List of works - Hai-Bing Zhou

A high-affinity subtype-selective fluorescent probe for estrogen receptor β imaging in living cells

scientific article published on 3 April 2018

A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer

scientific article published on 18 March 2018

Applications of Chiral Squaramides: From Asymmetric Organocatalysis to Biologically Active Compounds

scientific article published on 10 March 2016

Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides.

scientific article

Bicyclo[2.2.2]octanes: close structural mimics of the nuclear receptor-binding motif of steroid receptor coactivators.

scientific article published on 23 May 2007

Bisperoxovandium (pyridin-2-squaramide) targets both PTEN and ERK1/2 to confer neuroprotection

scientific article published on 27 January 2017

Construction of benzofuranone library via a metal-free, one-pot intermolecular condensation, and their application as efficient estrogen receptor β modulators

scientific article published on 29 October 2019

Design and synthesis of heteroaromatic-based benzenesulfonamide derivatives as potent inhibitors of H5N1 influenza A virus

scientific article published on 23 November 2018

Design, synthesis and biological evaluation of novel estrogen-derived steroid metal complexes.

scientific article published on 9 May 2013

Development of [F-18]fluorine-substituted Tanaproget as a progesterone receptor imaging agent for positron emission tomography.

scientific article

Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo[2.2.1]heptene scaffold and evaluation of their antiproliferative effects in breast cancer cells

scientific article published on 14 November 2012

Dual functional small molecule fluorescent probes for image-guided estrogen receptor-specific targeting coupled potent antiproliferative potency for breast cancer therapy.

scientific article published on 4 May 2017

Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands

scientific article

Enantioselective inhibition of reverse transcriptase (RT) of HIV-1 by non-racemic indole-based trifluoropropanoates developed by asymmetric catalysis using recyclable organocatalysts

scientific article published on 8 November 2013

Enantioselective synthesis of novel pyrano[3,2-c]chromene derivatives as AChE inhibitors via an organocatalytic domino reaction

scientific article published on 21 December 2017

Establishment of evaluation criteria for the development of high quality ERα-targeted fluorescent probes

scientific article published on 28 August 2020

Fluorine-18 labeling and biodistribution studies on peroxisome proliferator-activated receptor-gamma ligands: potential positron emission tomography imaging agents.

scientific article published on February 2009

Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins

scientific article published on 19 October 2016

High-throughput screening assays for estrogen receptor by using coumestrol, a natural fluorescence compound

scientific article

Highly diastereoselective synthesis of quaternary α-trifluoromethyl α-amino acids from chiral imines of trifluoropyruvate.

scientific article published on 20 September 2010

Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors

scientific article

Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide.

scientific article published on 21 February 2012

Imaging progesterone receptor in breast tumors: synthesis and receptor binding affinity of fluoroalkyl-substituted analogues of tanaproget.

scientific article

Isocyanides as Influenza A Virus Subtype H5N1 Wild-Type M2 Channel Inhibitors

scientific article published on 7 September 2015

NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

scientific article

Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer.

scientific article published on 20 May 2015

Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer

scientific article published on 16 August 2018

Novel rhodium-catalyzed reaction of thiazolidine derivatives with carbodiimides.

scientific article published in November 2004

One-step pathway to selenoisobenzofuran-1(3H)-imine derivatives through highly selective selenocyclization of olefinic amides with benzeneselenyl chloride.

scientific article

Oxabicycloheptene Sulfonate Protects Against β-Amyloid-induced Toxicity by Activation of PI3K/Akt and ERK Signaling Pathways Via GPER1 in C6 Cells.

scientific article

Predictive features of ligand-specific signaling through the estrogen receptor

scientific article

Rational design and optimization of selenophenes with basic side chains as novel potent selective estrogen receptor modulators (SERMs) for breast cancer therapy

scientific article published on 24 May 2017

Rational design of ERα targeting hypoxia turn-on fluorescent probes with antiproliferative activity for breast cancer

scientific article published on 10 August 2020

Recent advances in gossypol derivatives and analogs: a chemistry and biology view

scientific article

Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus

scientific article

Selenophenes: Introducing a New Element into the Core of Non-Steroidal Estrogen Receptor Ligands

scientific article

Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains.

