List of works - Thomas Gautier

Activated platelets contribute to oxidized low-density lipoproteins and dysfunctional high-density lipoproteins through a phospholipase A2-dependent mechanism

scientific article published on 31 October 2011

ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma.

scientific article published in March 2012

Apolipoprotein B is regulated by gonadotropins and constitutes a predictive biomarker of IVF outcomes

scientific article published on 21 May 2016

Apolipoprotein CI deficiency markedly augments plasma lipoprotein changes mediated by human cholesteryl ester transfer protein (CETP) in CETP transgenic/ApoCI-knocked out mice.

scientific article

Apolipoprotein CI is a physiological regulator of cholesteryl ester transfer protein activity in human plasma but not in rabbit plasma.

scientific article published on 05 May 2009

Apolipoprotein CI knock-out mice display impaired memory functions

scientific article published in January 2011

Biliary sterol secretion is required for functional in vivo reverse cholesterol transport in mice

scientific article published on 04 December 2010

Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus.

scientific article

CETP activity is not associated with carotid intima-media thickness in patients with poorly controlled type 2 diabetes

scientific article published on 12 April 2019

Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.

scientific article

Constitutive androstane receptor activation stimulates faecal bile acid excretion and reverse cholesterol transport in mice.

scientific article published on 23 November 2010

Constitutive inhibition of plasma CETP by apolipoprotein C1 is blunted in dyslipidemic patients with coronary artery disease ⬇️

scientific article published on April 2, 2012

Deletion of lysophosphatidylcholine acyltransferase3 in myeloid cells worsens hepatic steatosis after a high fat diet

scientific article published on 11 December 2020

Development of abdominal aortic aneurysm is decreased in mice with plasma phospholipid transfer protein deficiency.

scientific article

Dual labeling of lipopolysaccharides for SPECT-CT imaging and fluorescence microscopy.

scientific article published on 20 December 2013

Effect of cholesteryl ester transfer protein (CETP) expression on diet-induced hyperlipidemias in transgenic rats.

scientific article published in February 2005

Expression of simian CETP in normolipidemic Fisher rats has a profound effect on large sized apoE-containing HDL.

scientific article published in December 2002

Expression of type IIA secretory phospholipase A2 inhibits cholesteryl ester transfer protein activity in transgenic mice

scientific article

Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice

scientific article published on 25 April 2013

Fine-tuning nucleophosmin in macrophage differentiation and activation.

scientific article

Glucocorticoids impair HDL-mediated cholesterol efflux besides increased HDL cholesterol concentration - a proof of concept

scientific article published on 01 June 2020

Glycation of apolipoprotein C1 impairs its CETP inhibitory property: pathophysiological relevance in patients with type 1 and type 2 diabetes

scientific article published on 26 February 2014

Hemodialysis reduces plasma apolipoprotein C-I concentration making VLDL a better substrate for lipoprotein lipase

scientific article published on 01 August 2007

Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer protein.

scientific article

High density lipoprotein (HDL) particles from end-stage renal disease patients are defective in promoting reverse cholesterol transport

scientific article published on 02 February 2017

Human CETP lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice

scientific article published on 09 December 2020

Human apoA-I expression in CETP transgenic rats leads to lower levels of apoC-I in HDL and to magnification of CETP-mediated lipoprotein changes

scientific journal article

Human apolipoprotein C-I accounts for the ability of plasma high density lipoproteins to inhibit the cholesteryl ester transfer protein activity

scientific article

Human apolipoprotein C-I expression in mice impairs learning and memory functions.

scientific article published on 26 December 2007

Human seminal plasma displays significant phospholipid transfer activity due to the presence of active phospholipid transfer protein

scientific article published on 01 August 2003

Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits

scientific article (publication date: 2014)

Inhibition of mitophagy drives macrophage activation and anti-bacterial defense during sepsis

scientific article published on 06 August 2020

Intra-Abdominal Lipopolysaccharide Clearance and Inactivation in Peritonitis: Key Roles for Lipoproteins and the Phospholipid Transfer Protein

scientific article published on 12 May 2021

Is It Time to Reconsider the Lipopolysaccharide Paradigm in Acute Graft-Versus-Host Disease?

