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List of works by Richard Pestell

15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB.

scientific article published on February 2004

3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation

scientific article

5-Azacitidine restores and amplifies the bicalutamide response on preclinical models of androgen receptor expressing or deficient prostate tumors

scientific article published on August 2010

A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation

scientific article published on August 2008

A direct quantification method for measuring plasma MicroRNAs identified potential biomarkers for detecting metastatic breast cancer

scientific article published on 08 March 2016

A study of cytotoxic synergy of UCN-01 and flavopiridol in syngeneic pair of cell lines

scientific article published in August 2005

AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter

scientific article (publication date: 15 October 2003)

ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer

scientific article

Accelerated aging in the tumor microenvironment: connecting aging, inflammation and cancer metabolism with personalized medicine

scientific article published on July 2011

Acetylation and nuclear receptor action

scientific article

Acetylation in hormone signaling and the cell cycle

scientific article

Acetylation in nuclear receptor signaling and the role of sirtuins

scientific article published on 28 December 2007

Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth

scientific article

Acetylation of nuclear receptors in cellular growth and apoptosis

scientific article published in September 2004

Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer

scientific article published on June 2013

Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells

scientific article

Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis

scientific article published on December 2009

Activation of Transcription Factors AP-1 and NF-κB in Murine Chagasic Myocarditis ⬇️

scientific article published on May 1, 2003

Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2.

scientific article

Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment

scientific article

Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment

Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization ⬇️

scientific article published on September 25, 2003

Akt1 governs breast cancer progression in vivo

scientific article

Altered Rho GTPase signaling pathways in breast cancer cells.

scientific article published on March 2004

Altered expression of DACH1 and cyclin D1 in endometrial cancer.

scientific article

Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration

scientific article published on 7 January 2008

Alternative Cyclin D1 Splice Forms Differentially Regulate the DNA Damage Response ⬇️

scientific article published on October 12, 2010

Amino Acids Regulate Hepatocyte Proliferation through Modulation of Cyclin D1 Expression ⬇️

scientific article published on 07 May 2003

An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1

scientific article published on 01 December 2018

An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers

scientific article

An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation

scientific article

Analysis of Nuclear Receptor Acetylation ⬇️

scientific article published on 01 January 2011

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function

scientific article

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

scientific article published on 15 November 2011

Antibiotics for cancer therapy

scientific article published on February 2015

Antisense to cyclin D1 inhibits VEGF-stimulated growth of vascular endothelial cells: implication of tumor vascularization

scientific article published on August 2006

Attenuation of Forkhead signaling by the retinal determination factor DACH1.

scientific article

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production

scientific article

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

scientific article

BCL-2 family protein, BAD is down-regulated in breast cancer and inhibits cell invasion

scientific article

BRCA1 Inhibition of Telomerase Activity in Cultured Cells ⬇️

scientific article published on December 1, 2003

BRCA1 gene in breast cancer

scientific article

BRCA1 in hormone-responsive cancers ⬇️

scientific article published on October 1, 2003

BRCA1 regulates acetylation and ubiquitination of estrogen receptor-alpha

scientific article

Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases.

scientific article published on 05 April 2012

Biological functions of CDK5 and potential CDK5 targeted clinical treatments

scientific article published on 6 January 2017

Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation

scientific article

Bombesin regulates cyclin D1 expression through the early growth response protein Egr-1 in prostate cancer cells

scientific article published on November 2005

Bone morphogenetic protein signaling regulates postnatal hair follicle differentiation and cycling

scientific article

Breast Cancer Stem Cell Isolation.

scientific article published on January 2016

Breast cancer cell proliferation is inhibited by BAD: regulation of cyclin D1.

scientific article published on August 2007

Breast cancer stem cells.

scientific article published on 09 January 2012

C-jun inhibits mammary apoptosis in vivo

scientific article

CAPER, a novel regulator of human breast cancer progression

scientific article

CAV1 inhibits metastatic potential in melanomas through suppression of the integrin/Src/FAK signaling pathway

scientific article

CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion.

scientific article published on 22 January 2018

CCR5 antagonist blocks metastasis of basal breast cancer cells

scientific article

CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines.

scientific article

CCR5-Mediated Signaling Is Involved in Invasion of Glioblastoma Cells in Its Microenvironment

scientific article published on 12 June 2020

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis

scientific article

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.

