List of works - Paola Menichini

3-Methyl-3-deazaadenine, a stable isostere of N3-methyl-adenine, is efficiently bypassed by replication in vivo and by transcription in vitro.

scientific article

5-Methylcytosine at HpaII sites in p53 is not hypermutable after UVC irradiation

scientific article published in December 1999

Altered centrosomes in ataxia-telangiectasia cells and rapamycin-treated Chinese hamster cells.

scientific article

Autophagy induced by SAHA affects mutant P53 degradation and cancer cell survival

scientific article published on 19 February 2019

Characterization of the p53 mutants ability to inhibit p73β transactivation using a yeast-based functional assay

scientific article published on 01 August 2003

Comparison of the biological effects of MMS and Me-lex, a minor groove methylating agent: clarifying the role of N3-methyladenine.

scientific article

Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes.

scientific article

Etoposide-resistance in a neuroblastoma model cell line is associated with 13q14.3 mono-allelic deletion and miRNA-15a/16-1 down-regulation

scientific article published in Scientific Reports

Gambogic acid counteracts mutant p53 stability by inducing autophagy.

scientific article published on 26 November 2016

High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells.

scientific article published on September 2009

Increased risk of colorectal adenomas in Italian subjects carrying the p53 PIN3 A2-Pro72 haplotype

scientific article published on 01 January 2006

Influences of base excision repair defects on the lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent.

scientific article published on 31 May 2002

Lack of mutagenicity and clastogenicity of PNAEmu-NLS targeted to a regulatory sequence of the translocated c-myc oncogene in Burkitt's lymphoma.

scientific article published on 8 January 2007

Mutagenicity of N3-methyladenine: a multi-translesion polymerase affair.

scientific article published on January 2010

Mutation spectra analysis suggests that N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosourea-induced lesions are subject to transcription-coupled repair in Escherichia coli

scientific article published on 01 May 1997

PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells.

scientific article published on 12 October 2010

PRIMA-1 induces autophagy in cancer cells carrying mutant or wild type p53.

scientific article published on 29 March 2013

PRIMA-1 synergizes with adriamycin to induce cell death in non-small cell lung cancer cells.

scientific article

Partial characterization of SUVi, a new mammalian gene induced by UV-C and expressed during the S phase of the cell cycle.

scientific article

Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent.

scientific article published on 7 January 2008

SUVi and BACH1: a new subfamily of mammalian helicases?

scientific article (publication date: November 2001)

Stable formation of mutated p53 multimers in a Chinese hamster cell line causes defective p53 nuclear localization and abrogates its residual function.

scientific article published on August 2006

Strand specificity for UV-induced DNA repair and mutations in the Chinese hamster HPRT gene ⬇️

scientific article published on May 11, 1991

TP63 mutations are frequent in cutaneous melanoma, support UV etiology, but their role in melanomagenesis is unclear.

scientific article published on 14 August 2017

The kinetics of p53-binding and histone acetylation at target promoters do not strictly correlate with gene expression after UV damage.

scientific article

Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code

scientific article

Transcriptional functionality of germ line p53 mutants influences cancer phenotype.

scientific article

Transcriptional properties of feline p53 and its tumour-associated mutants: a yeast-based approach

scientific article published on 18 October 2007

p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system

scientific article

∆N-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites

scientific article

List of works by Paola Menichini

3-Methyl-3-deazaadenine, a stable isostere of N3-methyl-adenine, is efficiently bypassed by replication in vivo and by transcription in vitro.

5-Methylcytosine at HpaII sites in p53 is not hypermutable after UVC irradiation

Altered centrosomes in ataxia-telangiectasia cells and rapamycin-treated Chinese hamster cells.

Autophagy induced by SAHA affects mutant P53 degradation and cancer cell survival

Characterization of the p53 mutants ability to inhibit p73β transactivation using a yeast-based functional assay

Comparison of the biological effects of MMS and Me-lex, a minor groove methylating agent: clarifying the role of N3-methyladenine.

Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes.

Etoposide-resistance in a neuroblastoma model cell line is associated with 13q14.3 mono-allelic deletion and miRNA-15a/16-1 down-regulation

Gambogic acid counteracts mutant p53 stability by inducing autophagy.

High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells.

Increased risk of colorectal adenomas in Italian subjects carrying the p53 PIN3 A2-Pro72 haplotype

Influences of base excision repair defects on the lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent.

Lack of mutagenicity and clastogenicity of PNAEmu-NLS targeted to a regulatory sequence of the translocated c-myc oncogene in Burkitt's lymphoma.

Mutagenicity of N3-methyladenine: a multi-translesion polymerase affair.

Mutation spectra analysis suggests that N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosourea-induced lesions are subject to transcription-coupled repair in Escherichia coli

PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells.

PRIMA-1 induces autophagy in cancer cells carrying mutant or wild type p53.

PRIMA-1 synergizes with adriamycin to induce cell death in non-small cell lung cancer cells.

Partial characterization of SUVi, a new mammalian gene induced by UV-C and expressed during the S phase of the cell cycle.

Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent.

SUVi and BACH1: a new subfamily of mammalian helicases?

Stable formation of mutated p53 multimers in a Chinese hamster cell line causes defective p53 nuclear localization and abrogates its residual function.

Strand specificity for UV-induced DNA repair and mutations in the Chinese hamster HPRT gene ⬇️

TP63 mutations are frequent in cutaneous melanoma, support UV etiology, but their role in melanomagenesis is unclear.

The kinetics of p53-binding and histone acetylation at target promoters do not strictly correlate with gene expression after UV damage.

Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code

Transcriptional functionality of germ line p53 mutants influences cancer phenotype.

Transcriptional properties of feline p53 and its tumour-associated mutants: a yeast-based approach

p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system

∆N-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites