List of works - Renate König

A neutralization assay for chikungunya virus infections in a multiplex format

scientific article

A probability-based approach for the analysis of large-scale RNAi screens.

scientific article published on 9 September 2007

APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication

scientific article

APOBEC4 Enhances the Replication of HIV-1.

scientific article

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency.

scientific article

Catch Shiny Droplets in Suspension-Finding the Needle in a Haystack.

scientific article

Complementary function of the two catalytic domains of APOBEC3G.

scientific article

Coreceptor Switch of [MLV(SIVagm)] pseudotype vectors by V3-loop exchange.

scientific article

Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit.

scientific article published on 8 June 2018

Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir

scientific article published on 12 September 2020

Engineered CD4- and CXCR4-using simian immunodeficiency virus from African green monkeys is neutralization sensitive and replicates in nonstimulated lymphocytes.

scientific article published on November 2002

Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi-Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1)

scientific article published on 09 January 2020

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication

scientific article (publication date: 3 October 2008)

HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2

scientific article

Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not Sensed in Infected Hepatocytes

scientific article published on 29 May 2020

High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus

scientific article published on 21 January 2015

Host cell factors in HIV replication: meta-analysis of genome-wide studies

scientific article

Human host factors required for influenza virus replication

scientific article

ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53

scientific article published on 27 August 2019

Identifying HIV-1 host cell factors by genome-scale RNAi screening.

scientific article published on 21 July 2010

Induced pluripotent stem cell line (PEIi003-A) derived from an apparently healthy male individual

scientific article published on 04 December 2019

Induced pluripotent stem cells (iPSCs) derived from a renpenning syndrome patient with c.459_462delAGAG mutation in PQBP1 (PEIi001-A)

scientific article published on 15 October 2019

Insights into Innate Sensing of Prototype Foamy Viruses in Myeloid Cells

scientific article published on 26 November 2019

Interferon but not MxB inhibits foamy retroviruses

scientific article published on 20 November 2015

Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.

scientific article

Intertwined: SAMHD1 cellular functions, restriction, and viral evasion strategies

scientific article published on 16 March 2019

MLV-derived retroviral vectors selective for CD4-expressing cells and resistant to neutralization by sera from HIV-infected patients.

scientific article

Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.

scientific article

NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.

scientific article published on April 2016

PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.

scientific article published in June 2015

Picking the Survivor! CRISPR Reveals HIV Dependency Factors.

scientific article published on 20 February 2017

Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ.

scientific article

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Recent strategies and progress in identifying host factors involved in virus replication.

scientific article published on 22 June 2015

Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.

scientific article published on 27 May 2016

Retroviral vectors for vaccine development: induction of HIV-1-specific humoral and cellular immune responses in rhesus macaques using a novel MLV(HIV-1) pseudotype vector

scientific article published on 24 March 2006

Role of Innate Genes in HIV Replication

scientific article

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

scientific article

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection

scientific article published in December 2011

SARS-CoV-2 immunogenicity at the crossroads

scientific article published on 13 May 2020

Sensor Sensibility-HIV-1 and the Innate Immune Response

scientific article published on 20 January 2020

Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

scientific article (publication date: May 2004)

Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif

scientific article (publication date: 11 July 2003)

Structure determination of helical filaments by solid-state NMR spectroscopy

scientific article

Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation.

scientific article

Systems-biology approaches to discover anti-viral effectors of the human innate immune response

scientific article

Tumor suppressor cylindromatosis (CYLD) controls HIV transcription in an NF-κB-dependent manner

scientific article published on 23 April 2014

Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line

scientific article published on 14 April 2016

USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1

article

Virulence Profile: Renate König

scientific article published on 6 October 2017

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

scientific article published on 22 February 2017

Y-box-binding protein 1 supports the early and late steps of HIV replication

scientific article published in PLoS ONE

List of works by Renate König

A neutralization assay for chikungunya virus infections in a multiplex format

A probability-based approach for the analysis of large-scale RNAi screens.

APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication

APOBEC4 Enhances the Replication of HIV-1.

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency.

Catch Shiny Droplets in Suspension-Finding the Needle in a Haystack.

Complementary function of the two catalytic domains of APOBEC3G.

Coreceptor Switch of [MLV(SIVagm)] pseudotype vectors by V3-loop exchange.

Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit.

Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir

Engineered CD4- and CXCR4-using simian immunodeficiency virus from African green monkeys is neutralization sensitive and replicates in nonstimulated lymphocytes.

Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi-Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1)

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication

HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2

Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not Sensed in Infected Hepatocytes

High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus

Host cell factors in HIV replication: meta-analysis of genome-wide studies

Human host factors required for influenza virus replication

ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53

Identifying HIV-1 host cell factors by genome-scale RNAi screening.

Induced pluripotent stem cell line (PEIi003-A) derived from an apparently healthy male individual

Induced pluripotent stem cells (iPSCs) derived from a renpenning syndrome patient with c.459_462delAGAG mutation in PQBP1 (PEIi001-A)

Insights into Innate Sensing of Prototype Foamy Viruses in Myeloid Cells

Interferon but not MxB inhibits foamy retroviruses

Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.

Intertwined: SAMHD1 cellular functions, restriction, and viral evasion strategies

MLV-derived retroviral vectors selective for CD4-expressing cells and resistant to neutralization by sera from HIV-infected patients.

Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.

NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.

PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.

Picking the Survivor! CRISPR Reveals HIV Dependency Factors.

Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ.

Proceedings of the Frontiers of Retrovirology Conference 2016.

Recent strategies and progress in identifying host factors involved in virus replication.

Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.

Retroviral vectors for vaccine development: induction of HIV-1-specific humoral and cellular immune responses in rhesus macaques using a novel MLV(HIV-1) pseudotype vector

Role of Innate Genes in HIV Replication

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection

SARS-CoV-2 immunogenicity at the crossroads

Sensor Sensibility-HIV-1 and the Innate Immune Response

Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif

Structure determination of helical filaments by solid-state NMR spectroscopy

Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation.

Systems-biology approaches to discover anti-viral effectors of the human innate immune response

Tumor suppressor cylindromatosis (CYLD) controls HIV transcription in an NF-κB-dependent manner

Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line

USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1

Virulence Profile: Renate König

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

Y-box-binding protein 1 supports the early and late steps of HIV replication