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List of works by Rima Rozen

A common polymorphism in methionine synthase reductase increases risk of premature coronary artery disease

scientific article published in June 2000

A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida

scientific article (publication date: August 1999)

A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development

scientific journal article

A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment.

scientific article published on 23 June 2010

Age Dependence of the Influence of Methylenetetrahydrofolate Reductase Genotype on Plasma Homocysteine Level ⬇️

scientific article published on November 1, 2003

Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.

scientific article published in July 2008

Antioxidant vitamins, long-chain fatty acids, and spontaneous preterm birth

scientific article

Antisense inhibition of methylenetetrahydrofolate reductase reduces cancer cell survival in vitro and tumor growth in vivo

scientific article

ApcMin/+ mouse model of colon cancer: gene expression profiling in tumors

scientific article published in December 2004

Assignment of the gene (UQCRFS1) for the Rieske iron-sulfur protein subunit of the mitochondrial cytochrome bc1 complex to the 22q13 and 19q12-q13.1 regions of the human genome

scientific article

Assignment of the gene for the core protein II (UQCRC2) subunit of the mitochondrial cytochrome bc1 complex to human chromosome 16p12

scientific article

Assignment of the gene for the cytochrome c1 subunit of the mitochondrial cytochrome bc1 complex (CYC1) to human chromosome 8q24.3

scientific article

Associations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption

scientific article

Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency

scientific journal article

Biochemistry and genetics of folate metabolism.

scientific article published on 15 December 2010

Cerebral vascular complication and hyperhomocysteinemia in a cystinotic uremic child

scientific article published on 01 January 1999

Characterization of a pseudogene for murine methylenetetrahydrofolate reductase

scientific article published on October 1, 2003

Characterization of mutations in severe methylenetetrahydrofolate reductase deficiency reveals an FAD-responsive mutation

scientific article

Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria

article

Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida

article

Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes.

scientific article

DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line

scientific article published on 11 September 2012

Design and rationale of a genetic cohort study on congenital cardiac disease: experiences from a multi-institutional platform in Quebec

Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.

scientific article published on July 2010

Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice

scientific article published on 24 September 2012

Disturbed one-carbon metabolism causing adverse reproductive outcomes in mice is associated with altered expression of apolipoprotein AI and inflammatory mediators PPARα, interferon-γ, and interleukin-10

scientific article published on 18 January 2012

Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency

scientific article published on 04 October 2018

Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice

scientific article published on 20 November 2003

Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice

scientific article published on 26 June 2003

Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency

scientific journal article

Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study.

scientific article published in January 2003

Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease

scientific article published on 26 January 2006

Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer

scientific article published on 7 December 2007

Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice

scientific article

Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk

scientific article

Frequency and phenotypic consequences of the 3199del6 CFTR mutation in French Canadians

scientific article published on 01 March 2005

Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients

scientific article published on 29 October 2013

Genetic and nutritional deficiencies in folate metabolism influence tumorigenicity in Apcmin/+ mice.

scientific article

Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects

article

High Dietary Folate in Mice Alters Immune Response and Reduces Survival after Malarial Infection

scientific article published on 24 November 2015

High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.

scientific article

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.

scientific article

High folic acid intake increases methylation-dependent expression of Lsr and dysregulates hepatic cholesterol homeostasis

scientific article published on 18 November 2020

High intake of folic acid disrupts embryonic development in mice ⬇️

scientific article published on December 22, 2010

Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF-kappaB/iNOS.

scientific article

Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency

scientific article

Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders

scientific article

Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency.

scientific article published on 23 June 2009

Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice

scientific article published in January 2003

Impact of methylenetetrahydrofolate reductase deficiency and low dietary folate on the development of neural tube defects in splotch mice

scientific article published in January 2006

Increased resistance to malaria in mice with methylenetetrahydrofolate reductase (Mthfr) deficiency suggests a mechanism for selection of the MTHFR 677C>T (c.665C>T) variant

scientific article published on 31 March 2014

Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation

scientific article published on 17 November 2004

Influence of methylenetetrahydrofolate reductase genotype, age, vitamin B-12, and folate status on plasma homocysteine in children

scientific article published in December 2000

Inherited Thrombophilia and Preeclampsia Within a Multicenter Cohort: The Montreal Preeclampsia Study

Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study

scientific article

Interview with Rima Rozen

scientific article

Intestinal neoplasia induced by low dietary folate is associated with altered tumor expression profiles and decreased apoptosis in mouse normal intestine

scientific article published on 28 January 2009

Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease.

scientific article

Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects

scientific article published on 01 April 2018

Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice

scientific article published on 17 February 2010

Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN‐γ in spleen and placenta, and through reduction of methylation potential ⬇️

scientific article published on October 30, 2012

Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.

scientific article published in November 2006

MTHFD1 formyltetrahydrofolate synthetase deficiency, a model for the MTHFD1 R653Q variant, leads to congenital heart defects in mice

scientific article published on 26 September 2015

MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring

scientific article

Maternal folate deficiency affects proliferation, but not apoptosis, in embryonic mouse heart

scientific article published on 01 July 2006

Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice

scientific article published in July 2005

Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency

scientific article published on 14 April 2008

Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase

scientific article

Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice

scientific article

Methotrexate-induced apoptosis is enhanced by altered expression of methylenetetrahydrofolate reductase.

scientific article published in October 2009

Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid

scientific article (publication date: June 2003)

Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice

scientific article published in June 2009

Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy ⬇️

scientific article published on May 1, 2003

Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians

scientific article published on 01 November 1996

Methylenetetrahydrofolate reductase: a link between folate and riboflavin?

scientific article published on 01 August 2002

Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates

scientific article published on 01 November 2004

Microarray analysis of brain RNA in mice with methylenetetrahydrofolate reductase deficiency and hyperhomocysteinemia

scientific article published on 01 January 2002

Mild methylenetetrahydrofolate reductase deficiency alters inflammatory and lipid pathways in liver

scientific article published on 23 November 2018

Moderate Folic Acid Supplementation in Pregnant Mice Results in Behavioral Alterations in Offspring with Sex-Specific Changes in Methyl Metabolism

scientific article published on 08 June 2020

Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development

scientific article published on 5 October 2016

Moderately high intake of folic acid has a negative impact on mouse embryonic development ⬇️

scientific article published on November 2, 2012

Molecular cloning, expression and physical mapping of the human methionine synthase reductase gene

scientific article (publication date: 15 November 1999)

Molecular genetics of MTHFR: polymorphisms are not all benign

scientific article

Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.

scientific article

Mthfr as a modifier of the retinal phenotype of Crb1(rd8/rd8) mice.

scientific article published on 29 November 2015

Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms

scientific article

Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors

scientific article published on 6 September 2016

Murine diet/tissue and human brain tumorigenesis alter Mthfr/MTHFR 5'-end methylation

scientific article

Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation

scientific article published on August 2010

Oncogenic role of PDK4 in human colon cancer cells

scientific article published on 16 February 2017

Plasma homocysteine concentration changes after renal transplantation in children

scientific article published on 22 May 2002

Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome

scientific article

Postnatal cerebellar defects in mice deficient in methylenetetrahydrofolate reductase

scientific article

Prenatal diagnosis for severe methylenetetrahydrofolate reductase deficiency by linkage analysis and enzymatic assay.

scientific article published in April 2005

Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency

scientific article published on 5 September 2014

Regulatory studies of murine methylenetetrahydrofolate reductase reveal two major promoters and NF-kappaB sensitivity

scientific article published on 3 October 2005

Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.

scientific article published in January 1996

Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia

scientific article published on April 2015

Risk of congenital heart defects is influenced by genetic variation in folate metabolism

scientific article

SLC7A9 mutations in all three cystinuria subtypes

scientific article published in November 2002

Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus.

scientific article published on 4 April 2012

Severe methylenetetrahydrofolate reductase deficiency: clinical clues to a potentially treatable cause of adult-onset hereditary spastic paraplegia

scientific article published in July 2014

Small artery mechanics in hyperhomocysteinemic mice: effects of angiotensin II.

scientific article published in May 2004

Spina bifida, folate metabolism, and dietary folate intake in a Northern Canadian aboriginal population

scientific article

Steatosis in Mice Is Associated with Gender, Folate Intake, and Expression of Genes of One-Carbon Metabolism ⬇️

scientific article published on August 19, 2010

Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate

scientific article published on 01 April 2008

Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice

scientific article published on 5 May 2010

Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice ⬇️

scientific article published on January 1, 2002

Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair

scientific article published on 28 December 2010

Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation ⬇️

scientific article published on July 19, 2011

Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation

scientific article

The MTHFD1 1958G>A variant is associated with elevated C-reactive protein and body mass index in Canadian women from a premature birth cohort

scientific article published on 11 December 2013

The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects

scientific article

The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr

scientific article

Transient neonatal cystinuria

scientific article published in February 2005

Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency

scientific article published on October 2008

Vasculopathic and thrombophilic risk factors for spontaneous preterm birth

scientific article

β,β-Carotene 15,15′-monooxygenase and its substrate β-carotene modulate migration and invasion in colorectal carcinoma cells ⬇️

scientific article published on June 26, 2013

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