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List of works by Robert B. Darnell

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

scientific article published on 12 August 2019

A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing

scientific journal article

A call for transparent reporting to optimize the predictive value of preclinical research

scientific article

A destructive feedback loop mediated by CXCL10 in central nervous system inflammatory disease.

scientific article

A new cause of limbic encephalopathy

scientific article published on 01 August 2005

A novel adaptor-related protein complex

scientific article published on May 1996

AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke

scientific article published on 01 July 2019

AGO HITS-CLIP reveals distinct miRNA regulation of white and brown adipose tissue identity

scientific article published on 08 April 2021

ATM binds to β-adaptin in cytoplasmic vesicles ⬇️

scientific article published on August 18, 1998

Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cells.

scientific article

An RNA map predicting Nova-dependent splicing regulation

scientific article

An alternative mode of microRNA target recognition

scientific article published on 12 February 2012

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. ⬇️

scientific article

Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation

scientific article

Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer

scientific article

Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps

scientific article

Autoimmune encephalopathy: the spectrum widens

scientific article published on 01 July 2009

BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice

scientific article published on 24 August 2015

CLIP (Cross-Linking and Immunoprecipitation) Identification of RNAs Bound by a Specific Protein ⬇️

scientific article (publication date: November 2012)

CLIP identifies Nova-regulated RNA networks in the brain

scientific article (publication date: 14 November 2003)

CLIP: a method for identifying protein-RNA interaction sites in living cells

scientific article

Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons

Cellular immune suppression in paraneoplastic neurologic syndromes targeting intracellular antigens

scientific article published on September 2012

Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition.

scientific article published in October 2005

Comparing sequencing assays and human-machine analyses in actionable genomics for glioblastoma

scientific article

Comprehensive Identification of mRNA Polyadenylation Sites by PAPERCLIP.

scientific article published in January 2017

Correction to: Sequencing and curation strategies for identifying candidate glioblastoma treatments

scientific article published on 02 August 2019

Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells

scientific article

Dendritic cell vaccines containing lymphocytes produce improved immunogenicity in patients with cancer.

scientific article

Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo ⬇️

scientific article published on February 5, 2013

Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN- / on antigen cross-presentation

scientific article published on 03 October 2006

Differential 3' Processing of Specific Transcripts Expands Regulatory and Protein Diversity Across Neuronal Cell Types.

scientific article published on 26 March 2018

Differential NOVA2-Mediated Splicing in Excitatory and Inhibitory Neurons Regulates Cortical Development and Cerebellar Function

scientific article published on 09 January 2019

Disease variants in genomes of 44 centenarians.

scientific article

Effective antigen cross-presentation by prostate cancer patients' dendritic cells: implications for prostate cancer immunotherapy

scientific article published on 01 January 2004

Elavl3 is essential for the maintenance of Purkinje neuron axons

scientific article published on 9 February 2018

Evolution of Nova-dependent splicing regulation in the brain

scientific article

Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition.

scientific article published on 12 August 2017

FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory

scientific article published on 20 December 2019

Genomic Patterns of De Novo Mutation in Simplex Autism.

scientific article published on 27 September 2017

Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita

scientific article published on 30 September 2019

Global mapping of miRNA-target interactions in cattle (Bos taurus).

scientific article published on 15 August 2017

HITS-CLIP yields genome-wide insights into brain alternative RNA processing

scientific article

Harnessing naturally occurring tumor immunity: a clinical vaccine trial in prostate cancer

scientific article

Hepatitis C virus RNA functionally sequesters miR-122

scientific article (publication date: 12 March 2015)

Identification of targetable BRAF ΔN486_P490 variant by whole-genome sequencing leading to dabrafenib-induced remission of a BRAF-mutant pancreatic adenocarcinoma

scientific article published on 13 December 2019

Immune Escape via a Transient Gene Expression Program Enables Productive Replication of a Latent Pathogen

scientific article

Immunologic complexity in neurons

scientific article published on 01 November 1998

Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls

scientific article published on 17 June 2010

Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes

scientific article

Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer.

scientific article

Machine learning integration of rheumatoid arthritis synovial histology and RNAseq data identifies three disease subtypes.