scientific article

Caloric restriction augments radiation efficacy in breast cancer

scientific article published on 21 May 2013

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors

scientific article

Cancer metabolism: a therapeutic perspective

scientific article published on 4 May 2016

Cancer metabolism: a therapeutic perspective

scientific article published on 17 January 2017

Cancer stem cell metabolism

scientific article

Cancer stem cells

scientific article published on 02 September 2012

Cancer stem cells and the cell cycle: targeting the drive behind breast cancer.

scientific article published in March 2009

Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activation

scientific article published on 22 December 2012

Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature

scientific article published on May 2009

Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug

scientific article

Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms

scientific article

Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts

scientific article

Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness

scientific article

Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion

scientific article published on 7 September 2004

Caveolin-1 in breast cancer

scientific article

Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide

scientific article published on 17 April 2013

Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression

scientific article published on 17 May 2007

Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia

scientific article published on October 2002

Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status

scientific article published in June 2006

Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition

scientific article published on November 2011

Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice

scientific article

Caveolin-1 regulates the anti-atherogenic properties of macrophages

scientific article published on 17 October 2014

Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers

scientific article published on November 2006

Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts

scientific article published on March 2009

Caveolin-1-deficient mice have an increased mammary stem cell population with upregulation of Wnt/beta-catenin signaling

scientific article

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

scientific article

Caveolin-1-deficient mice show defects in innate immunity and inflammatory immune response during Salmonella enterica serovar Typhimurium infection

scientific article

Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5.

scientific article

Cell cycle regulatory proteins in the liver in murine Trypanosoma cruzi infection

scientific article

Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth

scientific journal article

Cell fate determination factor Dachshund reprograms breast cancer stem cell function

scientific article

Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation

scientific article published on 12 December 2013

ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice

scientific article

ChIP sequencing of cyclin D1 reveals a transcriptional role inchromosomal instability in mice ⬇️

Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders

scientific article published on 30 March 2009

Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia

scientific article published on 25 March 2004

Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis

scientific article published on 10 April 2013

Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette

scientific article

Construction of a novel DNA decoy that inhibits the oncogenic beta-catenin/T-cell factor pathway

scientific article published on April 2006

Corrigendum to "Role of UHRF1 in malignancy and its function as a therapeutic target for molecular docking towards the SRA domain" [Int. J. Biochem. Cell Biol. 114 (September 2019) 105558]

scientific article published on 05 August 2019

Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice

scientific article published in January 2005

Cyclin D1 Induces Chromosomal Instability ⬇️

scientific article published on March 1, 2012

Cyclin D1 Promotes Androgen-Dependent DNA Damage Repair in Prostate Cancer Cells

scientific article published on 18 November 2015

Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis.

scientific article

Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity

scientific article

Cyclin D1 determines estrogen signaling in the mammary gland in vivo

scientific article

Cyclin D1 determines mitochondrial function in vivo

scientific article

Cyclin D1 functions in cell migration

scientific article

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice

scientific journal article

Cyclin D1 governs adhesion and motility of macrophages

scientific article

Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer.

scientific article published on January 2013

Cyclin D1 induction of cellular migration requires p27(KIP1).

scientific article published on October 2006

Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment

scientific article (publication date: 29 April 2005)

Cyclin D1 integrates G9a-mediated histone methylation

scientific article published on 04 February 2019

Cyclin D1 integrates estrogen-mediated DNA damage repair signaling

scientific article

Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3.

scientific article published on March 2006

Cyclin D1 promotes secretion of pro-oncogenic immuno-miRNAs and piRNAs

scientific article published on 01 April 2020

Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling

scientific article published on June 2006

Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism

scientific article

Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function

scientific article

Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation

scientific article

Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgen-independent prostate cancer cells to DNA damage

scientific article published on 12 December 2015

Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgen-independent prostate cancer cells to DNA damage

scientific article published on September 2016

Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome

scientific article published on 11 March 2018

Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells

scientific article

Cyclins and Cell Cycle Control in Cancer and Disease ⬇️

scientific article published on November 1, 2012

Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells.

scientific article published on 31 July 2017

Cytokine CCL5 and receptor CCR5 axis in glioblastoma multiforme

scientific article published on 20 November 2019

Cytokine production and inflammation drive autophagy in the tumor microenvironment: role of stromal caveolin-1 as a key regulator

scientific article

DACH1 antagonizes CXCL8 to repress tumorigenesis of lung adenocarcinoma and improve prognosis.

scientific article published on 10 April 2018

DACH1 inhibits transforming growth factor-beta signaling through binding Smad4

scientific article

DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth

scientific article

DACH1 negatively regulates the human RANK ligand gene expression in stromal/preosteoblast cells

scientific article published on April 2008

DACH1 suppresses breast cancer as a negative regulator of CD44.

