List of works - Céline Galès

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation

scientific article

Adult resident cardiomyocytes wake up: new axis for cardiac tissue regeneration

scientific article

Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling

scientific article

An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and trafficking

scientific article

Analysis of Arrestin Recruitment to Chemokine Receptors by Bioluminescence Resonance Energy Transfer.

scientific article published on 29 November 2015

Atomic force and electron microscopic-based study of sarcolemmal surface of living cardiomyocytes unveils unexpected mitochondrial shift in heart failure.

scientific article published on 17 May 2014

Atomic force microscopy-single-molecule force spectroscopy unveils GPCR cell surface architecture

scientific article published on 10 March 2022

Biased signaling at chemokine receptors

scientific article

Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing delta-opioid receptors and heterotrimeric G proteins.

scientific article

Biophysical properties of cardiomyocyte surface explored by multiparametric AFM.

scientific article published on 2 March 2017

CODA-RET reveals functional selectivity as a result of GPCR heteromerization

scientific article

Cardiac cAMP: production, hydrolysis, modulation and detection

scientific article

Cardiac fibroblasts regulate sympathetic nerve sprouting and neurocardiac synapse stability

scientific article

Cardioprotective Angiotensin-(1-7) Peptide Acts as a Natural-Biased Ligand at the Angiotensin II Type 1 Receptor.

scientific article

Cardiotoxicity of chemotherapies

scientific article published on 21 June 2012

Characterization of humoral immune responses induced by immunization with plasmid DNA expressing HIV-1 Nef accessory protein

scientific article published on 01 October 1998

Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: insight into nanoscale organization of signal transduction

scientific article

Coexpression of CCR7 and CXCR4 During B Cell Development Controls CXCR4 Responsiveness and Bone Marrow Homing

scientific article published on 18 December 2019

Conformational rearrangements and signaling cascades involved in ligand-biased mitogen-activated protein kinase signaling through the beta1-adrenergic receptor.

scientific article

Deciphering biased inverse agonism of cangrelor and ticagrelor at P2Y receptor

article

Deciphering biased-agonism complexity reveals a new active AT1 receptor entity.

scientific article published on 27 May 2012

Delineating biased ligand efficacy at 7TM receptors from an experimental perspective

scientific article published on 20 April 2016

Detecting and imaging protein-protein interactions during G protein-mediated signal transduction in vivo and in situ by using fluorescence-based techniques.

scientific article

Differential β₂-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines

scientific article

Dosage-dependent regulation of cell proliferation and adhesion through dual β2-adrenergic receptor/cAMP signals.

scientific article published on 5 December 2013

Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling

scientific article published on 23 February 2015

Ephrin-B1 is a novel specific component of the lateral membrane of the cardiomyocyte and is essential for the stability of cardiac tissue architecture cohesion

scientific article published on 02 February 2012

Evaluation of upconverting nanoparticles towards heart theranostics

scientific article published on 09 December 2019

Evidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptor

scientific article (publication date: 13 August 1999)

Exercise training-induced modification in autonomic nervous system: An update for cardiac patients.

scientific article

Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.

scientific article

Functional enhancement of AT1R potency in the presence of the TPαR is revealed by a comprehensive 7TM receptor co-expression screen

scientific article

Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes

scientific article published on 8 November 2011

Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands.

scientific article

G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors.

scientific article published on 22 March 2011

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.

scientific article published on 9 April 2018

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

scientific article

Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity

scientific article

Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation.

scientific article published on 3 August 2016

Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells.

scientific article published in July 2006

High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor.

scientific article published on September 2003

High-intensity interval exercise improves vagal tone and decreases arrhythmias in chronic heart failure.

scientific article published in October 2013

Homologous regulation of the alpha2C-adrenoceptor subtype in human hepatocarcinoma, HepG2.

scientific article published on January 1999

Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2-adrenoceptors.

scientific article

Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies

scientific article (publication date: May 2003)

Mapping HA-tagged protein at the surface of living cells by atomic force microscopy

scientific article published on January 2015

Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling

scientific article

Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes Gq protein activation without affecting its association with the receptor

scientific article published on 01 June 2000

Nanoscale structural mapping as a measure of maturation in the murine frontal cortex

scientific article published on 4 August 2017

Nouveau dialogue entre récepteurs et protéines G trimériques : « une danse à corps enlacés »

scientific article published on 01 November 2007

Partial Agonist and Biased Signaling Properties of the Synthetic Enantiomers J113863/UCB35625 at Chemokine Receptors CCR2 and CCR5.

scientific article

Probing heterotrimeric G protein activation: applications to biased ligands.

scientific article published on January 2012

Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes.

scientific article published on 13 August 2006

Real-time monitoring of receptor and G-protein interactions in living cells.

scientific article

Role of the ubiquitin-proteasome system in the regulation of P2Y13 receptor expression: impact on hepatic HDL uptake

scientific article published on 13 September 2013

Short-term effects of a 3-week interval training program on heart rate variability in chronic heart failure. A randomised controlled trial

scientific article published on 25 July 2019

Signaling Properties of Chemerin Receptors CMKLR1, GPR1 and CCRL2.

