List of works - Ken-ichi Takao

Asymmetric construction of all-carbon quaternary stereocenters by chiral-auxiliary-mediated Claisen rearrangement and total synthesis of (+)-bakuchiol

scientific article published on 08 November 2012

Asymmetric total syntheses of (+)-cheimonophyllon e and (+)-cheimonophyllal

scientific article published in September 2002

Asymmetric total syntheses of (+)-mycoepoxydiene and related natural product (-)-1893A: application of one-pot ring-opening/cross/ring-closing metathesis to construct their 9-oxabicyclo[4.2.1]nona-2,4-diene skeleton.

scientific article published in December 2004

Biological activities of 1,1,6-trisubstituted indanes: beyond magainin 2.

scientific article

Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action.

scientific article

Determination of the absolute structure of (+)-akaterpin.

scientific article published in January 2012

Enantioselective Organocatalytic Construction of Spiroindane Derivatives by Intramolecular Friedel-Crafts-Type 1,4-Addition

scientific article published on 25 April 2016

Enantioselective Total Synthesis of (-)-Misramine

scientific article published on 06 August 2018

Highly diastereoselective 1,4-addition of an organocuprate to methyl alpha-D-gluco-, alpha-D-manno-, or alpha-D-galactopyranosides tethering an alpha,beta-unsaturated ester. Novel asymmetric access to beta-C-substituted butanoic acids.

scientific article

Identification of seco-clavilactone B as a small-molecule actin polymerization inhibitor

scientific article

Identification of topoisomerases as molecular targets of cytosporolide C and its analog

scientific article published on 06 June 2019

Identification of vibsanin A analog as a novel HSP90 inhibitor

scientific article published on 09 December 2019

Preparation and properties of thermosensitive hydrogel microcapsules

scientific article published on 01 August 2001

Recent advances in natural product synthesis by using intramolecular Diels-Alder reactions.

scientific article

Stereoselective Synthesis of the Tricyclic Core of (-)-Callophycoic Acid A

scientific article published on 24 January 2020

Syntheses and absolute stereochemistries of UPA0043 and UPA0044, cytotoxic antibiotics having a p-quinone-methide structure

scientific article published on 01 December 2001

Synthesis and evaluation of biological activities of vibsanin A analogs.

scientific article published on 31 August 2017

Synthetic studies of the spirocyclic cyclohexene part of versipelostatin, a novel GRP78/Bip molecular chaperone downregulator

scientific article published on 30 January 2013

Synthetic studies of zoanthamine/norzoanthamine: biogenetic-like one-step construction of the heterocyclic aminal core (CDEFG ring) from a monocyclic precursor

scientific article published on 01 September 2000

Synthetic study of macquarimicins: highly stereoselective construction of the AB-ring system

scientific article published on 01 September 2001

Total Syntheses of (+)-Aquatolide and Related Humulanolides

scientific article published on 24 June 2019

Total Synthesis and Structural Revision of Clavilactone D.

scientific article published on 3 February 2017

Total Synthesis of (+)-Cytosporolide A via a Biomimetic Hetero-Diels-Alder Reaction

scientific article published on 11 December 2015

Total Synthesis of Clavilactones.

scientific article published on 31 January 2018

Total syntheses of (+)- and (-)-pestalotiopsin A.

scientific article published in September 2009

Total syntheses of (+)-1893B and its three diastereomers and evaluation of their biological activities

scientific article published on 01 August 2006

Total syntheses of natural tubelactomicins B, D, and E: establishment of their stereochemistries

scientific article published on 11 July 2007

Total synthesis of (+)-clavilactone A and (-)-clavilactone B by ring-opening/ring-closing metathesis.

scientific article

Total synthesis of (+)-macquarimicin A

scientific article published on 01 December 2003

Total synthesis of (+)-tubelactomicin A. 1. Stereoselective synthesis of the lower-half segment by an intramolecular Diels-Alder approach

scientific article published on 01 May 2005

Total synthesis of (+)-tubelactomicin A. 2. Synthesis of the upper-half segment and completion of the total synthesis

scientific article published on 01 May 2005

Total synthesis of (+)-vibsanin A

scientific article published on 26 January 2015

Total synthesis of (+/-)-mycoepoxydiene, a novel fungal metabolite having an oxygen-bridged cyclooctadiene skeleton

scientific article published on 01 August 2002

Total synthesis of (-)-mniopetal E, a novel biologically intriguing drimane sesquiterpenoid

scientific article published on 01 December 2000

Total synthesis of (-)-norzoanthamine.

