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List of works by Roland Stocker

A critical role for thioredoxin-interacting protein in diabetes-related impairment of angiogenesis

scientific article

A phosphatidylcholine-BODIPY 581/591 conjugate allows mapping of oxidative stress in P. falciparum-infected erythrocytes.

scientific article published in May 2009

A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL.

scientific article published on 02 October 2008

AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway

scientific article published on 25 November 2021

AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation

scientific article

Absence of systemic oxidative stress and increased CSF prostaglandin F2α in progressive MS.

scientific article published on 30 June 2016

Absence of the biliverdin reductase-a gene is associated with increased endogenous oxidative stress

scientific article published on 28 November 2017

Actions of “antioxidants” in the protection against atherosclerosis

scientific article published on August 15, 2012

Acute hypertriglyceridaemia in humans increases the triglyceride content and decreases the anti-inflammatory capacity of high density lipoproteins.

scientific article published on 21 November 2008

Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and FasL-Fas engagement

scientific journal article

Anti-atherosclerotic and anti-diabetic properties of probucol and related compounds

scientific article published on January 2008

Antioxidant activities of bile pigments

scientific article published in October 2004

Antioxidant defenses in human blood plasma and extra-cellular fluids

scientific article published on April 2016

Antioxidants in Translational Medicine

scientific article

Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging

scientific article

Assessment of myeloperoxidase activity by the conversion of hydroethidine to 2-chloroethidium

scientific article published on 16 January 2014

Association between both lipid and protein oxidation and the risk of fatal or non-fatal coronary heart disease in a human population

scientific article published on 01 January 2009

Barocycler-Based Concurrent Multiomics Method To Assess Molecular Changes Associated with Atherosclerosis Using Small Amounts of Arterial Tissue from a Single Mouse

scientific article published on 25 September 2019

Behavioral and cognitive data in mice with different tryptophan-metabolizing enzymes knocked out.

scientific article

Biodegradable and plasma-treated electrospun scaffolds coated with recombinant Olfactomedin-like 3 for accelerating wound healing and tissue regeneration

scientific article published on 29 September 2016

Biomarkers of Oxidative Stress Study IV: Ozone exposure of rats and its effect on antioxidants in plasma and bronchoalveolar lavage fluid

scientific article published on July 22, 2011

Biomarkers of oxidative stress study V: ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine

scientific article published on 19 April 2013

COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10

scientific article published on 23 March 2020

Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice

scientific article

Characterization of plasma labile heme in hemolytic conditions

scientific article

Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein

scientific article

Characterization of the kynurenine pathway in human oligodendrocytes

scientific article published in November 2007

Characterization of the oxidation products of BO-653 formed during peroxyl radical-mediated oxidation of human plasma

scientific article published in January 2005

Clinical Relevance of Biomarkers of Oxidative Stress

scientific article

CoQ₁₀ Function and Role in Heart Failure and Ischemic Heart Disease

scientific article published on 13 May 2015

Coenzyme Q(10) supplementation inhibits aortic lipid oxidation but fails to attenuate intimal thickening in balloon-injured New Zealand white rabbits.

scientific article published in August 2003

Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits

scientific article published in August 2002

Correction: AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation

scientific article published on 21 July 2016

Correction: Cultivation at high osmotic pressure confers ubiquinone 8-independent protection of respiration on Escherichia coli

scientific article published on 01 February 2020

Corrigendum to “Characterization of an indoliamine 2,3-dioxygenase-like protein found in humans and mice” [Gene (2007) 203–213]

article

Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboons

scientific article

Cryo-EM reveals distinct conformations of ATP synthase on exposure to ATP

Cultivation at high osmotic pressure confers ubiquinone 8-independent protection of respiration on Escherichia coli

scientific article published on 11 December 2019

Cultivation at high osmotic pressure confers ubiquinone 8–independent protection of respiration on Escherichia coli

scientific article published in 2020

Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells

scientific article

DNAzyme targeting c-jun suppresses skin cancer growth.

scientific article

Dealcoholized red wine decreases atherosclerosis in apolipoprotein E gene-deficient mice independently of inhibition of lipid peroxidation in the artery wall

scientific article published on 01 January 2004

Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function.

scientific article published on 14 June 2016

Destroyingc-junMessenger: New Insights into Biological Mechanisms of DNAzyme Function

scientific article published on June 1, 2012

Detailed protocol to assess in vivo and ex vivo myeloperoxidase activity in mouse models of vascular inflammation and disease using hydroethidine

scientific article published on 13 May 2016

Detection of reactive oxygen species derived from the family of NOX NADPH oxidases

scientific article published on September 13, 2012

Detection of specifically oxidized apolipoproteins in oxidized HDL

scientific article published on 01 January 2008

Determination of the nature of the heme environment in nitrosyl indoleamine 2,3-dioxygenase using Multiple-scattering analyses of X-ray absorption fine structure

scientific article published in May 2004

Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: a critical role for heme oxygenase-1.

