List of works - Frank Kozielski

"Snapshots"of Ispinesib-induced Conformational Changes in the Mitotic Kinesin Eg5

scientific article

A model of the microtubule-kinesin complex based on electron cryomicroscopy and X-ray crystallography

scientific article published on 01 February 1998

An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex

scientific article

Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding

scientific article

Conformation of the Drosophila motor protein non-claret disjunctional in solution from X-ray and neutron scattering.

scientific article published on 2 May 2001

Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2

scientific article published on 06 October 2020

Crystal structure of the motor domain of the human kinetochore protein CENP-E

scientific article

Crystallization and Preliminary X-Ray Analysis of the Single-Headed and Double-Headed Motor Protein Kinesin ⬇️

scientific article published on June 1, 1997

Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore-associated protein CENP-E using an automated crystallization procedure

scientific article

Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases

article

Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.

scientific article

Elucidating the functionality of kinesins: an overview of small molecule inhibitors.

scientific article published on 06 October 2011

Essential kinesins: characterization of Caenorhabditis elegans KLP-15.

scientific article published in May 2005

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.

scientific article published on 19 September 2006

Human kinetochore-associated kinesin CENP-E visualized at 17 A resolution bound to microtubules.

scientific article published on 27 July 2006

In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.

scientific article published in September 2004

Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives.

scientific article published on 12 January 2012

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

scientific article published in January 2003

Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching.

scientific article

Kinesins and cancer.

scientific article

Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents

scientific article published on 15 May 2006

Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines.

scientific article

New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations

scientific article published on 24 December 2015

New chemical tools for investigating human mitotic kinesin Eg5.

scientific article

Optimized S -Trityl- l -cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models

scientific article

Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5.

scientific article

Proteome analysis of microtubule-associated proteins and their interacting partners from mammalian brain.

scientific article

Receptor–Ligand Interaction-Based Virtual Screening for Novel Eg5/Kinesin Spindle Protein Inhibitors ⬇️

scientific article published on March 22, 2012

Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor.

scientific article published on October 2010

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

scientific article published on 28 February 2006

STLC-resistant cell lines as tools to classify chemically divergent Eg5 targeting agents according to their mode of action and target specificity.

scientific article published on 13 September 2013

Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol

scientific article

Structural insights into a unique inhibitor binding pocket in kinesin spindle protein

scientific article

Structural insights into human Kif7, a kinesin involved in Hedgehog signalling

scientific article

Structural variations in protein superfamilies: actin and tubulin

scientific article published on 08 January 2009

Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5

scientific article

Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

scientific article published on 12 February 2008

Structure-activity relationships and molecular docking of novel dihydropyrimidine-based mitotic Eg5 inhibitors.

scientific article published in October 2010

Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives.

scientific article published on 10 March 2009

The Crystal Structure of Dimeric Kinesin and Implications for Microtubule-Dependent Motility ⬇️

scientific article published on December 26, 1997

The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition

scientific article

The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal development

scientific article

The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations

scientific article

The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins.

scientific article

The structure of human neuronal Rab6B in the active and inactive form.

scientific article

The structure of the ternary Eg5–ADP–ispinesib complex

scientific article

Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity

scientific article

Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5

scientific article published on 01 January 2006

List of works by Frank Kozielski

"Snapshots"of Ispinesib-induced Conformational Changes in the Mitotic Kinesin Eg5

A model of the microtubule-kinesin complex based on electron cryomicroscopy and X-ray crystallography

An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex

Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding

Conformation of the Drosophila motor protein non-claret disjunctional in solution from X-ray and neutron scattering.

Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2

Crystal structure of the motor domain of the human kinetochore protein CENP-E

Crystallization and Preliminary X-Ray Analysis of the Single-Headed and Double-Headed Motor Protein Kinesin ⬇️

Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore-associated protein CENP-E using an automated crystallization procedure

Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases

Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.

Elucidating the functionality of kinesins: an overview of small molecule inhibitors.

Essential kinesins: characterization of Caenorhabditis elegans KLP-15.

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.

Human kinetochore-associated kinesin CENP-E visualized at 17 A resolution bound to microtubules.

In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.

Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives.

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching.

Kinesins and cancer.

Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents

Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines.

New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations

New chemical tools for investigating human mitotic kinesin Eg5.

Optimized S -Trityl- l -cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models

Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5.

Proteome analysis of microtubule-associated proteins and their interacting partners from mammalian brain.

Receptor–Ligand Interaction-Based Virtual Screening for Novel Eg5/Kinesin Spindle Protein Inhibitors ⬇️

Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor.

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

STLC-resistant cell lines as tools to classify chemically divergent Eg5 targeting agents according to their mode of action and target specificity.

Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol

Structural insights into a unique inhibitor binding pocket in kinesin spindle protein

Structural insights into human Kif7, a kinesin involved in Hedgehog signalling

Structural variations in protein superfamilies: actin and tubulin

Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5

Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

Structure-activity relationships and molecular docking of novel dihydropyrimidine-based mitotic Eg5 inhibitors.

Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives.

The Crystal Structure of Dimeric Kinesin and Implications for Microtubule-Dependent Motility ⬇️

The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition

The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal development

The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations

The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins.

The structure of human neuronal Rab6B in the active and inactive form.

The structure of the ternary Eg5–ADP–ispinesib complex

Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity

Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5