List of works - Lucjan S Wyrwicz

A European survey on the insights of patients living with metastatic colorectal cancer: the patient journey before, during and after diagnosis - an Eastern European perspective

scientific article published on 01 September 2020

A common cis-element in promoters of protein synthesis and cell cycle genes

scientific article published on 09 March 2007

A phase II study of avelumab in MSI-H metastatic colorectal cancer patients - Trial in progress

scientific article published on 01 June 2018

ARLTS1 Trp149Stop Mutation and the Risk of Ovarian Cancer

scientific article published on 01 May 2007

Adding oxaliplatin (OX) do neoadjuvant therapy of locally advanced rectal cancer (LARC): Still promising option?

scientific article published on 01 June 2018

Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines

scientific article published on 2 January 2013

Application of 3D-Jury, GRDB, and Verify3D in fold recognition

scientific article published on January 2003

Association between Preoperative Pelvic Irradiation and Toxicity of Subsequent Chemotherapy in Rectal Cancer.

scientific article

AutoMotif Server for prediction of phosphorylation sites in proteins using support vector machine: 2007 update

scientific article published on 8 November 2007

AutoMotif server: prediction of single residue post-translational modifications in proteins

article by Dariusz Plewczynski et al published 15 May 2005 in Bioinformatics

AutoMotif server: prediction of single residue post-translational modifications in proteins

scientific article

Avelumab (anti-PD-L1) as first-line switch-maintenance or second-line therapy in patients with advanced gastric or gastroesophageal junction cancer: phase 1b results from the JAVELIN Solid Tumor trial

scientific article published on 04 February 2019

Avelumab in patients with previously treated metastatic melanoma: phase 1b results from the JAVELIN Solid Tumor trial

scientific article published on 16 January 2019

Barrett's esophagus associates with a variant of IL23R gene

scientific article published on 14 June 2008

CD52 gene polymorphism and its potential effect on the response to alemtuzumab in renal transplant recipients.

scientific article

Characterization of hnRNP K protein-RNA interactions.

scientific article

Clinical relevance of molecular diagnostics in gastrointestinal (GI) cancer: European Society of Digestive Oncology (ESDO) expert discussion and recommendations from the 17th European Society for Medical Oncology (ESMO)/World Congress on Gastrointes

scientific article published on 21 October 2017

Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human

scientific article

Cooperative binding of the hnRNP K three KH domains to mRNA targets

scientific article published on 01 November 2004

Cytomegalovirus immediate early gene UL37 encodes a novel MHC-like protein.

scientific article

Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe

scientific article published in Mar 2022

Detailed mechanism of squalene epoxidase inhibition by terbinafine

scientific article published on 13 January 2011

Detecting reliable non interacting proteins (NIPs) significantly enhancing the computational prediction of protein-protein interactions using machine learning methods.

scientific article published on 7 January 2016

Distant homologs of anti-apoptotic factor HAX1 encode parvalbumin-like calcium binding proteins

scientific article

Does the addition of oxaliplatin to preoperative chemoradiation benefit cT4 or fixed cT3 rectal cancer treatment? A subgroup analysis from a prospective study.

scientific article

ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins

scientific article

Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients With First-line, Advanced Gastric Cancer: The KEYNOTE-062 Phase 3 Randomized Clinical Trial

scientific article published on 03 September 2020

Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial

scientific article published on 8 February 2018

Efficacy, safety, and pharmacokinetics of the anti-programmed cell death receptor-1 (PD-1) monoclonal antibody, tislelizumab (BGB-A317) in a phase 2, open-label, multicenter study to investigate in patients with unresectable hepatocellular carcinoma

scientific article published on 01 June 2018

Epstein-Barr virus late gene transcription depends on the assembly of a virus-specific preinitiation complex

scientific article

FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases

scientific article

First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial ⬇️

journal article from 'The Lancet' published in 2021

Fold recognition insights into function of herpes ICP4 protein.

scientific article published on 17 September 2007

Functional features of gene expression profiles differentiating gastrointestinal stromal tumours according to KIT mutations and expression

scientific article

GROWTH RATE OF PARAGANGLIOMAS RELATED TO GERMLINE MUTATIONS OF THE SDHX GENES.