scientific article published on 7 September 2013

Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis

scientific article published on February 2002

Endothelial indoleamine 2,3-dioxygenase-1 regulates the placental vascular tone and is deficient in intrauterine growth restriction and pre-eclampsia.

scientific article

Equivalent lipid oxidation profiles in advanced atherosclerotic lesions of carotid endarterectomy plaques obtained from symptomatic type 2 diabetic and nondiabetic subjects

scientific article published on 15 May 2010

Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis.

scientific article published on 19 May 2016

Evidence that phospholipids play a key role in pre-beta apoA-I formation and high-density lipoprotein remodeling

scientific article published in October 2002

Extended-duration thromboprophylaxis with enoxaparin after arthroscopic surgery of the anterior cruciate ligament: a prospective, randomized, placebo-controlled study

scientific article published on 01 July 2007

Finite element models can reproduce the effect of nucleotomy on the multi-axial compliance of human intervertebral discs

scientific article published on 16 June 2020

Flavivirus infection induces indoleamine 2,3-dioxygenase in human monocyte-derived macrophages via tumor necrosis factor and NF-κB.

scientific article published on February 2012

Flavonoid-Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial.

scientific article published on 30 October 2017

Formation of methionine sulfoxide-containing specific forms of oxidized high-density lipoproteins

scientific article

Gestational stress induces the unfolded protein response, resulting in heart defects

scientific article

Haem oxygenase-1 and cardiovascular disease: mechanisms and therapeutic potential

scientific article published on June 1, 2011

Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and Development

scientific article published on 20 November 2011

Heme Oxygenases in Cardiovascular Health and Disease

scientific article published on October 2016

Heme moves to center stage in cerebral malaria

scientific article published in June 2007

Heme oxygenase and iron: from bacteria to humans

scientific article published on January 2009

Heme oxygenase-1 increases endothelial progenitor cells.

scientific article published on 18 June 2009

Heme oxygenase-1: a novel drug target for atherosclerotic diseases?

scientific article

Highly Efficient Activatable MRI Probe to Sense Myeloperoxidase Activity

scientific article published on 04 May 2021

Hmox1 (Heme Oxygenase-1) Protects Against Ischemia-Mediated Injury via Stabilization of HIF-1α (Hypoxia-Inducible Factor-1α)

scientific article published on 19 November 2020

Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide.

scientific article published on 10 January 2005

Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability

scientific article published on 01 January 2007

Hypochlorous acid impairs endothelium-derived nitric oxide bioactivity through a superoxide-dependent mechanism.

scientific article

Improved analysis of hydroethidine and 2-hydroxyethidium by HPLC and electrochemical detection

scientific article published on 10 July 2007

Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE(-/-) mice from the development of atherosclerosis

scientific article published on 02 March 2012

Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis

scientific article published on 02 May 2019

Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration

scientific article published on 27 December 2006

Insulin resistance is a cellular antioxidant defense mechanism

scientific article

Interplay between heme oxygenase-1 and the multifunctional transcription factor yin yang 1 in the inhibition of intimal hyperplasia

scientific article published on 28 October 2010

Intimal thickening after arterial balloon injury is increased by intermittent repetitive hypoxia, but intermittent repetitive hyperoxia is not protective.

scientific article published on 2 August 2005

Is hypochlorous acid (HOCl) involved in age-related nuclear cataract?

scientific article published in March 2002

Is kynurenine a novel and important vasodilator in human septic shock?

scientific article published on 11 August 2009

Kynurenine is a novel endothelium-derived vascular relaxing factor produced during inflammation

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

scientific article

Lack of inhibitory effect of HDL on TNFalpha-induced adhesion molecule expression in human aortic endothelial cells

scientific article published in December 2002

Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet.

scientific article published on 28 February 2006

Letter by Stocker and Maghzal regarding article, "Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans".

scientific article published in March 2014

Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase

scientific article

Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression

scientific article published on 24 February 2006

Maternal undernutrition reduces aortic wall thickness and elastin content in offspring rats without altering endothelial function

scientific article published on 01 October 2006

Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria

scientific article published on 9 September 2003

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.

scientific article

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

scientific article published on 29 March 2018

Molecular mechanisms underlying the antiatherosclerotic and antidiabetic effects of probucol, succinobucol, and other probucol analogues

scientific article published on June 2009

Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque

scientific article published on 01 September 2018

NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

scientific article published in August 2017

NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?

scientific article published on 12 August 2017

Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques.

