Search filters

List of works by John Simpson

16S pan-bacterial PCR can accurately identify patients with ventilator-associated pneumonia

scientific article published on 14 December 2016

A 29-year-old male with chest pain and haemoptysis.

scientific article published on November 2008

A national survey of the diagnosis and management of suspected ventilator-associated pneumonia.

scientific article

A novel subpopulation of monocyte-like cells in the human lung after lipopolysaccharide inhalation

scientific article published on 20 January 2012

A profile of lower-limb deep-vein thrombosis: the hidden menace of below-knee DVT

scientific article published on 15 June 2007

A randomized controlled trial of peripheral blood mononuclear cell depletion in experimental human lung inflammation.

scientific article published in August 2013

Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection

scientific article (publication date: August 2001)

Antibiotic prophylaxis for ventilator-associated pneumonia: more is less or less is more?

scientific article published on 01 November 2013

Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS.

scientific article published on 12 January 2017

Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation ⬇️

scientific article published on 8 November 2017

C5a mediates peripheral blood neutrophil dysfunction in critically ill patients

scientific article (publication date: July 2009)

Can mid-regional pro-adrenomedullin (MR-proADM) increase the prognostic accuracy of NEWS in predicting deterioration in patients admitted to hospital with mild to moderately severe illness? A prospective single-centre observational study ⬇️

scientific article published on 22 February 2019

Cathelicidin host defence peptide augments clearance of pulmonary Pseudomonas aeruginosa infection by its influence on neutrophil function in vivo

scientific article

Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study.

scientific article

Circulating tissue-type plasminogen activator and plasminogen activator inhibitor type 1 in proliferative diabetic retinopathy: a pilot study

scientific article published on 01 September 1999

Clinically suspected acute pulmonary embolism: a comparison of presentation, radiological features and outcome in patients with and without PE

scientific article published on 17 April 2009

Combined dysfunctions of immune cells predict nosocomial infection in critically ill patients

scientific article

Copy Number Variation of FCGR3B Is Associated with Susceptibility to Idiopathic Pulmonary Fibrosis

scientific article published in 2011

Cost Consequences for the NHS of Using a Two-Step Testing Method for the Detection of Clostridium difficile with a Point of Care, Polymerase Chain Reaction Test as the First Step

scientific article published on 14 October 2020

Cost implications for the NHS of using the Alere™ i Influenza A & B near patient test with nasal swabs

scientific article published on 01 August 2018

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

scientific article published on 07 December 2021

Diagnostic accuracy and cost analysis of the Alere™ i Influenza A&B near-patient test using throat swabs.

scientific article published on 27 May 2017

Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia.

scientific article

Diagnostic and economic evaluation of a point-of-care test for respiratory syncytial virus

scientific article published on 01 July 2020

Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia

scientific article

Differential response to bacteria, and TOLLIP expression, in the human respiratory tract.

scientific article

Dynamic susceptibility contrast 19 F-MRI of inhaled perfluoropropane: a novel approach to combined pulmonary ventilation and perfusion imaging

scientific article published on 29 August 2019

Early PREdiction of Severe Sepsis (ExPRES-Sepsis) study: protocol for an observational derivation study to discover potential leucocyte cell surface biomarkers

scientific article published on August 2016

Early PREdiction of sepsis using leukocyte surface biomarkers: the ExPRES-sepsis cohort study

scientific article published on 05 October 2018

Early clinical experiences with nintedanib in three UK tertiary interstitial lung disease centres

scientific article published on 3 November 2017

Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis.

scientific article published in November 2013

Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use (VAPrapid-2): study protocol for a randomised controlled trial

scientific article published on 16 July 2016

Efficiency and Health Economic Evaluations of BD OneFlow™ Flow Cytometry Reagents for Diagnosing Chronic Lymphoid Leukemia

scientific article published on 02 April 2019

Elafin (elastase-specific inhibitor) has anti-microbial activity against gram-positive and gram-negative respiratory pathogens

scientific article published on 01 June 1999

Emergency pre-hospital management of patients admitted with acute asthma

scientific article published on February 2000

Erratum to: 'Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use (VAPrapid-2): study protocol for a randomised controlled trial'.

