List of works by Malcolm Duthie

A rapid ELISA for the diagnosis of MB leprosy based on complementary detection of antibodies against a novel protein-glycolipid conjugate.

scientific article

A synthetic adjuvant to enhance and expand immune responses to influenza vaccines

scientific article (publication date: 27 October 2010)

Accurate Serodetection of Asymptomatic Leishmania donovani Infection by Use of Defined Antigens

scientific article published on 3 February 2016

Adjuvants

scientific article published on 25 July 2018

Advances toward Diagnostic Tools for Managing Zoonotic Visceral Leishmaniasis

scientific article published on 18 August 2018

Alteration of the serum biomarker profiles of visceral leishmaniasis during treatment

scientific article published on 31 October 2013

Alterations to antigen-specific immune responses before and after multidrug therapy of leprosy.

scientific article published on 2 July 2015

Analysis of antibody responses to Mycobacterium leprae phenolic glycolipid I, lipoarabinomannan, and recombinant proteins to define disease subtype-specific antigenic profiles in leprosy.

scientific article

Anti-natural octyl disaccharide-leprosy IDRI diagnostic (NDO-LID) antibodies as indicators of leprosy reactions and neuritis.

scientific article published on March 2017

Antigen-specific T-cell responses of leprosy patients

scientific article published on 10 September 2008

Antigen-specific secretion of IFNγ and CXCL10 in whole blood assay detects Mycobacterium leprae infection but does not discriminate asymptomatic infection from symptomatic leprosy.

scientific article published on 5 January 2017

Application of Mycobacterium Leprae-specific cellular and serological tests for the differential diagnosis of leprosy from confounding dermatoses.

scientific article published on 27 July 2016

Applying TLR synergy in immunotherapy: implications in cutaneous leishmaniasis.

scientific article

Assessing epidemiology of leprosy and socio-economic distribution of cases

scientific article published on 06 July 2018

Biomarkers for intracellular pathogens: establishing tools as vaccine and therapeutic endpoints for visceral leishmaniasis

scientific article

Both CD1d antigen presentation and interleukin-12 are required to activate natural killer T cells during Trypanosoma cruzi infection

scientific article

Clinical and epidemiological indicators and spatial analysis of leprosy cases in patients under 15 years old in an endemic area of Northeast Brazil: an ecological and time series study

scientific article published on 27 July 2019

Combination chemoprophylaxis and immunoprophylaxis in reducing the incidence of leprosy

scientific article

Comparative evaluation of antibody detection tests to facilitate the diagnosis of multibacillary leprosy

scientific article published on 28 January 2016

Comparison of Enzyme-Linked Immunosorbent Assay Using Either Natural Octyl Disaccharide-Leprosy IDRI Diagnostic or Phenolic Glycolipid-I Antigens for the Detection of Leprosy Patients in Colombia.

scientific article published on 6 November 2017

Computationally Designed Bispecific MD2/CD14 Binding Peptides Show TLR4 Agonist Activity

scientific article published on 22 October 2018

Correlates of GLA family adjuvants' activities

scientific article published on 23 October 2018

Could canine visceral leishmaniosis take hold in the UK?

scientific article published on 01 April 2019

Critical proinflammatory and anti-inflammatory functions of different subsets of CD1d-restricted natural killer T cells during Trypanosoma cruzi infection.

scientific article

Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant

scientific article published on 26 January 2011

Development and pre-clinical assessment of a 73 kD chimeric fusion protein as a defined sub-unit vaccine for leprosy.

scientific article published on 8 December 2012

Development of a high density hemagglutinin protein microarray to determine the breadth of influenza antibody responses

scientific article

Development of a mouse food pad model for detection of sub clinical leprosy

scientific article published on 01 December 2011

Development of a quantitative rapid diagnostic test for multibacillary leprosy using smart phone technology.

scientific article

Differential effects of UVA1 and UVB radiation on Langerhans cell migration in mice

scientific article published on 01 September 2000

Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum

scientific article published on 28 January 2019

Distinct Roles of Th17 and Th1 Cells in Inflammatory Responses Associated with the Presentation of Paucibacillary Leprosy and Leprosy Reactions

scientific article published on 20 April 2017

During acute Trypanosoma cruzi infection highly susceptible mice deficient in natural killer cells are protected by a single alpha-galactosylceramide treatment

scientific article published on 26 July 2006

Evaluation of diagnostic performance of rK28 ELISA using urine for diagnosis of visceral leishmaniasis

scientific article published on 04 July 2016

Evaluation of novel tools to facilitate the detection and characterization of leprosy patients in China

scientific article

High levels of soluble CD40 ligand and matrix metalloproteinase-9 in serum are associated with favorable clinical evolution in human visceral leishmaniasis.

scientific article

IL-18 and Subcapsular Lymph Node Macrophages are Essential for Enhanced B Cell Responses with TLR4 Agonist Adjuvants.

scientific article

Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy

scientific article published in 2012

Identifying Leprosy and Those at Risk of Developing Leprosy by Detection of Antibodies against LID-1 and LID-NDO

scientific article

Immunologically reactive M. leprae antigens with relevance to diagnosis and vaccine development

scientific article

Immunomodulatory and physical effects of oil composition in vaccine adjuvant emulsions.

scientific article

Immunomodulatory and physical effects of phospholipid composition in vaccine adjuvant emulsions.

scientific article

Impact of sequelae of visceral leishmaniasis and their contribution to ongoing transmission of Leishmania donovani

scientific article published on 01 August 2019

Insight toward early diagnosis of leprosy through analysis of the developing antibody responses of Mycobacterium leprae-infected armadillos.

scientific article

Integrative literature review of the reported uses of serological tests in leprosy management

scientific article

Interleukin 17A acts synergistically with interferon γ to promote protection against Leishmania infantum infection

scientific article published on October 2014

LepVax, a defined subunit vaccine that provides effective pre-exposure and post-exposure prophylaxis of M. leprae infection.

scientific article published on 28 March 2018

Micronutrients influencing the immune response in leprosy

scientific article published on January 2014

Multi-epitope proteins for improved serological detection of Trypanosoma cruzi infection and Chagas Disease.

scientific article published on 10 November 2015

Multibacillary leprosy patients with high and persistent serum antibodies to leprosy IDRI diagnostic-1/LID-1: higher susceptibility to develop type 2 reactions.

scientific article

Need for, and acceptability of, rapid diagnostic tests that can facilitate the diagnosis of leprosy

scientific article published on 01 June 2016

Nitazoxanide is active against Mycobacterium leprae.

scientific article published on 29 August 2017

Not All Antigens Are Created Equally: Progress, Challenges, and Lessons Associated with Developing a Vaccine for Leishmaniasis.

scientific article

Optimizing Immunization Strategies for the Induction of Antigen-Specific CD4 and CD8 T Cell Responses for Protection against Intracellular Parasites.

scientific article published on 27 July 2016

Optimizing manufacturing and composition of a TLR4 nanosuspension: physicochemical stability and vaccine adjuvant activity

scientific article published on 21 December 2013

Protection of mice from Mycobacterium tuberculosis by ID87/GLA-SE, a novel tuberculosis subunit vaccine candidate.

scientific article

Rapid quantitative serological test for detection of infection with Mycobacterium leprae, the causative agent of leprosy

scientific article published on 11 December 2013

Rational design and evaluation of a multiepitope chimeric fusion protein with the potential for leprosy diagnosis

scientific article

Real-time PCR in detection and quantitation of Leishmania donovani for the diagnosis of Visceral Leishmaniasis patients and the monitoring of their response to treatment

scientific article published on 28 September 2017

Recovery of antigen-specific T cell responses from dogs infected with Leishmania (L.) infantum by use of vaccine associated TLR-agonist adjuvant.

scientific article published on 21 September 2016

Screening and identification of immunoactive peptide mimotopes for the enhanced serodiagnosis of tuberculosis

scientific article published on 18 November 2015

Second coming: the re-emergence and modernization of immunotherapy by vaccines as a component of leprosy control

scientific article published on 12 October 2018

Selection of antigens and development of prototype tests for point-of-care leprosy diagnosis.

scientific article published on 20 August 2008

Semi-quantitative measurement of asymptomatic L. infantum infection and symptomatic visceral leishmaniasis in dogs using Dual-Path Platform® CVL.

scientific article published on 31 October 2016

Serologic follow-up of IgG responses against recombinant mycobacterial proteins ML0405, ML2331 and LID-1 in a leprosy hyperendemic area in Venezuela

scientific article published on 01 December 2012

Serological characterizations of tandem repeat proteins for detection of African trypanosome infection in cattle.

scientific article published on 14 September 2011

Seroreactivity to new Mycobacterium leprae protein antigens in different leprosy-endemic regions in Brazil.

scientific article published on December 2012

Social and environmental conditions related to Mycobacterium leprae infection in children and adolescents from three leprosy endemic regions of Colombia

scientific article published on 13 June 2019

Specific IgG antibody responses may be used to monitor leprosy treatment efficacy and as recurrence prognostic markers

article

Specific antibody responses as indicators of treatment efficacy for visceral leishmaniasis.

scientific article published on 19 November 2014

Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-γ.

scientific article published on 3 December 2014

Synergistic antigen combinations for the development of interferon gamma release assays for paucibacillary leprosy.

scientific article

The development and clinical evaluation of second-generation leishmaniasis vaccines.

scientific article

The effects of ultraviolet radiation on the human immune system.

scientific article

The potential for vaccination in leprosy elimination: new tools for targeted interventions.

scientific article published on December 2012

Treatment with alpha-galactosylceramide before Trypanosoma cruzi infection provides protection or induces failure to thrive

scientific article published on 01 June 2002

Trypanosoma cruzi-infected individuals demonstrate varied antibody responses to a panel of trans-sialidase proteins encoded by SA85-1 genes

article

Tuberculosis and leprosy infections in the Marshallese population of Arkansas, USA.

scientific article

Unexpectedly high leprosy seroprevalence detected using a random surveillance strategy in midwestern Brazil: A comparison of ELISA and a rapid diagnostic test

scientific article published on 23 February 2017

Use of defined TLR ligands as adjuvants within human vaccines.

scientific article published on January 2011

Utility and limitations of serodiagnostic tests in monitoring the response to treatment of leprosy patients

scientific article published on 03 January 2020

Utility of recombinant proteins LID-1 and PADL in screening for Mycobacterium leprae infection and leprosy.

scientific article published on 7 June 2014

Vaccination with the Surface Proteins MUL_2232 and MUL_3720 of Mycobacterium ulcerans Induces Antibodies but Fails to Provide Protection against Buruli Ulcer.

scientific article published on 5 February 2016

Vaccines for leishmaniasis and the implications of their development for American tegumentary leishmaniasis

scientific article published on 11 November 2019

Zoonotic Leprosy in the Southeastern United States

scientific article

sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis

scientific article

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