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List of works by Asako Otomo

A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice.

scientific article published on 4 March 2008

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

scientific article

ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics

scientific article

ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth

scientific article published on 19 March 2008

ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics

scientific article

Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function

scientific article published on 17 September 2018

An open-type microdevice to improve the quality of fluorescence labeling for axonal transport analysis in neurons

scientific article published on 09 May 2019

Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation

scientific article

Different human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in mice

scientific article

Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases

scientific article

Efficient differentiation and polarization of primary cultured neurons on poly(lactic acid) scaffolds with microgrooved structures

scientific article published on 21 April 2020

Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice

scientific article published on 20 July 2016

GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure.

scientific article published on 24 January 2014

Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain

scientific journal article

Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking

scientific article (publication date: 2010)

Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1(H46R) transgenic mouse model of ALS

scientific article published on 29 March 2011

Lower serum lipid levels are related to respiratory impairment in patients with ALS

scientific article published on 01 June 2010

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

scientific article published on 20 August 2018

Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration.

scientific article published on 4 May 2007

Natural history of young-adult amyotrophic lateral sclerosis

scientific article published on 01 August 2009

Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling.

scientific article

Sexually dimorphic expression of Dmrt1 and γH2AX in germ stem cells during gonadal development in Xenopus laevis

scientific article published on 26 February 2016

Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model.

scientific article published on 29 May 2018

The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis

scientific article published in Journal of Biological Chemistry

cDNA cloning of a new member of the FTZ-F1 subfamily from a rainbow trout ⬇️

scientific article published on February 11, 1998

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