scientific article

Neither plasma coenzyme Q10 concentration, nor its decline during pravastatin therapy, is linked to recurrent cardiovascular disease events: a prospective case-control study from the LIPID study

scientific article published on 10 October 2005

Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation.

scientific article published on 19 April 2013

New insights into intracellular locations and functions of heme oxygenase-1

scientific article

Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosine

scientific article published on 23 May 2006

Oxidized lipid accumulates in the presence of alpha-tocopherol in atherosclerosis.

scientific article published on May 2002

Pharmacologic induction of heme oxygenase-1.

scientific article published on December 2007

Pharmacological characterization of the seven human NOX isoforms and their inhibitors

scientific article published on 11 July 2019

Pharmacology and Clinical Drug Candidates in Redox Medicine

scientific article

Post-translational Regulation of Human Indoleamine 2,3-Dioxygenase Activity by Nitric Oxide

scientific article published in Journal of Biological Chemistry

Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice

scientific article published on 09 February 2007

Probucol inhibits in-stent thrombosis and neointimal hyperplasia by promoting re-endothelialization.

scientific article published on 10 March 2006

Probucol promotes functional reendothelialization in balloon-injured rabbit aortas

scientific article published on 7 April 2003

Probucol protects against hypochlorite-induced endothelial dysfunction: identification of a novel pathway of probucol oxidation to a biologically active intermediate.

scientific article

Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1.

scientific article published on 13 September 2004

Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice.

scientific article published on 16 June 2005

Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency.

scientific article published on 7 June 2006

Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK.

scientific article

Quinine-induced thrombocytopenia: drug-dependent GPIb/IX antibodies inhibit megakaryocyte and proplatelet production in vitro

scientific article

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

scientific article published on 15 November 2018

Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications

scientific article

Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration.

scientific article published on 12 June 2014

Regio- and stereo-chemical oxidation of linoleic acid by human myoglobin and hydrogen peroxide: Tyr(103) affects rate and product distribution.

scientific article published on July 2004

Regulation of vascular tone by S-nitroso-myoglobin

scientific article published on 01 January 2004

Reply to Sedlak and Snyder: The Little Bighorn of the Biliverdin Reductase Amplification Cycle.

scientific article published in November 2009

Serum amyloid A in uremic HDL promotes inflammation

scientific article published on 26 January 2012

Simultaneous determination of coenzyme Q10, cholesterol, and major cholesterylesters in human blood plasma

scientific article published on January 2004

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation

scientific article published on 13 February 2019

Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction.

scientific article

Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells

scientific article published on 27 July 2010

Succinobucol induces apoptosis in vascular smooth muscle cells

scientific article published on 21 December 2011

Sustained expression of heme oxygenase-1 alters iron homeostasis in nonerythroid cells.

scientific article published on 18 April 2012

The Yeast Homolog of Heme Oxygenase-1 Affords Cellular Antioxidant Protection via the Transcriptional Regulation of Known Antioxidant Genes

scientific article published on November 16, 2010

The benefit of coenzyme Q10 supplements in the management of chronic heart failure: a long tale of promise in the continued absence of clear evidence

scientific article published on January 16, 2013

The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria

scientific article published on 14 February 2002

The endothelium-derived hyperpolarizing factor, H2O2, promotes metal-ion efflux in aortic endothelial cells: elemental mapping by a hard X-ray microprobe

scientific article published in October 2006

The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactions

scientific article (publication date: 3 May 2002)

The lipophilic antioxidants alpha-tocopherol and coenzyme Q10 reduce the replicative lifespan of Saccharomyces cerevisiae

scientific article published on 18 April 2010

The role of placental tryptophan catabolism

scientific article

The role of vitamin E in atherosclerosis

scientific article

The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture.

scientific article

The selenazal drug ebselen potently inhibits indoleamine 2,3-dioxygenase by targeting enzyme cysteine residues

scientific article published in January 2010

The use of antioxidant supplements in coronary heart disease

scientific article

Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110α) signaling.

scientific article

Transition to 37°C reveals importance of NADPH in mitigating oxidative stress in stored RBCs

scientific article published on 01 November 2019

Tryptophan catabolism is unaffected in chronic granulomatous disease

scientific article published on 01 October 2014

Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis

scientific article published on 01 December 2011

Turning Catabolism into Usefulness—A Jaundiced View

scientific article published on June 29, 2011

Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice

scientific article published on 27 February 2011

Vascular microdissection, perfusion, and excision of the murine arterial tree for use in atherogenic disease investigations

scientific article published on 01 September 2003

Vitamin E is not deficient in human atherosclerotic plaques

scientific article published in July 2004

Vitamin E oxidation in human atherosclerotic lesions

scientific article published in February 2002

Vitamin E.

scientific article