scientific article

Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling

scientific article published on 22 December 2012

Specific roles of G(i) protein family members revealed by dissecting SST5 coupling in human pituitary cells

scientific article

Structural evidence for a new elaborate 3D-organization of the cardiomyocyte lateral membrane in adult mammalian cardiac tissues

scientific article published on 01 May 2019

Structure of cholecystokinin receptor binding sites and mechanism of activation/inactivation by agonists/antagonists.

scientific article published in December 2002

The experimental power of FR900359 to study Gq-regulated biological processes

scientific article

[Adult cardiomyocytes wake up: a big step towards cardiac regeneration].

scientific article published on 27 March 2013

[G-protein-coupled receptors plasticity and signalling].

scientific article published on 12 October 2012

alpha(2B)-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells.

scientific article published on May 2002

List of works by Céline Galès

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation

Adult resident cardiomyocytes wake up: new axis for cardiac tissue regeneration

Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling

An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and trafficking

Analysis of Arrestin Recruitment to Chemokine Receptors by Bioluminescence Resonance Energy Transfer.

Atomic force and electron microscopic-based study of sarcolemmal surface of living cardiomyocytes unveils unexpected mitochondrial shift in heart failure.

Atomic force microscopy-single-molecule force spectroscopy unveils GPCR cell surface architecture

Biased signaling at chemokine receptors

Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing delta-opioid receptors and heterotrimeric G proteins.

Biophysical properties of cardiomyocyte surface explored by multiparametric AFM.

CODA-RET reveals functional selectivity as a result of GPCR heteromerization

Cardiac cAMP: production, hydrolysis, modulation and detection

Cardiac fibroblasts regulate sympathetic nerve sprouting and neurocardiac synapse stability

Cardioprotective Angiotensin-(1-7) Peptide Acts as a Natural-Biased Ligand at the Angiotensin II Type 1 Receptor.

Cardiotoxicity of chemotherapies

Characterization of humoral immune responses induced by immunization with plasmid DNA expressing HIV-1 Nef accessory protein

Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: insight into nanoscale organization of signal transduction

Coexpression of CCR7 and CXCR4 During B Cell Development Controls CXCR4 Responsiveness and Bone Marrow Homing

Conformational rearrangements and signaling cascades involved in ligand-biased mitogen-activated protein kinase signaling through the beta1-adrenergic receptor.

Deciphering biased inverse agonism of cangrelor and ticagrelor at P2Y receptor

Deciphering biased-agonism complexity reveals a new active AT1 receptor entity.

Delineating biased ligand efficacy at 7TM receptors from an experimental perspective

Detecting and imaging protein-protein interactions during G protein-mediated signal transduction in vivo and in situ by using fluorescence-based techniques.

Differential β₂-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines

Dosage-dependent regulation of cell proliferation and adhesion through dual β2-adrenergic receptor/cAMP signals.

Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling

Ephrin-B1 is a novel specific component of the lateral membrane of the cardiomyocyte and is essential for the stability of cardiac tissue architecture cohesion

Evaluation of upconverting nanoparticles towards heart theranostics

Evidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptor

Exercise training-induced modification in autonomic nervous system: An update for cardiac patients.

Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.

Functional enhancement of AT1R potency in the presence of the TPαR is revealed by a comprehensive 7TM receptor co-expression screen

Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes

Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands.

G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors.

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity

Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation.

Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells.

High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor.

High-intensity interval exercise improves vagal tone and decreases arrhythmias in chronic heart failure.

Homologous regulation of the alpha2C-adrenoceptor subtype in human hepatocarcinoma, HepG2.

Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2-adrenoceptors.

Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies

Mapping HA-tagged protein at the surface of living cells by atomic force microscopy

Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling

Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes Gq protein activation without affecting its association with the receptor

Nanoscale structural mapping as a measure of maturation in the murine frontal cortex

Nouveau dialogue entre récepteurs et protéines G trimériques : « une danse à corps enlacés »

Partial Agonist and Biased Signaling Properties of the Synthetic Enantiomers J113863/UCB35625 at Chemokine Receptors CCR2 and CCR5.

Probing heterotrimeric G protein activation: applications to biased ligands.

Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes.

Real-time monitoring of receptor and G-protein interactions in living cells.

Role of the ubiquitin-proteasome system in the regulation of P2Y13 receptor expression: impact on hepatic HDL uptake

Short-term effects of a 3-week interval training program on heart rate variability in chronic heart failure. A randomised controlled trial

Signaling Properties of Chemerin Receptors CMKLR1, GPR1 and CCRL2.

Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling

Specific roles of G(i) protein family members revealed by dissecting SST5 coupling in human pituitary cells

Structural evidence for a new elaborate 3D-organization of the cardiomyocyte lateral membrane in adult mammalian cardiac tissues

Structure of cholecystokinin receptor binding sites and mechanism of activation/inactivation by agonists/antagonists.

The experimental power of FR900359 to study Gq-regulated biological processes

[Adult cardiomyocytes wake up: a big step towards cardiac regeneration].

[G-protein-coupled receptors plasticity and signalling].

alpha(2B)-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells.