List of works - Vadim Gaponenko

13C CPMAS spectroscopy of deuterated proteins: CP dynamics, line shapes, and T1 relaxation

scientific article published on 01 January 2005

A novel method for the production of fully modified K-Ras 4B.

scientific article

Application of reductive ¹³C-methylation of lysines to enhance the sensitivity of conventional NMR methods.

scientific article published on 18 June 2013

Asymmetrical ligand-induced cross-regulation of chemokine (C-X-C motif) receptor 4 by α1-adrenergic receptors at the heteromeric receptor complex.

scientific article published on 9 February 2018

Biased antagonism of CXCR4 avoids antagonist tolerance

article

Breaking symmetry in the structure determination of (large) symmetric protein dimers.

scientific article

Calculation of z-coordinates and orientational restraints using a metal binding tag

scientific article published on 01 December 2000

Calmodulin (CaM) Activates PI3Kα by Targeting the "Soft" CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85α

scientific article published on 08 August 2018

Calmodulin and PI3K Signaling in KRAS Cancers

scientific article published on 18 February 2017

Cardiac troponin I inhibitory peptide: location of interaction sites on troponin C

scientific article published on 01 March 2000

Commercially available antibodies directed against α-adrenergic receptor subtypes and other G protein-coupled receptors with acceptable selectivity in flow cytometry experiments.

scientific article

Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L

scientific article published on 22 April 2013

Derivation of structural restraints using a thiol-reactive chelator.

scientific article published in September 2002

Detection of protein-ligand interactions by NMR using reductive methylation of lysine residues.

scientific article published on 26 September 2008

Differences in lysine pKa values may be used to improve NMR signal dispersion in reductively methylated proteins.

scientific article published on 12 March 2009

Diluting abundant spins by isotope edited radio frequency field assisted diffusion.

scientific article published in June 2004

Effects of troponin I phosphorylation on conformational exchange in the regulatory domain of cardiac troponin C

scientific article published on 01 June 1999

Efficient and precise measurement of H(alpha)-C(alpha), C(alpha)-C', C(alpha)-C(beta) and H(N)-N residual dipolar couplings from 2D H(N)-N correlation spectra

scientific article published on 01 January 2005

Expression, purification, and characterization of soluble K-Ras4B for structural analysis.

scientific article published on 8 June 2010

First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand.

scientific article published on 30 May 2009

Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.

scientific article published on 16 June 2017

Functional and structural consequences of chemokine (C-X-C motif) receptor 4 activation with cognate and non-cognate agonists.

scientific article published on 28 April 2017

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site

scientific article

GTP-Dependent K-Ras Dimerization

scientific article published on 4 June 2015

Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function.

scientific article

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

scientific article

High-sensitivity observation of dipolar exchange and NOEs between exchangeable protons in proteins by 3D solid-state NMR spectroscopy.

scientific article published in November 2003

Honokiol is a FOXM1 antagonist

scientific article published on 24 January 2018

Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle.

scientific article published in January 2018

Improving the accuracy of NMR structures of large proteins using pseudocontact shifts as long-range restraints.

scientific article published in March 2004

Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit.

scientific article

Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region

scientific article

Mixed lineage kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-activated kinase 1

scientific article published on 21 January 2019

NMR analysis of cardiac troponin C-troponin I complexes: effects of phosphorylation

scientific article published on 01 June 1999

New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle.

scientific article published on 20 June 2016

Novel peptide nanoparticle-biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness

article

Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3

scientific article published in PLoS ONE

Peptide structure stabilization by membrane anchoring and its general applicability to the development of potent cell-permeable inhibitors.

scientific article

Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH2 Domains

scientific article published in November 2017

Photoreactive "nanorulers" detect a novel conformation of full length HDAC3-SMRT complex in solution

scientific article published on 02 October 2013

Plasma membrane regulates Ras signaling networks

scientific article published on October 2015

ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

scientific article

Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target

scientific article published on 01 December 2007

Regulatory domain conformational exchange and linker region flexibility in cardiac troponin C bound to cardiac troponin I

scientific article published on 01 July 2000

Solution structures of the C-terminal domain of cardiac troponin C free and bound to the N-terminal domain of cardiac troponin I

scientific article

Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles

scientific article

The HCMV Assembly Compartment Is a Dynamic Golgi-Derived MTOC that Controls Nuclear Rotation and Virus Spread.

