List of works - Jean-Christophe Roux

A codon-optimized Mecp2 transgene corrects breathing deficits and improves survival in a mouse model of Rett syndrome.

scientific article

A knock-in mouse model for KCNQ2-related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment

scientific article published on 02 April 2020

Biogenic amines and their metabolites are differentially affected in the Mecp2-deficient mouse brain ⬇️

scientific article published on May 24, 2011

Biogenic amines in Rett syndrome: the usual suspects.

scientific article

Carotid chemodenervation approach to study oxygen sensing in brain stem catecholaminergic cells.

scientific article

Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice

scientific journal article

DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease.

scientific article published on 11 September 2013

Developmental plasticity of the carotid chemoafferent pathway in rats that are hypoxic during the prenatal period.

scientific article published in November 2007

Effect of desipramine on patients with breathing disorders in RETT syndrome. ⬇️

scientific article published on 27 December 2017

GABA and glutamate pathways are spatially and developmentally affected in the brain of Mecp2-deficient mice

scientific article

Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice

scientific article published on 08 January 2020

Isoform-specific anti-MeCP2 antibodies confirm that expression of the e1 isoform strongly predominates in the brain.

scientific article published on 4 October 2013

Long-term prenatal hypoxia alters maturation of brain catecholaminergic systems and motor behavior in rats.

scientific article published in November 2004

Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice

scientific journal article

Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway

scientific journal article

Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse ⬇️

scientific article published on October 14, 2010

Mutations in BCAP31 cause a severe X-linked phenotype with deafness, dystonia, and central hypomyelination and disorganize the Golgi apparatus

scientific article published on September 2013

Neurochemical development of the brainstem catecholaminergic cell groups in rat.

scientific article published in January 2003

Neurochemical reorganization of O2 chemoreflex pathway after carotid body denervation in rats

scientific article published on 01 January 2000

Noradrenaline deficiency as the origin of respiratory disorders in Rett syndrome an animal model

scientific article published in January 2006

O2-sensing after carotid chemodenervation: hypoxic ventilatory responsiveness and upregulation of tyrosine hydroxylase mRNA in brainstem catecholaminergic cells

scientific article published on 01 September 2000

Possible modulation of the mouse respiratory rhythm generator by A1/C1 neurones.

scientific article published on 22 November 2005

Postnatal development of neural chemoafferent pathway and respiration is altered following prenatal nicotine exposure in rats.

scientific article

Prenatal hypoxia and early postnatal maturation of the chemoafferent pathway.

scientific article published in January 2003

Prenatal hypoxia impairs the early postnatal development of the carotid chemoafferent pathway.

scientific article

Prenatal hypoxia impairs the postnatal development of neural and functional chemoafferent pathway in rat

scientific article published on 01 April 2000

Progressive motor and respiratory metabolism deficits in post-weaning Mecp2-null male mice.

scientific article published on 14 August 2010

Progressive noradrenergic deficits in the locus coeruleus of Mecp2 deficient mice.

scientific article

Rett syndrome from bench to bedside: recent advances.

scientific article

Severe offtarget effects following intravenous delivery of AAV9-MECP2 in a female mouse model of Rett syndrome

scientific article published on 28 December 2020

Spatiotemporal expression in mouse brain of Kiaa2022, a gene disrupted in two patients with severe mental retardation.

scientific article

State‐of‐the‐art therapies for Rett syndrome

scientific article published in 2022

Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome.

scientific article published in April 2007

Tyrosine hydroxylase deficit in the chemoafferent and the sympathoadrenergic pathways of the Mecp2 deficient mouse.

scientific article published on 24 September 2008

Ventilatory and central neurochemical reorganisation of O2 chemoreflex after carotid sinus nerve transection in rat

scientific article published on 01 February 2000

List of works by Jean-Christophe Roux

A codon-optimized Mecp2 transgene corrects breathing deficits and improves survival in a mouse model of Rett syndrome.

A knock-in mouse model for KCNQ2-related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment

Biogenic amines and their metabolites are differentially affected in the Mecp2-deficient mouse brain ⬇️

Biogenic amines in Rett syndrome: the usual suspects.

Carotid chemodenervation approach to study oxygen sensing in brain stem catecholaminergic cells.

Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice

DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease.

Developmental plasticity of the carotid chemoafferent pathway in rats that are hypoxic during the prenatal period.

Effect of desipramine on patients with breathing disorders in RETT syndrome. ⬇️

GABA and glutamate pathways are spatially and developmentally affected in the brain of Mecp2-deficient mice

Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice

Isoform-specific anti-MeCP2 antibodies confirm that expression of the e1 isoform strongly predominates in the brain.

Long-term prenatal hypoxia alters maturation of brain catecholaminergic systems and motor behavior in rats.

Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice

Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway

Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse ⬇️

Mutations in BCAP31 cause a severe X-linked phenotype with deafness, dystonia, and central hypomyelination and disorganize the Golgi apparatus

Neurochemical development of the brainstem catecholaminergic cell groups in rat.

Neurochemical reorganization of O2 chemoreflex pathway after carotid body denervation in rats

Noradrenaline deficiency as the origin of respiratory disorders in Rett syndrome an animal model

O2-sensing after carotid chemodenervation: hypoxic ventilatory responsiveness and upregulation of tyrosine hydroxylase mRNA in brainstem catecholaminergic cells

Possible modulation of the mouse respiratory rhythm generator by A1/C1 neurones.

Postnatal development of neural chemoafferent pathway and respiration is altered following prenatal nicotine exposure in rats.

Prenatal hypoxia and early postnatal maturation of the chemoafferent pathway.

Prenatal hypoxia impairs the early postnatal development of the carotid chemoafferent pathway.

Prenatal hypoxia impairs the postnatal development of neural and functional chemoafferent pathway in rat

Progressive motor and respiratory metabolism deficits in post-weaning Mecp2-null male mice.

Progressive noradrenergic deficits in the locus coeruleus of Mecp2 deficient mice.

Rett syndrome from bench to bedside: recent advances.

Severe offtarget effects following intravenous delivery of AAV9-MECP2 in a female mouse model of Rett syndrome

Spatiotemporal expression in mouse brain of Kiaa2022, a gene disrupted in two patients with severe mental retardation.

State‐of‐the‐art therapies for Rett syndrome

Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome.

Tyrosine hydroxylase deficit in the chemoafferent and the sympathoadrenergic pathways of the Mecp2 deficient mouse.

Ventilatory and central neurochemical reorganisation of O2 chemoreflex after carotid sinus nerve transection in rat