List of works - Hideki Nishitoh

A mouse model reveals that Mfsd2a is critical for unfolded protein response upon exposure to tunicamycin

scientific article published on 24 November 2016

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants

scientific article published on 01 November 2012

A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.

scientific article published on 18 August 2015

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

scientific article published on June 2008

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.

scientific article published on 12 February 2009

ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction

scientific article (publication date: 20 October 2000)

ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney

scientific article published in Nature Communications

Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin.

scientific article

Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells

scientific article (publication date: 31 March 2000)

CHOP is a multifunctional transcription factor in the ER stress response ⬇️

scientific article published on December 30, 2011

ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue

scientific article published on 06 February 2020

Endoplasmic reticulum quality control by garbage disposal

scientific article published on 30 June 2018

GCN5 is essential for IRF-4 gene expression followed by transcriptional activation of Blimp-1 in immature B cells

scientific article published on 26 September 2013

GCN5 is involved in regulation of immunoglobulin heavy chain gene expression in immature B cells.

scientific article published on 18 April 2014

GCN5 protects vertebrate cells against UV-irradiation via controlling gene expression of DNA polymerase η.

scientific article

Growth/Differentiation Factor-5 Induces Angiogenesisin Vivo

scientific article published on 01 August 1997

Histone acetyltransferase PCAF is involved in transactivation of Bcl-6 and Pax5 genes in immature B cells.

scientific article published on 8 October 2015

Histone acetyltransferase p300/CBP-associated factor is an effective suppressor of secretory immunoglobulin synthesis in immature B cells.

scientific article

Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA.

scientific article

Lack of GCN5 remarkably enhances the resistance against prolonged endoplasmic reticulum stress-induced apoptosis through up-regulation of Bcl-2 gene expression

scientific article

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

scientific article

Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1.

scientific article

Monitoring Lipid Droplet Dynamics in Living Cells by Using Fluorescent Probes

scientific article published on 11 January 2019

Paired box gene 5 isoforms A and B have different functions in transcriptional regulation of B cell development-related genes in immature B cells.

scientific article

Paradigm shift from 'Compartment' to 'Zone' in the understanding of organelles

scientific article published on 01 February 2019

Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.

scientific article

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP

scientific journal article

Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells

scientific article published on 19 March 2014

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

scientific article

RbAp48 is essential for viability of vertebrate cells and plays a role in chromosome stability.

scientific article published on 15 December 2015

Role of the unfolded protein response in the development of central nervous system.

scientific article published in September 2017

Roles of MAPKKK ASK1 in stress-induced cell death.

scientific article

SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency

scientific article published on 26 September 2013

STT3B-Dependent Posttranslational N-Glycosylation as a Surveillance System for Secretory Protein ⬇️

scientific article published on May 17, 2012

Signaling pathways from the endoplasmic reticulum and their roles in disease

scientific article published on July 2013

Stress responses from the endoplasmic reticulum in cancer

scientific article

Survival and apoptosis signals in ER stress: the role of protein kinases.

scientific article published in September 2004

Targeting ASK1 in ER stress-related neurodegenerative diseases.

scientific article published on June 2009

The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.

scientific article published on 24 November 2015

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.

scientific article

The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

scientific article

The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts.

scientific article published on 20 January 2014

Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.

scientific article published in July 2001

USP14 inhibits ER-associated degradation via interaction with IRE1alpha

scientific article

[Identification of receptors for bone morphogenetic proteins]

scientific article published on 01 March 1997

[Molecular mechanisms of ALS-linked mutant SOD1-induced motor neuron death].

scientific article

List of works by Hideki Nishitoh

A mouse model reveals that Mfsd2a is critical for unfolded protein response upon exposure to tunicamycin

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants

A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.

ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction

ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney

Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin.

Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells

CHOP is a multifunctional transcription factor in the ER stress response ⬇️

ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue

Endoplasmic reticulum quality control by garbage disposal

GCN5 is essential for IRF-4 gene expression followed by transcriptional activation of Blimp-1 in immature B cells

GCN5 is involved in regulation of immunoglobulin heavy chain gene expression in immature B cells.

GCN5 protects vertebrate cells against UV-irradiation via controlling gene expression of DNA polymerase η.

Growth/Differentiation Factor-5 Induces Angiogenesisin Vivo

Histone acetyltransferase PCAF is involved in transactivation of Bcl-6 and Pax5 genes in immature B cells.

Histone acetyltransferase p300/CBP-associated factor is an effective suppressor of secretory immunoglobulin synthesis in immature B cells.

Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA.

Lack of GCN5 remarkably enhances the resistance against prolonged endoplasmic reticulum stress-induced apoptosis through up-regulation of Bcl-2 gene expression

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1.

Monitoring Lipid Droplet Dynamics in Living Cells by Using Fluorescent Probes

Paired box gene 5 isoforms A and B have different functions in transcriptional regulation of B cell development-related genes in immature B cells.

Paradigm shift from 'Compartment' to 'Zone' in the understanding of organelles

Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP

Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

RbAp48 is essential for viability of vertebrate cells and plays a role in chromosome stability.

Role of the unfolded protein response in the development of central nervous system.

Roles of MAPKKK ASK1 in stress-induced cell death.

SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency

STT3B-Dependent Posttranslational N-Glycosylation as a Surveillance System for Secretory Protein ⬇️

Signaling pathways from the endoplasmic reticulum and their roles in disease

Stress responses from the endoplasmic reticulum in cancer

Survival and apoptosis signals in ER stress: the role of protein kinases.

Targeting ASK1 in ER stress-related neurodegenerative diseases.

The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.

The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts.

Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.

USP14 inhibits ER-associated degradation via interaction with IRE1alpha

[Identification of receptors for bone morphogenetic proteins]

[Molecular mechanisms of ALS-linked mutant SOD1-induced motor neuron death].