scientific article

Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool

article

Dachshund binds p53 to block the growth of lung adenocarcinoma cells

scientific article published on 14 March 2013

Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8.

scientific article

Dietary n-3 polyunsaturated fatty acids fail to reduce prostate tumorigenesis in the PB-ErbB-2 x Pten(+/-) preclinical mouse model

scientific article published on 15 May 2010

Dietary restriction: standing up for sirtuins

scientific article published on August 2010

Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells

scientific article published in February 2005

Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties

scientific article published on 01 April 2002

Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation

scientific journal article

Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase

scientific article

Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia

scientific article

Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells

scientific article

Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.

scientific article

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

scientific article

Double homozygous missense mutations in DACH1 and BMP4 in a patient with bilateral cystic renal dysplasia ⬇️

scientific article published on December 21, 2012

Dual fluorescent molecular substrates selectively report the activation, sustainability and reversibility of cellular PKB/Akt activity

scientific article published on January 2013

Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells

scientific article (publication date: 21 May 2003)

E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination

scientific article published on May 2002

EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1.

scientific article published on May 2013

EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer

scientific article

Endogenous Dach1 in cancer

scientific article published on 23 September 2015

Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1.

scientific article

Energy transfer in "parasitic" cancer metabolism: mitochondria are the powerhouse and Achilles' heel of tumor cells

scientific article

Epigenetic regulation of nuclear steroid receptors

scientific article published on 17 July 2006

Epigenetics and the estrogen receptor

scientific article published on November 2006

ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo

scientific article

ErbB-2-induced mammary tumor growth: the role of cyclin D1 and p27Kip1.

scientific article

ErbB2 induces Notch1 activity and function in breast cancer cells

scientific article published on September 2008

Erratum: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts

scientific article published on October 2015

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts

scientific article

Examining the role of cyclin D1 in breast cancer.

scientific article published on June 2011

Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancer

scientific article published on September 2006

FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas.

scientific article published on 12 October 2015

Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells

scientific article published on 15 September 2002

Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways.

scientific article published in July 2002

Galectin-3 enhances cyclin D(1) promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells

scientific article

Gastrin-induced gastric adenocarcinoma growth is mediated through cyclin D1.

scientific article published on 26 February 2003

Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells.

scientific article published on April 2004

Gene expression phenotypic models that predict the activity of oncogenic pathways

scientific article

Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration

scientific article published on 6 March 2012

Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions

scientific article published on April 2009

Genetic ablation of caveolin-1 in mammary epithelial cells increases milk production and hyper-activates STAT5a signaling

scientific article published on 9 March 2006

Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance

scientific article published on 15 December 2011

Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling

scientific article published on 15 June 2010

Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1.

scientific article

HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis

scientific article

Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism

scientific article

Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance

scientific article published on 26 May 2016

High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A

scientific journal article

Histone acetylation/deacetylation as a regulator of cell cycle gene expression

scientific article

Hormonal control of androgen receptor function through SIRT1

scientific article

Hormonal therapy promotes hormone-resistant phenotype by increasing DNMT activity and expression in prostate cancer models

scientific article published on 11 October 2011

Hormone-induced DNA damage response and repair mediated by cyclin D1 in breast and prostate cancer

scientific article published on 20 July 2017

Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy

scientific article published on 30 August 2008

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs "fertilizer".

scientific article

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue

scientific article published on December 2011

IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.

scientific article

Identification of a cyclin D1 network in prostate cancer that antagonizes epithelial-mesenchymal restraint

scientific article published on 26 November 2013

Imaging spontaneous MMTVneu transgenic murine mammary tumors: targeting metabolic activity versus genetic products

scientific article published on 15 December 2009

In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb.

scientific article published in September 2002

Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells ⬇️

scientific article published on January 1, 2002

Inhibition of cyclin D1 gene transcription by Brg-1.

scientific article published on 12 December 2007

Interferon-beta activates multiple signaling cascades in primary human microglia

scientific article

Intestinal tumor progression is associated with altered function of KLF5

scientific journal article

Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism

scientific article published on 15 January 2012

Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

scientific article

Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics

scientific article

Kinase independent oncogenic cyclin D1.

scientific article published on 7 July 2015

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis

scientific article

Long and noncoding RNAs (lnc-RNAs) determine androgen receptor dependent gene expression in prostate cancer growth in vivo

scientific article

Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria

scientific article

Loss of caveolin-1 causes the hyper-proliferation of intestinal crypt stem cells, with increased sensitivity to whole body gamma-radiation

scientific article

Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice

scientific article

Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation

scientific journal article

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation

scientific article published in June 2010

MAT1 correlates with molecular subtypes and predicts poor survival in breast cancer

scientific article published on 01 June 2018

MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma.

