-angiogenic therapies of squamous cell lung carcinoma.

scientific article

Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non-competitive inhibitors

scientific article published on 28 August 2018

Thrombospondin-1 is part of a Slug-independent motility and metastatic program in cutaneous melanoma, in association with VEGFR-1 and FGF-2.

scientific article published on 13 October 2014

Vascular endothelial growth factor receptor-1 is deposited in the extracellular matrix by endothelial cells and is a ligand for the alpha 5 beta 1 integrin.

scientific article

miR-126-3p down-regulation contributes to dabrafenib acquired resistance in melanoma by up-regulating ADAM9 and VEGF-A

scientific article published on 21 June 2019

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