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List of works by Sebastiaan Winkler

1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg-dependent binding ⬇️

scientific article published on 07 March 2019

A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity.

scientific article

Affinity Purification of Human DNA Repair/Transcription Factor TFIIH Using Epitope-tagged Xeroderma Pigmentosum B Protein ⬇️

scientific article published on January 9, 1998

DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.

scientific article

Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complex ⬇️

scientific article published on August 1, 2012

Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1.

scientific article

E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity

scientific article

Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma

scientific article published on 06 October 2020

From a DNA helicase to brittle hair

scientific article published on 01 October 1998

Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex

scientific article

Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription

scientific article

Improved expression and purification of the Helicobacter pylori adhesin BabA through the incorporation of a hexa-lysine tag.

scientific article published on 25 October 2014

Menin links estrogen receptor activation to histone H3K4 trimethylation

scientific article published on 01 May 2006

Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae

scientific article published in May 2007

Phosphonium Polymethacrylates for Short Interfering RNA Delivery: Effect of Polymer and RNA Structural Parameters on Polyplex Assembly and Gene Knockdown

scientific article published on 23 September 2015

Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7

scientific article

RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes.

scientific article published on 19 January 2013

Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA.

scientific article

Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches.

scientific article

Structure-based approaches to create new E2-E3 enzyme pairs

scientific article published on 01 January 2005

TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.

scientific article

The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence

scientific article

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex

scientific article

The central region of CNOT1 and CNOT9 stimulate deadenylation by the Ccr4 Not nuclease module

scientific article published on 09 November 2018

The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module.

scientific article published on 6 May 2015

The mammalian anti-proliferative BTG/Tob protein family

scientific article

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