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List of works by Paul Dent

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines

scientific article

17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species

scientific article

2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process.

scientific article published on May 2005

7-hydroxystaurosporine (UCN-01) and ionizing radiation combine to inhibit the growth of Bcl-2-overexpressing U937 leukemia cells through a non-apoptotic mechanism.

scientific article

A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2.

scientific article published on 2 June 2004

A Serotype 5/3 Adenovirus Expressing MDA-7/IL-24 Infects Renal Carcinoma Cells and Promotes Toxicity of Agents That Increase Ros and Ceramide Levels ⬇️

scientific article published on November 30, 2010

A fiber-modified mesothelin promoter-based conditionally replicating adenovirus for treatment of ovarian cancer

scientific article

A mosaic fiber adenovirus serotype 5 vector containing reovirus sigma 1 and adenovirus serotype 3 knob fibers increases transduction in an ovarian cancer ex vivo system via a coxsackie and adenovirus receptor-independent pathway

scientific article

AR-12 Inhibits Chaperone Proteins Preventing Virus Replication and the Accumulation of Toxic Misfolded Proteins

scientific article published on 16 September 2016

Acquired and innate resistance to the cancer-specific apoptosis-inducing cytokine, mda-7/IL-24: not insurmountable therapeutic problems

scientific article

Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.

scientific article published on February 2005

Activation of MAP kinase pathways by TRAIL: don't expect the obvious

scientific article

Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes

scientific article published in February 2002

Adaphostin and bortezomib induce oxidative injury and apoptosis in imatinib mesylate-resistant hematopoietic cells expressing mutant forms of Bcr/Abl

scientific article published on 14 February 2006

Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma

scientific article

Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network

scientific article published on 19 October 2011

An adenoviral vector expressing human adenovirus 5 and 3 fiber proteins for targeting heterogeneous cell populations ⬇️

scientific article published on September 9, 2010

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda -7/IL-24–mediated toxicity ⬇️

scientific article published on May 9, 2011

Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation

scientific article published on 18 August 2005

Approaches for monitoring signal transduction changes in normal and cancer cells

scientific article published on January 2007

Arsenic in leukemia: a RSKy business

scientific article published on 15 August 2013

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

scientific article

Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis

scholarly article

Autophagy and the functional roles of Atg5 and beclin-1 in the anti-tumor effects of 3beta androstene 17alpha diol neuro-steroid on malignant glioma cells

scientific article published on 16 April 2009

Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24)

scientific article published on September 2011

Autophagy: cancer's friend or foe?

scientific article

BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing

scientific article published on 29 May 2009

Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24.

scientific article published on November 2003

Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress

scientific article

Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes ⬇️

scientific article published on May 1, 2003

Bile acids as regulatory molecules

scientific article published on 03 April 2009

Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes

scientific article published in February 2004

Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes

scientific article

Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway

scientific article

Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation

scientific article

Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms

scientific article published on 23 March 2004

Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF-κB and Bim

scientific article

CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies

scientific article

CHK1 Inhibitors in Combination Chemotherapy: Thinking Beyond the Cell Cycle ⬇️

scientific article published on April 1, 2011

CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential

scientific article

Cancer Terminator Viruses and Approaches for Enhancing Therapeutic Outcomes ⬇️

scientific article published on January 1, 2012

Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo ⬇️

scientific article published on July 12, 2011

Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

scientific article published on February 2008

Celecoxib enhances [sorafenib + sildenafil] lethality in cancer cells and reverts platinum chemotherapy resistance

scientific article published on 29 September 2015

Ceramide in the prostate

scientific article published on 19 August 2013

Characterization of Cdk9(55) and differential regulation of two Cdk9 isoforms

scientific article

Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis

scientific article

Chimeric adenoviral vectors incorporating a fiber of human adenovirus 3 efficiently mediate gene transfer into prostate cancer cells

scientific article

Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells

scientific article

Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to ST1571.

scientific article published in November 2002

Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species

scientific article

Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells

scientific article published in December 2003

Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism

scientific article published in November 2002

Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells

scientific article published on 28 August 2013

Conjugated Bile Acids Activate the Sphingosine–1–Phosphate Receptor 2 in Primary Rodent Hepatocytes ⬇️

scientific article published on November 30, 2011

Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes

scientific article

Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling

scientific article

Constitutive activation of NF-kappaB in human hepatocellular carcinoma: evidence of a cytoprotective role.

scientific article

Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol

scientific article

Conversion of drug-induced differentiation to apoptosis by pharmacologic cyclin-dependent kinase inhibitors

scientific article

Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, a

scientific article

Crosstalk between ERK, AKT, and cell survival

scientific article published on 14 January 2014

Cyclin D1 overexpression increases the susceptibility of human U266 myeloma cells to CDK inhibitors through a process involving p130-, p107- and E2F-dependent S phase entry

scientific article published on 15 February 2006

Cyclin kinase inhibitor p21 potentiates bile acid-induced apoptosis in hepatocytes that is dependent on p53.

scientific article

Cystine dimethyl ester induces apoptosis through regulation of PKC-δ and PKC-ε in prostate cancer cells

scientific article

Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer

scientific article

Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2.

scientific article

DMC: novel celecoxib derivatives to rap cancer

scientific article

Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation

scientific article

Differential regulation of autophagy and cell viability by ceramide species

scientific article

Differential requirement of the epidermal growth factor receptor for G protein-mediated activation of transcription factors by lysophosphatidic acid

scientific article

Disruption of IκB Kinase (IKK)-mediated RelA Serine 536 Phosphorylation Sensitizes Human Multiple Myeloma Cells to Histone Deacetylase (HDAC) Inhibitors ⬇️

scientific article published on August 4, 2011

Disruption of Src function potentiates Chk1-inhibitor–induced apoptosis in human multiple myeloma cells in vitro and in vivo ⬇️

scientific article published on December 10, 2010

Dissecting the roles of checkpoint kinase 1/CDC2 and mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 in relation to 7-hydroxystaurosporine-induced apoptosis in human multiple myeloma cells

scientific article published on 29 August 2006

EGFRvIII-mediated radioresistance through a strong cytoprotective response

scientific article published in August 2003

ERK plays the baddie (again).

scientific article published on 5 September 2013

Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells

scientific article published on May 2012

Enhanced prostate cancer gene transfer and therapy using a novel serotype chimera cancer terminator virus (Ad.5/3-CTV).

scientific article

Enhanced transduction of malignant glioma with a double targeted Ad5/3-RGD fiber-modified adenovirus

scientific article published in September 2006

Enhancing CHK1 inhibitor lethality in glioblastoma ⬇️

scientific article published on April 1, 2012

Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery

scientific article

Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling

scientific article published on April 2003

Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells

scientific article

Eradication of therapy-resistant human prostate tumors using a cancer terminator virus

scientific article published on June 2007

Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach

scientific article

Ethanol reduces p38 kinase activation and cyclin D1 protein expression after partial hepatectomy in rats

scientific article

Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response

scientific article published on February 2007

Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

scientific article published on 7 December 2007

FADD the bad in head and neck cancer

scientific article published on 15 August 2013

Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.

scientific article

Fingolimod augments Pemetrexed killing of non-small cell lung cancer and overcomes resistance to ERBB inhibition

scientific article published on 02 November 2018

Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells

scientific article published in September 2002

Follicle-stimulating hormone activates extracellular signal-regulated kinase but not extracellular signal-regulated kinase kinase through a 100-kDa phosphotyrosine phosphatase

scientific article

Future Approaches for the Therapy of Malignant Glioma: Targeting Genes Mediating Invasion ⬇️

scientific article published on April 1, 2012

GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease

scientific article

GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases

scientific article published on October 2015

Gene profiling and the cyclin-dependent kinase inhibitor flavopiridol: what's in a name?

scientific article published in July 2004

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.

scientific article published on February 2005

HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo

scientific article published on 9 October 2017

HDAC inhibitors enhance the immunotherapy response of melanoma cells

scientific article published on 17 May 2017

HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells

scientific article published on 18 December 2013

HDACIs and the inhibition of invasive potential

scientific article published on 15 August 2013

HIV protease inhibitor lopinavir-induced TNF-alpha and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages

scientific article published on 31 March 2009

HSPA5/Dna K may be a useful target for human disease therapies

scientific article

Histone Deacetylase Inhibitors Interact with Melanoma Differentiation Associated-7/Interleukin-24 to Kill Primary Human Glioblastoma Cells ⬇️

scientific article published on 09 May 2013

Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway

scientific article

Histone deacetylase inhibitors activate NF-κB in human leukemia cells through an ATM/NEMO-related pathway

scientific article published on August 2016

Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells ⬇️

scientific article published on May 1, 2003

Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy

scientific article published on 22 August 2013

Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24.

