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List of works by Christopher Keene

A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease.

scientific article published in October 2001

A case of nodular fasciitis causing compressive optic neuropathy

scientific article published on 01 March 2014

A comparative atlas of single-cell chromatin accessibility in the human brain

scientific article published on 12 October 2023

A diagnostic dilemma: infectious versus noninfectious multifocal choroiditis with panuveitis.

scientific article published on 28 January 2013

APOE genotype-dependent modulation of astrocyte chemokine CCL3 production.

scientific article published on 4 August 2014

APOE3, but not APOE4, bone marrow transplantation mitigates behavioral and pathological changes in a mouse model of Alzheimer disease

scientific article published on 4 July 2013

Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease.

scientific article published on 11 January 2013

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

scientific article published on 01 December 2019

An anatomic transcriptional atlas of human glioblastoma.

scientific article

Antagonism of neuronal prostaglandin E(2) receptor subtype 1 mitigates amyloid β neurotoxicity in vitro

scientific article

Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation

scientific article

Apolipoprotein E isoform-dependent microglia migration

scientific article

Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease

scientific article

Association between Cholesterol Exposure and Neuropathological Findings: The ACT Study

scientific article published on 19 July 2017

Associations between Use of Specific Analgesics and Concentrations of Amyloid-β 42 or Phospho-Tau in Regions of Human Cerebral Cortex.

scientific article published on 8 December 2017

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Author Correction: Human neocortical expansion involves glutamatergic neuron diversification

scientific article published in 2022

Autoimmune lymphocytic hypophysitis in association with autoimmune eye disease and sequential treatment with infliximab and rituximab.

scientific article published in August 2015

Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain

scientific article published on 01 May 2019

Biomarkers for Alzheimer’s disease

scientific article published on 01 August 2007

Cerebral cortical Aβ42 and PHF-τ in 325 consecutive brain autopsies stratified by diagnosis, location, and APOE.

scientific article

Characterization of cognitive impairments and neurotransmitter changes in a novel transgenic mouse lacking Slc10a4

scientific article published on 18 March 2016

Clinical-pathologic correlations in vascular cognitive impairment and dementia

scientific article published on 28 August 2015

Comparative cellular analysis of motor cortex in human, marmoset and mouse

scientific article published on 06 October 2021

Comparative transcriptomics reveals human-specific cortical features

scientific article published on 12 October 2023

Correction: Genetic data and cognitively defined late-onset Alzheimer's disease subgroups

scientific article published on 15 January 2019

DNA methylation of TOMM40-APOE-APOC2 in Alzheimer's disease.

scientific article published on 25 January 2018

Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia

scientific article published on 15 January 2015

Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models.

scientific article published on 21 November 2012

Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease

scientific article

Eicosanoid receptor subtype‐mediated opposing regulation of TLR‐stimulated expression of astrocyte glial‐derived neurotrophic factor

scientific article published on April 12, 2012

Epigenetic signature and enhancer activity of the human APOE gene.

scientific article

Erratum: Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome

scientific article published in Nature

First confirmed case of chronic traumatic encephalopathy in a professional bull rider

scientific article published on 28 December 2017

Flow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer's disease.

scientific article

Genetic data and cognitively defined late-onset Alzheimer's disease subgroups.

scientific article published on 4 December 2018

Genetic data and cognitively-defined late-onset Alzheimer's disease subgroups

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice

scientific article published on 22 January 2019

Genetic variants and functional pathways associated with resilience to Alzheimer's disease

scientific article published on 01 August 2020

Glucose levels during life and neuropathologic findings at autopsy among people never treated for diabetes.

scientific article published in August 2016

Hemorrhagic collision metastasis in a cerebral arteriovenous malformation

scientific article published on 19 September 2014

Hemorrhagic collision metastasis in a cerebral arteriovenous malformation

scientific article

Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE ε4.

scientific article

Human neocortical expansion involves glutamatergic neuron diversification

scientific article

Immunohistochemical profiling including beta-catenin in conjunctival melanocytic lesions

scientific article published in February 2017

Impaired Eukaryotic Elongation Factor 1A Expression in Alzheimer's Disease

scientific article

Importance of home study visit capacity in dementia studies

scientific article published on 18 November 2015

Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study

scientific article published on 14 June 2017

Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer's disease

scientific article published on 10 May 2021

Interindividual variation in human cortical cell type abundance and expression

scientific article published on 12 October 2023

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.

scientific article published in June 2019

Malignant Peripheral Nerve Sheath Tumor of the Lower Eyelid: Case Presentation and Literature Review

scientific article published on 20 May 2015

Massive intractable hemoptysis due to idiopathic granulomatous pulmonary veno-occlusive disease.

scientific article published in May 2013

Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

scientific article published on 12 October 2023

Multiplexed In-cell Immunoassay for Same-sample Protein Expression Profiling.

scientific article

Mutational status of IDH1 in uveal melanoma

scientific article published on 04 May 2016

Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos.

scientific article

Neural induction of adult bone marrow and umbilical cord stem cells.

scientific article

Neuropathological Comparison of Adult Onset and Juvenile Huntington's Disease with Cerebellar Atrophy: A Report of a Father and Son.

scientific article published on 11 October 2017

Neuropathological and transcriptomic characteristics of the aged brain.

scientific article

Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults.

scientific article

Novel mutations in ataxia telangiectasia and AOA2 associated with prolonged survival

scientific article

Orbital Metastasis of Undifferentiated/Anaplastic Thyroid Carcinoma.

scientific article published in September 2015

Orbital extension of anterior uveal melanoma after Baerveldt tube shunt implantation.

scientific article published in December 2014

Orbital neoplasms in adults: clinical, radiologic, and pathologic review.

scientific article published on October 2013

Orbital peripheral nerve sheath tumors.

scientific article

Partial depletion of striatal dopamine enhances penetrance of cognitive deficits in a transgenic mouse model of Alzheimer's disease

scientific article published on 30 March 2015

Performance of a Condensed Protocol That Reduces Effort and Cost of NIA-AA Guidelines for Neuropathologic Assessment of Alzheimer Disease.

scientific article published on 6 January 2017

Perivascular, but not parenchymal, cerebral engraftment of donor cells after non-myeloablative bone marrow transplantation

scientific article published on 06 April 2013

Pluripotency of mesenchymal stem cells derived from adult marrow

scientific article (publication date: 4 July 2002)

Precision Medicine: Clarity for the Complexity of Dementia.

scientific article published on 24 December 2015

Primary Gliosarcoma of the Optic Nerve: A Unique Adult Optic Pathway Glioma.

scientific article published on 11 October 2016

Prostaglandin E2 receptor subtype 2 regulation of scavenger receptor CD36 modulates microglial Aβ42 phagocytosis

scientific article

Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2.

scientific article published on 23 April 2009

Proteomics of human neurodegenerative diseases

scientific article published on October 2008

Psychosis in Spinocerebellar Ataxias: a Case Series and Study of Tyrosine Hydroxylase in Substantia Nigra.

scientific article

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

scientific article

Relative contributions of severe dopaminergic neuron ablation and dopamine depletion to cognitive impairment.

scientific article

Reply: LATE to the PART-y

scientific article published on 01 September 2019

Resistance to Alzheimer Disease Neuropathologic Changes and Apparent Cognitive Resilience in the Nun and Honolulu-Asia Aging Studies.

scientific article published on 11 May 2017

Retinal neovascularization and endogenous fungal endophthalmitis in intravenous drug users.

scientific article

Role of Cerebrospinal Fluid and Plasma Biomarkers in the Diagnosis of Neurodegenerative Disorders and Mild Cognitive Impairment

scientific article published on October 1, 2011

Selective dendritic degeneration of medium spiny neurons in dementia with Lewy bodies.

scientific article published in May 2006

Severely impaired learning and altered neuronal morphology in mice lacking NMDA receptors in medium spiny neurons.

scientific article

Sex differences in the genetic predictors of Alzheimer's pathology

scientific article published on 01 September 2019

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau

scientific article published on 01 August 2018

Sex-specific genetic predictors of Alzheimer's disease biomarkers

scientific article published on 02 July 2018

Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex

scientific article published on 12 October 2023

Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression

scientific article published on 12 April 2021

Single-cell DNA methylation and 3D genome architecture in the human brain

scientific article published on 12 October 2023

Suppressed Retinal Degeneration in Aged Wild Type and APPswe/PS1ΔE9 Mice by Bone Marrow Transplantation

scientific article published on June 4, 2013

Suppressed microglial E prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation.

scientific article published on 6 January 2011

Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies

scientific article

Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight

article

Systematic analysis of dark and camouflaged genes: disease-relevant genes hiding in plain sight: Supplemental figures

article

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

scientific article published on May 2016

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

scientific article published on 01 October 2016

Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.

scientific article

The APOE Gene is Differentially Methylated in Alzheimer's Disease.

scientific article

The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features.

scientific article published on 30 October 2017

The co-occurrence of Alzheimer's disease and Huntington's disease: a neuropathological study of 15 elderly Huntington's disease subjects

scientific article published in January 2014

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy

scientific article

The microvascular extracellular matrix in brains with Alzheimer's disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA)

scientific article published on 29 September 2020

The phosphatase calcineurin regulates pathological TDP-43 phosphorylation.

scientific article published on 29 July 2016

Therapeutic implications of the prostaglandin pathway in Alzheimer's disease

scientific article published on 13 January 2014

Therapeutic targets in prostaglandin E2 signaling for neurologic disease.

scientific article published on January 2008

Transcriptomic cytoarchitecture reveals principles of human neocortex organization

scientific article published on 12 October 2023

Transcriptomic diversity of cell types across the adult human brain

scientific article published on 12 October 2023

Unusually long duration and delayed penetrance in a family with FTD and mutation in MAPT (V337M).

scientific article

Vasodilator Dysfunction and Oligodendrocyte Dysmaturation in Aging White Matter.

scientific article published on 28 December 2017

Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice

scientific article published on 8 September 2014

Wild-type microglia do not reverse pathology in mouse models of Rett syndrome

scientific article

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

scientific article published on 01 January 2020