List of works - Joel D. A. Tyndall

A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production.

scientific article

A theory of mode of action of azolylalkylquinolines as DNA binding agents using automated flexible ligand docking.

scientific article published on 18 April 2006

Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei.

scientific article

Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14.

scientific article published on 10 August 2015

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

scientific article

Beta-strand mimicking macrocyclic amino acids: templates for protease inhibitors with antiviral activity.

scientific article published on January 2002

Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists.

scientific article

Chemical Tools for Studying Lipid-Binding Class A G Protein-Coupled Receptors.

scientific article published on July 2017

Chlamydia Serine Protease Inhibitor, targeting HtrA, as a New Treatment for Koala Chlamydia infection

scientific article published on 17 August 2016

Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.

scientific article published on 20 January 2005

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

scientific article

Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism

scientific article

CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic target.

scientific article published on 08 June 2017

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

scientific article published in December 1999

Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from alpha-aminosuberic acid.

scientific article published on December 2006

Determination of alpha-conotoxin binding modes on neuronal nicotinic acetylcholine receptors.

scientific article

Development of selective, fluorescent cannabinoid type 2 receptor ligands based on a 1,8-naphthyridin-2-(1)-one-3-carboxamide scaffold

article

Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates

scientific article published on 23 September 2009

Expression, purification, crystallization and preliminary crystallographic analysis of a thermostable lipase from Bacillus stearothermophilus P1

article

Homology modeling and functional testing of an ABCA1 mutation causing Tangier disease

scientific article published on 29 June 2011

Honey bee dopamine and octopamine receptors linked to intracellular calcium signaling have a close phylogenetic and pharmacological relationship.

scientific article

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.

scientific article published on 12 July 2013

In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F.

scientific article

Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains.

scientific article published on 3 July 2013

Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteases.

scientific article published in July 2001

Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor

scientific article

Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure.

scientific article

Pinnatoxins E, F and G target multiple nicotinic receptor subtypes.

scientific article

Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.

scientific article published in April 2004

Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependent oxidation of epicatechins

scientific article published on 01 September 2014

Proteases and protease inhibitors in infectious diseases

scientific article published on 17 November 2017

Proteases universally recognize beta strands in their active sites

scientific article (publication date: March 2005)

Proteolytic activation of Chlamydia trachomatis HTRA is mediated by PDZ1 domain interactions with protease domain loops L3 and LC and beta strand β5.

scientific article published on 13 September 2013

Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions.

scientific article published on 19 October 2004

Stability, Kinetic, and Mechanistic Investigation of 1,8-Self-Immolative Cinnamyl Ether Spacers for Controlled Release of Phenols and Generation of Resonance and Inductively Stabilized Methides.

scientific article published on 12 January 2017

Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.

scientific article

Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals

scientific article

Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA)

scientific article published in November 2011

Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery

scientific journal article

Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase

scientific article published on 18 May 2016

Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis.

scientific article

Update 1 of: Beta-strand mimetics.

scientific article published on 12 April 2010

Variable Expression of GLIPR1 Correlates with Invasive Potential in Melanoma Cells

scientific article published on 30 August 2013

[Fe₂L₃]⁴⁺ cylinders derived from bis(bidentate) 2-pyridyl-1,2,3-triazole "click" ligands: synthesis, structures and exploration of biological activity.

scientific article published on 29 May 2013

the active site residue V266 of Chlamydial HtrA is critical for substrate binding during both in vitro and in vivo conditions

scientific article published on 21 February 2012

List of works by Joel D. A. Tyndall

A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production.

A theory of mode of action of azolylalkylquinolines as DNA binding agents using automated flexible ligand docking.

Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei.

Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14.

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

Beta-strand mimicking macrocyclic amino acids: templates for protease inhibitors with antiviral activity.

Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists.

Chemical Tools for Studying Lipid-Binding Class A G Protein-Coupled Receptors.

Chlamydia Serine Protease Inhibitor, targeting HtrA, as a New Treatment for Koala Chlamydia infection

Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism

CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic target.

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from alpha-aminosuberic acid.

Determination of alpha-conotoxin binding modes on neuronal nicotinic acetylcholine receptors.

Development of selective, fluorescent cannabinoid type 2 receptor ligands based on a 1,8-naphthyridin-2-(1)-one-3-carboxamide scaffold

Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates

Expression, purification, crystallization and preliminary crystallographic analysis of a thermostable lipase from Bacillus stearothermophilus P1

Homology modeling and functional testing of an ABCA1 mutation causing Tangier disease

Honey bee dopamine and octopamine receptors linked to intracellular calcium signaling have a close phylogenetic and pharmacological relationship.

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.

In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F.

Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains.

Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteases.

Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor

Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure.

Pinnatoxins E, F and G target multiple nicotinic receptor subtypes.

Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.

Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependent oxidation of epicatechins

Proteases and protease inhibitors in infectious diseases

Proteases universally recognize beta strands in their active sites

Proteolytic activation of Chlamydia trachomatis HTRA is mediated by PDZ1 domain interactions with protease domain loops L3 and LC and beta strand β5.

Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions.

Stability, Kinetic, and Mechanistic Investigation of 1,8-Self-Immolative Cinnamyl Ether Spacers for Controlled Release of Phenols and Generation of Resonance and Inductively Stabilized Methides.

Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.

Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals

Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA)

Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery

Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase

Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis.

Update 1 of: Beta-strand mimetics.

Variable Expression of GLIPR1 Correlates with Invasive Potential in Melanoma Cells

[Fe₂L₃]⁴⁺ cylinders derived from bis(bidentate) 2-pyridyl-1,2,3-triazole "click" ligands: synthesis, structures and exploration of biological activity.

the active site residue V266 of Chlamydial HtrA is critical for substrate binding during both in vitro and in vivo conditions