scientific article published on January 2007

Synthesis and SARs of indole-based α-amino acids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

scientific article

Synthesis and structure-activity relationships of novel hybrid ferrocenyl compounds based on a bicyclic core skeleton for breast cancer therapy

scientific article published on 18 May 2016

Synthesis of seven-membered ring diazepin-2-ones via palladium-catalyzed highly regioselective cyclization of 2-vinylpyrrolidines with aryl isocyanates

scientific article published on 01 May 2003

Thiophene-core estrogen receptor ligands having superagonist activity.

scientific article published on 15 April 2013

Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor.

scientific article published on 07 April 2014

List of works by Hai-Bing Zhou

A high-affinity subtype-selective fluorescent probe for estrogen receptor β imaging in living cells

A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer

Applications of Chiral Squaramides: From Asymmetric Organocatalysis to Biologically Active Compounds

Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides.

Bicyclo[2.2.2]octanes: close structural mimics of the nuclear receptor-binding motif of steroid receptor coactivators.

Bisperoxovandium (pyridin-2-squaramide) targets both PTEN and ERK1/2 to confer neuroprotection

Construction of benzofuranone library via a metal-free, one-pot intermolecular condensation, and their application as efficient estrogen receptor β modulators

Design and synthesis of heteroaromatic-based benzenesulfonamide derivatives as potent inhibitors of H5N1 influenza A virus

Design, synthesis and biological evaluation of novel estrogen-derived steroid metal complexes.

Development of [F-18]fluorine-substituted Tanaproget as a progesterone receptor imaging agent for positron emission tomography.

Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo[2.2.1]heptene scaffold and evaluation of their antiproliferative effects in breast cancer cells

Dual functional small molecule fluorescent probes for image-guided estrogen receptor-specific targeting coupled potent antiproliferative potency for breast cancer therapy.

Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands

Enantioselective inhibition of reverse transcriptase (RT) of HIV-1 by non-racemic indole-based trifluoropropanoates developed by asymmetric catalysis using recyclable organocatalysts

Enantioselective synthesis of novel pyrano[3,2-c]chromene derivatives as AChE inhibitors via an organocatalytic domino reaction

Establishment of evaluation criteria for the development of high quality ERα-targeted fluorescent probes

Fluorine-18 labeling and biodistribution studies on peroxisome proliferator-activated receptor-gamma ligands: potential positron emission tomography imaging agents.

Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins

High-throughput screening assays for estrogen receptor by using coumestrol, a natural fluorescence compound

Highly diastereoselective synthesis of quaternary α-trifluoromethyl α-amino acids from chiral imines of trifluoropyruvate.

Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors

Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide.

Imaging progesterone receptor in breast tumors: synthesis and receptor binding affinity of fluoroalkyl-substituted analogues of tanaproget.

Isocyanides as Influenza A Virus Subtype H5N1 Wild-Type M2 Channel Inhibitors

NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer.

Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer

Novel rhodium-catalyzed reaction of thiazolidine derivatives with carbodiimides.

One-step pathway to selenoisobenzofuran-1(3H)-imine derivatives through highly selective selenocyclization of olefinic amides with benzeneselenyl chloride.

Oxabicycloheptene Sulfonate Protects Against β-Amyloid-induced Toxicity by Activation of PI3K/Akt and ERK Signaling Pathways Via GPER1 in C6 Cells.

Predictive features of ligand-specific signaling through the estrogen receptor

Rational design and optimization of selenophenes with basic side chains as novel potent selective estrogen receptor modulators (SERMs) for breast cancer therapy

Rational design of ERα targeting hypoxia turn-on fluorescent probes with antiproliferative activity for breast cancer

Recent advances in gossypol derivatives and analogs: a chemistry and biology view

Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus

Selenophenes: Introducing a New Element into the Core of Non-Steroidal Estrogen Receptor Ligands

Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains.

Synthesis and SARs of indole-based α-amino acids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

Synthesis and structure-activity relationships of novel hybrid ferrocenyl compounds based on a bicyclic core skeleton for breast cancer therapy

Synthesis of seven-membered ring diazepin-2-ones via palladium-catalyzed highly regioselective cyclization of 2-vinylpyrrolidines with aryl isocyanates

Thiophene-core estrogen receptor ligands having superagonist activity.

Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor.