List of works - Sergio Simöes

A non-covalent strategy combining cationic lipids and CPPs to enhance the delivery of splice correcting oligonucleotides.

scientific article published on 30 March 2010

African swine fever virus p10 protein exhibits nuclear import capacity and accumulates in the nucleus during viral infection.

scientific article

African swine fever virus p37 structural protein is localized in nuclear foci containing the viral DNA at early post-infection times.

scientific article

Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies.

scientific article

Association of albumin or protamine to lipoplexes: enhancement of transfection and resistance to serum.

scientific article

Biodistribution and photodynamic efficacy of a water-soluble, stable, halogenated bacteriochlorin against melanoma.

scientific article

Biophysical characterization of cationic liposome-DNA complexes and their interaction with cells.

scientific article

Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications.

scientific article

Cationic liposome-DNA complexes as gene delivery vectors: Development and behaviour towards bone-like cells.

scientific article published on 20 February 2009

Cellular and molecular events associated with the antitumor response induced by the cytosine deaminase/5-fluorocytosine suicide gene therapy system in a rat liver metastasis model.

scientific article published on 22 June 2007

Cellular uptake of S4 13 -PV peptide occurs upon conformational changes induced by peptide–membrane interactions

scientific article published on 10 February 2006

Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology

scientific article

Ciprofloxacin sensitizes hormone-refractory prostate cancer cell lines to doxorubicin and docetaxel treatment on a schedule-dependent manner.

scientific article

Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment.

scientific article published on December 2010

Combined effects of singlet oxygen and hydroxyl radical in photodynamic therapy with photostable bacteriochlorins: Evidence from intracellular fluorescence and increased photodynamic efficacy in vitro

scientific article published on 14 January 2012

DNA pre-condensation with an amino acid-based cationic amphiphile. A viable approach for liposome-based gene delivery.

scientific article

Delivery of antiviral agents in liposomes.

scientific article

Development, characterization and in vitro evaluation of single or co-loaded imatinib mesylate liposomal formulations.

scientific article

Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs delivered in pH-sensitive liposomes.

scientific article published in April 2001

Gene delivery by cationic liposome-DNA complexes containing transferrin or serum albumin.

scientific article

Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusigenic peptides.

scientific article published in July 1998

Human serum albumin enhances DNA transfection by lipoplexes and confers resistance to inhibition by serum.

scientific article

Hydrophobic polymers for orodispersible films: a quality by design approach.

scientific article

Impact of anti-PLK1 siRNA-containing F3-targeted liposomes on the viability of both cancer and endothelial cells.

scientific article published on 7 May 2013

Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone.

scientific article

Improving lipoplex-mediated gene transfer into C6 glioma cells and primary neurons.

scientific article published on May 2004

In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on cell viability.

scientific article

Inoculated Cell Density as a Determinant Factor of the Growth Dynamics and Metastatic Efficiency of a Breast Cancer Murine Model

scientific article

Interaction of S413-PV cell penetrating peptide with model membranes: relevance to peptide translocation across biological membranes

article

Kinetic analysis of the initial steps involved in lipoplex--cell interactions: effect of various factors that influence transfection activity.

scientific article published in February 2001

Ligand-guided optimization of CXCR4 homology models for virtual screening using a multiple chemotype approach.

scientific article published on 20 October 2010

Lipid-based nanoparticles for siRNA delivery in cancer therapy: paradigms and challenges

scientific article published on 08 May 2012

Liposomal and viral vectors for gene therapy of the central nervous system.

scientific article

Liposomal imatinib-mitoxantrone combination: formulation development and therapeutic evaluation in an animal model of prostate cancer.

scientific article published on January 2011

Meeting the needs of breast cancer: A nucleolin's perspective.

scientific article published on 21 March 2018

Modeling dissolution of sparingly soluble multisized powders.

scientific article published in June 1997

Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers

scientific article published on 12 June 2018

Mucoadhesive oral films: The potential for unmet needs

scientific article published on 24 August 2015

New halogenated water-soluble chlorin and bacteriochlorin as photostable PDT sensitizers: synthesis, spectroscopy, photophysics, and in vitro photosensitizing efficacy.

scientific article published on October 2010

Novel oleanolic vinyl boronates: synthesis and antitumor activity.

scientific article published on 9 February 2013

On the formulation of pH-sensitive liposomes with long circulation times.

scientific article published on April 2004

Oral films: Current status and future perspectives II - Intellectual property, technologies and market needs

scientific article published on 14 March 2015

Oral films: Current status and future perspectives: I - Galenical development and quality attributes.

scientific article

Outlining critical quality attributes (CQAs) as guidance for the development of orodispersible films.

scientific article published on 27 June 2016

Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity.

scientific article published on October 2002

Physicochemical properties of transferrin-associated lipopolyplexes and their role in biological activity.

scientific article

Quality by design in pharmaceutical manufacturing: A systematic review of current status, challenges and future perspectives

scientific article published on 17 December 2019

S4(13)-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA.

scientific article

Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy.

scientific article published on 9 April 2010

Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR.

scientific article

Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer.

scientific article

Sterically stabilized ph-sensitive liposomes

scientific article published on 01 January 2004

Sterols as anticancer agents: synthesis of ring-B oxygenated steroids, cytotoxic profile, and comprehensive SAR analysis.

scientific article

Successful transfection of lymphocytes by ternary lipoplexes.

scientific article

Survivin silencing as a promising strategy to enhance the sensitivity of cancer cells to chemotherapeutic agents.

scientific article published on 17 June 2011

Targeted gene delivery into peripheral sensorial neurons mediated by self-assembled vectors composed of poly(ethylene imine) and tetanus toxin fragment c.

scientific article

Targeting cancer stem cells and non-stem cancer cells: the potential of lipid-based nanoparticles.

scientific article published on 14 November 2017

Technology evaluation: LErafAON, NeoPharm.

scientific article

Tf-lipoplex-mediated NGF gene transfer to the CNS: neuronal protection and recovery in an excitotoxic model of brain injury.

scientific article

Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo.

scientific article published on 11 November 2009

Tf-lipoplexes for neuronal siRNA delivery: a promising system to mediate gene silencing in the CNS.

scientific article

The cancer stem cell phenotype as a determinant factor of the heterotypic nature of breast tumors

scientific article

Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer.

scientific article published on 14 September 2017

Transfection of human macrophages by lipoplexes via the combined use of transferrin and pH-sensitive peptides

scientific article published on 01 February 1999

Transfection of oral cancer cells mediated by transferrin-associated lipoplexes: mechanisms of cell death induced by herpes simplex virus thymidine kinase/ganciclovir therapy.

scientific article published on 14 September 2006

Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response.

scientific article

Transferrin-associated lipoplexes as gene delivery systems: relevance of mode of preparation and biophysical properties.

scientific article published on 21 February 2008

Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment.

scientific article published on 18 June 2013

Two African swine fever virus proteins derived from a common precursor exhibit different nucleocytoplasmic transport activities.

scientific article published on September 2004

siRNA delivery by a transferrin-associated lipid-based vector: a non-viral strategy to mediate gene silencing.

scientific article published on March 2007

List of works by Sergio Simöes

A non-covalent strategy combining cationic lipids and CPPs to enhance the delivery of splice correcting oligonucleotides.

African swine fever virus p10 protein exhibits nuclear import capacity and accumulates in the nucleus during viral infection.

African swine fever virus p37 structural protein is localized in nuclear foci containing the viral DNA at early post-infection times.

Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies.

Association of albumin or protamine to lipoplexes: enhancement of transfection and resistance to serum.

Biodistribution and photodynamic efficacy of a water-soluble, stable, halogenated bacteriochlorin against melanoma.

Biophysical characterization of cationic liposome-DNA complexes and their interaction with cells.

Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications.

Cationic liposome-DNA complexes as gene delivery vectors: Development and behaviour towards bone-like cells.

Cellular and molecular events associated with the antitumor response induced by the cytosine deaminase/5-fluorocytosine suicide gene therapy system in a rat liver metastasis model.

Cellular uptake of S4 13 -PV peptide occurs upon conformational changes induced by peptide–membrane interactions

Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology

Ciprofloxacin sensitizes hormone-refractory prostate cancer cell lines to doxorubicin and docetaxel treatment on a schedule-dependent manner.

Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment.

