Search filters

List of works by Charles Boswell

A novel side-bridged hybrid phosphonate/acetate pendant cyclam: synthesis, characterization, and 64Cu small animal PET imaging

scientific article published on 06 December 2008

An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2.

scientific article published on January 2013

Antibody delivery of drugs and radionuclides: factors influencing clinical pharmacology.

scientific article published on June 2011

Antibody-mediated stabilization of NRG1 induces behavioral and electrophysiological alterations in adult mice.

scientific article

Auger electrons: lethal, low energy, and coming soon to a tumor cell nucleus near you.

scientific article

Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer

scientific article published on 22 October 2019

Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes.

scientific article published in March 2004

Comparative physiology of mice and rats: radiometric measurement of vascular parameters in rodent tissues.

scientific article published on 21 April 2014

Compartmental tissue distribution of antibody therapeutics: experimental approaches and interpretations.

scientific article published on 31 May 2012

Conjugation of monoclonal antibodies with TETA using activated esters: biological comparison of 64Cu-TETA-1A3 with 64Cu-BAT-2IT-1A3.

scientific article published in December 2001

Development and evaluation of a novel method for preclinical measurement of tissue vascular volume.

scientific article published on 12 August 2010

Development of radioimmunotherapeutic and diagnostic antibodies: an inside-out view.

scientific article

Differential effects of predosing on tumor and tissue uptake of an 111In-labeled anti-TENB2 antibody-drug conjugate.

scientific article

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

scientific article

Dynamics of protein-protein docking: cytochrome c and cytochrome c peroxidase revisited

scientific article published on 01 October 1998

Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow ⬇️

scientific article published on March 15, 2011

Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model.

scientific article published on 5 January 2012

Effects of charge on antibody tissue distribution and pharmacokinetics.

scientific article

Enhanced tumor retention of a radiohalogen label for site-specific modification of antibodies.

scientific article published on 5 November 2013

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics

scientific article

Evaluation of Fluorophotometry to Assess the Vitreal Pharmacokinetics of Protein Therapeutics

scientific article published on October 2015

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge

scientific article

Hyaluronic Acid-Antibody Fragment Bioconjugates for Extended Ocular Pharmacokinetics

scientific article published on 11 October 2019

Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats ⬇️

scientific article published on October 3, 2011

Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice

scientific article

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

scientific article

Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics ⬇️

scientific article published on May 18, 2012

Polyclonal antibodies to xenogeneic endothelial cells induce apoptosis and block support of tumor growth in mice.

scientific article published on June 2003

Preclinical pharmacokinetic characterization of an adipose tissue-targeting monoclonal antibody in obese and non-obese animals

scientific article published on 12 September 2017

Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor.

scientific article published on 26 February 2016

Production, characterization, and in vivo half-life extension of polymeric IgA molecules in mice

scientific article published on 09 June 2019

Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor

scientific article

Radiolabeling and in vivo behavior of copper-64-labeled cross-bridged cyclam ligands.

scientific article published in January 2002

Relative Target Affinities of T Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model.

scientific article published on 16 January 2018

Site-specific conjugation allows modulation of click reaction stoichiometry for pretargeted SPECT imaging

scientific article published on 04 October 2018

Synthesis of a cross-bridged cyclam derivative for peptide conjugation and 64Cu radiolabeling.

scientific article published on 3 July 2008

Synthesis, characterization, and biological evaluation of integrin alphavbeta3-targeted PAMAM dendrimers.

scientific article published on 07 June 2008

Tissue Physiology of Cynomolgus Monkeys: Cross-Species Comparison and Implications for Translational Pharmacology

article

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants.

scientific article published on 27 January 2014

Validation of a novel CHX-A'' derivative suitable for peptide conjugation: small animal PET/CT imaging using yttrium-86-CHX-A''-octreotide.

scientific article published in July 2006

Vascular physiology and protein disposition in a preclinical model of neurodegeneration.

scientific article published on 25 February 2013

Paulina is supported by:

About Paulina

Help