scientific article published on 26 September 2016

Establishment of an immortalized human subglottic epithelial cell line

scientific article published on 08 January 2019

Evaluation of the effect of diagnostic methodology on the reported incidence of ventilator-associated pneumonia

scientific article published on 12 February 2009

Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients

scientific article published on 9 February 2018

Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2-agonists, corticosteroids, and critical illness.

scientific article published on 17 September 2015

Fcγ receptor IIIb (CD16b) polymorphisms are associated with susceptibility to idiopathic pulmonary fibrosis.

scientific article

Functional characterisation of human pulmonary monocyte-like cells in lipopolysaccharide-mediated acute lung inflammation

scientific article

Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function.

scientific article

Home treatment of COPD exacerbation selected by DECAF score: a non-inferiority, randomised controlled trial and economic evaluation

scientific article published on 21 April 2018

Hospital-acquired pneumonia surveillance-an unmet need

scientific article published on 03 August 2017

IPF: time for the (ciliary) beat generation?

scientific article published on 04 September 2013

Improving the use of sputum cultures in lower respiratory tract infection

scientific article published on 01 January 2013

In vivo mononuclear cell tracking using superparamagnetic particles of iron oxide: feasibility and safety in humans.

scientific article published on 10 July 2012

Leukoreduced blood transfusion does not increase circulating soluble markers of inflammation: a randomized controlled trial

scientific article

Lipopolysaccharide inhalation recruits monocytes and dendritic cell subsets to the alveolar airspace

scientific article published on 30 April 2019

Low-pathogenicity Mycoplasma spp. alter human monocyte and macrophage function and are highly prevalent among patients with ventilator-acquired pneumonia

scientific article

Ly6ChiMonocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis

scientific article published in September 2011

MPLA inhibits release of cytotoxic mediators from human neutrophils while preserving efficient bacterial killing.

scientific article

Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury.

scientific article

Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome

scientific article published on 3 May 2017

Optimized and accelerated 19 F-MRI of inhaled perfluoropropane to assess regional pulmonary ventilation

scientific article published on 17 May 2019

Oropharyngeal Microbiota in Frail Older Patients Unaffected by Time in Hospital.

scientific article

Pet ownership and asthma morbidity

scientific article published on 01 January 2000

Predictive value of cell-surface markers in infections in critically ill patients: protocol for an observational study (ImmuNe FailurE in Critical Therapy (INFECT) Study).

scientific article published on 18 July 2016

Prognostic significance of the lung scintigraphy scan result and corresponding chest X-ray in patients with suspected pulmonary embolism.

scientific article published in September 2010

Pulmonary and systemic effects of mononuclear leukapheresis

scientific article published on 12 April 2012

Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis

scientific article published on 31 July 2018

Randomised, double-blind, placebo-controlled pilot trial of omeprazole in idiopathic pulmonary fibrosis

scientific article published on 04 January 2019

Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus

scientific article

Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis

scientific article published on 22 June 2020

Reflux in idiopathic pulmonary fibrosis: treatment informed by an integrated approach

scientific article published on 01 October 2018

Regulation of Adenovirus-Mediated Elafin Transgene Expression by Bacterial Lipopolysaccharide

article

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages

scientific article published on 06 July 2009

Serial characterisation of monocyte and neutrophil function after lung resection

scientific article published on 16 September 2014

Should We Tip Our CAPs to Statins?

scientific article published on 01 November 2019

Single-cell multi-omics analysis of the immune response in COVID-19

scientific article published on 20 April 2021

Starting home nebulizer therapy: patients' expectations and subsequent outcome at 2 months

scientific article published on 01 August 1998

The Intensive Care Society recommended bundle of interventions for the prevention of ventilator-associated pneumonia

scientific article published on 20 April 2016

The PEARL score predicts 90-day readmission or death after hospitalisation for acute exacerbation of COPD.

scientific article published on 24 February 2017

The heterogeneity of systemic inflammation in bronchiectasis.

scientific article published on 17 April 2017

The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system.

scientific article published on 22 June 2006

The management of pulmonary tuberculosis in adults notified in Scotland in 1993

scientific article published on 01 November 1998

Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment

scientific article published on 05 March 2009

Validation of the DECAF score to predict hospital mortality in acute exacerbations of COPD

scientific article published on February 2016

Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung

scientific article published on 01 December 2012

Paulina is supported by:

About Paulina

Help