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List of works by Ulrika S H Simonsson

A Pharmacokinetic-Pharmacodynamic Model of Morphine Exposure and Subsequent Morphine Consumption in Postoperative Pain

scientific article published on 11 January 2016

A Recirculatory Model for Pharmacokinetics and the Effects on Bispectral Index After Intravenous Infusion of the Sedative and Anesthetic AZD3043 in Healthy Volunteers.

scientific article published on 19 June 2015

A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions.

scientific article published on 14 December 2017

A model based assessment of the CYP2B6 and CYP2C19 inductive properties by artemisinin antimalarials: implications for combination regimens.

scientific article

A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis

scientific article published on 01 June 2020

A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations

scientific article published on 9 November 2017

A multistate tuberculosis pharmacometric model: a framework for studying anti-tubercular drug effects in vitro.

scientific article published on 24 December 2015

A pharmacometric pulmonary model predicting the extent and rate of distribution from plasma to epithelial lining fluid and alveolar cells--using rifampicin as an example

scientific article

A semimechanistic pharmacokinetic-enzyme turnover model for rifampin autoinduction in adult tuberculosis patients.

scientific article published on 17 January 2012

A two-compartment effect site model describes the bispectral index after different rates of propofol infusion.

scientific article published on 23 April 2010

An example of optimal phase II design for exposure response modelling ⬇️

scientific article published on September 25, 2010

An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics.

scientific article

Analysis of opioid consumption in clinical trials: a simulation based analysis of power of four approaches.

scientific article published on 7 April 2017

Application of the Multistate Tuberculosis Pharmacometric Model in Patients With Rifampicin-Treated Pulmonary Tuberculosis

scientific article published on 17 May 2016

Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9.

scientific article published in July 2003

Assessing Pharmacodynamic Interactions in Mice using the Multistate Tuberculosis Pharmacometric and General Pharmacodynamic Interaction Models

scientific article published on 28 June 2017

Blood-brain barrier transport helps to explain discrepancies in in vivo potency between oxycodone and morphine.

scientific article

Comparisons of Analysis Methods for Assessment of Pharmacodynamic Interactions Including Design Recommendations

scientific article published on 21 June 2018

D optimal designs for three Poisson dose–response models ⬇️

scientific article published on February 19, 2013

Edoxaban Exposure-Response Analysis and Clinical Utility Index Assessment in Patients With Symptomatic Deep-Vein Thrombosis or Pulmonary Embolism.

scientific article published on 15 April 2016

Enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4'-hydroxymephenytoin in human plasma and urine by liquid chromatography/tandem mass spectrometry.

scientific article published in January 2006

Evaluation of initial and steady-state gatifloxacin pharmacokinetics and dose in pulmonary tuberculosis patients by using monte carlo simulations.

scientific article published on 17 June 2013

Evaluation of optimized bronchoalveolar lavage sampling designs for characterization of pulmonary drug distribution

scientific article published on 28 August 2015

Improved power for TB Phase IIa trials using a model-based pharmacokinetic-pharmacodynamic approach compared with commonly used analysis methods.

scientific article published on 16 May 2017

In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin.

scientific article published in September 2006

In vivo blood-brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics.

scientific article published on 8 June 2006

Individualised dosing algorithm and personalised treatment of high-dose rifampicin for tuberculosis

scientific article published on 25 July 2019

Intra- and extracellular activities of trimethoprim-sulfamethoxazole against susceptible and multidrug-resistant Mycobacterium tuberculosis

scientific article published on 22 September 2014

Medical Device Apps: An Introduction to Regulatory Affairs for Developers

scientific article published on 26 June 2020

Mobile Health Apps for Improvement of Tuberculosis Treatment: Descriptive Review

scientific article published on 21 April 2020

Model based design and analysis of phase II HIV-1 trials.

scientific article published on 11 July 2013

Model-based approach to dose optimization of lopinavir/ritonavir when co-administered with rifampicin.

scientific article

Modelling of pain intensity and informative dropout in a dental pain model after naproxcinod, naproxen and placebo administration ⬇️

scientific article published on June 1, 2011

Moxifloxacin population pharmacokinetics and model-based comparison of efficacy between moxifloxacin and ofloxacin in African patients

scientific article

Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine

scientific article published on 14 May 2012

Non-linear mixed effects modeling of antiretroviral drug response after administration of lopinavir, atazanavir and efavirenz containing regimens to treatment-naïve HIV-1 infected patients ⬇️

scientific article published on October 2, 2011

Optimal adaptive design in clinical drug development: a simulation example

scientific article published on 01 October 2007

Performance of nonlinear mixed effects models in the presence of informative dropout.

scientific article published on 25 November 2014

Pharmacokinetics of desmopressin administrated as an oral lyophilisate dosage form in children with primary nocturnal enuresis and healthy adults.

scientific article published in October 2006

Population Pharmacokinetics of Edoxaban in Patients with Non-Valvular Atrial Fibrillation in the ENGAGE AF-TIMI 48 Study, a Phase III Clinical Trial.

scientific article published on 7 March 2016

Population pharmacokinetics of edoxaban and its main metabolite in a dedicated renal impairment study.

scientific article published on 30 June 2015

Population pharmacokinetics of edoxaban in patients with symptomatic deep-vein thrombosis and/or pulmonary embolism--the Hokusai-VTE phase 3 study

scientific article

Population pharmacokinetics of ethambutol in South African tuberculosis patients.

scientific article

Population pharmacokinetics of lopinavir and ritonavir in combination with rifampicin-based antitubercular treatment in HIV-infected children.

scientific article published on January 2012

Population pharmacokinetics of lopinavir in combination with rifampicin-based antitubercular treatment in HIV-infected South African children.

scientific article

Population pharmacokinetics of morphine and morphine-6-glucuronide following rectal administration--a dose escalation study

scientific article published on 5 December 2014

Population pharmacokinetics of nevirapine in combination with rifampicin-based short course chemotherapy in HIV- and tuberculosis-infected South African patients.

scientific article

Population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children with tuberculosis: in silico evaluation of currently recommended doses

scientific article published on 31 January 2014

Population pharmacokinetics of rifampin in pulmonary tuberculosis patients, including a semimechanistic model to describe variable absorption

scientific article published on 7 April 2008

Population pharmacokinetics of rifapentine and its primary desacetyl metabolite in South African tuberculosis patients.

scientific article

Population pharmacokinetics, optimised design and sample size determination for rifampicin, isoniazid, ethambutol and pyrazinamide in the mouse

scientific article

Repeated Time-to-event Analysis of Consecutive Analgesic Events in Postoperative Pain

scientific article published on 23 October 2015

Simultaneous enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4'-hydroxymephenytoin in human plasma by liquid chromatography.

scientific article

The implications of model-informed drug discovery and development for tuberculosis

scientific article

The multistate tuberculosis pharmacometric model: a semi-mechanistic pharmacokinetic-pharmacodynamic model for studying drug effects in an acute tuberculosis mouse model

scientific article published on 15 February 2017

The use of liquid chromatography/mass spectrometry for quantitative analysis of oxycodone, oxymorphone and noroxycodone in Ringer solution, rat plasma and rat brain tissue.

scientific article published in January 2004

Transforming Translation Through Quantitative Pharmacology for High-Impact Decision Making in Drug Discovery and Development

scientific article published on 10 November 2019

Variability in the population pharmacokinetics of pyrazinamide in South African tuberculosis patients

scientific article published on 10 May 2006

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