List of works - Ryuta Muromoto

A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3.

scientific article published on 5 April 2016

A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases.

scientific article published on 26 May 2017

Anti-IL-17A blocking antibody reduces cyclosporin A-induced relapse in experimental autoimmune encephalomyelitis mice

scientific article published on 26 August 2016

BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation

scientific article

Biochanin A enhances RORγ activity through STAT3-mediated recruitment of NCOA1.

scientific article published in June 2017

CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic Ba/F3 cells

scientific article published on 21 June 2015

Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1.

scientific article

Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3.

scientific article published on April 2003

Death Domain-associated Protein (DAXX)-mediated Regulation of Transcription and Cell Death ⬇️

scientific article published on 01 January 2012

Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents

scientific article

Dimethyl fumarate dampens IL-17-ACT1-TBK1 axis-mediated phosphorylation of Regnase-1 and suppresses IL-17-induced IκB-ζ expression

scientific article published on 09 November 2019

Enhanced c-Fms/M-CSF receptor signaling and wound-healing process in bone marrow-derived macrophages of signal-transducing adaptor protein-2 (STAP-2) deficient mice

scientific article published on 01 September 2008

IL-17A plays a central role in the expression of psoriasis signature genes through the induction of IκB-ζ in keratinocytes.

scientific article

Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.

scientific article published on 24 January 2012

Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.

scientific article

Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.

scientific article published on 23 January 2011

Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.

scientific article

Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.

scientific article

IκB-ζ Expression Requires Both TYK2/STAT3 Activity and IL-17-Regulated mRNA Stabilization

scientific article published on 16 May 2019

Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons.

scientific article published on 16 September 2013

KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression

scientific article published on 31 March 2008

Kaposi's sarcoma-associated herpesvirus-encoded LANA associates with glucocorticoid receptor and enhances its transcriptional activities

scientific article published on 29 May 2015

Krüppel-associated box-associated protein 1 negatively regulates TNF-α-induced NF-κB transcriptional activity by influencing the interactions among STAT3, p300, and NF-κB/p65

scientific article published on 01 August 2011

Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.

scientific article published on December 2003

Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.

scientific article published on 06 April 2011

Nuclear retention of STAT3 through the coiled-coil domain regulates its activity.

scientific article published on October 2005

PDLIM2 Inhibits T Helper 17 Cell Development and Granulomatous Inflammation Through Degradation of STAT3 ⬇️

scientific article published on December 6, 2011

PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction.

scientific article

Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines.

scientific article published on 9 November 2005

Physical and functional interactions between Daxx and STAT3

scientific article

Physical and functional interactions between STAT3 and KAP1.

scientific article published on 26 November 2007

Physical and functional interactions between STAT3 and ZIP kinase

scientific journal article

Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3

scientific article (publication date: 5 September 2003)

STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body

scientific article published on 28 May 2015

STAP-2 interacts with Pyk2 and enhances Pyk2 activity in T-cells

scientific article published on 3 May 2017

STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis.

scientific article published on 9 January 2012

STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation

scientific journal article

STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization.

scientific article

Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML

scientific article published on 13 July 2020

Signal-transducing adaptor protein-2 controls the IgE-mediated, mast cell-mediated anaphylactic responses

scientific article published on 10 March 2014

Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.

scientific article

Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase.

scientific article

Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis

scientific article published on 15 April 2014

Silencing mediator of retinoic acid and thyroid hormone receptor regulates enhanced activation of signal transducer and activator of transcription 3 by epstein-barr virus-derived epstein-barr nuclear antigen 2.

scientific article published in July 2009

Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation.

scientific article published on July 2006

Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-beta signaling.

scientific article

Synthesis of Chiral cis-Cyclopropane Bearing Indole and Chromone as Potential TNFα Inhibitors

scientific article published on 24 July 2018

The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction.

scientific article

The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.

scientific article published on 28 February 2009

The novel α4B murine α4 integrin protein splicing variant inhibits α4 protein-dependent cell adhesion.

scientific article published on 22 April 2014

The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl.

scientific article published on 3 May 2009

Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.

scientific article

Tyk2 is a therapeutic target for psoriasis-like skin inflammation.

scientific article published on 17 December 2013

Tyrosine kinase 2 interacts with and phosphorylates receptor for activated C kinase-1, a WD motif-containing protein.

scientific article published in July 2004

Y14 positively regulates TNF-α-induced NF-κB transcriptional activity via interacting RIP1 and TRADD beyond an exon junction complex protein.

scientific article published on July 2013

Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4)

scientific article

List of works by Ryuta Muromoto

A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3.

A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases.

Anti-IL-17A blocking antibody reduces cyclosporin A-induced relapse in experimental autoimmune encephalomyelitis mice

BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation

Biochanin A enhances RORγ activity through STAT3-mediated recruitment of NCOA1.

CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic Ba/F3 cells

Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1.

Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3.

Death Domain-associated Protein (DAXX)-mediated Regulation of Transcription and Cell Death ⬇️

Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents

Dimethyl fumarate dampens IL-17-ACT1-TBK1 axis-mediated phosphorylation of Regnase-1 and suppresses IL-17-induced IκB-ζ expression

Enhanced c-Fms/M-CSF receptor signaling and wound-healing process in bone marrow-derived macrophages of signal-transducing adaptor protein-2 (STAP-2) deficient mice

IL-17A plays a central role in the expression of psoriasis signature genes through the induction of IκB-ζ in keratinocytes.

Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.

Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.

Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.

Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.

Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.

IκB-ζ Expression Requires Both TYK2/STAT3 Activity and IL-17-Regulated mRNA Stabilization

Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons.

KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression

Kaposi's sarcoma-associated herpesvirus-encoded LANA associates with glucocorticoid receptor and enhances its transcriptional activities

Krüppel-associated box-associated protein 1 negatively regulates TNF-α-induced NF-κB transcriptional activity by influencing the interactions among STAT3, p300, and NF-κB/p65

Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.

Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.

Nuclear retention of STAT3 through the coiled-coil domain regulates its activity.

PDLIM2 Inhibits T Helper 17 Cell Development and Granulomatous Inflammation Through Degradation of STAT3 ⬇️

PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction.

Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines.

Physical and functional interactions between Daxx and STAT3

Physical and functional interactions between STAT3 and KAP1.

Physical and functional interactions between STAT3 and ZIP kinase

Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3

STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body

STAP-2 interacts with Pyk2 and enhances Pyk2 activity in T-cells

STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis.

STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation

STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization.

Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML

Signal-transducing adaptor protein-2 controls the IgE-mediated, mast cell-mediated anaphylactic responses

Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.

Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase.

Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis

Silencing mediator of retinoic acid and thyroid hormone receptor regulates enhanced activation of signal transducer and activator of transcription 3 by epstein-barr virus-derived epstein-barr nuclear antigen 2.

Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation.

Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-beta signaling.

Synthesis of Chiral cis-Cyclopropane Bearing Indole and Chromone as Potential TNFα Inhibitors

The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction.

The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.

The novel α4B murine α4 integrin protein splicing variant inhibits α4 protein-dependent cell adhesion.

The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl.

Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.

Tyk2 is a therapeutic target for psoriasis-like skin inflammation.

Tyrosine kinase 2 interacts with and phosphorylates receptor for activated C kinase-1, a WD motif-containing protein.

Y14 positively regulates TNF-α-induced NF-κB transcriptional activity via interacting RIP1 and TRADD beyond an exon junction complex protein.

Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4)