scientific article published on 9 August 2017

LPCAT3 deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis

scientific article published on 18 May 2018

Liver X Receptor–Mediated Induction of Cholesteryl Ester Transfer Protein Expression Is Selectively Impaired in Inflammatory Macrophages

scientific article published on 13 August 2009

Liver X receptor activation promotes polyunsaturated fatty acid synthesis in macrophages: relevance in the context of atherosclerosis

scientific article published on 02 April 2015

Low cholesteryl ester transfer protein (CETP) concentration but normal CETP activity in serum from patients with short-term hypothyroidism Lack of relationship to lipoprotein abnormalities.

scientific article published in May 2003

Low preoperative cholesterol level is a risk factor of sepsis and poor clinical outcome in patients undergoing cardiac surgery with cardiopulmonary bypass.

scientific article published in May 2014

Molecular mechanism of the blockade of plasma cholesteryl ester transfer protein by its physiological inhibitor apolipoprotein CI

scientific article published on 13 September 2005

Plasma PLTP (phospholipid-transfer protein): an emerging role in 'reverse lipopolysaccharide transport' and innate immunity

scientific article published on 01 August 2011

Plasma apolipoprotein C1 concentration is associated with plasma triglyceride concentration but not with visceral fat and liver fat content in people with type 1 diabetes

scientific article published on 22 May 2019

Plasma apolipoprotein C1 concentration is associated with plasma triglyceride concentration, but not visceral fat, in patients with type 2 diabetes.

scientific article

Polysaccharide Chain Length of Lipopolysaccharides From Salmonella Minnesota Is a Determinant of Aggregate Stability, Plasma Residence Time and Proinflammatory Propensity in vivo

scientific article published on 02 August 2019

Quantitative lipopolysaccharide analysis using HPLC/MS/MS and its combination with the limulus amebocyte lysate assay

scientific article published on 28 May 2015

Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis.

scientific article

Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase

scientific article

Simvastatin but not bezafibrate decreases plasma lipoprotein-associated phospholipase A₂ mass in type 2 diabetes mellitus: relevance of high sensitive C-reactive protein, lipoprotein profile and low-density lipoprotein (LDL) electronegativity

scientific article published on 04 June 2012

Sleeve Gastrectomy Alters Intestinal Permeability in Diet-Induced Obese Mice

scientific article published on 20 April 2017

The potential of cholesteryl ester transfer protein as a therapeutic target

scientific article published on 27 July 2015

Worsening of diet-induced atherosclerosis in a new model of transgenic rabbit expressing the human plasma phospholipid transfer protein

scientific article published on 20 January 2011

List of works by Thomas Gautier

Activated platelets contribute to oxidized low-density lipoproteins and dysfunctional high-density lipoproteins through a phospholipase A2-dependent mechanism

ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma.

Apolipoprotein B is regulated by gonadotropins and constitutes a predictive biomarker of IVF outcomes

Apolipoprotein CI deficiency markedly augments plasma lipoprotein changes mediated by human cholesteryl ester transfer protein (CETP) in CETP transgenic/ApoCI-knocked out mice.

Apolipoprotein CI is a physiological regulator of cholesteryl ester transfer protein activity in human plasma but not in rabbit plasma.

Apolipoprotein CI knock-out mice display impaired memory functions

Biliary sterol secretion is required for functional in vivo reverse cholesterol transport in mice

Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus.

CETP activity is not associated with carotid intima-media thickness in patients with poorly controlled type 2 diabetes

Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.

Constitutive androstane receptor activation stimulates faecal bile acid excretion and reverse cholesterol transport in mice.

Constitutive inhibition of plasma CETP by apolipoprotein C1 is blunted in dyslipidemic patients with coronary artery disease ⬇️

Deletion of lysophosphatidylcholine acyltransferase3 in myeloid cells worsens hepatic steatosis after a high fat diet

Development of abdominal aortic aneurysm is decreased in mice with plasma phospholipid transfer protein deficiency.

