List of works - Xiukun Lin

A novel anti-tumor protein extracted from Meretrix meretrix Linnaeus induces cell death by increasing cell permeability and inhibiting tubulin polymerization.

scientific article published on October 2009

A novel polypeptide extracted from Ciona savignyi induces apoptosis through a mitochondrial-mediated pathway in human colorectal carcinoma cells.

scientific article

A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma.

scientific article

A novel polypeptide from shark cartilage with potent anti-angiogenic activity

scientific article published on 12 February 2007

Active fraction of clove induces apoptosis via PI3K/Akt/mTOR-mediated autophagy in human colorectal cancer HCT-116 cells

scientific article published on 02 July 2018

Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway

scientific article published on 21 May 2015

Aplysin sensitizes cancer cells to TRAIL by suppressing P38 MAPK/survivin pathway

scientific article

Aqueous extract of clove inhibits tumor growth by inducing autophagy through AMPK/ULK pathway

scientific article published on 16 April 2019

Basic anatomy and tumor biology of the RPS6KA6 gene that encodes the p90 ribosomal S6 kinase-4 ⬇️

scientific article published on May 21, 2012

Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, a marine algae derived bromophenol, inhibits the growth of Botrytis cinerea and interacts with DNA molecules.

scientific article

CI431, an Aqueous Compound from Ciona intestinalis L., Induces Apoptosis through a Mitochondria‐Mediated Pathway in Human Hepatocellular Carcinoma Cells ⬇️

scientific article published on July 21, 2011

CS5931, A Novel Marine Polypeptide, Inhibits Migration and Invasion of Cancer Cells Via Interacting with Enolase 1

scientific article published on 01 January 2018

CS5931, a novel polypeptide in Ciona savignyi, represses angiogenesis via inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs).

scientific article published on 13 March 2014

Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells.

scientific article published on 7 July 2015

Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA.

scientific article

Characterization of the high cytochalasin E and rosellichalasin producing-Aspergillus sp. nov. F1 isolated from marine solar saltern in China ⬇️

scientific article published on August 22, 2012

Cloning, characterization and expression of a cDNA encoding a granulin-like polypeptide in Ciona savignyi.

scientific article

Cloning, expression and cytotoxicity of granulin A, a novel polypeptide contained in human progranulin.

scientific article published on 30 April 2016

Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis.

scientific article

Culture at a Higher Temperature Mildly Inhibits Cancer Cell Growth but Enhances Chemotherapeutic Effects by Inhibiting Cell-Cell Collaboration.

scientific article published on 23 October 2015

Development of Certain Protein Kinase Inhibitors with the Components from Traditional Chinese Medicine.

scientific article published on January 2016

Granulin A Synergizes with Cisplatin to Inhibit the Growth of Human Hepatocellular Carcinoma

scientific article published on 07 October 2018

Heat Shock Proteins and Cancer.

scientific article published on 21 December 2016

Identification of Streptomyces sp. nov. WH26 producing cytotoxic compounds isolated from marine solar saltern in China.

scientific article

Induction of apoptosis, G₀/G₁ phase arrest and microtubule disassembly in K562 leukemia cells by Mere15, a novel polypeptide from Meretrix meretrix Linnaeus

scientific article

Interaction between granulin A and enolase 1 attenuates the migration and invasion of human hepatoma cells

scientific article

Isolation and characterization of marine Brevibacillus sp. S-1 collected from South China Sea and a novel antitumor peptide produced by the strain.

scientific article

Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism.

scientific article published on 2 December 2015

Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, induces mitochondrial apoptosis in K562 cells and inhibits topoisomerase I in vitro.

scientific article published on 29 March 2012

Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems.

scientific article published on 7 September 2015

Maslinic acid as an effective anticancer agent

scientific article published on 30 July 2018

Maslinic acid induces autophagy by down-regulating HSPA8 in pancreatic cancer cells

scientific article published on 08 March 2018

Mere15, a novel polypeptide from Meretrix meretrix, inhibits adhesion, migration and invasion of human lung cancer A549 cells via down-regulating MMPs.

scientific article

Oleanolic acid arrests cell cycle and induces apoptosis via ROS‐mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells ⬇️

scientific article published on June 8, 2012

Oleanolic acid induces metabolic adaptation in cancer cells by activating the AMP-activated protein kinase pathway

scientific article

Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways.