scientific article published in January 2009

Total synthesis of (-)-pestalotiopsin A

scientific article published on 01 January 2008

Total synthesis of macquarimicins using an intramolecular Diels-Alder approach inspired by a biosynthetic pathway.

scientific article published in September 2004

List of works by Ken-ichi Takao

Asymmetric construction of all-carbon quaternary stereocenters by chiral-auxiliary-mediated Claisen rearrangement and total synthesis of (+)-bakuchiol

Asymmetric total syntheses of (+)-cheimonophyllon e and (+)-cheimonophyllal

Asymmetric total syntheses of (+)-mycoepoxydiene and related natural product (-)-1893A: application of one-pot ring-opening/cross/ring-closing metathesis to construct their 9-oxabicyclo[4.2.1]nona-2,4-diene skeleton.

Biological activities of 1,1,6-trisubstituted indanes: beyond magainin 2.

Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action.

Determination of the absolute structure of (+)-akaterpin.

Enantioselective Organocatalytic Construction of Spiroindane Derivatives by Intramolecular Friedel-Crafts-Type 1,4-Addition

Enantioselective Total Synthesis of (-)-Misramine

Highly diastereoselective 1,4-addition of an organocuprate to methyl alpha-D-gluco-, alpha-D-manno-, or alpha-D-galactopyranosides tethering an alpha,beta-unsaturated ester. Novel asymmetric access to beta-C-substituted butanoic acids.

Identification of seco-clavilactone B as a small-molecule actin polymerization inhibitor

Identification of topoisomerases as molecular targets of cytosporolide C and its analog

Identification of vibsanin A analog as a novel HSP90 inhibitor

Preparation and properties of thermosensitive hydrogel microcapsules

Recent advances in natural product synthesis by using intramolecular Diels-Alder reactions.

Stereoselective Synthesis of the Tricyclic Core of (-)-Callophycoic Acid A

Syntheses and absolute stereochemistries of UPA0043 and UPA0044, cytotoxic antibiotics having a p-quinone-methide structure

Synthesis and evaluation of biological activities of vibsanin A analogs.

Synthetic studies of the spirocyclic cyclohexene part of versipelostatin, a novel GRP78/Bip molecular chaperone downregulator

Synthetic studies of zoanthamine/norzoanthamine: biogenetic-like one-step construction of the heterocyclic aminal core (CDEFG ring) from a monocyclic precursor

Synthetic study of macquarimicins: highly stereoselective construction of the AB-ring system

Total Syntheses of (+)-Aquatolide and Related Humulanolides

Total Synthesis and Structural Revision of Clavilactone D.

Total Synthesis of (+)-Cytosporolide A via a Biomimetic Hetero-Diels-Alder Reaction

Total Synthesis of Clavilactones.

Total syntheses of (+)- and (-)-pestalotiopsin A.

Total syntheses of (+)-1893B and its three diastereomers and evaluation of their biological activities

Total syntheses of natural tubelactomicins B, D, and E: establishment of their stereochemistries

Total synthesis of (+)-clavilactone A and (-)-clavilactone B by ring-opening/ring-closing metathesis.

Total synthesis of (+)-macquarimicin A

Total synthesis of (+)-tubelactomicin A. 1. Stereoselective synthesis of the lower-half segment by an intramolecular Diels-Alder approach

Total synthesis of (+)-tubelactomicin A. 2. Synthesis of the upper-half segment and completion of the total synthesis

Total synthesis of (+)-vibsanin A

Total synthesis of (+/-)-mycoepoxydiene, a novel fungal metabolite having an oxygen-bridged cyclooctadiene skeleton

Total synthesis of (-)-mniopetal E, a novel biologically intriguing drimane sesquiterpenoid

Total synthesis of (-)-norzoanthamine.

Total synthesis of (-)-pestalotiopsin A

Total synthesis of macquarimicins using an intramolecular Diels-Alder approach inspired by a biosynthetic pathway.