List of works - Hirotake Tsukamoto

Activation of TLR3 and its adaptor TICAM-1 increases miR-21 levels in extracellular vesicles released from human cells

scientific article published on 18 April 2018

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

scientific article published on 08 October 2009

An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs.

scientific article published on 4 January 2016

B-Raf contributes to sustained extracellular signal-regulated kinase activation associated with interleukin-2 production stimulated through the T cell receptor.

scientific article published on 31 August 2004

Bim Dictates Naive CD4 T Cell Lifespan and the Development of Age-Associated Functional Defects ⬇️

scientific article published on September 15, 2010

CXCL10 and CCL2 mRNA expression in monocytes is inversely correlated with the HLA-DR lower fraction of monocytes in patients with renal cell carcinoma.

scientific article published on 20 January 2016

Cancer therapy with major histocompatibility complex-deficient and interferon β-producing myeloid cells derived from allogeneic embryonic stem cells

scientific article published on 07 August 2019

Combined Blockade of IL6 and PD-1/PD-L1 Signaling Abrogates Mutual Regulation of Their Immunosuppressive Effects in the Tumor Microenvironment

scientific article published on 02 July 2018

Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens

scientific article

Extracellular Vesicles Deliver Host and Virus RNA and Regulate Innate Immune Response

scientific article published on 20 March 2017

HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling

scientific article published on 29 May 2020

Identification of CDCA1-derived long peptides bearing both CD4+ and CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients.

scientific article published in January 2014

Identification of glypican-3-derived long peptides activating both CD8(+) and CD4(+) T cells; prolonged overall survival in cancer patients with Th cell response

scientific article published on 31 August 2015

Identification of immunogenic LY6K long peptide encompassing both CD4(+) and CD8(+) T-cell epitopes and eliciting CD4(+) T-cell immunity in patients with malignant disease

scientific article

Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor.

scientific article published on 28 May 2013

Immune-suppressive effects of interleukin-6 on T-cell-mediated anti-tumor immunity.

scientific article published in November 2017

Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression

scientific article published on 29 April 2013

Nivolumab-induced colitis in a patient with malignant melanoma: A case report and immunological analysis

scientific article published on 25 March 2019

Proliferation potential-related protein, an ideal esophageal cancer antigen for immunotherapy, identified using complementary DNA microarray analysis.

scholarly article

Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections.

scientific article

Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression.

scientific article published on 24 February 2017

Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells

scientific article

Systematic analysis of the combinatorial nature of epitopes recognized by TCR leads to identification of mimicry epitopes for glutamic acid decarboxylase 65-specific TCRs.

scientific article

TCR ligand avidity determines the mode of B-Raf/Raf-1/ERK activation leading to the activation of human CD4+ T cell clone.

scientific article published on July 2006

Unique T cell proliferation associated with PKCmu activation and impaired ZAP-70 phosphorylation in recognition of overexpressed HLA/partially agonistic peptide complexes.

scientific article published on June 2003

Wnt signaling regulates hemopoiesis through stromal cells.

scientific article

Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response.

scientific article published on 19 September 2017

List of works by Hirotake Tsukamoto

Activation of TLR3 and its adaptor TICAM-1 increases miR-21 levels in extracellular vesicles released from human cells

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs.

B-Raf contributes to sustained extracellular signal-regulated kinase activation associated with interleukin-2 production stimulated through the T cell receptor.

Bim Dictates Naive CD4 T Cell Lifespan and the Development of Age-Associated Functional Defects ⬇️

CXCL10 and CCL2 mRNA expression in monocytes is inversely correlated with the HLA-DR lower fraction of monocytes in patients with renal cell carcinoma.

Cancer therapy with major histocompatibility complex-deficient and interferon β-producing myeloid cells derived from allogeneic embryonic stem cells

Combined Blockade of IL6 and PD-1/PD-L1 Signaling Abrogates Mutual Regulation of Their Immunosuppressive Effects in the Tumor Microenvironment

Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens

Extracellular Vesicles Deliver Host and Virus RNA and Regulate Innate Immune Response

HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling

Identification of CDCA1-derived long peptides bearing both CD4+ and CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients.

Identification of glypican-3-derived long peptides activating both CD8(+) and CD4(+) T cells; prolonged overall survival in cancer patients with Th cell response

Identification of immunogenic LY6K long peptide encompassing both CD4(+) and CD8(+) T-cell epitopes and eliciting CD4(+) T-cell immunity in patients with malignant disease

Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor.

Immune-suppressive effects of interleukin-6 on T-cell-mediated anti-tumor immunity.

Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression

Nivolumab-induced colitis in a patient with malignant melanoma: A case report and immunological analysis

Proliferation potential-related protein, an ideal esophageal cancer antigen for immunotherapy, identified using complementary DNA microarray analysis.

Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections.

Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression.

Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells

Systematic analysis of the combinatorial nature of epitopes recognized by TCR leads to identification of mimicry epitopes for glutamic acid decarboxylase 65-specific TCRs.

TCR ligand avidity determines the mode of B-Raf/Raf-1/ERK activation leading to the activation of human CD4+ T cell clone.

Unique T cell proliferation associated with PKCmu activation and impaired ZAP-70 phosphorylation in recognition of overexpressed HLA/partially agonistic peptide complexes.

Wnt signaling regulates hemopoiesis through stromal cells.

Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response.