scientific article

MEK/ERK inhibitor U0126 increases the radiosensitivity of rhabdomyosarcoma cells in vitro and in vivo by downregulating growth and DNA repair signals

scientific article published in January 2011

Mammary gland selective excision of c-jun identifies its role in mRNA splicing

scientific article

Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis

scientific article

Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells

scientific article

Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells

scientific article

Mechanisms for Helicobacter pylori CagA-induced cyclin D1 expression that affect cell cycle

scientific article published on 7 June 2006

Mechanisms for progenitor cell-mediated repair for ischemic heart injury.

scientific article published on January 2012

Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation

scientific article published on April 2007

Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth

scientific article

Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells

scientific article

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.

scientific article

Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells

scientific article (publication date: September 2006)

Methylglyoxal Modification of mSin3A Links Glycolysis to Angiopoietin-2 Transcription

scientific article published on 01 February 2007

Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription

scientific article published on 12 January 2006

MicroRNA-mediated cancer metastasis regulation via heterotypic signals in the microenvironment

scientific article published on January 2014

Minireview: Cyclin D1: normal and abnormal functions

scientific article

Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth

scientific article

Mitochondrial mass and DNA repair in breast cancer stem cells

scientific article published on 11 November 2015

Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue

scientific article

Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection

scientific article published on December 2011

Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB

scientific article published on 26 March 2008

New Roles of Cyclin D1 ⬇️

scientific article published on July 1, 2013

Notch1-induced transformation of RKE-1 cells requires up-regulation of cyclin D1.

scientific article published in August 2006

Novel oncogene-induced metastatic prostate cancer cell lines define human prostate cancer progression signatures

scientific article published on 30 November 2012

Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo

scientific article published on 06 April 2009

Nuclear receptor modifications and endocrine cell proliferation

scientific article

Nutrient restriction and radiation therapy for cancer treatment: when less is more

scientific article published on 8 January 2013

Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4.

scientific article published on 08 July 2013

Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression

scientific article

Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and present.

scientific article published on 03 January 2014

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

scientific article

PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b

scientific article

PPARgamma activation induces autophagy in breast cancer cells

scientific article published on 26 June 2009

Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes

scientific article published on 5 February 2004

Phosphorylation of estrogen receptor alpha blocks its acetylation and regulates estrogen sensitivity.

scientific article

Positherapy: targeted nuclear therapy of breast cancer with 18F-2-deoxy-2-fluoro-D-glucose.

scientific article published in February 2005

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

scientific article

Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology

scientific article published on 10 July 2019

Recent advances in inducible expression in transgenic mice

scientific article

Recent advances of bispecific antibodies in solid tumors

scientific article published on 20 September 2017

Recent advances of highly selective CDK4/6 inhibitors in breast cancer

scientific article

Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncology

scientific article published on 20 June 2019

Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA

scientific article

Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta

scientific article

Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin

scientific journal article

Regulation of host cell cyclin D1 by Trypanosoma cruzi in myoblasts

scientific article published on 18 November 2007

Regulation of progesterone receptor signaling by BRCA1 in mammary cancer

scientific article

Regulation of the androgen receptor by SET9-mediated methylation

scientific article published on 19 October 2010

Regulation of the androgen receptor by SET9-mediated methylation

scientific article published on 22 May 2013

Remembering team science is for the patients

scientific article published on 2 April 2006

Reverse Warburg effect in a patient with aggressive B-cell lymphoma: is lactic acidosis a paraneoplastic syndrome?

scientific article

Role of BRCA1 in heat shock response

scientific article published on January 2003

Role of Cancer Stem Cells in Metastasis

Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection

scientific article

Role of UHRF1 in malignancy and its function as a therapeutic target for molecular docking towards the SRA domain

scientific article published on 22 June 2019

Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence

scientific article

SIRT1 Modulates Aggregation and Toxicity through Deacetylation of the Androgen Receptor in Cell Models of SBMA ⬇️

scientific article published on November 30, 2011

SIRT1 and endocrine signaling

scientific article

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1

scientific article

Selective cytotoxicity of synthesized procyanidin 3-O-galloylepicatechin-4b, 8-3-O-galloylcatechin to human cancer cells

scientific article

Senescence and epigenetic dysregulation in cancer

scientific article

Signal Transduction Mediated by Cyclin D1: from Mitogens to Cell Proliferation: A Molecular Target with Therapeutic Potential

article

Signal transduction inhibitors in cellular function

scientific article published on January 2004

Signal transduction mediated by cyclin D1: from mitogens to cell proliferation: a molecular target with therapeutic potential

scientific article

Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors

scientific article

Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration.

