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List of works by Alfred Vertegaal

A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair

scientific article published on 26 February 2021

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes

scientific article

A comprehensive compilation of SUMO proteomics.

scientific article published on 20 July 2016

A high-yield double-purification proteomics strategy for the identification of SUMO sites.

scientific article published on 11 August 2016

A proteomic study of SUMO-2 target proteins

scientific article

BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis

scientific article published in 2024

Chemical Tools and Biochemical Assays for SUMO Specific Proteases (SENPs)

scientific article published on 05 August 2019

Chromokinesin KIF4A teams up with Stathmin 1 to regulate abscission in a SUMO-dependent manner

scientific article published on 26 June 2020

Converging Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Signaling: Improved Methodology Identifies Co-modified Target Proteins.

scientific article published on 26 September 2017

Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates

scientific article published on 18 May 2022

Differential expression of tapasin and immunoproteasome subunits in adenovirus type 5- versus type 12-transformed cells

scientific journal article

Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics

scientific article

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation

scientific article published on 09 June 2021

Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesis.

scientific article published on 17 November 2017

Guiding Mitotic Progression by Crosstalk between Post-translational Modifications.

scientific article published on 24 February 2018

Identification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function.

scientific article

Identification of proximal SUMO-dependent interactors using SUMO-ID

scientific article published on 18 November 2021

Ikappa Balpha is a target for the mitogen-activated 90kDa ribosomal S6 kinase ⬇️

scientific article published on June 2, 1997

In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy

scientific article

Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies

scientific article published on 08 July 2019

Label-Free Identification and Quantification of SUMO Target Proteins.

scientific article published on January 2016

Mapping the SUMOylated landscape

scientific article

Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation

scientific article published on 01 March 2021

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining.

scientific article

Probing ubiquitin and SUMO conjugation and deconjugation

scientific article published on 27 March 2018

Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells.

scientific article published in December 2000

Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress

scientific article

RNF12 controls embryonic stem cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for degradation ⬇️

scientific article published on May 3, 2012

RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha.

scientific article

Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining

scientific article published on 20 August 2013

SUMO in the DNA damage response

scientific article published in June 2015

SUMO targets the APC/C to regulate transition from metaphase to anaphase.

scientific article published on 16 March 2018

SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.

scientific article published on 10 March 2015

SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.

scientific article published on 26 February 2015

SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock

scientific article published on 01 January 2019

SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer

scientific article

Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif

scientific article

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation

scientific article published on 23 January 2017

Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention

scientific article published on 01 March 2021

System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability.

scientific article

System-wide identification of wild-type SUMO-2 conjugation sites

scientific article published on 15 June 2015

The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity.

scientific article published on December 2000

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

scientific article published on 27 November 2017

The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation

scientific article published on 04 September 2019

Total Chemical Synthesis of SUMO and SUMO-Based Probes for Profiling the Activity of SUMO-Specific Proteases

scientific article published on 14 June 2018

Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation

scientific article published on 01 January 2020

USP7: combining tools towards selectivity

scientific article published on 01 April 2019

Ubiquitin-dependent and independent roles of SUMO in proteostasis

scientific article published on 22 June 2016

Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4).

scientific article

Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein

scientific article published on 27 February 2014

Uncovering Ubiquitin and Ubiquitin-like Signaling Networks ⬇️

scientific article published on October 17, 2011

Uncovering global SUMOylation signaling networks in a site-specific manner

scientific article

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks

scientific article

Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining

scientific article published on 12 November 2021

c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4

scientific article

cDNA micro array identification of a gene differentially expressed in adenovirus type 5- versus type 12-transformed cells

scientific article (publication date: 29 December 2000)

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