List of works - Nick J. Spencer

5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT.

scientific article published on 05 August 2013

A composite fibre optic catheter for monitoring peristaltic transit of an intra-luminal bead

scientific article published on 30 November 2015

A fibre optic catheter for simultaneous measurement of longitudinal and circumferential muscular activity in the gastrointestinal tract

scientific article published on 01 April 2011

A novel anterograde neuronal tracing technique to selectively label spinal afferent nerve endings that encode noxious and innocuous stimuli in visceral organs.

scientific article published on 3 December 2013

A novel method for quantifying periodicity and time delay in dynamic neural networks using unstable subaction potential threshold depolarizations

scientific article published on 29 January 2020

A novel mode of sympathetic reflex activation mediated by the enteric nervous system

scientific article published on 16 July 2020

A population of nonneuronal GFRα3-expressing cells in the bone marrow resembles nonmyelinating Schwann cells

scientific article published on 14 July 2019

Activation of intestinal spinal afferent endings by changes in intra-mesenteric arterial pressure.

scientific article

Activation of neural circuitry and Ca2+ waves in longitudinal and circular muscle during CMMCs and the consequences of rectal aganglionosis in mice.

scientific article published on 5 October 2006

Alteration in propagating colonic contractions by dairy proteins in isolated rat large intestine

scientific article published on 11 September 2019

An Enteric Occult Reflex Underlies Accommodation and Slow Transit in the Distal Large Bowel

scientific article published on 23 February 2007

An experimental method to identify neurogenic and myogenic active mechanical states of intestinal motility

scientific article published on 11 April 2013

An in vitro rat model of colonic motility to determine the effect of β-casomorphin-5 on propagating contractions.

scientific article published in November 2014

Anatomic modifications in the enteric nervous system of piebald mice and physiological consequences to colonic motor activity

scientific article published on 08 December 2005

Ascending excitatory neural pathways modulate slow phasic myogenic contractions in the isolated human colon

scientific article published on 01 May 2013

By what mechanism does ondansetron inhibit colonic migrating motor complexes: does it require endogenous serotonin in the gut wall?

scientific article published on 17 April 2013

CGRPα within the Trpv1-Cre population contributes to visceral nociception

scientific article

Can colonic migrating motor complexes occur in mice lacking the endothelin-3 gene?

scientific article published on 01 May 2015

Characteristics of colonic migrating motor complexes in neuronal NOS (nNOS) knockout mice

scientific article published on 14 October 2013

Characterization of alternating neurogenic motor patterns in mouse colon

scientific article published on 30 November 2020

Characterization of motor patterns in isolated human colon: are there differences in patients with slow-transit constipation?

scientific article published on 29 September 2011

Characterization of primary afferent spinal innervation of mouse uterus.

scientific article

Characterization of projections of longitudinal muscle motor neurons in human colon

scientific article published on 29 July 2019

Characterization of properties underlying rhythmicity in mouse portal vein.

scientific article published in March 2003

Characterization of putative interneurons in the myenteric plexus of human colon

scientific article published on 24 August 2020

Chronic constipation: lessons from animal studies.

scientific article published on February 2011

Clinic booklets: help or hindrance in patient education?

scientific article published on 01 April 1981

Constitutively Active 5-HT Receptors: An Explanation of How 5-HT Antagonists Inhibit Gut Motility in Species Where 5-HT is Not an Enteric Neurotransmitter?

scientific article

Control of intrinsic pacemaker frequency and velocity of colonic migrating motor complexes in mouse

scientific article published on 8 May 2014

CrossTalk opposing view: 5-HT is not necessary for peristalsis

scientific article published on 01 August 2015

Damage from dissection is associated with reduced neuro-musclar transmission and gap junction coupling between circular muscle cells of guinea pig ileum, in vitro.

scientific article published on 22 August 2014

Different types of spinal afferent nerve endings in stomach and esophagus identified by anterograde tracing from dorsal root ganglia.