scientific article

Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy.

scientific article published on 31 July 2014

Oleanolic acid potentiates the antitumor activity of 5-fluorouracil in pancreatic cancer cells

scientific article published on 19 July 2012

Oleanolic acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type M isoforms

scientific article (publication date: 2014)

PBN11-8, a Cytotoxic Polypeptide Purified from Marine Bacillus, Suppresses Invasion and Migration of Human Hepatocellular Carcinoma Cells by Targeting Focal Adhesion Kinase Pathways ⬇️

scientific article published on 19 September 2018

Piperlongumine as anticancer agent: The story so far about killing many birds with one stone

scientific article published on 30 August 2018

Preparation and Antitumor Activity of CS5931, A Novel Polypeptide from Sea Squirt Ciona Savignyi

scientific article published on 21 March 2016

Prostate Cancer Stem Cells: Viewing Signaling Cascades at a Finer Resolution

scientific article published on 4 February 2016

Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells.

scientific article published on 26 March 2015

Recovery of recombinant zebrafish p53 protein from inclusion bodies and its binding activity to p53 mRNA in vitro.

scientific article

Regulation of signaling pathways by β-elemene in cancer progression and metastasis

scientific article published on 25 March 2019

Role of microRNA-26b in glioma development and its mediated regulation on EphA2

scientific article

Sequence analysis and functional study of thymidylate synthase from zebrafish, Danio rerio.

scientific article published in May 2006

Silencing myostatin gene by RNAi in sheep embryos.

scientific article

Synthesis of butyl-isobutyl-phthalate and its interaction with α-glucosidase in vitro

scientific article published on 23 September 2010

Teratogenic jervine increases the activity of doxorubicin in MCF-7/ADR cells by inhibiting ABCB1

scientific article published on 14 June 2019

Thymidylate synthase as a translational regulator of cellular gene expression

scientific article (publication date: 18 July 2002)

Translational autoregulation of thymidylate synthase and dihydrofolate reductase.

scientific article published in September 2004

Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment

scientific article published on 23 March 2012

Zinc-Doped Copper Oxide Nanocomposites Inhibit the Growth of Human Cancer Cells through Reactive Oxygen Species-Mediated NF-κB Activations.

scientific article

Zinc-Doped Copper Oxide Nanocomposites Inhibit the Growth of Pancreatic Cancer by Inducing Autophagy Through AMPK/mTOR Pathway

scientific article published on 02 April 2019

Zinc-doped copper oxide nanocomposites reverse temozolomide resistance in glioblastoma by inhibiting AKT and ERK1/2

scientific article published on 01 June 2018

Zn-doped CuO nanocomposites inhibit tumor growth by NF-κB pathway cross-linked autophagy and apoptosis

scientific article published on 05 November 2018

miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2.

scientific article

α-Glucosidase inhibition and the in vivo hypoglycemic effect of butyl-isobutyl-phthalate derived from the Laminaria japonica rhizoid.

scientific article published on November 2010

List of works by Xiukun Lin

A novel anti-tumor protein extracted from Meretrix meretrix Linnaeus induces cell death by increasing cell permeability and inhibiting tubulin polymerization.

A novel polypeptide extracted from Ciona savignyi induces apoptosis through a mitochondrial-mediated pathway in human colorectal carcinoma cells.

A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma.

A novel polypeptide from shark cartilage with potent anti-angiogenic activity

Active fraction of clove induces apoptosis via PI3K/Akt/mTOR-mediated autophagy in human colorectal cancer HCT-116 cells

Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway

Aplysin sensitizes cancer cells to TRAIL by suppressing P38 MAPK/survivin pathway

Aqueous extract of clove inhibits tumor growth by inducing autophagy through AMPK/ULK pathway

Basic anatomy and tumor biology of the RPS6KA6 gene that encodes the p90 ribosomal S6 kinase-4 ⬇️

Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, a marine algae derived bromophenol, inhibits the growth of Botrytis cinerea and interacts with DNA molecules.

CI431, an Aqueous Compound from Ciona intestinalis L., Induces Apoptosis through a Mitochondria‐Mediated Pathway in Human Hepatocellular Carcinoma Cells ⬇️

CS5931, A Novel Marine Polypeptide, Inhibits Migration and Invasion of Cancer Cells Via Interacting with Enolase 1

CS5931, a novel polypeptide in Ciona savignyi, represses angiogenesis via inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs).

Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells.

Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA.

Characterization of the high cytochalasin E and rosellichalasin producing-Aspergillus sp. nov. F1 isolated from marine solar saltern in China ⬇️

Cloning, characterization and expression of a cDNA encoding a granulin-like polypeptide in Ciona savignyi.

Cloning, expression and cytotoxicity of granulin A, a novel polypeptide contained in human progranulin.

Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis.

Culture at a Higher Temperature Mildly Inhibits Cancer Cell Growth but Enhances Chemotherapeutic Effects by Inhibiting Cell-Cell Collaboration.

Development of Certain Protein Kinase Inhibitors with the Components from Traditional Chinese Medicine.

Granulin A Synergizes with Cisplatin to Inhibit the Growth of Human Hepatocellular Carcinoma

Heat Shock Proteins and Cancer.

Identification of Streptomyces sp. nov. WH26 producing cytotoxic compounds isolated from marine solar saltern in China.

Induction of apoptosis, G₀/G₁ phase arrest and microtubule disassembly in K562 leukemia cells by Mere15, a novel polypeptide from Meretrix meretrix Linnaeus

Interaction between granulin A and enolase 1 attenuates the migration and invasion of human hepatoma cells

Isolation and characterization of marine Brevibacillus sp. S-1 collected from South China Sea and a novel antitumor peptide produced by the strain.

Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism.

Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, induces mitochondrial apoptosis in K562 cells and inhibits topoisomerase I in vitro.

Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems.

Maslinic acid as an effective anticancer agent

Maslinic acid induces autophagy by down-regulating HSPA8 in pancreatic cancer cells

Mere15, a novel polypeptide from Meretrix meretrix, inhibits adhesion, migration and invasion of human lung cancer A549 cells via down-regulating MMPs.

Oleanolic acid arrests cell cycle and induces apoptosis via ROS‐mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells ⬇️

Oleanolic acid induces metabolic adaptation in cancer cells by activating the AMP-activated protein kinase pathway

Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways.

Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy.

Oleanolic acid potentiates the antitumor activity of 5-fluorouracil in pancreatic cancer cells

Oleanolic acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type M isoforms

PBN11-8, a Cytotoxic Polypeptide Purified from Marine Bacillus, Suppresses Invasion and Migration of Human Hepatocellular Carcinoma Cells by Targeting Focal Adhesion Kinase Pathways ⬇️

Piperlongumine as anticancer agent: The story so far about killing many birds with one stone

Preparation and Antitumor Activity of CS5931, A Novel Polypeptide from Sea Squirt Ciona Savignyi

Prostate Cancer Stem Cells: Viewing Signaling Cascades at a Finer Resolution

Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells.

Recovery of recombinant zebrafish p53 protein from inclusion bodies and its binding activity to p53 mRNA in vitro.

Regulation of signaling pathways by β-elemene in cancer progression and metastasis

Role of microRNA-26b in glioma development and its mediated regulation on EphA2

Sequence analysis and functional study of thymidylate synthase from zebrafish, Danio rerio.

Silencing myostatin gene by RNAi in sheep embryos.

Synthesis of butyl-isobutyl-phthalate and its interaction with α-glucosidase in vitro

Teratogenic jervine increases the activity of doxorubicin in MCF-7/ADR cells by inhibiting ABCB1

Thymidylate synthase as a translational regulator of cellular gene expression

Translational autoregulation of thymidylate synthase and dihydrofolate reductase.

Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment

Zinc-Doped Copper Oxide Nanocomposites Inhibit the Growth of Human Cancer Cells through Reactive Oxygen Species-Mediated NF-κB Activations.

Zinc-Doped Copper Oxide Nanocomposites Inhibit the Growth of Pancreatic Cancer by Inducing Autophagy Through AMPK/mTOR Pathway

Zinc-doped copper oxide nanocomposites reverse temozolomide resistance in glioblastoma by inhibiting AKT and ERK1/2

Zn-doped CuO nanocomposites inhibit tumor growth by NF-κB pathway cross-linked autophagy and apoptosis

miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2.

α-Glucosidase inhibition and the in vivo hypoglycemic effect of butyl-isobutyl-phthalate derived from the Laminaria japonica rhizoid.