scientific article

Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation.

scientific article published on 26 October 2007

Small Non-coding RNAs Govern Mammary Gland Tumorigenesis ⬇️

scientific article published on March 1, 2012

Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells.

scientific article

Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor

scientific article published on 4 December 2006

Spatially discrete, light-driven protein expression

scientific article published on December 2002

Stabilization of SMAR1 mRNA by PGA2 involves a stem loop structure in the 5' UTR

scientific article

Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells

scientific article published on November 2006

Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

scientific article (publication date: June 2009)

Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth

scientific article published on 4 August 2017

Stromal glycolysis and MCT4 are hallmarks of DCIS progression to invasive breast cancer

scientific article published on 27 August 2013

Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment

scientific article

Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts

scientific journal article

Targeting tumor-initiating cells: eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction

scientific article published on March 2015

The CCL5/CCR5 axis promotes metastasis in basal breast cancer ⬇️

scientific article published on April 1, 2013

The Canonical NF-κB Pathway Governs Mammary Tumorigenesis in Transgenic Mice and Tumor Stem Cell Expansion ⬇️

scientific article published on December 15, 2010

The Dachshund gene in development and hormone-responsive tumorigenesis

scientific article

The G protein coupled receptor CCR5 in cancer

scientific article published on 10 January 2020

The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression

scientific article

The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation

scientific article

The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity.

scientific article

The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox

scientific article

The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism

scientific article

The cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signaling

scientific article

The cell fate determination factor dachshund inhibits androgen receptor signaling and prostate cancer cellular growth

scientific article

The dialyzable leukocyte extract Transferon TM inhibits tumor growth and brain metastasis in a murine model of prostate cancer

scientific article published on 22 March 2018

The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module

scientific article

The functional significance of nuclear receptor acetylation

scientific article published on 7 February 2007

The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells

scientific article

The metastatic potential of triple-negative breast cancer is decreased via caloric restriction-mediated reduction of the miR-17~92 cluster

scientific article

The potential to target CCL5/CCR5 in breast cancer.

scientific article published on 26 September 2014

The retinal determination gene network: from developmental regulator to cancer therapeutic target

scientific article

The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

scientific article

The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

scientific article

The role of CD44 in epithelial-mesenchymal transition and cancer development

scientific article

The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.

scientific article

The role of breast cancer stem cells in metastasis and therapeutic implications

scientific article

The type 1 insulin-like growth factor receptor and resistance to DACH1 ⬇️

scientific article published on June 15, 2011

Time-Lapse Video Microscopy for Assessment of EYFP-Parkin Aggregation as a Marker for Cellular Mitophagy

scientific article

Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation

scientific article

Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy

scientific article published in June 2009

Trans-repression of beta-catenin activity by nuclear receptors

scientific article published on 12 September 2003

Transcription Elongation Regulator 1 Is a Co-integrator of the Cell Fate Determination Factor Dachshund Homolog 1 ⬇️

scientific article published on October 18, 2010

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

scientific article

Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts ⬇️

scientific article

Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells

scientific article published on September 2004

Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells

scientific article published in January 2006

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors

scientific article published on 15 June 2010

Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

scientific article

Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment

scientific article

Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells

scientific article

Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation

scientific article

Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis

scientific article published on 17 November 2011

beta-catenin signaling and regulation of cyclin D1 promoter in NRK-49F cells transformed by down-regulation of the tumor suppressor lysyl oxidase

scientific article published on September 2005

c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion

scientific article

c-Jun is required for TGF-β-mediated cellular migration via nuclear Ca²⁺ signaling

scientific article published on 5 April 2011

miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1.

scientific article

miR-221/222 promotes S-phase entry and cellular migration in control of basal-like breast cancer.

scientific article

miRNAs regulate stem cell self-renewal and differentiation ⬇️

scientific article published on September 25, 2012

microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling

scientific article

microRNA, cell cycle, and human breast cancer

scientific article

p21-activated Kinase-1 Signaling Mediates Cyclin D1 Expression in Mammary Epithelial and Cancer Cells ⬇️

scientific article (publication date: 9 January 2004)

p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo.

scientific article published on 26 October 2009

p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling

scientific journal article

p300 Modulates the BRCA1 inhibition of estrogen receptor activity ⬇️

scientific article published on January 1, 2002

v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1.

scientific article published on 15 September 2016

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