scientific article published on 14 April 2016

Disinhibition during myoelectric complexes in the mouse colon ⬇️

scientific article published on June 30, 1998

Distinct patterns of myogenic motor activity identified in isolated human distal colon with high-resolution manometry

scientific article published on 06 May 2020

Distribution, projections, and association with calbindin baskets of motor neurons, interneurons, and sensory neurons in guinea-pig distal colon

scientific article published on 04 January 2019

Diversity of neurogenic smooth muscle electrical rhythmicity in mouse proximal colon

scientific article published on 02 December 2019

Effects of optogenetic activation of the enteric nervous system on gastrointestinal motility in mouse small intestine

scientific article published on 19 September 2020

Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility

scientific article published on 09 March 2020

Evidence that myoelectric complexes in the isolated mouse colon may not be of myogenic origin ⬇️

scientific article published on July 10, 1998

Extrinsic Sensory Innervation of the Gut: Structure and Function.

scientific article

Extrinsic primary afferent signalling in the gut.

scientific article published on 26 February 2013

Family and carer smoking control programmes for reducing children's exposure to environmental tobacco smoke

scientific article (published 2008-10-07)

Firing patterns and functional roles of different classes of spinal afferents in rectal nerves during colonic migrating motor complexes in mouse colon

scientific article published on 24 May 2012

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques

scientific article published on 11 July 2019

Functional changes in low- and high-threshold afferents in obstruction-induced bladder overactivity

scientific article published on 25 March 2019

High-resolution colonic motility recordings in vivo compared with ex vivo recordings after colectomy, in patients with slow transit constipation.

scientific article published on 9 June 2016

Hydrogen peroxide preferentially activates capsaicin-sensitive high threshold afferents via TRPA1 channels in the guinea pig bladder.

scientific article published on 28 October 2016

ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine

scientific article

Identification and mechanosensitivity of viscerofugal neurons ⬇️

scientific article published on August 27, 2012

Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle

scientific article published on 28 May 2018

Identification of different functional types of spinal afferent neurons innervating the mouse large intestine using a novel CGRPα transgenic reporter mouse

scientific article published on 28 January 2016

Identification of different types of spinal afferent nerve endings that encode noxious and innocuous stimuli in the large intestine using a novel anterograde tracing technique

scientific article (publication date: 2014)

Identification of functional intramuscular rectal mechanoreceptors in aganglionic rectal smooth muscle from piebald lethal mice

scientific article published on 24 January 2008

Identification of multiple distinct neurogenic motor patterns that can occur simultaneously in the guinea-pig distal colon

scientific article published on 18 October 2018

Identification of neurogenic intestinal motility patterns in silver perch (Bidyanus bidyanus) that persist over wide temperature ranges

scientific article published on 19 December 2020

Identification of spinal afferent nerve endings in the colonic mucosa and submucosa that communicate directly with the spinal cord: The gut-brain axis

scientific article published on 07 January 2020

Identification of the visceral pain pathway activated by noxious colorectal distension in mice.

scientific article

Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells

scientific article

Identifying spinal afferent (sensory) nerve endings that innervate the marrow cavity and periosteum using anterograde tracing

scientific article published on 23 January 2020

Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice

scientific article

Imaging activation of peptidergic spinal afferent varicosities within visceral organs using novel CGRPα-mCherry reporter mice.

scientific article published on 22 September 2016

Imaging stretch-activated firing of spinal afferent nerve endings in mouse colon

scientific article

Inhibitory neurotransmission in the circular muscle layer of mouse colon ⬇️

scientific article published on May 28, 1998

Innervation Changes Induced by Inflammation in the Murine Vagina

scientific article published on 30 December 2017

Insights into the mechanisms underlying colonic motor patterns

scientific article published on 15 March 2016

Intrinsic sensory neurons provide direct input to motor neurons and interneurons in mouse distal colon via varicose baskets

scientific article published on 31 January 2020

Is There a Role for Endogenous 5-HT in Gastrointestinal Motility? How Recent Studies Have Changed Our Understanding.

scientific article

Is serotonin in enteric nerves required for distension-evoked peristalsis and propulsion of content in guinea-pig distal colon?

scientific article

Localization of the Sensory Neurons and Mechanoreceptors Required for Stretch-Evoked Colonic Migrating Motor Complexes in Mouse Colon ⬇️

scientific article published on December 21, 2011

Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice

scientific article published on 10 August 2021

Loss of responsiveness of circular smooth muscle cells from the guinea pig ileum is associated with changes in gap junction coupling.

scientific article published on 29 March 2012

Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung's disease.

scientific article published on 14 February 2011

Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?

scientific article

Mechanosensory S-neurons rather than AH-neurons appear to generate a rhythmic motor pattern in guinea-pig distal colon.