scientific article published on 14 December 2016

Gene expression alterations induced by low molecular weight heparin during bowel anastomosis healing in rats

scientific article published on March 18, 2011

Guidelines from the Polish Surgical Society and Polish Society of Oncological Surgery Concerning Quality Assurance for Centres Performing Cytoreductive Procedures and HIPEC Procedures in the Treatment of Primary and Secondary Peritoneal Tumours

scientific article published on 16th Jun 2020

Guidelines of the Association of Polish Surgeons and the Polish Society of Surgical Oncology on the accreditation of healthcare centers providing cytoreductive surgery and HIPEC for primary and secondary peritoneal cancers

scientific article published on 18th May 2020

HSV-1 UL45 encodes a carbohydrate binding C-type lectin protein

scientific article

Hematological Toxicity of Hypofractionated Radiotherapy: A Review of the Available Evidence

article

Herpes glycoprotein gL is distantly related to chemokine receptor ligands.

scientific article

Heterogeneous nuclear ribonucleoprotein K enhances insulin-induced expression of mitochondrial UCP2 protein

scientific journal article

Heterogeneous nuclear ribonucleoprotein K protein associates with multiple mitochondrial transcripts within the organelle.

scientific article

High-density Peptide Arrays Help to Identify Linear Immunogenic B-cell Epitopes in Individuals Naturally Exposed to Malaria Infection

scientific article published on 10 January 2019

Homologues of HSV-1 nuclear egress factor UL34 are potential phosphoinositide-binding proteins.

scientific article

How unique is the rice transcriptome?

scientific article

Identification of Herpes TATT-binding protein.

scientific article

Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-beta1 (PRKCB1) gene locus

scientific article published on 01 August 2003

Impact of pelvic bone marrow irradiation on the hematological toxicity of subsequent chemotherapy in rectal cancer

scientific article published on 12 December 2018

Integrating genomics, proteomics and bioinformatics in translational studies of molecular medicine.

scientific article published on September 2009

Interleukin-1 receptor antagonist levels predict favorable outcome after bermekimab, a first-in-class true human interleukin-1α antibody, in a phase III randomized study of advanced colorectal cancer

scientific article published on 12 December 2018

Is there any association of dose received by pelvic bone marrow in preoperative radiotherapy in rectal cancer with hematological toxicity of subsequent oxaliplatin-based chemotherapy?

scientific article published on 01 June 2018

KMAD: knowledge-based multiple sequence alignment for intrinsically disordered proteins.

scientific article published on 14 November 2015

Landscape of the hnRNP K protein-protein interactome

scientific journal article

LigProf: a simple tool for in silico prediction of ligand-binding sites

scientific article published on 03 January 2007

Ligand.Info small-molecule Meta-Database.

scientific article published in December 2004

Long-course oxaliplatin-based preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized phase III study.

scientific article published on 15 February 2016

Long-course preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study

scientific article published on 01 August 2019

Lymphocyte-to-monocyte ratio (LMR) is prognostic factor for selection of neoadjuvant treatment in locally advanced rectal cancer patients: Sub-set analysis of Polish-2 study

scientific article published on 01 June 2017

MABp1 as a novel antibody treatment for advanced colorectal cancer: a randomised, double-blind, placebo-controlled, phase 3 study

scientific article published on 13 January 2017

Mapping the substrate binding site of phenylacetone monooxygenase from Thermobifida fusca by mutational analysis.

scientific article

Mediastinal paragangliomas related to SDHx gene mutations.

scientific article published on 30 September 2016

Microarray Inspector: tissue cross contamination detection tool for microarray data

scientific article

Mitochondria-associated satellite I RNA binds to hnRNP K protein

scientific journal article

Molecular defense mechanisms of Barrett's metaplasia estimated by an integrative genomics

scientific article published on 30 March 2007

Molecular determinants archetypical to the phylum Nematoda

scientific article

Molecular phylogenetics of the RrmJ/fibrillarin superfamily of ribose 2'-O-methyltransferases.

scientific article

Neoadjuvant chemotherapy with or without oxaliplatin after short-course radiotherapy in high-risk rectal cancer: A subgroup analysis from a prospective study

scientific article published on 16 August 2020

Neoadjuvant treatment for unresectable rectal cancer: an interim analysis of a multicentre randomized study

scientific article published on 13 April 2013

Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer

scientific article published in March 2022

ORFeus: Detection of distant homology using sequence profiles and predicted secondary structure

scientific article

P-095MSCMCC gastric cancer cohort: indirect comparison between adjuvant chemoradiation and perioperative chemotherapy in gastric cancer patients in a referral site.

