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List of works by Lars Jordheim

5'-nucleotidase cN-II emerges as a new predictive biomarker of response to gemcitabine/platinum combination chemotherapy in non-small cell lung cancer

scientific article published on 16 February 2018

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases.

scientific article published on June 2013

Bacterial deoxyribonucleoside kinases are poor suicide genes in mammalian cells.

scientific article

Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation.

scientific article published on 18 July 2016

CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates

scientific article published on 17 August 2018

Calcium channel blockers impair the antitumor activity of anti-CD20 monoclonal antibodies by blocking EGR-1 induction

scientific article published on 26 August 2020

Cell proliferation and drug sensitivity of human glioblastoma cells are altered by the stable modulation of cytosolic 5'-nucleotidase II.

scientific article

Characterization of a gemcitabine-resistant murine leukemic cell line: reversion of in vitro resistance by a mononucleotide prodrug.

scientific article published on August 2004

Characterization of an inhibitory dynamic pharmacophore for the ERCC1-XPA interaction using a combined molecular dynamics and virtual screening approach.

scientific article

Cytosolic 5'-Nucleotidase II Silencing in a Human Lung Carcinoma Cell Line Opposes Cancer Phenotype with a Concomitant Increase in p53 Phosphorylation

scientific article published on 20 July 2018

Cytosolic 5'-nucleotidase II interacts with the leucin rich repeat of NLR family member Ipaf.

scientific article published on 26 March 2015

Deoxycytidine kinase and cN-II nucleotidase expression in blast cells predict survival in acute myeloid leukaemia patients treated with cytarabine.

scientific article

Detecting differential allelic expression using high-resolution melting curve analysis: application to the breast cancer susceptibility gene CHEK2.

scientific article

Determination and quantification of intracellular fludarabine triphosphate, cladribine triphosphate and clofarabine triphosphate by LC-MS/MS in human cancer cells

scientific article

Determination of the enzymatic activity of cytosolic 5'-nucleotidase cN-II in cancer cells: development of a simple analytical method and related cell line models.

scientific article published on 22 May 2015

Development of gene therapy in association with clinically used cytotoxic deoxynucleoside analogues.

scientific article published on 03 April 2009

Do hENT1 and RRM1 predict the clinical benefit of gemcitabine in pancreatic cancer?

scientific article published on August 2013

Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation

scientific article published on 24 September 2020

Expanding the clinical relevance of the 5'-nucleotidase cN-II/NT5C2

scientific article published on 25 October 2018

Expression of domains for protein-protein interaction of nucleotide excision repair proteins modifies cancer cell sensitivity to platinum derivatives and genomic stability.

scientific article

F-ara-AMP is a substrate of cytoplasmic 5'-nucleotidase II (cN-II): HPLC and NMR studies of enzymatic dephosphorylation

scientific article published on 01 March 2006

Fully validated assay for the quantification of endogenous nucleoside mono- and triphosphates using online extraction coupled with liquid chromatography-tandem mass spectrometry.

scientific article published on 15 March 2014

Functions of the multi-interacting protein KIDINS220/ARMS in cancer and other pathologies.

scientific article published on 27 November 2017

Further evidences for pharmacogenetic assessment of nucleoside analogue-treated patients ⬇️

scientific article published on November 4, 2010

Gemcitabine is active against clinical multiresistant Staphylococcus aureus strains and is synergistic with gentamicin.

scientific article published on 23 March 2012

Identification and characterization of inhibitors of cytoplasmic 5'-nucleotidase cN-II issued from virtual screening

scientific article

Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach

scientific article

Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface.

scientific article

In vitro susceptibility of CD4+ and CD8+ T cell subsets to fludarabine ⬇️

scientific article published on December 1, 2003

Increased expression of the large subunit of ribonucleotide reductase is involved in resistance to gemcitabine in human mammary adenocarcinoma cells.

scientific article published on August 2005

Influence of p53 and p21(WAF1) expression on sensitivity of cancer cells to cladribine.

scientific article published on January 2003

Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines

scientific article published on 23 December 2019

Lead optimization and biological evaluation of fragment-based cN-II inhibitors

scientific article published on 14 February 2019

Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma

scientific article published on 13 June 2012

Liquid chromatographic methods for the determination of endogenous nucleotides and nucleotide analogs used in cancer therapy: a review.

scientific article published on 24 May 2010

Nano-encapsulation of vitamin D3 active metabolites for application in chemotherapy: formulation study and in vitro evaluation.

scientific article published on 8 December 2012

Neutrophils protect lymphoma cells against cytotoxic and targeted therapies through CD11b/ICAM-1 binding.

scientific article published on 18 August 2017

Polymeric nanocapsules as drug carriers for sustained anticancer activity of calcitriol in breast cancer cells

scientific article published on 14 August 2018

Preparation, characterization and in vitro evaluation of a new nucleotide analogue prodrug cyclodextrin inclusion complexes.

scientific article

Pyrimidine nucleoside analogs in cancer treatment.

scientific article published on October 2003

Recent developments to improve the efficacy of cytotoxic nucleoside analogues.

scientific article published on June 2006

Regulation and activity of cytosolic 5'-nucleotidase II. A bifunctional allosteric enzyme of the Haloacid Dehalogenase superfamily involved in cellular metabolism.

scientific article

Regulation of tumor infiltrated innate immune cells by adenosine

scientific article published on 12 June 2020

Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene

scientific article

Sensitivity and gene expression profile of fresh human acute myeloid leukemia cells exposed ex vivo to AS602868 ⬇️

scientific article published on September 16, 2010

Sensitization of ara-C-resistant lymphoma cells by a pronucleotide analogue.

scientific article published in October 2003

Simultaneous analysis of eight nucleoside triphosphates in cell lines by liquid chromatography coupled with tandem mass spectrometry.

scientific article published on 25 September 2009

Single nucleotide polymorphisms in ABCB1 and CBR1 can predict toxicity to R-CHOP type regimens in patients with diffuse non-Hodgkin lymphoma

scientific article published on 30 January 2015

Stably transfected adherent cancer cell models with decreased expression of 5'-nucleotidase cN-II.

scientific article published on December 2016

Structural insights into the inhibition of cytosolic 5'-nucleotidase II (cN-II) by ribonucleoside 5'-monophosphate analogues

scientific article

Structure-activity relationships of β-hydroxyphosphonate nucleoside analogues as cytosolic 5'-nucleotidase II potential inhibitors: synthesis, in vitro evaluation and molecular modeling studies

scientific article published on 24 February 2014

Substrate cycles and drug resistance to 1-beta-D-arabinofuranosylcytosine (araC).

scientific article

Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors

scientific article published on 02 August 2018

Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors

scientific article published on 08 March 2019

Synthesis of Substituted 5'-Aminoadenosine Derivatives and Evaluation of Their Inhibitory Potential toward CD73

scientific article published on 25 July 2019

The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent

scientific article published on 09 October 2018

The druggability of intracellular nucleotide-degrading enzymes

scientific article

The purine analog fludarabine acts as a cytosolic 5′-nucleotidase II inhibitor

scientific article published on 02 February 2015

The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer.

scientific article published on 14 December 2010

Therapeutic enhancement of ER stress by insulin-like growth factor I sensitizes myeloma cells to proteasomal inhibitors.

scientific article published on 14 May 2013

Therapeutic perspectives for cN-II in cancer.

scientific article published on January 2013

Unexpected Growth-Promoting Effect of Oxaliplatin in Excision Repair Cross-Complementation Group 1 Transfected Human Colon Cancer Cells

scientific article published on 26 July 2018

Use of designed experiments for the improvement of pre-analytical workflow for the quantification of intracellular nucleotides in cultured cell lines.

scientific article

Zidovudine (AZT) has a bactericidal effect on enterobacteria and induces genetic modifications in resistant strains.

scientific article

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