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List of works by Tim C P Somervaille

A personalised medicine approach for ponatinib-resistant chronic myeloid leukaemia

scientific article published on 23 February 2015

A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia

scientific article published on 01 March 2020

A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival.

scientific article published on 31 March 2014

AXL Inhibition Extinguishes Primitive JAK2 Mutated Myeloproliferative Neoplasm Progenitor Cells

scientific article published on 04 June 2019

Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage

scientific article published in July 2016

BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors

scientific article published on 7 April 2016

Blast cells surviving acute myeloid leukemia induction therapy are in cycle with a signature of FOXM1 activity

scientific article published on 28 October 2021

CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1.

scientific article published on 31 July 2013

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis

scientific article published on 02 October 2019

Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia.

scientific article published in January 2018

Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

scientific article published on 9 January 2017

Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1.

scientific article published on 24 August 2017

Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1.

scientific article published on 11 September 2017

Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1.

scientific article

Different levels of p38 MAP kinase activity mediate distinct biological effects in primary human erythroid progenitors

scientific article

Direct comparison of quantitative digital PCR and 2-hydroxyglutarate enantiomeric ratio for IDH mutant allele frequency assessment in myeloid malignancy

scientific article published on 19 June 2015

Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.

scientific article published on 5 December 2016

Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management

Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia

scientific article published on 08 January 2020

EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

scientific article published on 01 September 2018

EVI1 oncoprotein expression and CtBP1-association oscillate through the cell cycle

scientific article published on 26 September 2020

EVI1 phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal

scientific article published on 20 October 2020

Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment

scientific article published on 10 March 2014

Emerging Epigenetic Therapeutic Targets in Acute Myeloid Leukemia

scientific article published on 06 September 2019

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia.

scientific article published in March 2018

Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells

scientific article

Fatal invasive aspergillosis of the larynx.

scientific article published on 4 January 2013

First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia

scientific article published on 14 October 2020

Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia

scientific article published on 01 September 2015

Frequent reconstitution of IDH2(R140Q) mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia.

scientific article published on 27 April 2016

Fulminant hepatic failure caused by adenovirus infection following bone marrow transplantation for Hodgkin's disease

scientific article published on 01 July 1999

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy.

scientific article published on 17 September 2008

Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells?

scientific article published on 8 May 2010

Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax.

scientific article published in September 2001

Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family

scientific article published on October 2008

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

scientific article published on February 2009

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

scientific article published on October 2006

Intraocular relapse of childhood acute lymphoblastic leukaemia

scientific article published on 01 April 2003

KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease

scientific article published on June 2015

LSD1 inhibition: a therapeutic strategy in cancer?

scientific article

LSD1 inhibitors disrupt the GFI1 transcription repressor complex

scientific article published on 01 August 2018

Leukemogenic Activity of Cohesin Rings True.

scientific article published in December 2015

Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.

scientific article

MicroRNA programs in normal and aberrant stem and progenitor cells.

scientific article

Nanofluidic Allele-Specific Digital PCR Method for Quantifying IDH1 and IDH2 Mutation Burden in Acute Myeloid Leukemia.

scientific article

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.

scientific article published on 23 February 2018

Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis

scientific article published on 20 March 2019

PU.1 and Junb: suppressing the formation of acute myeloid leukemia stem cells.

scientific article published in December 2006

Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability

scientific article published in 2013

Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia

scientific article published on 28 November 2019

Preview. Mutant CEBPA: Priming Stem Cells for Myeloid Leukemogenesis

scientific article published on 01 November 2009

Prognostic factors for mortality with fungal blood stream infections in patients with hematological and non-hematological malignancies.

scientific article published on October 2013

Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches

scientific article published on 23 May 2017

Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches

scientific article published on 19 December 2017

Response to tyrosine kinase inhibitors in myeloid neoplasms associated with PCM1-JAK2, BCR-JAK2 and ETV6-ABL1 fusion genes

scientific article published on 12 April 2020

Revert the SIRT: Normalizing SIRT1 Activity in Myelodysplastic Stem Cells

scientific article published on 01 September 2018

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.

scientific article

Sudden onset bilateral deafness as a presentation of chronic myeloid leukaemia

scientific article published on 30 October 2012

TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells.

scientific article published on 4 April 2013

Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer

scientific article published on 10 November 2020

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

scientific article published on 25 April 2019

The Diverse Consequences of Deregulation in Cancer

scientific article published on 05 February 2019

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

scientific article published on 29 March 2012

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

scientific article published on October 2005

The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression

scientific article

The variety of leukemic stem cells in myeloid malignancy.

scientific article published on 08 July 2013

Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia ⬇️

scientific article published on 19 January 2016

Variable product purity and functional capacity after CD34 selection: a direct comparison of the CliniMACS (v2.1) and Isolex 300i (v2.5) clinical scale devices

scientific article published in July 2002

Very high frequencies of leukaemia-initiating cells in precursor T-acute lymphoblastic leukaemia may be obscured by cryopreservation.

scientific article

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