scientific article

P-225The addition of oxaliplatin increases pathological complete response: a meta-analysis of randomized controlled trials on radiochemotherapy in rectal cancer.

scientific article published on 21 June 2016

Palliative radiotherapy and chemotherapy instead of surgery in symptomatic rectal cancer with synchronous unresectable metastases: a phase II study

scientific article published on 06 September 2013

Palliative radiotherapy and chemotherapy instead of surgery in symptomatic rectal cancer with synchronous unresectable metastases: long-term results of a phase II study.

scientific article

Pembrolizumab with or without chemotherapy versus chemotherapy for first-line treatment of advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma: The Phase 3 KEYNOTE-062 Study

scientific article published on 01 July 2019

Phase II randomized study of two oxaliplatin and 5-fluorouracil regimens in the second line palliative chemotherapy of metastatic pancreatic cancer patients (MazoviaGI-1)

scientific article published on 01 June 2017

Phase III, randomised trial of avelumab versus physician's choice of chemotherapy as third-line treatment of patients with advanced gastric or gastro-oesophageal junction cancer: primary analysis of JAVELIN Gastric 300

scientific article published on 01 October 2018

Plant nitric oxide synthase: a never-ending story?

article

Polish clinical practice guideline on hyperthermic intraperitoneal chemotherapy (HIPEC) with cytoreductive surgery in peritoneal malignancy treatment

scientific article published on 29 August 2014

Pre-treatment endogenous interleukin-1 receptor antagonist (IL-1Ra) levels in metastatic colorectal cancer (mCRC) patients are associated with clinical outcomes after anti-interleukin-1a therapy (MABp1)

scientific article published on 01 June 2017

Predicting protein structures accurately

scientific article

Prognostic value of microRNA expression in operable non-small cell lung cancer patients

scientific article

Prolonged enteral nutrition after total gastrectomy due to cancer: Phase III study

scientific article published on 01 June 2017

ProteinSplit: splitting of multi-domain proteins using prediction of ordered and disordered regions in protein sequences for virtual structural genomics

scientific article

Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

scientific article published on 01 October 2018

Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

scientific article published on 01 July 2017

Safety, efficacy and patient-reported outcomes with trifluridine/tipiracil in pretreated metastatic colorectal cancer: results of the PRECONNECT study

scientific article published on 01 June 2020

ShapeGTB: The role of local DNA shape in prioritization of functional variants in human promoters with machine learning

scientific article

ShapeGTB: the role of local DNA shape in prioritization of functional variants in human promoters with machine learning

scientific article published on 29 November 2018

Structural bioinformatics of the general transcription factor TFIID.

scientific article

Structure prediction, evolution and ligand interaction of CHASE domain

scientific article

Support-vector-machine classification of linear functional motifs in proteins.

scientific article

Target specific compound identification using a support vector machine.

scientific article

The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation

scientific article

The Phaeodactylum genome reveals the evolutionary history of diatom genomes

scientific article

The binding activity of yeast RNAs to yeast Hek2p and mammalian hnRNP K proteins, determined using the three-hybrid system

scientific article published on 01 January 2005

The distribution of human endogenous retrovirus K-113 in health and autoimmune diseases in Poland

scientific article published on 22 February 2011

The feasibility of short-course radiotherapy in a watch-and-wait policy for rectal cancer

scientific article published on 24 May 2017

The fold recognition of CP2 transcription factors gives new insights into the function and evolution of tumor suppressor protein p53.

scientific article

The international open-label early-access study of trifluridine/tipiracil (TAS-102) in patients with pretreated metastatic colorectal cancer (phase IIIb)

scientific article published on 01 June 2017

The mitotic entry regulator NIPA is a prototypic BIR domain protein.

scientific article published on 6 May 2008

The role of serum tumour markers, inflammation-based markers and circulating tumour cells as surrogate biomarkers of early response to neoadjuvant systemic treatment in patients with resectable gastric cancer

scientific article published on 01 June 2017

Three clinical variants of gastroesophageal reflux disease form two distinct gene expression signatures.

scientific article

Uncharacterized DUF1574 leptospira proteins are SGNH hydrolases.