scientific article published in April 2018

The Structural Basis of the Farnesylated and Methylated KRas4B Interaction with Calmodulin

scientific article published on 05 September 2019

The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding

scientific article published on 19 December 2015

The higher level of complexity of K-Ras4B activation at the membrane

scientific article published on 30 December 2015

The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin

scientific article published on August 2009

The structure of monomeric components of self-assembling CXCR4 antagonists determines the architecture of resulting nanostructures.

scientific article

Vemurafenib Inhibits Active PTK6 in PTEN-null Prostate Tumor Cells

scientific article published on 29 March 2019

α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies

scientific article published in Scientific Reports

α1-Adrenergic Receptors Function Within Hetero-Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C-X-C motif) Receptor 4 in Vascular Smooth Muscle Cells.

scientific article published on 17 August 2017

List of works by Vadim Gaponenko

13C CPMAS spectroscopy of deuterated proteins: CP dynamics, line shapes, and T1 relaxation

A novel method for the production of fully modified K-Ras 4B.

Application of reductive ¹³C-methylation of lysines to enhance the sensitivity of conventional NMR methods.

Asymmetrical ligand-induced cross-regulation of chemokine (C-X-C motif) receptor 4 by α1-adrenergic receptors at the heteromeric receptor complex.

Biased antagonism of CXCR4 avoids antagonist tolerance

Breaking symmetry in the structure determination of (large) symmetric protein dimers.

Calculation of z-coordinates and orientational restraints using a metal binding tag

Calmodulin (CaM) Activates PI3Kα by Targeting the "Soft" CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85α

Calmodulin and PI3K Signaling in KRAS Cancers

Cardiac troponin I inhibitory peptide: location of interaction sites on troponin C

Commercially available antibodies directed against α-adrenergic receptor subtypes and other G protein-coupled receptors with acceptable selectivity in flow cytometry experiments.

Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L

Derivation of structural restraints using a thiol-reactive chelator.

Detection of protein-ligand interactions by NMR using reductive methylation of lysine residues.

Differences in lysine pKa values may be used to improve NMR signal dispersion in reductively methylated proteins.

Diluting abundant spins by isotope edited radio frequency field assisted diffusion.

Effects of troponin I phosphorylation on conformational exchange in the regulatory domain of cardiac troponin C

Efficient and precise measurement of H(alpha)-C(alpha), C(alpha)-C', C(alpha)-C(beta) and H(N)-N residual dipolar couplings from 2D H(N)-N correlation spectra

Expression, purification, and characterization of soluble K-Ras4B for structural analysis.

First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand.

Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.

Functional and structural consequences of chemokine (C-X-C motif) receptor 4 activation with cognate and non-cognate agonists.

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site

GTP-Dependent K-Ras Dimerization

Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function.

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

High-sensitivity observation of dipolar exchange and NOEs between exchangeable protons in proteins by 3D solid-state NMR spectroscopy.

Honokiol is a FOXM1 antagonist

Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle.

Improving the accuracy of NMR structures of large proteins using pseudocontact shifts as long-range restraints.

Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit.

Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region

Mixed lineage kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-activated kinase 1

NMR analysis of cardiac troponin C-troponin I complexes: effects of phosphorylation

New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle.

Novel peptide nanoparticle-biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness

Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3

Peptide structure stabilization by membrane anchoring and its general applicability to the development of potent cell-permeable inhibitors.

Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH2 Domains

Photoreactive "nanorulers" detect a novel conformation of full length HDAC3-SMRT complex in solution

Plasma membrane regulates Ras signaling networks

ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target

Regulatory domain conformational exchange and linker region flexibility in cardiac troponin C bound to cardiac troponin I

Solution structures of the C-terminal domain of cardiac troponin C free and bound to the N-terminal domain of cardiac troponin I

Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles

The HCMV Assembly Compartment Is a Dynamic Golgi-Derived MTOC that Controls Nuclear Rotation and Virus Spread.

The Structural Basis of the Farnesylated and Methylated KRas4B Interaction with Calmodulin

The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding

The higher level of complexity of K-Ras4B activation at the membrane

The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin

The structure of monomeric components of self-assembling CXCR4 antagonists determines the architecture of resulting nanostructures.

Vemurafenib Inhibits Active PTK6 in PTEN-null Prostate Tumor Cells

α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies

α1-Adrenergic Receptors Function Within Hetero-Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C-X-C motif) Receptor 4 in Vascular Smooth Muscle Cells.