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List of works by Bryan Ks Yeung

Back to the future: lessons learned in modern target-based and whole-cell lead optimization of antimalarials.

scientific article published on January 2012

Construction and characterization of a manganese-binding site in cytochrome c peroxidase: towards a novel manganese peroxidase

scientific article published on 01 March 1997

Determination of binding affinities of triplex forming oligonucleotides using a fluorescent intercalator displacement (FID) assay.

scientific article

Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit.

scientific article published on 4 February 2017

Facile C1 Epimerization of alpha-1-sulfonamidyl-2-deoxy-2-iodo- glycopyranosides

scientific article published on 01 February 2001

Gram-scale syntheses of the (1-->3)-linked and (1-->4)-linked hyaluronan disaccharides.

scientific article published in May 2004

Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages

scientific article published on 6 July 2014

Mechanistic study of the spiroindolones: a new class of antimalarials.

scientific article published on 24 August 2012

Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance

scientific article (publication date: 5 July 2016)

Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials

scientific article (publication date: 13 February 2013)

Natural product drug discovery: the successful optimization of ISP-1 and halichondrin B ⬇️

scientific article published on June 22, 2011

Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model

scientific article

Progressing the global antimalarial portfolio: finding drugs which target multiple Plasmodium life stages.

scientific article

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

scientific article published on July 2010

Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi.

scientific article

Synthesis of isochrysohermidin-distamycin hybrids.

scientific article published in June 2003

Synthesis of two hyaluronan trisaccharides

scientific article published on 01 May 2000

Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design

scientific article

The Kapakahines, Cyclic Peptides from the Marine Sponge Cribrochalina olemda

scientific article published on 01 October 1996

The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites

scientific article

The Spiroindolone Drug Candidate NITD609 Potently Inhibits Gametocytogenesis and Blocks Plasmodium falciparum Transmission to Anopheles Mosquito Vector ⬇️

scientific article published on April 16, 2012

UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

scientific article (publication date: 19 September 2016)

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