scientific article

Understanding of metastatic colorectal cancer (mCRC) in the real world: Initial results from a European survey on the unmet needs of patients living with metastatic colorectal cancer

scientific article published on 01 June 2018

Unexpected domain composition of MACC1 links MET signaling and apoptosis.

scientific article

Watch and wait policy after preoperative radiotherapy for rectal cancer; management of residual lesions that appear clinically benign.

scientific article published on 22 October 2015

Zasady stosowania dootrzewnowej chemioterapii w hipertermii (HIPEC) w leczeniu nowotworów złośliwych powierzchni otrzewnej w połączeniu z zabiegami cytoredukcyjnymi: zalecenia krajowe

scientific article published on 8 January 2015

mRNA cap-1 methyltransferase in the SARS genome

scientific article published in June 2003

List of works by Lucjan S Wyrwicz

A European survey on the insights of patients living with metastatic colorectal cancer: the patient journey before, during and after diagnosis - an Eastern European perspective

A common cis-element in promoters of protein synthesis and cell cycle genes

A phase II study of avelumab in MSI-H metastatic colorectal cancer patients - Trial in progress

ARLTS1 Trp149Stop Mutation and the Risk of Ovarian Cancer

Adding oxaliplatin (OX) do neoadjuvant therapy of locally advanced rectal cancer (LARC): Still promising option?

Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines

Application of 3D-Jury, GRDB, and Verify3D in fold recognition

Association between Preoperative Pelvic Irradiation and Toxicity of Subsequent Chemotherapy in Rectal Cancer.

AutoMotif Server for prediction of phosphorylation sites in proteins using support vector machine: 2007 update

AutoMotif server: prediction of single residue post-translational modifications in proteins

AutoMotif server: prediction of single residue post-translational modifications in proteins

Avelumab (anti-PD-L1) as first-line switch-maintenance or second-line therapy in patients with advanced gastric or gastroesophageal junction cancer: phase 1b results from the JAVELIN Solid Tumor trial

Avelumab in patients with previously treated metastatic melanoma: phase 1b results from the JAVELIN Solid Tumor trial

Barrett's esophagus associates with a variant of IL23R gene

CD52 gene polymorphism and its potential effect on the response to alemtuzumab in renal transplant recipients.

Characterization of hnRNP K protein-RNA interactions.

Clinical relevance of molecular diagnostics in gastrointestinal (GI) cancer: European Society of Digestive Oncology (ESDO) expert discussion and recommendations from the 17th European Society for Medical Oncology (ESMO)/World Congress on Gastrointes

Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human

Cooperative binding of the hnRNP K three KH domains to mRNA targets

Cytomegalovirus immediate early gene UL37 encodes a novel MHC-like protein.

Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe

Detailed mechanism of squalene epoxidase inhibition by terbinafine

Detecting reliable non interacting proteins (NIPs) significantly enhancing the computational prediction of protein-protein interactions using machine learning methods.

Distant homologs of anti-apoptotic factor HAX1 encode parvalbumin-like calcium binding proteins

Does the addition of oxaliplatin to preoperative chemoradiation benefit cT4 or fixed cT3 rectal cancer treatment? A subgroup analysis from a prospective study.

ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins

Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients With First-line, Advanced Gastric Cancer: The KEYNOTE-062 Phase 3 Randomized Clinical Trial

Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial

Efficacy, safety, and pharmacokinetics of the anti-programmed cell death receptor-1 (PD-1) monoclonal antibody, tislelizumab (BGB-A317) in a phase 2, open-label, multicenter study to investigate in patients with unresectable hepatocellular carcinoma

Epstein-Barr virus late gene transcription depends on the assembly of a virus-specific preinitiation complex

FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases

First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial ⬇️

Fold recognition insights into function of herpes ICP4 protein.

Functional features of gene expression profiles differentiating gastrointestinal stromal tumours according to KIT mutations and expression

GROWTH RATE OF PARAGANGLIOMAS RELATED TO GERMLINE MUTATIONS OF THE SDHX GENES.

