List of works - Daniel Ketelhuth

3-Hydroxyanthralinic acid Metabolism Controls the Hepatic Srebp/Lipoprotein axis, Inhibits Inflammasome Activation in Macrophages, and Decreases Atherosclerosis in LDLR-/- Mice

scientific article published on 07 October 2019

Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice.

scientific article published on 7 May 2018

Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis

scientific article published on 01 August 2018

Adaptive Response of T and B Cells in Atherosclerosis

scientific article published in February 2016

Apolipoprotein B100 danger-associated signal 1 (ApoBDS-1) triggers platelet activation and boosts platelet-leukocyte proinflammatory responses

scientific article published on 08 May 2014

Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients.

scientific article

Atherosclerosis Susceptibility in Mice Is Independent of the V1 Immunoglobulin Heavy Chain Gene

scientific article

Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice

scientific article published on 07 April 2006

Autoantibody response to chromatographic fractions from oxidized LDL in unstable angina patients and healthy controls.

scientific article

Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall

scientific article published on 06 October 2011

ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages

scientific article published on 01 October 2018

Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans

scientific article published on 14 August 2020

Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma

scientific article published on 21 August 2019

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

article

Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability

scientific article published on 01 May 2019

High-density lipoprotein inhibits the uptake of modified low- density lipoprotein and the expression of CD36 and FcgammaRI.

scientific article

Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population

scientific article published on 15 November 2017

Hypercholesterolemia Induces Differentiation of Regulatory T Cells in the Liver.

scientific article published on 18 April 2017

Identification of a danger-associated peptide from apolipoprotein B100 (ApoBDS-1) that triggers innate proatherogenic responses.

scientific article

Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology

scientific article published on 01 January 2019

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

scientific article published on 01 July 2019

Immunomodulatory effects of interferon-γ on human fetal cardiac mesenchymal stromal cells

scientific article published on 04 December 2019

Immunostaining of Lymphocytes in Mouse Atherosclerotic Plaque

scientific article published on January 2015

Immunotherapy with tolerogenic apolipoprotein B-100-loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic mice

scientific article published on 28 February 2011

Increased microvascular permeability in the hamster cheek pouch induced by oxidized low density lipoprotein (oxLDL) and some fragmented apolipoprotein B proteins.

scientific article

Increased uptake of oxLDL does not exert lipotoxic effects in insulin-secreting cells

scientific article published on 01 May 2019

Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis

scientific article

Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice.

scientific article published on 5 March 2015

Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice.

scientific article

Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis

scientific article published on 18 February 2010

Isolation, characterization and biological activity of acidic phospholipase A2 isoforms from Bothrops jararacussu snake venom.

scientific article

Lack of invariant natural killer T cells affects lipid metabolism in adipose tissue of diet-induced obese mice.

scientific article published on 21 March 2013

Lipid-driven immunometabolic responses in atherosclerosis

scientific article published on 01 October 2018

Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice.

scientific article published in November 2018

Macrophages take up triacylglycerol-rich emulsions at a faster rate upon co-incubation with native and modified LDL: An investigation on the role of natural chylomicrons in atherosclerosis.

scientific article published in January 2002

Matrix metalloproteinases in atherothrombosis.

scientific article published on March 2010

Modulation of autoimmunity and atherosclerosis - common targets and promising translational approaches against disease.

scientific article published on 11 March 2015

Mycobacterium bovis BCG killed by extended freeze-drying induces an immunoregulatory profile and protects against atherosclerosis.

scientific article published on 12 September 2013

Proinflammatory Action of a New Electronegative Low-Density Lipoprotein Epitope

scientific article published on 20 August 2019

Quantification of Atherosclerosis in Mice

scientific article published on 12 June 2019

Role of PPAR-gamma in the modulation of CD36 and FcgammaRII induced by LDL with low and high degrees of oxidation during the differentiation of the monocytic THP-1 cell line.

scientific article

Soy protein containing isoflavones favorably influences macrophage lipoprotein metabolism but not the development of atherosclerosis in CETP transgenic mice

scientific article published on 01 July 2006

Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response

scientific article published on 6 April 2015

Subcutaneous immunization with heat shock protein-65 reduces atherosclerosis in Apoe−/− mice

scientific article published on 24 June 2011

The autoantibody repertoire against copper- or macrophage-modified LDL differs in normolipidemics and hypercholesterolemic patients.

