List of works - Maria Domenica Castellone

A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.

scientific article published in November 2007

A loss-of-function genetic screening identifies novel mediators of thyroid cancer cell viability.

scientific article

Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12.

scientific article

Biomarkers in thyroid tumor research: new diagnostic tools and potential targets of molecular-based therapy

scientific article published in January 2011

Brief report: Mesenchymal stromal cell atrophy in coculture increases aggressiveness of transformed cells.

scientific article published on June 2013

Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13.

scientific article

Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma.

scientific article

Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection.

scientific article published on December 2006

Dysregulated RET signaling in thyroid cancer.

scientific article published on June 2008

Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).

scientific article

Extracellular superoxide dismutase induces mouse embryonic fibroblast proliferative burst, growth arrest, immortalization, and consequent in vivo tumorigenesis.

scientific article published on 19 February 2014

Extracellular superoxide dismutase is a thyroid differentiation marker down-regulated in cancer.

scientific article published on 16 August 2010

Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI.

scientific article

FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma

scientific article published on 21 September 2012

Gene expression changes in a patient presenting nonleukaemic nasal granulocytic sarcoma to acute myelogenous leukaemia using 40 K cDNA microarray

scientific article published on 01 August 2006

Human embryonic stem cell-derived mesenchymal stromal cell transplantation in a rat hind limb injury model.

scientific article

Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes.

scientific article

NCOA4 transcriptional coactivator inhibits activation of DNA replication origins

scientific article published on 05 June 2014

OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome.

scientific article published on 6 November 2007

Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness.

scientific article

Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness.

scientific article published on November 2005

Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

scientific article published on 17 November 2005

Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase.

scientific article published on May 2003

RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho.

scientific article

RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase.

scientific article published on January 2007

Receptor tyrosine kinase inhibitors in thyroid cancer.

scientific article published on December 2008

Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.

scientific article published on 25 August 2005

Robo4 signaling in endothelial cells implies attraction guidance mechanisms.

scientific article published on 15 February 2006

SOD3 decreases ischemic injury derived apoptosis through phosphorylation of Erk1/2, Akt, and FoxO3a.

scientific article

The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

scientific article

The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation.

scientific article published on 17 February 2009

Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic factors.

scientific article published in July 2003

List of works by Maria Domenica Castellone

A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.

A loss-of-function genetic screening identifies novel mediators of thyroid cancer cell viability.

Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12.

Biomarkers in thyroid tumor research: new diagnostic tools and potential targets of molecular-based therapy

Brief report: Mesenchymal stromal cell atrophy in coculture increases aggressiveness of transformed cells.

Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13.

Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma.

Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection.

Dysregulated RET signaling in thyroid cancer.

Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).

Extracellular superoxide dismutase induces mouse embryonic fibroblast proliferative burst, growth arrest, immortalization, and consequent in vivo tumorigenesis.

Extracellular superoxide dismutase is a thyroid differentiation marker down-regulated in cancer.

Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI.

FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma

Gene expression changes in a patient presenting nonleukaemic nasal granulocytic sarcoma to acute myelogenous leukaemia using 40 K cDNA microarray

Human embryonic stem cell-derived mesenchymal stromal cell transplantation in a rat hind limb injury model.

Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes.

NCOA4 transcriptional coactivator inhibits activation of DNA replication origins

OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome.

Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness.

Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness.

Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase.

RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho.

RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase.

Receptor tyrosine kinase inhibitors in thyroid cancer.

Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.

Robo4 signaling in endothelial cells implies attraction guidance mechanisms.

SOD3 decreases ischemic injury derived apoptosis through phosphorylation of Erk1/2, Akt, and FoxO3a.

The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation.

Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic factors.