scientific article published on 08 March 2009

Human chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo

scientific article

Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatment

scientific article published on 18 October 2006

Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth ⬇️

scientific article published on May 8, 2003

Induction of Apoptosis in BCR/ABL+ Cells By Histone Deacetylase Inhibitors Involves Reciprocal Effects on the RAF/MEK/ERK and JNK Pathways ⬇️

scientific article published on September 1, 2003

Induction of apoptosis in human leukemia cells by the CDK1 inhibitor CGP74514A.

scientific article published on March 2002

Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process

scientific article

Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis

scientific article

Induction of tumor necrosis factor by bryostatin 1 is involved in synergistic interactions with paclitaxel in human myeloid leukemia cells

scientific article

Infectivity enhanced adenoviral-mediated mda-7/IL-24 gene therapy for ovarian carcinoma

scientific article published in August 2004

Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy

scientific article

Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo ⬇️

scientific article published on November 1, 2010

Inhibition of MEK/ERK1/2 sensitizes lymphoma cells to sorafenib-induced apoptosis

scientific article

Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition

scientific article published in September 2003

Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes

scientific article

Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma

scientific article

Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes

scientific article published in April 2002

Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells

scientific article published on May 2002

Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells

scientific article published on January 2008

Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells

scientific article published on 26 November 2003

Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells

scientific article published on 9 July 2008

Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin

scientific article published on November 2007

Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells

scientific article published in June 2002

Ionizing radiation causes a dose-dependent release of transforming growth factor alpha in vitro from irradiated xenografts and during palliative treatment of hormone-refractory prostate carcinoma

scientific article

Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer

scientific article

Irofulven: resurgence for alkylating therapy in cancer?

scientific article

Janus-faced Kupffer cells in tumor metastasis

scientific article published on 15 August 2013

Kinase inhibitors and cytotoxic drug resistance.

scientific article

LBH-589 (panobinostat) potentiates fludarabine anti-leukemic activity through a JNK- and XIAP-dependent mechanism ⬇️

scientific article published on November 8, 2011

Lapatinib and Obatoclax Kill Breast Cancer Cells through Reactive Oxygen Species-Dependent Endoplasmic Reticulum Stress ⬇️

scientific article published on September 18, 2012

Lapatinib and Obatoclax Kill Tumor Cells through Blockade of ERBB1/3/4 and through Inhibition of BCL-xL and MCL-1 ⬇️

scientific article published on February 22, 2012

Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation

scientific article published on 10 June 2008

Loss of the Bcl-2 phosphorylation loop domain is required to protect human myeloid leukemia cells from flavopiridol-mediated mitochondrial damage and apoptosis

scientific article published in March 2002

Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling

scientific article

MAPK pathways in radiation responses

scientific article

MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity.

scientific article published in July 2003

MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells

scientific article published on 10 August 2004

MDA-7/IL-24 as a cancer therapeutic: from bench to bedside

scientific article

MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors

scientific article published on 19 March 2008

MDA-7/IL-24 regulates proliferation, invasion and tumor cell radiosensitivity: a new cancer therapy?

scientific article

MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism

scientific article

MDA-7/IL-24: multifunctional cancer killing cytokine

scientific article

MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine

scientific article

MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma

scientific article published on 10 December 2012

MDA-9/syntenin is a key regulator of glioma pathogenesis

scientific article published on 04 December 2013

MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo

scientific article published on 15 October 2006

MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism

scientific article

MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual Abl/Src inhibitor BMS-354/825

scientific article published on 11 January 2007

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

scientific article

Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways

scientific article

Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions

scientific article

Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine

scientific article

Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol

scientific article published on 3 September 2008

Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein

scientific article published on October 2004

Melanoma Differentiation-associated Gene 7/IL-24 Exerts Cytotoxic Effects by Altering the Alternative Splicing of Bcl-x Pre-mRNA via the SRC/PKCδ Signaling Axis

scientific article published on 12 August 2016

Melanoma differentiation associated gene-7 (mda-7)/IL-24: a 'magic bullet' for cancer therapy?

