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List of works by Richard Paules

A characterization of cytostatic factor activity from Xenopus eggs and c-mos-transformed cells ⬇️

scientific article published on July 1, 1991

A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics.

scientific article published on 20 February 2018

A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

scientific article

ATM requirement in gene expression responses to ionizing radiation in human lymphoblasts and fibroblasts.

scientific article

ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation.

scientific article

Ability of the c- mos Product to Associate with and Phosphorylate Tubulin ⬇️

scientific article published on February 8, 1991

An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage

scientific article

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

scientific article (publication date: March 2003)

Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance.

scientific article

Arsenite malignantly transforms human prostate epithelial cells in vitro by gene amplification of mutated KRAS

article

Assessing gene significance from cDNA microarray expression data via mixed models

scientific article (publication date: 2001)

Ataxia telangiectasia-mutated dependent DNA damage checkpoint functions regulate gene expression in human fibroblasts.

scientific article published on August 2007

BMDExpress 2: Enhanced transcriptomic dose-response analysis workflow

scientific article published on 01 May 2019

Blood gene expression profiling of an early acetaminophen response.

scientific article published in March 2016

Blood gene expression signatures predict exposure levels.

scholarly article

Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen

scientific article published on 21 December 2015

CEBS--Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data.

scientific article

Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.

scientific article

Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies

scientific article published on 26 July 2018

Computational selection of distinct class- and subclass-specific gene expression signatures.

scientific article published in June 2002

Consistency of predictive signature genes and classifiers generated using different microarray platforms.

scientific article

Correction: Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage.

scientific article published on 7 July 2017

DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs.

scientific article

DNA damage responses in murine Pre-B cells with genetic deficiencies in damage response genes

scientific article published on 22 November 2019

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

scientific article

DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells

scientific article published on January 2008

Deregulation of specific E2F complexes by the v-mos oncogene ⬇️

scientific article published on June 26, 1997

Detection and Prioritization of Developmentally Neurotoxic and/or Neurotoxic Compounds Using Zebrafish

scientific article published on 01 March 2019

Development of a Zebrafish S1500+ Sentinel Gene Set for High-Throughput Transcriptomics

scientific article published on 12 June 2019

Differential gene expression profiling in whole blood during acute systemic inflammation in lipopolysaccharide-treated rats.

scientific article published in March 2005

Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats.

scientific article published on 29 March 2005

Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes.

scientific article

Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix.

scientific article published on 22 February 2007

From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.

scientific article

Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluations

scientific article published on 01 February 2007

Gene expression analysis reveals chemical-specific profiles

scientific article published on 01 June 2002

Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases

scientific article

Gene expression profiling of rat livers reveals indicators of potential adverse effects.

scientific article published on 14 April 2004

Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals

scientific article published on 13 August 2013

Genome-wide small RNA sequencing and gene expression analysis reveals a microRNA profile of cancer susceptibility in ATM-deficient human mammary epithelial cells.

scientific article

Genomic indicators in the blood predict drug-induced liver injury.

scientific article

Genomic-derived markers for early detection of calcineurin inhibitor immunosuppressant-mediated nephrotoxicity ⬇️

scientific article published on August 24, 2011

Identification of distinct and common gene expression changes after oxidative stress and gamma and ultraviolet radiation.

scientific article published in June 2003

Intersection of toxicogenomics and high throughput screening in the Tox21 program: an NIEHS perspective

scientific article (publication date: 2015)

Major carcinogenic pathways identified by gene expression analysis of peritoneal mesotheliomas following chemical treatment in F344 rats.

scientific article published on 07 February 2006

Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations.

scientific article published in July 2002

Microarray data analysis of mouse neoplasia.

scientific article

Molecular effects of 1-naphthyl-methylcarbamate and solar radiation exposures on human melanocytes

scientific article published on 6 November 2016

Molecular mechanisms of environmental carcinogenesis ⬇️

scientific article published on May 1, 1995

Moving Forward in Human Cancer Risk Assessment ⬇️

scientific article published on December 13, 2010

Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses

scientific article published on 11 June 2007

Oxidative stress and cell cycle checkpoint function.

scientific article

Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.

scientific article

Perturbation of microRNAs in Rat Heart during Chronic Doxorubicin Treatment ⬇️

scientific article published on July 31, 2012

Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage

scientific article

Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM.

scientific article

Screening for Developmental Neurotoxicity at the National Toxicology Program: The Future Is Here

scientific article published on 01 January 2019

Serum starved v-mos-transformed cells are unable to appropriately downregulate cyclins and CDKs ⬇️

scientific article published on June 26, 1997

Standardizing global gene expression analysis between laboratories and across platforms.

scientific article

Systematic variation normalization in microarray data to get gene expression comparison unbiased.

scientific article

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

scientific article

The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals Using High-throughput Transcriptomics and Benchmark Concentration Modeling

scientific article published on 01 June 2019

The US Federal Tox21 Program: A strategic and operational plan for continued leadership.

scientific article published on 8 March 2018

The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance

scientific article

The human decatenation checkpoint.

scientific article

Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.

scientific article published in November 2017

Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward human relevance

article

Use of transcriptomics in understanding mechanisms of drug-induced toxicity

scientific article

pp39mos is associated with p34cdc2 kinase in c-mosxe-transformed NIH 3T3 cells ⬇️

scientific article published on August 1, 1992

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