Dual labeling of lipopolysaccharides for SPECT-CT imaging and fluorescence microscopy.

Effect of cholesteryl ester transfer protein (CETP) expression on diet-induced hyperlipidemias in transgenic rats.

Expression of simian CETP in normolipidemic Fisher rats has a profound effect on large sized apoE-containing HDL.

Expression of type IIA secretory phospholipase A2 inhibits cholesteryl ester transfer protein activity in transgenic mice

Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice

Fine-tuning nucleophosmin in macrophage differentiation and activation.

Glucocorticoids impair HDL-mediated cholesterol efflux besides increased HDL cholesterol concentration - a proof of concept

Glycation of apolipoprotein C1 impairs its CETP inhibitory property: pathophysiological relevance in patients with type 1 and type 2 diabetes

Hemodialysis reduces plasma apolipoprotein C-I concentration making VLDL a better substrate for lipoprotein lipase

Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer protein.

High density lipoprotein (HDL) particles from end-stage renal disease patients are defective in promoting reverse cholesterol transport

Human CETP lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice

Human apoA-I expression in CETP transgenic rats leads to lower levels of apoC-I in HDL and to magnification of CETP-mediated lipoprotein changes

Human apolipoprotein C-I accounts for the ability of plasma high density lipoproteins to inhibit the cholesteryl ester transfer protein activity

Human apolipoprotein C-I expression in mice impairs learning and memory functions.

Human seminal plasma displays significant phospholipid transfer activity due to the presence of active phospholipid transfer protein

Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits

Inhibition of mitophagy drives macrophage activation and anti-bacterial defense during sepsis

Intra-Abdominal Lipopolysaccharide Clearance and Inactivation in Peritonitis: Key Roles for Lipoproteins and the Phospholipid Transfer Protein

Is It Time to Reconsider the Lipopolysaccharide Paradigm in Acute Graft-Versus-Host Disease?

LPCAT3 deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis

Liver X Receptor–Mediated Induction of Cholesteryl Ester Transfer Protein Expression Is Selectively Impaired in Inflammatory Macrophages

Liver X receptor activation promotes polyunsaturated fatty acid synthesis in macrophages: relevance in the context of atherosclerosis

Low cholesteryl ester transfer protein (CETP) concentration but normal CETP activity in serum from patients with short-term hypothyroidism Lack of relationship to lipoprotein abnormalities.

Low preoperative cholesterol level is a risk factor of sepsis and poor clinical outcome in patients undergoing cardiac surgery with cardiopulmonary bypass.

Molecular mechanism of the blockade of plasma cholesteryl ester transfer protein by its physiological inhibitor apolipoprotein CI

Plasma PLTP (phospholipid-transfer protein): an emerging role in 'reverse lipopolysaccharide transport' and innate immunity

Plasma apolipoprotein C1 concentration is associated with plasma triglyceride concentration but not with visceral fat and liver fat content in people with type 1 diabetes

Plasma apolipoprotein C1 concentration is associated with plasma triglyceride concentration, but not visceral fat, in patients with type 2 diabetes.

Polysaccharide Chain Length of Lipopolysaccharides From Salmonella Minnesota Is a Determinant of Aggregate Stability, Plasma Residence Time and Proinflammatory Propensity in vivo

Quantitative lipopolysaccharide analysis using HPLC/MS/MS and its combination with the limulus amebocyte lysate assay

Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis.

Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase

Simvastatin but not bezafibrate decreases plasma lipoprotein-associated phospholipase A₂ mass in type 2 diabetes mellitus: relevance of high sensitive C-reactive protein, lipoprotein profile and low-density lipoprotein (LDL) electronegativity

Sleeve Gastrectomy Alters Intestinal Permeability in Diet-Induced Obese Mice

The potential of cholesteryl ester transfer protein as a therapeutic target

Worsening of diet-induced atherosclerosis in a new model of transgenic rabbit expressing the human plasma phospholipid transfer protein