scientific article published on 22 February 2018

Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis

scientific article

Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data

scientific article

Memory, synaptic translation, and...prions?

scientific article published in December 2003

Mouse Chromosomal Locations of Nine Genes Encoding Homologs of Human Paraneoplastic Neurologic Disorder Antigens ⬇️

scientific article published on October 15, 1997

Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy

scientific article

NMDA receptor as a target in paraneoplastic encephalitis

scientific article published on 01 January 2007

NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.

scientific article published on 25 May 2016

NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.

scientific article

NOVA2-mediated RNA regulation is required for axonal pathfinding during development

scientific article

Neuroimmunology of the paraneoplastic neurological degenerations

scientific article

Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability

scientific article

Nova regulates brain-specific splicing to shape the synapse

scientific article

Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system

scientific article

Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling

scientific article

Observing the invisible: successful tumor immunity in humans

scientific article published on 01 March 2003

Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain

scientific article

PAPERCLIP Identifies MicroRNA Targets and a Role of CstF64/64tau in Promoting Non-canonical poly(A) Site Usage.

scientific article published on 30 March 2016

Paraneoplastic Syndromes Involving the Nervous System ⬇️

scientific article published on October 16, 2003

Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion-Driven Cancer

scientific article published on 15 March 2019

Prediction of clustered RNA-binding protein motif sites in the mammalian genome.

scientific article published on 18 May 2013

Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice.

scientific article published on 08 May 2013

Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain

scientific article

RNA Regulation in Neurologic Disease and Cancer ⬇️

scientific article published on September 30, 2010

RNA binding proteins and the regulation of neuronal synaptic plasticity.

scientific article

RNA logic in time and space

scientific article published on 01 September 2002

RNA processing and its regulation: global insights into biological networks

scientific article (publication date: 2010)

RNA protein interaction in neurons

scientific article

Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies

scientific article

Ri/Nova gene‐associated paraneoplastic subacute motor neuronopathy ⬇️

scientific article published on March 5, 2013

Sequencing and curation strategies for identifying candidate glioblastoma treatments

scientific article published on 25 April 2019

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation.

scientific article published on 23 February 2018

Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1.

scientific article published in April 2004

Splicing regulation in neurologic disease

scientific article published on October 2006

Structural insights into mis-regulation of protein kinase A in human tumors.

scientific article

Successful Targeted Therapy of Refractory Pediatric Fusion-Positive Secretory Breast Carcinoma

scientific article published on 18 August 2017

T cells presenting viral antigens or autoantigens induce cytotoxic T cell anergy.

scientific article published on 2 November 2017

The Future of Cross-Linking and Immunoprecipitation (CLIP)

scientific article published on 01 August 2018

The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development

scientific journal article

The fragile X mental retardation protein, FMRP, recognizes G-quartets

scientific article published on January 2004

The importance of defining the paraneoplastic neurologic disorders

scientific article published on 01 June 1999

The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia ⬇️

scientific article published on October 27, 1998

The neuronal nuclear antigen recognized by the human anti-Ri autoantibody is expressed in central but not peripheral nervous system neurons

article

The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium channels

scientific article

The onconeural antigen cdr2 is a novel APC/C target that acts in mitosis to regulate c-myc target genes in mammalian tumor cells

scientific article

The polymerase chain reaction: Application to nervous system disease ⬇️

scientific article published on October 1, 1993

The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain

scientific article published on May 2000

Tolerance to the neuron-specific paraneoplastic HuD antigen

scientific article

Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting

scientific article

Tumor immunity in small-cell lung cancer

scientific article published in March 2004

Turkey must end violent response to protests

scientific article

T cells targeting a neuronal paraneoplastic antigen mediate tumor rejection and trigger CNS autoimmunity with humoral activation.

scientific article published on November 2014

Whole Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma

scientific article published on 6 March 2018

Whole Genome Sequencing-Based Discovery of Structural Variants in Glioblastoma

scientific article published in January 2018

Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk

scientific article published on 27 May 2019

ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity.

scientific article

cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation.

scientific article

miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity

scientific article

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