scientific article published on May 2007

Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner

scientific article published on February 2003

Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species.

scientific article published on December 2003

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma

scientific article published on 23 November 2006

Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress

scientific article

Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways

scientific article

Melanoma differentiation associated gene-7/interleukin-24 reverses multidrug resistance in human colorectal cancer cells

scientific article published on November 2007

Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo

scientific article published on August 2003

Met in lung cancer.

scientific article published on 11 March 2014

Minting a new class of polo-like-kinase inhibitors

scientific article

Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727

scientific article published on 09 September 2013

Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.

scientific article published on September 2008

Molecular target-based therapy of pancreatic cancer

scientific article published on February 2006

Multi-kinase inhibition in ovarian cancer

scientific article published on 18 October 2013

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function

scientific article published on 12 February 2016

Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo

scientific article published on 31 May 2016

Multi-kinase modulation for colon cancer therapy

scientific article published on 16 August 2013

Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling

scientific journal article

Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling

scientific article published on September 2016

Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance

scientific article published on January 2009

NF-kappaB protects rat ARL-6 hepatocellular carcinoma cells against hydrogen peroxide-induced apoptosis

scientific article published on 3 November 2005

New methods to control neuroblastoma growth

scientific article

Nexavar/Stivarga and viagra interact to kill tumor cells

scientific article published on September 2015

Non-BRAF targeted therapies for melanoma: protein kinase inhibitors in Phase II clinical trials

scientific article published on 06 February 2014

Non-canonical p53 signaling to promote invasion

scientific article published on 16 August 2013

Not so WEE: targeting G₂/M to kill mesothelioma cells

scientific article

OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies

scientific article published on August 2015

OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins

scientific article

OSU-03012 interacts with lapatinib to kill brain cancer cells ⬇️

scientific article published on September 18, 2012

OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells

scientific article published on 18 April 2006

OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells

scientific article published on 08 January 2008

OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing ⬇️

scientific article published on February 15, 2012

Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo ⬇️

scientific article published on March 12, 2012

Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.

scientific article published on 4 January 2012

Ovarian cancer targeted adenoviral-mediated mda-7/IL-24 gene therapy

scientific article published on 12 October 2005

PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells

scientific article published on May 2013

PARP inhibitors are not all equal

scientific article published on 26 August 2013

PDE5 inhibitors enhance celecoxib killing in multiple tumor types

scientific article

PDE5 inhibitors enhance the lethality of [pemetrexed + sorafenib].

scientific article published on 9 January 2017

PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide

scientific article published on 26 November 2016

PDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells

scientific article

PERK-dependent regulation of HSP70 expression and the regulation of autophagy

scientific article published on 17 January 2008

PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells

scientific article published on 13 February 2008

PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells

scientific article

PI3K: A rational target for ovarian cancer therapy?

scientific article

Palbociclib augments Neratinib killing of tumor cells that is further enhanced by HDAC inhibition

scientific article published on 05 September 2018

Pazopanib and HDAC inhibitors interact to kill sarcoma cells

scientific article

Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells

scientific article published on January 2002

Pharmocologic inhibitors of the mitogen activated protein kinase cascade have the potential to interact with ionizing radiation exposure to induce cell death in carcinoma cells by multiple mechanisms

scientific article

Phase I study of pemetrexed with sorafenib in advanced solid tumors

scientific article published on 18 May 2016

Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells

scientific article published on 18 December 2013

Phosphorylation of the myosin-binding subunit of myosin phosphatase by Raf-1 and inhibition of phosphatase activity

scientific article (publication date: 25 January 2002)

Poly(ADP-ribose) Polymerase 1 Modulates the Lethality of CHK1 Inhibitors in Mammary Tumors ⬇️

scientific article published on May 17, 2012

Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells

scientific article

Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3)

scientific journal article

Potentiation of the lethality of the histone deacetylase inhibitor LAQ824 by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells

scientific article published on November 2005

Prior exposure of pancreatic tumors to [sorafenib + vorinostat] enhances the efficacy of an anti-PD-1 antibody

scientific article published on 24 August 2018

Progression elevated gene-3, PEG-3, induces genomic instability in rodent and human tumor cells

scientific article

Protein kinase C-dependent activation of the tumor necrosis factor receptor-mediated extrinsic cell death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol

scientific article published in January 2003

RLIP76 in defense of radiation poisoning

scientific article published on October 2008

RLIP76 is a major determinant of radiation sensitivity

scientific article published in July 2005

Radiation-induced PARP activation is enhanced through EGFR-ERK signaling

scientific article published on August 2007

Radiation-induced cell signaling: inside-out and outside-in

scientific article published on March 2007

Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.

scientific article

Radiotherapy-induced signal transduction

scientific article

Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways

scientific article

Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic

scientific article published on 13 June 2016

Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling

scientific article

Regulation of OSU-03012 toxicity by ER stress proteins and ER stress-inducing drugs

scientific article

Regulation of autophagy by ceramide-CD95-PERK signaling

scientific article published on 5 October 2008

Regulation of dimethyl-fumarate toxicity by proteasome inhibitors

scientific article

Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and AUG3.

scientific article published in April 2003

Repurposing Tecfidera for cancer

scientific article published on 16 July 2016

Resveratrol Sensitizes Acute Myelogenous Leukemia Cells to Histone Deacetylase Inhibitors through Reactive Oxygen Species-Mediated Activation of the Extrinsic Apoptotic Pathway ⬇️

scientific article published on August 24, 2012

Reversing translational suppression and induction of toxicity in pancreatic cancer cells using a chemoprevention gene therapy approach

scientific article

Ribonucleotide reductase inhibition: regulation of the radiosensitive phenotype via NF kappa B and Bcl-2.

scientific article

Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions

scientific article published on October 2008

Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival

scientific article

Ruxolitinib synergizes with DMF to kill via BIM+BAD-induced mitochondrial dysfunction and via reduced SOD2/TRX expression and ROS

scientific article published on 12 March 2016

Searching for a cure: gene therapy for glioblastoma

scientific article published on 02 September 2008

Sequence dependent exposure of mammary carcinoma cells to Taxotere and the MEK1/2 inhibitor U0126 causes enhanced cell killing in vitro

scientific article published on November 2003

Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95

scientific article published on 24 December 2015

Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction ⬇️

scientific article published on September 30, 2010

Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death

scientific article published on August 2011

Simultaneous interruption of signal transduction and cell cycle regulatory pathways: implications for new approaches to the treatment of childhood leukemias

scientific article published on June 2007

Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells ⬇️

scientific article published on August 3, 2010

Sorafenib Enhances Pemetrexed Cytotoxicity through an Autophagy-Dependent Mechanism in Cancer Cells ⬇️

scientific article published on May 27, 2011

Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells ⬇️

scientific article published on May 1, 2012

Sorafenib and HDAC inhibitors synergize with TRAIL to kill tumor cells

scientific article

Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling

scientific article published on 07 June 2012

Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms

scientific article published on 29 May 2009

Sorafenib/regorafenib and lapatinib interact to kill CNS tumor cells

scientific article

Sorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene inhibition interact to kill tumor cells

scientific article published on 22 July 2013

Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation

scientific article published on 30 January 2007

Strategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomas

scholarly article

Stress and radiation-induced activation of multiple intracellular signaling pathways

scientific article

Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways

scientific article published on 8 May 2003

Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress

journal article published in 2006

Synergistic combinations of signaling pathway inhibitors: mechanisms for improved cancer therapy

scientific article published on 22 April 2009

Synergistic interactions between DMAG and mitogen-activated protein kinase kinase 1/2 inhibitors in Bcr/abl+ leukemia cells sensitive and resistant to imatinib mesylate

scientific article published on April 2006

Synergistic interactions between vorinostat and sorafenib in chronic myelogenous leukemia cells involve Mcl-1 and p21CIP1 down-regulation

scientific article

TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition

scientific article published on 25 January 2018

Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity

scientific article

Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva

scientific article published on June 2008

Targeting Mcl-1 for the therapy of cancer

scientific article

Targeting breast cancer-initiating/stem cells with melanoma differentiation-associated gene-7/interleukin-24.