scientific article

Morphological Identification Of Thoracolumbar Spinal Afferent Nerve Endings In Mouse Uterus

scientific article published on 15 November 2020

Morphological evidence for novel enteric neuronal circuitry in guinea pig distal colon

article

Motility patterns in mouse colon: gastrointestinal dysfunction induced by anticancer chemotherapy

scientific article published on December 2016

Neural mechanisms of peristalsis in the isolated rabbit distal colon: a neuromechanical loop hypothesis.

scientific article published on 16 April 2014

Neural motor complexes propagate continuously along the full length of mouse small intestine and colon

scientific article published on 11 November 2019

Neurally mediated propagating discrete clustered contractions superimposed on myogenic ripples in ex vivo segments of human ileum

scientific article published on 13 November 2014

Neurogenic and myogenic motor activity in the colon of the guinea pig, mouse, rabbit, and rat.

scientific article published on 19 September 2013

Neurogenic and myogenic motor patterns of rabbit proximal, mid, and distal colon

scientific article published on May 3, 2012

Neurogenic and myogenic patterns of electrical activity in isolated intact mouse colon.

scientific article published on 18 April 2017

Neuromechanical factors involved in the formation and propulsion of fecal pellets in the guinea-pig colon.

scientific article published on 6 August 2015

New insights into neurogenic cyclic motor activity in the isolated guinea-pig colon.

scientific article published on 26 April 2017

Optogenetic Induction of Colonic Motility in Mice

scientific article published on 18 May 2018

Optogenetic control of the enteric nervous system and gastrointestinal transit

scientific article published on 18 February 2019

Peptidergic nerve fibers in the urethra: Morphological and neurochemical characteristics in female mice of reproductive age.

scientific article

Peristalsis and fecal pellet propulsion do not require nicotinic, purinergic, 5-HT3, or NK3 receptors in isolated guinea pig distal colon

scientific article published in April 2010

Peristalsis and propulsion of colonic content can occur after blockade of major neuroneuronal and neuromuscular transmitters in isolated guinea pig colon.

scientific article published on 10 October 2013

Postoperative ileus-An ongoing conundrum

scientific article published on 30 November 2020

Potentiation of a functional autoantibody in narcolepsy by a cholinesterase inhibitor.

scientific article published on 5 October 2009

Promotility Action of the Probiotic Bifidobacterium lactis HN019 Extract Compared with Prucalopride in Isolated Rat Large Intestine.

scientific article published on 26 January 2017

Quantitative immunohistochemical co-localization of TRPV1 and CGRP in varicose axons of the murine oesophagus, stomach and colorectum

scientific article published on 14 May 2015

Rebuttal from Nick J. Spencer, Tiong Cheng Sia, Simon J Brookes, Marcello Costa and Damien J. Keating

scientific article published on 01 August 2015

Recent advances in enteric neurobiology: mechanosensitive interneurons.

scientific article published on November 2007

Regional differences in nutrient-induced secretion of gut serotonin.

scientific article

Release of 5-hydroxytryptamine from the mucosa is not required for the generation or propagation of colonic migrating motor complexes.

scientific article published on 24 September 2009

Roles of three distinct neurogenic motor patterns during pellet propulsion in guinea-pig distal colon

scientific article published on 01 October 2019

Sensory nerve endings arising from single spinal afferent neurons that innervate both circular muscle and myenteric ganglia in mouse colon: colon-brain axis

scientific article published on 25 March 2020

Septal interstitial cells of Cajal conduct pacemaker activity to excite muscle bundles in human jejunum

scientific article

Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability

scientific article published on 15 December 2015

Spatial and temporal mapping of pacemaker activity in interstitial cells of Cajal in mouse ileum in situ

scientific article published on 28 December 2005

Spinal Afferent Innervation of the Colon and Rectum

scientific article published on 04 December 2018

Spinal afferent nerve endings in visceral organs: recent advances

scientific article published on 17 November 2016

Spontaneous and evoked inhibitory junction potentials in the circular muscle layer of mouse colon ⬇️

scientific article published on April 30, 1998

Structure-function relationship of sensory endings in the gut and bladder.

scientific article published on 14 August 2009

Switching off pain at the source: is this the end for opioid pain relief?

scientific article published on 17 December 2015

Synaptic activation of putative sensory neurons by hexamethonium-sensitive nerve pathways in mouse colon

scientific article published on 21 September 2017

Targeted electrophysiological analysis of viscerofugal neurons in the myenteric plexus of guinea-pig colon

article

Techniques to identify and temporally correlate calcium transients between multiple regions of interest in vertebrate neural circuits.

scientific article

Temporal relationships between wall motion, intraluminal pressure, and flow in the isolated rabbit small intestine

scientific article published on 30 December 2010

The Diverse Metabolic Roles of Peripheral Serotonin.

scientific article published on March 2017

The Mechanism and Spread of Pacemaker Activity Through Myenteric Interstitial Cells of Cajal in Human Small Intestine

article by Hyun–Tai Lee et al published May 2007 in Gastroenterology

The effect of luminal content and rate of occlusion on the interpretation of colonic manometry

scientific article published on 10 December 2012

The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon.

scientific article

The presence of 5-HT in myenteric varicosities is not due to uptake of 5-HT released from the mucosa during dissection: use of a novel method for quantifying 5-HT immunoreactivity in myenteric ganglia

article

Tracking gastrointestinal transit of solids in aged rats as pharmacological models of chronic dysmotility.

scientific article published on 29 March 2016

Translating peripheral bladder afferent mechanosensitivity to neuronal activation within the lumbosacral spinal cord of mice

scientific article published on 01 April 2019

Visceral pain - Novel approaches for optogenetic control of spinal afferents.

scientific article published on 6 February 2018

Viscerofugal neurons recorded from guinea‐pig colonic nerves after organ culture ⬇️

scientific article published on July 19, 2012

What is the role of endogenous gut serotonin in the control of gastrointestinal motility?

scientific article published on 21 June 2018

List of works by Nick J. Spencer

5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT.

A composite fibre optic catheter for monitoring peristaltic transit of an intra-luminal bead

A fibre optic catheter for simultaneous measurement of longitudinal and circumferential muscular activity in the gastrointestinal tract

A novel anterograde neuronal tracing technique to selectively label spinal afferent nerve endings that encode noxious and innocuous stimuli in visceral organs.

A novel method for quantifying periodicity and time delay in dynamic neural networks using unstable subaction potential threshold depolarizations

A novel mode of sympathetic reflex activation mediated by the enteric nervous system

A population of nonneuronal GFRα3-expressing cells in the bone marrow resembles nonmyelinating Schwann cells

Activation of intestinal spinal afferent endings by changes in intra-mesenteric arterial pressure.

Activation of neural circuitry and Ca2+ waves in longitudinal and circular muscle during CMMCs and the consequences of rectal aganglionosis in mice.

Alteration in propagating colonic contractions by dairy proteins in isolated rat large intestine

An Enteric Occult Reflex Underlies Accommodation and Slow Transit in the Distal Large Bowel

An experimental method to identify neurogenic and myogenic active mechanical states of intestinal motility

An in vitro rat model of colonic motility to determine the effect of β-casomorphin-5 on propagating contractions.

Anatomic modifications in the enteric nervous system of piebald mice and physiological consequences to colonic motor activity

Ascending excitatory neural pathways modulate slow phasic myogenic contractions in the isolated human colon

By what mechanism does ondansetron inhibit colonic migrating motor complexes: does it require endogenous serotonin in the gut wall?

CGRPα within the Trpv1-Cre population contributes to visceral nociception

Can colonic migrating motor complexes occur in mice lacking the endothelin-3 gene?

Characteristics of colonic migrating motor complexes in neuronal NOS (nNOS) knockout mice

Characterization of alternating neurogenic motor patterns in mouse colon

Characterization of motor patterns in isolated human colon: are there differences in patients with slow-transit constipation?

Characterization of primary afferent spinal innervation of mouse uterus.

Characterization of projections of longitudinal muscle motor neurons in human colon

Characterization of properties underlying rhythmicity in mouse portal vein.

Characterization of putative interneurons in the myenteric plexus of human colon

Chronic constipation: lessons from animal studies.

Clinic booklets: help or hindrance in patient education?

Constitutively Active 5-HT Receptors: An Explanation of How 5-HT Antagonists Inhibit Gut Motility in Species Where 5-HT is Not an Enteric Neurotransmitter?

Control of intrinsic pacemaker frequency and velocity of colonic migrating motor complexes in mouse

CrossTalk opposing view: 5-HT is not necessary for peristalsis

Damage from dissection is associated with reduced neuro-musclar transmission and gap junction coupling between circular muscle cells of guinea pig ileum, in vitro.

Different types of spinal afferent nerve endings in stomach and esophagus identified by anterograde tracing from dorsal root ganglia.

Disinhibition during myoelectric complexes in the mouse colon ⬇️

Distinct patterns of myogenic motor activity identified in isolated human distal colon with high-resolution manometry

Distribution, projections, and association with calbindin baskets of motor neurons, interneurons, and sensory neurons in guinea-pig distal colon

Diversity of neurogenic smooth muscle electrical rhythmicity in mouse proximal colon

Effects of optogenetic activation of the enteric nervous system on gastrointestinal motility in mouse small intestine

Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility

Evidence that myoelectric complexes in the isolated mouse colon may not be of myogenic origin ⬇️

Extrinsic Sensory Innervation of the Gut: Structure and Function.

Extrinsic primary afferent signalling in the gut.

Family and carer smoking control programmes for reducing children's exposure to environmental tobacco smoke

Firing patterns and functional roles of different classes of spinal afferents in rectal nerves during colonic migrating motor complexes in mouse colon

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques

Functional changes in low- and high-threshold afferents in obstruction-induced bladder overactivity

High-resolution colonic motility recordings in vivo compared with ex vivo recordings after colectomy, in patients with slow transit constipation.

Hydrogen peroxide preferentially activates capsaicin-sensitive high threshold afferents via TRPA1 channels in the guinea pig bladder.

ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine

Identification and mechanosensitivity of viscerofugal neurons ⬇️

Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle

Identification of different functional types of spinal afferent neurons innervating the mouse large intestine using a novel CGRPα transgenic reporter mouse

Identification of different types of spinal afferent nerve endings that encode noxious and innocuous stimuli in the large intestine using a novel anterograde tracing technique

Identification of functional intramuscular rectal mechanoreceptors in aganglionic rectal smooth muscle from piebald lethal mice

Identification of multiple distinct neurogenic motor patterns that can occur simultaneously in the guinea-pig distal colon

Identification of neurogenic intestinal motility patterns in silver perch (Bidyanus bidyanus) that persist over wide temperature ranges

Identification of spinal afferent nerve endings in the colonic mucosa and submucosa that communicate directly with the spinal cord: The gut-brain axis

Identification of the visceral pain pathway activated by noxious colorectal distension in mice.

Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells

Identifying spinal afferent (sensory) nerve endings that innervate the marrow cavity and periosteum using anterograde tracing

Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice

Imaging activation of peptidergic spinal afferent varicosities within visceral organs using novel CGRPα-mCherry reporter mice.

Imaging stretch-activated firing of spinal afferent nerve endings in mouse colon

Inhibitory neurotransmission in the circular muscle layer of mouse colon ⬇️

Innervation Changes Induced by Inflammation in the Murine Vagina

Insights into the mechanisms underlying colonic motor patterns

Intrinsic sensory neurons provide direct input to motor neurons and interneurons in mouse distal colon via varicose baskets

Is There a Role for Endogenous 5-HT in Gastrointestinal Motility? How Recent Studies Have Changed Our Understanding.

Is serotonin in enteric nerves required for distension-evoked peristalsis and propulsion of content in guinea-pig distal colon?

Localization of the Sensory Neurons and Mechanoreceptors Required for Stretch-Evoked Colonic Migrating Motor Complexes in Mouse Colon ⬇️

Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice

Loss of responsiveness of circular smooth muscle cells from the guinea pig ileum is associated with changes in gap junction coupling.

Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung's disease.

Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?

Mechanosensory S-neurons rather than AH-neurons appear to generate a rhythmic motor pattern in guinea-pig distal colon.

Morphological Identification Of Thoracolumbar Spinal Afferent Nerve Endings In Mouse Uterus

Morphological evidence for novel enteric neuronal circuitry in guinea pig distal colon

Motility patterns in mouse colon: gastrointestinal dysfunction induced by anticancer chemotherapy

Neural mechanisms of peristalsis in the isolated rabbit distal colon: a neuromechanical loop hypothesis.

Neural motor complexes propagate continuously along the full length of mouse small intestine and colon