List of works - Stefan F Lichtenthaler

A novel substrate for analyzing Alzheimer's disease gamma-secretase

scientific article published on 01 June 1999

Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking ⬇️

scientific article published on February 1, 2012

Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.

scientific article published on July 1999

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

scientific article published on 30 August 2017

An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome.

scientific article published on 19 December 2016

An optimized quantitative proteomics method establishes the cell type-resolved mouse brain secretome

scientific article published on 21 September 2020

BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines

scientific article published on 26 July 2018

BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains

scientific article published on 06 July 2018

BACE2 distribution in major brain cell types and identification of novel substrates

scientific article published on 01 January 2018

Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

scientific article published on June 2010

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.

scientific article published on 26 December 2016

CADASIL brain vessels show a HTRA1 loss-of-function profile

scientific article published on 03 May 2018

Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer's Disease

scientific article published on 22 February 2019

Cell biology. Sheddase gets guidance

scientific article published on 01 January 2012

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

scientific article published on 09 September 2019

Chlamydia-induced curvature of the host-cell plasma membrane is required for infection

scientific article published on 21 January 2020

Cleavage efficiency of the intramembrane protease γ‐secretase is reduced by the palmitoylation of a substrate's transmembrane domain

scientific article published in 2024

Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10.

scientific article

Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain

scientific article published on 28 November 2018

Degradome of soluble ADAM10 and ADAM17 metalloproteases

scientific article published on 17 June 2019

Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.

scientific article

Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies

scientific article published on 29 July 2016

Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR

scientific article published on 13 September 2019

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.

scientific article published on 29 July 2016

Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.

scientific article published in May 2013

F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion.

scientific article published on 9 December 2010

Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells

scientific article published on 02 July 2019

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

scientific article published on 08 June 2020

Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system

scientific article published on 24 June 2019

Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System.

scientific article published on 25 July 2016

GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.

scientific article published on September 2006

Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation.

scientific article published on 17 April 2018

In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria

scientific article published on 22 January 2019

Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor

scientific article published in Scientific Reports

Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression

scientific article published on 24 June 2019

Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties

scientific article published on 11 November 2019

Large-scale screens for cDNAs with in vivo activity

scientific article published on 01 January 2005

Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments

scientific article published in December 2012

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

scientific article published on 07 January 2019

MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro

scientific article published on January 2016

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.

scientific article

Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1

scientific article published on 27 December 2019

Mutations in the transmembrane domain of APP altering gamma-secretase specificity

scientific article published on 01 December 1997

Non-cell-autonomous function of DR6 in Schwann cell proliferation.

scientific article published on 19 February 2018

Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein.

scientific article

NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease

scientific article published on 01 April 2019

Pathology-linked protease caught in action

scientific article published on 01 February 2019

Prion replication in the mammalian cytosol: Functional regions within a prion domain driving induction, propagation and inheritance.

scientific article

Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments

scientific article published on 05 July 2018

Proteomic Substrate Identification for Membrane Proteases in the Brain

scientific article

QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain

scientific article published on 03 December 2019

Rational correction of pathogenic conformational defects in HTRA1

scientific article published in 2024

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

scientific article

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.

scientific article published on 05 October 2016

Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3

scientific article published on 22 June 2020

Shedding of BAFF/APRIL Receptors Controls B Cells

scientific article published on 30 July 2018

Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins

scientific article published on 7 February 2019

Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins

scientific article published on 01 May 2019

Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins

scientific article published on 07 February 2019

Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer's Disease Mouse Models

scientific article published on 30 June 2016

Tau deletion reduces plaque-associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease

scientific article published on 07 November 2019

The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban

scientific article published on 07 February 2019

The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation.

scientific article published on 7 February 2018

gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.

scientific article published on 29 January 2003

iRHOM2 takes control of rheumatoid arthritis ⬇️

scientific article published on January 25, 2013

α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential ⬇️

scientific article published on 02 December 2010

List of works by Stefan F Lichtenthaler

A novel substrate for analyzing Alzheimer's disease gamma-secretase

Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking ⬇️

Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome.

An optimized quantitative proteomics method establishes the cell type-resolved mouse brain secretome

BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines

BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains

BACE2 distribution in major brain cell types and identification of novel substrates

Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.

CADASIL brain vessels show a HTRA1 loss-of-function profile

Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer's Disease

Cell biology. Sheddase gets guidance

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Chlamydia-induced curvature of the host-cell plasma membrane is required for infection

Cleavage efficiency of the intramembrane protease γ‐secretase is reduced by the palmitoylation of a substrate's transmembrane domain

Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10.

Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain

Degradome of soluble ADAM10 and ADAM17 metalloproteases

Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.

Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies

Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.

Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.

F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion.

Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system

Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System.

GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.

Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation.

In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria

Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor

Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression

Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties

Large-scale screens for cDNAs with in vivo activity

Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.

Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1

Mutations in the transmembrane domain of APP altering gamma-secretase specificity

Non-cell-autonomous function of DR6 in Schwann cell proliferation.

Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein.

NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease

Pathology-linked protease caught in action

Prion replication in the mammalian cytosol: Functional regions within a prion domain driving induction, propagation and inheritance.

Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments

Proteomic Substrate Identification for Membrane Proteases in the Brain

QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain

Rational correction of pathogenic conformational defects in HTRA1

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.

Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3

Shedding of BAFF/APRIL Receptors Controls B Cells

Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins

Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins

Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins

Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer's Disease Mouse Models

Tau deletion reduces plaque-associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease

The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban

The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation.

gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.

iRHOM2 takes control of rheumatoid arthritis ⬇️

α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential ⬇️