scientific article

Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts

scientific article published on September 2009

Targeting the Bcl-2 family for cancer therapy

scientific article

The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways

scientific article published on 22 September 2009

The Bruton tyrosine kinase (BTK) inhibitor PCI‐32765 synergistically increases proteasome inhibitor activity in diffuse large‐B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells sensitive or resistant to bortezomib ⬇️

scientific article published on January 30, 2013

The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo

scientific article published on 27 January 2017

The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells

scientific article

The Regulation of Tumor Suppressor Genes by Oncogenes

scientific article published on January 1, 2003

The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling

scientific article published on 26 February 2016

The cyclin-dependent kinase inhibitor p21(CIP1/WAF1) blocks paclitaxel-induced G2M arrest and attenuates mitochondrial injury and apoptosis in p53-null human leukemia cells

scientific article

The development of MDA-7/IL-24 as a cancer therapeutic ⬇️

scientific article published on August 21, 2010

The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells

scientific article published on June 2005

The flip side of doxorubicin: Inflammatory and tumor promoting cytokines

scientific article published on 12 August 2013

The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib

scientific article published in May 2004

The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide

scientific article

The irreversible ERBB1/2/4 inhibitor neratinib interacts with the BCL-2 inhibitor venetoclax to kill mammary cancer cells.

scientific article published on 15 January 2018

The irreversible ERBB1/2/4 inhibitor neratinib interacts with the PARP1 inhibitor niraparib to kill ovarian cancer cells

scientific article published on 6 February 2018

The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress

scientific article

The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process ⬇️

scientific article published on April 15, 2003

The levels of mutant K-RAS and mutant N-RAS are rapidly reduced in a Beclin1 / ATG5 -dependent fashion by the irreversible ERBB1/2/4 inhibitor neratinib

scientific article

The multi-hit hypothesis in basal-like breast cancer

scientific article published on 15 August 2013

The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation

scientific article

The neuro-steroid, 5-androstene 3β,17α diol; induces endoplasmic reticulum stress and autophagy through PERK/eIF2α signaling in malignant glioma cells and transformed fibroblasts ⬇️

scientific article published on September 18, 2010

The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo

scientific article

The potential of virus-based gene therapies for treatment of metastatic kidney cancer ⬇️

scientific article published on June 1, 2011

The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571.

scientific article published on 31 July 2003

The role of cell signalling in the crosstalk between autophagy and apoptosis

scientific article published on 02 December 2013

The role of signal transduction pathways in drug and radiation resistance.

scientific article

The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism

scientific article

The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism

scientific article published on 15 September 2005

Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells

scientific article published on 24 March 2008

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

scientific article

Transient exposure of mammary tumors to PD184352 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth

scientific article published on November 2005

Tumor necrosis factor-alpha expressed constitutively in erythroid cells or induced by erythropoietin has negative and stimulatory roles in normal erythropoiesis and erythroleukemia

scientific article published on 29 August 2002

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically expres

scientific article

Unconventional Approaches to Modulating the Immunogenicity of Tumor Cells.

scientific article published on 3 January 2018

Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells

scientific article

Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway

scientific article published on 14 July 2010

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation

scientific article published on 12 October 2008

Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation

scientific article published on September 2008

Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate

scientific article published on 27 May 2008

[Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration

scientific article published on 26 December 2017

[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling

scientific article

[pemetrexed + sildenafil], via autophagy-dependent HDAC down-regulation, enhances the immunotherapy response of NSCLC cells

scientific article

mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.

scientific article

mda-7 (IL-24): signaling and functional roles.

scientific article

mda-7(IL-24) Inhibits Growth and Enhances Radiosensitivity of Glioma Cells In Vitro via JNK Signaling ⬇️

scientific article published on July 1, 2003

mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity ⬇️

scientific article published on October 1, 2010

mda-7/IL-24: exploiting cancer's Achilles' heel

scientific article

mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine

scientific article published on 7 February 2006

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