Gene expression alterations induced by low molecular weight heparin during bowel anastomosis healing in rats

Guidelines from the Polish Surgical Society and Polish Society of Oncological Surgery Concerning Quality Assurance for Centres Performing Cytoreductive Procedures and HIPEC Procedures in the Treatment of Primary and Secondary Peritoneal Tumours

Guidelines of the Association of Polish Surgeons and the Polish Society of Surgical Oncology on the accreditation of healthcare centers providing cytoreductive surgery and HIPEC for primary and secondary peritoneal cancers

HSV-1 UL45 encodes a carbohydrate binding C-type lectin protein

Hematological Toxicity of Hypofractionated Radiotherapy: A Review of the Available Evidence

Herpes glycoprotein gL is distantly related to chemokine receptor ligands.

Heterogeneous nuclear ribonucleoprotein K enhances insulin-induced expression of mitochondrial UCP2 protein

Heterogeneous nuclear ribonucleoprotein K protein associates with multiple mitochondrial transcripts within the organelle.

High-density Peptide Arrays Help to Identify Linear Immunogenic B-cell Epitopes in Individuals Naturally Exposed to Malaria Infection

Homologues of HSV-1 nuclear egress factor UL34 are potential phosphoinositide-binding proteins.

How unique is the rice transcriptome?

Identification of Herpes TATT-binding protein.

Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-beta1 (PRKCB1) gene locus

Impact of pelvic bone marrow irradiation on the hematological toxicity of subsequent chemotherapy in rectal cancer

Integrating genomics, proteomics and bioinformatics in translational studies of molecular medicine.

Interleukin-1 receptor antagonist levels predict favorable outcome after bermekimab, a first-in-class true human interleukin-1α antibody, in a phase III randomized study of advanced colorectal cancer

Is there any association of dose received by pelvic bone marrow in preoperative radiotherapy in rectal cancer with hematological toxicity of subsequent oxaliplatin-based chemotherapy?

KMAD: knowledge-based multiple sequence alignment for intrinsically disordered proteins.

Landscape of the hnRNP K protein-protein interactome

LigProf: a simple tool for in silico prediction of ligand-binding sites

Ligand.Info small-molecule Meta-Database.

Long-course oxaliplatin-based preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized phase III study.

Long-course preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study

Lymphocyte-to-monocyte ratio (LMR) is prognostic factor for selection of neoadjuvant treatment in locally advanced rectal cancer patients: Sub-set analysis of Polish-2 study

MABp1 as a novel antibody treatment for advanced colorectal cancer: a randomised, double-blind, placebo-controlled, phase 3 study

Mapping the substrate binding site of phenylacetone monooxygenase from Thermobifida fusca by mutational analysis.

Mediastinal paragangliomas related to SDHx gene mutations.

Microarray Inspector: tissue cross contamination detection tool for microarray data

Mitochondria-associated satellite I RNA binds to hnRNP K protein

Molecular defense mechanisms of Barrett's metaplasia estimated by an integrative genomics

Molecular determinants archetypical to the phylum Nematoda

Molecular phylogenetics of the RrmJ/fibrillarin superfamily of ribose 2'-O-methyltransferases.

Neoadjuvant chemotherapy with or without oxaliplatin after short-course radiotherapy in high-risk rectal cancer: A subgroup analysis from a prospective study

Neoadjuvant treatment for unresectable rectal cancer: an interim analysis of a multicentre randomized study

Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer

ORFeus: Detection of distant homology using sequence profiles and predicted secondary structure

P-095MSCMCC gastric cancer cohort: indirect comparison between adjuvant chemoradiation and perioperative chemotherapy in gastric cancer patients in a referral site.

P-225The addition of oxaliplatin increases pathological complete response: a meta-analysis of randomized controlled trials on radiochemotherapy in rectal cancer.

Palliative radiotherapy and chemotherapy instead of surgery in symptomatic rectal cancer with synchronous unresectable metastases: a phase II study

Palliative radiotherapy and chemotherapy instead of surgery in symptomatic rectal cancer with synchronous unresectable metastases: long-term results of a phase II study.

Pembrolizumab with or without chemotherapy versus chemotherapy for first-line treatment of advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma: The Phase 3 KEYNOTE-062 Study

Phase II randomized study of two oxaliplatin and 5-fluorouracil regimens in the second line palliative chemotherapy of metastatic pancreatic cancer patients (MazoviaGI-1)

Phase III, randomised trial of avelumab versus physician's choice of chemotherapy as third-line treatment of patients with advanced gastric or gastro-oesophageal junction cancer: primary analysis of JAVELIN Gastric 300

Plant nitric oxide synthase: a never-ending story?