Combined effects of singlet oxygen and hydroxyl radical in photodynamic therapy with photostable bacteriochlorins: Evidence from intracellular fluorescence and increased photodynamic efficacy in vitro

DNA pre-condensation with an amino acid-based cationic amphiphile. A viable approach for liposome-based gene delivery.

Delivery of antiviral agents in liposomes.

Development, characterization and in vitro evaluation of single or co-loaded imatinib mesylate liposomal formulations.

Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs delivered in pH-sensitive liposomes.

Gene delivery by cationic liposome-DNA complexes containing transferrin or serum albumin.

Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusigenic peptides.

Human serum albumin enhances DNA transfection by lipoplexes and confers resistance to inhibition by serum.

Hydrophobic polymers for orodispersible films: a quality by design approach.

Impact of anti-PLK1 siRNA-containing F3-targeted liposomes on the viability of both cancer and endothelial cells.

Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone.

Improving lipoplex-mediated gene transfer into C6 glioma cells and primary neurons.

In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on cell viability.

Inoculated Cell Density as a Determinant Factor of the Growth Dynamics and Metastatic Efficiency of a Breast Cancer Murine Model

Interaction of S413-PV cell penetrating peptide with model membranes: relevance to peptide translocation across biological membranes

Kinetic analysis of the initial steps involved in lipoplex--cell interactions: effect of various factors that influence transfection activity.

Ligand-guided optimization of CXCR4 homology models for virtual screening using a multiple chemotype approach.

Lipid-based nanoparticles for siRNA delivery in cancer therapy: paradigms and challenges

Liposomal and viral vectors for gene therapy of the central nervous system.

Liposomal imatinib-mitoxantrone combination: formulation development and therapeutic evaluation in an animal model of prostate cancer.

Meeting the needs of breast cancer: A nucleolin's perspective.

Modeling dissolution of sparingly soluble multisized powders.

Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers

Mucoadhesive oral films: The potential for unmet needs

New halogenated water-soluble chlorin and bacteriochlorin as photostable PDT sensitizers: synthesis, spectroscopy, photophysics, and in vitro photosensitizing efficacy.

Novel oleanolic vinyl boronates: synthesis and antitumor activity.

On the formulation of pH-sensitive liposomes with long circulation times.

Oral films: Current status and future perspectives II - Intellectual property, technologies and market needs

Oral films: Current status and future perspectives: I - Galenical development and quality attributes.

Outlining critical quality attributes (CQAs) as guidance for the development of orodispersible films.

Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity.

Physicochemical properties of transferrin-associated lipopolyplexes and their role in biological activity.

Quality by design in pharmaceutical manufacturing: A systematic review of current status, challenges and future perspectives

S4(13)-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA.

Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy.

Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR.

Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer.

Sterically stabilized ph-sensitive liposomes

Sterols as anticancer agents: synthesis of ring-B oxygenated steroids, cytotoxic profile, and comprehensive SAR analysis.

Successful transfection of lymphocytes by ternary lipoplexes.

Survivin silencing as a promising strategy to enhance the sensitivity of cancer cells to chemotherapeutic agents.

Targeted gene delivery into peripheral sensorial neurons mediated by self-assembled vectors composed of poly(ethylene imine) and tetanus toxin fragment c.

Targeting cancer stem cells and non-stem cancer cells: the potential of lipid-based nanoparticles.

Technology evaluation: LErafAON, NeoPharm.

Tf-lipoplex-mediated NGF gene transfer to the CNS: neuronal protection and recovery in an excitotoxic model of brain injury.

Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo.

Tf-lipoplexes for neuronal siRNA delivery: a promising system to mediate gene silencing in the CNS.

The cancer stem cell phenotype as a determinant factor of the heterotypic nature of breast tumors

Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer.

Transfection of human macrophages by lipoplexes via the combined use of transferrin and pH-sensitive peptides

Transfection of oral cancer cells mediated by transferrin-associated lipoplexes: mechanisms of cell death induced by herpes simplex virus thymidine kinase/ganciclovir therapy.

Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response.

Transferrin-associated lipoplexes as gene delivery systems: relevance of mode of preparation and biophysical properties.

Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment.

Two African swine fever virus proteins derived from a common precursor exhibit different nucleocytoplasmic transport activities.

siRNA delivery by a transferrin-associated lipid-based vector: a non-viral strategy to mediate gene silencing.