scientific article published in March 2004

The immunometabolic role of indoleamine 2,3-dioxygenase in atherosclerotic cardiovascular disease: immune homeostatic mechanisms in the artery wall

scientific article published on 01 July 2019

The inflammatory cytokine interferon-gamma inhibits sortilin-1 expression in hepatocytes via the JAK/STAT pathway.

scientific article

The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis

scientific article published on 9 September 2017

The role of matrix metalloproteinases in atherothrombosis.

scientific article

The role of the kynurenine pathway of tryptophan metabolism in cardiovascular disease. An emerging field.

scientific article published on 19 January 2015

The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice ⬇️

scientific article published on 18 June 2012

Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis.

scientific article published on 14 February 2013

Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts

scientific article

Vaccination against T-cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis

scientific article

List of works by Daniel Ketelhuth

3-Hydroxyanthralinic acid Metabolism Controls the Hepatic Srebp/Lipoprotein axis, Inhibits Inflammasome Activation in Macrophages, and Decreases Atherosclerosis in LDLR-/- Mice

Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice.

Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis

Adaptive Response of T and B Cells in Atherosclerosis

Apolipoprotein B100 danger-associated signal 1 (ApoBDS-1) triggers platelet activation and boosts platelet-leukocyte proinflammatory responses

Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients.

Atherosclerosis Susceptibility in Mice Is Independent of the V1 Immunoglobulin Heavy Chain Gene

Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice

Autoantibody response to chromatographic fractions from oxidized LDL in unstable angina patients and healthy controls.

Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall

ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages

Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans

Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability

High-density lipoprotein inhibits the uptake of modified low- density lipoprotein and the expression of CD36 and FcgammaRI.

Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population

Hypercholesterolemia Induces Differentiation of Regulatory T Cells in the Liver.

Identification of a danger-associated peptide from apolipoprotein B100 (ApoBDS-1) that triggers innate proatherogenic responses.

Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Immunomodulatory effects of interferon-γ on human fetal cardiac mesenchymal stromal cells

Immunostaining of Lymphocytes in Mouse Atherosclerotic Plaque

Immunotherapy with tolerogenic apolipoprotein B-100-loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic mice

Increased microvascular permeability in the hamster cheek pouch induced by oxidized low density lipoprotein (oxLDL) and some fragmented apolipoprotein B proteins.

Increased uptake of oxLDL does not exert lipotoxic effects in insulin-secreting cells

Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis

Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice.

Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice.

Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis

Isolation, characterization and biological activity of acidic phospholipase A2 isoforms from Bothrops jararacussu snake venom.

Lack of invariant natural killer T cells affects lipid metabolism in adipose tissue of diet-induced obese mice.

Lipid-driven immunometabolic responses in atherosclerosis

Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice.

Macrophages take up triacylglycerol-rich emulsions at a faster rate upon co-incubation with native and modified LDL: An investigation on the role of natural chylomicrons in atherosclerosis.

Matrix metalloproteinases in atherothrombosis.

Modulation of autoimmunity and atherosclerosis - common targets and promising translational approaches against disease.

Mycobacterium bovis BCG killed by extended freeze-drying induces an immunoregulatory profile and protects against atherosclerosis.

Proinflammatory Action of a New Electronegative Low-Density Lipoprotein Epitope

Quantification of Atherosclerosis in Mice

Role of PPAR-gamma in the modulation of CD36 and FcgammaRII induced by LDL with low and high degrees of oxidation during the differentiation of the monocytic THP-1 cell line.

Soy protein containing isoflavones favorably influences macrophage lipoprotein metabolism but not the development of atherosclerosis in CETP transgenic mice

Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response

Subcutaneous immunization with heat shock protein-65 reduces atherosclerosis in Apoe−/− mice

The autoantibody repertoire against copper- or macrophage-modified LDL differs in normolipidemics and hypercholesterolemic patients.

The immunometabolic role of indoleamine 2,3-dioxygenase in atherosclerotic cardiovascular disease: immune homeostatic mechanisms in the artery wall

The inflammatory cytokine interferon-gamma inhibits sortilin-1 expression in hepatocytes via the JAK/STAT pathway.

The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis

The role of matrix metalloproteinases in atherothrombosis.

The role of the kynurenine pathway of tryptophan metabolism in cardiovascular disease. An emerging field.

The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice ⬇️

Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis.

Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts

Vaccination against T-cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis