List of works - David B Lovejoy

2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.

scientific article

2-hydroxy-1-naphthaldehyde 2-methylthiosemicarbazone

scientific article published on 15 March 2000

ATP7A is a novel target of retinoic acid receptor beta2 in neuroblastoma cells.

scientific article published on January 2009

Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: A pilot study.

scientific article published on 22 May 2018

Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity.

scientific article published on 24 October 2015

Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents

scientific article published on October 2010

Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool

scientific article published on 26 August 2013

Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes.

scientific article published on 12 July 2011

Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents.

scientific article published on 27 April 2008

Characterisation of the kynurenine pathway in skin-derived fibroblasts and keratinocytes.

scientific article published on June 2015

Chelators at the cancer coalface: desferrioxamine to Triapine and beyond.

scientific article published on December 2006

Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-β and tau

scientific article published on 01 April 2019

DNA nanoclew templated spherical nucleic acids for siRNA delivery

scientific article published on 23 March 2018

Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo ⬇️

scientific article published on March 1, 2013

Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.

scientific article

Development of a Rapid Fluorescence-Based High-Throughput Screening Assay to Identify Novel Kynurenine 3-Monooxygenase Inhibitor Scaffolds

scientific article published on 8 February 2018

Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers ⬇️

scientific article published on August 15, 2012

Dipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity

scientific article published on 01 November 2006

Effect of iron chelators with potent anti-proliferative activity on the expression of molecules involved in cell cycle progression and growth

scientific article published on 01 January 1999

Four cytotoxic N4-substituted thiosemicarbazones derived from 2-hydroxynaphthalene-1-carboxaldehyde ⬇️

scientific article published on October 22, 2003

HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents

scientific article

Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity

scientific article

Inhibiting the kynurenine pathway in spinal cord injury: Multiple therapeutic potentials?

scientific article published on 01 December 2018

Involvement of quinolinic acid in the neuropathogenesis of amyotrophic lateral sclerosis.

scientific article published on 2 June 2016

Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9

scientific article

Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity.

scientific article

Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms

scientific article published on 21 January 2019

Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression

scientific article published on 03 February 2017

Label-Free Fluorescent Poly(amidoamine) Dendrimer for Traceable and Controlled Drug Delivery

scientific article published on 24 April 2019

Major developments in the design of inhibitors along the kynurenine pathway

scientific article published on 2 May 2017

Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer.

scientific article published on 6 July 2010

Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect

scientific article published on 16 April 2012

Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment.

scientific article published on 18 May 2004

Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.

scientific article

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer's disease

scientific article published on 10 October 2019

Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-β Load

scientific article published on 06 June 2020

The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action

scientific article

The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: an EPR study.

scientific article published on 23 July 2010

The medicinal chemistry of novel iron chelators for the treatment of cancer.

scientific article published on January 2011

The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosis

scientific article

Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.

scientific article published on September 2009

Understanding the role of the kynurenine pathway in human breast cancer immunobiology

scientific article

List of works by David B Lovejoy

2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.

2-hydroxy-1-naphthaldehyde 2-methylthiosemicarbazone

ATP7A is a novel target of retinoic acid receptor beta2 in neuroblastoma cells.

Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: A pilot study.

Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity.

Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents

Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool

Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes.

Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents.

Characterisation of the kynurenine pathway in skin-derived fibroblasts and keratinocytes.

Chelators at the cancer coalface: desferrioxamine to Triapine and beyond.

Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-β and tau

DNA nanoclew templated spherical nucleic acids for siRNA delivery

Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo ⬇️

Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.

Development of a Rapid Fluorescence-Based High-Throughput Screening Assay to Identify Novel Kynurenine 3-Monooxygenase Inhibitor Scaffolds

Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers ⬇️

Dipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity

Effect of iron chelators with potent anti-proliferative activity on the expression of molecules involved in cell cycle progression and growth

Four cytotoxic N4-substituted thiosemicarbazones derived from 2-hydroxynaphthalene-1-carboxaldehyde ⬇️

HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents

Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity

Inhibiting the kynurenine pathway in spinal cord injury: Multiple therapeutic potentials?

Involvement of quinolinic acid in the neuropathogenesis of amyotrophic lateral sclerosis.

Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9

Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity.

Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms

Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression

Label-Free Fluorescent Poly(amidoamine) Dendrimer for Traceable and Controlled Drug Delivery

Major developments in the design of inhibitors along the kynurenine pathway

Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer.

Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect

Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment.

Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer's disease

Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-β Load

The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action

The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: an EPR study.

The medicinal chemistry of novel iron chelators for the treatment of cancer.

The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosis

Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.

Understanding the role of the kynurenine pathway in human breast cancer immunobiology