List of works - Yuichi Sekine

A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3.

scientific article published on 5 April 2016

A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration

scientific article published on 20 November 2019

Adaptor protein STAP-2 modulates cellular signaling in immune systems.

scientific article published on January 2014

BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation

scientific article

CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic Ba/F3 cells

scientific article published on 21 June 2015

Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.

scientific article published on March 2004

DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118.

scientific article

Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3.

scientific article published on April 2003

Determination of the transphosphorylation sites of Jak2 kinase.

scientific article

Enhanced c-Fms/M-CSF receptor signaling and wound-healing process in bone marrow-derived macrophages of signal-transducing adaptor protein-2 (STAP-2) deficient mice

scientific article published on 01 September 2008

Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration

scientific article published in April 2018

Human neuroepithelial stem cell regional specificity enables spinal cord repair through a relay circuit

scientific article published in Nature Communications

Inhibiting poly(ADP-ribosylation) improves axon regeneration

scientific article (publication date: 4 October 2016)

Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury.

scientific article

Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.

scientific article

Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.

scientific article published on 23 January 2011

Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.

scientific article

Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.

scientific article

KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression

scientific article published on 31 March 2008

Krüppel-associated box-associated protein 1 negatively regulates TNF-α-induced NF-κB transcriptional activity by influencing the interactions among STAT3, p300, and NF-κB/p65

scientific article published on 01 August 2011

Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination

scientific article published on 06 May 2019

Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor

scientific article (publication date: 27 June 2003)

Nuclear retention of STAT3 through the coiled-coil domain regulates its activity.

scientific article published on October 2005

PDLIM2 Inhibits T Helper 17 Cell Development and Granulomatous Inflammation Through Degradation of STAT3 ⬇️

scientific article published on December 6, 2011

Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines.

scientific article published on 9 November 2005

Physical and functional interactions between Daxx and STAT3

scientific article

Physical and functional interactions between STAP-2/BKS and STAT5.

scientific article

Physical and functional interactions between STAT3 and KAP1.

scientific article published on 26 November 2007

Physical and functional interactions between STAT3 and ZIP kinase

scientific journal article

Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma

scientific article published on 25 February 2019

Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells.

scientific article

Regulation of STAT3-mediated signaling by LMW-DSP2

scientific article

STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body

scientific article published on 28 May 2015

STAP-2 interacts with Pyk2 and enhances Pyk2 activity in T-cells

scientific article published on 3 May 2017

STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis.

scientific article published on 9 January 2012

STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation

scientific journal article

STAP-2 positively regulates FcεRI-mediated basophil activation and basophil-dependent allergic inflammatory reactions

scientific article published on 01 April 2019

STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization.

scientific article

Signal-transducing adaptor protein-2 controls the IgE-mediated, mast cell-mediated anaphylactic responses

scientific article published on 10 March 2014

Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.

scientific article

Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase.

scientific article

Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis

scientific article published on 15 April 2014

Silencing mediator of retinoic acid and thyroid hormone receptor regulates enhanced activation of signal transducer and activator of transcription 3 by epstein-barr virus-derived epstein-barr nuclear antigen 2.

scientific article published in July 2009

Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation.

scientific article published on July 2006

Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-beta signaling.

scientific article

The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction.

scientific article

The Nogo receptor NgR1 mediates infection by mammalian reovirus.

scientific article published on June 2014

The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.

scientific article published on 28 February 2009

The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury.

scientific article published on 3 April 2018

The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl.

scientific article published on 3 May 2009

The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival

scientific article published on 01 February 2020

Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.

scientific article

Tyk2 is a therapeutic target for psoriasis-like skin inflammation.

scientific article published on 17 December 2013

Tyrosine kinase 2 interacts with and phosphorylates receptor for activated C kinase-1, a WD motif-containing protein.

scientific article published in July 2004

UBE1a Suppresses Herpes Simplex Virus-1 Replication

scientific article published on 04 December 2020

Y14 positively regulates TNF-α-induced NF-κB transcriptional activity via interacting RIP1 and TRADD beyond an exon junction complex protein.

scientific article published on July 2013

Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4)

scientific article

List of works by Yuichi Sekine

A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3.

A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration

Adaptor protein STAP-2 modulates cellular signaling in immune systems.

BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation

CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic Ba/F3 cells

Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.

DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118.

Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3.

Determination of the transphosphorylation sites of Jak2 kinase.

Enhanced c-Fms/M-CSF receptor signaling and wound-healing process in bone marrow-derived macrophages of signal-transducing adaptor protein-2 (STAP-2) deficient mice

Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration

Human neuroepithelial stem cell regional specificity enables spinal cord repair through a relay circuit

Inhibiting poly(ADP-ribosylation) improves axon regeneration

Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury.

Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.

Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.

Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.

Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.

KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression

Krüppel-associated box-associated protein 1 negatively regulates TNF-α-induced NF-κB transcriptional activity by influencing the interactions among STAT3, p300, and NF-κB/p65

Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination

Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor

Nuclear retention of STAT3 through the coiled-coil domain regulates its activity.

PDLIM2 Inhibits T Helper 17 Cell Development and Granulomatous Inflammation Through Degradation of STAT3 ⬇️

Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines.

Physical and functional interactions between Daxx and STAT3

Physical and functional interactions between STAP-2/BKS and STAT5.

Physical and functional interactions between STAT3 and KAP1.

Physical and functional interactions between STAT3 and ZIP kinase

Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma

Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells.

Regulation of STAT3-mediated signaling by LMW-DSP2

STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body

STAP-2 interacts with Pyk2 and enhances Pyk2 activity in T-cells

STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis.

STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation

STAP-2 positively regulates FcεRI-mediated basophil activation and basophil-dependent allergic inflammatory reactions

STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization.

Signal-transducing adaptor protein-2 controls the IgE-mediated, mast cell-mediated anaphylactic responses

Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.

Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase.

Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis

Silencing mediator of retinoic acid and thyroid hormone receptor regulates enhanced activation of signal transducer and activator of transcription 3 by epstein-barr virus-derived epstein-barr nuclear antigen 2.

Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation.

Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-beta signaling.

The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction.

The Nogo receptor NgR1 mediates infection by mammalian reovirus.

The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.

The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury.

The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl.

The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival

Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.

Tyk2 is a therapeutic target for psoriasis-like skin inflammation.

Tyrosine kinase 2 interacts with and phosphorylates receptor for activated C kinase-1, a WD motif-containing protein.

UBE1a Suppresses Herpes Simplex Virus-1 Replication

Y14 positively regulates TNF-α-induced NF-κB transcriptional activity via interacting RIP1 and TRADD beyond an exon junction complex protein.

Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4)