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List of works by John R. Mackey

A Uridine Glucuronosyltransferase 2B7 Polymorphism Predicts Epirubicin Clearance and Outcomes in Early-Stage Breast Cancer.

scientific article published on 25 September 2015

A machine learned classifier that uses gene expression data to accurately predict estrogen receptor status

scientific article

A multicenter randomized trial of the effects of exercise dose and type on psychosocial distress in breast cancer patients undergoing chemotherapy.

scientific article published on 5 March 2014

A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors.

scientific article published on 13 March 2015

A phase II trial of triamcinolone hexacetanide for symptomatic recurrent malignant ascites

scientific article published on 01 March 2000

A two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility.

scientific article

Adjuvant docetaxel, doxorubicin, and cyclophosphamide in node-positive breast cancer: 10-year follow-up of the phase 3 randomised BCIRG 001 trial.

scientific article

Adjuvant targeted therapy in early breast cancer.

scientific article published on March 2009

Adjuvant trastuzumab in HER2-positive breast cancer

scientific article published on October 2011

Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling.

scientific article

An exploratory study of body composition as a determinant of epirubicin pharmacokinetics and toxicity.

scientific article published on 5 March 2010

Analysis of Fcγ receptor IIIa and IIa polymorphisms: lack of correlation with outcome in trastuzumab-treated breast cancer patients

scientific article published on 13 April 2012

Association of FABP5 expression with poor survival in triple-negative breast cancer: implication for retinoic acid therapy

scientific article

BCIRG 001 molecular analysis: prognostic factors in node-positive breast cancer patients receiving adjuvant chemotherapy.

scientific article published on 24 June 2010

Barriers to supervised exercise training in a randomized controlled trial of breast cancer patients receiving chemotherapy

scientific article published on 20 February 2008

Benefit from adjuvant taxanes and endocrine responsiveness in breast cancer.

scientific article published on 17 October 2007

Breast cancer prediction using genome wide single nucleotide polymorphism data.

scientific article

Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial.

scientific article published on 09 February 2009

CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid

scientific article published on 5 July 2015

Can Quantifying Hormone Receptor Levels Guide the Choice of Adjuvant Endocrine Therapy for Breast Cancer? ⬇️

scientific article published on March 21, 2011

Canadian initiatives for locally advanced breast cancer research and treatment: inaugural meeting of the Canadian Consortium for LABC

Cancer therapy-induced cardiac toxicity in early breast cancer: addressing the unresolved issues.

scientific article published on December 2012

Cardiac management during adjuvant trastuzumab therapy: recommendations of the Canadian Trastuzumab Working Group.

scientific article

Cardiopulmonary function and age-related decline across the breast cancer survivorship continuum

scientific article

Cardiovascular reserve and risk profile of postmenopausal women after chemoendocrine therapy for hormone receptor--positive operable breast cancer.

scientific article published in October 2007

Cardiovascular risk profile of patients with HER2/neu-positive breast cancer treated with anthracycline-taxane-containing adjuvant chemotherapy and/or trastuzumab.

scientific article

Characterization of a gemcitabine-resistant murine leukemic cell line: reversion of in vitro resistance by a mononucleotide prodrug.

scientific article published on August 2004

Class III -Tubulin Expression and Benefit from Adjuvant Cisplatin/Vinorelbine Chemotherapy in Operable Non-Small Cell Lung Cancer: Analysis of NCIC JBR.10

article

Class III beta-tubulin expression in tumor cells predicts response and outcome in patients with non-small cell lung cancer receiving paclitaxel

scientific article published on 01 December 2005

Class III beta-tubulin is a marker of paclitaxel resistance in carcinomas of unknown primary site

scientific article published on 22 September 2006

Concurrent weekly carboplatin and radiotherapy for nasopharyngeal carcinoma: report of a joint phase II study.

scientific article published in February 2001

DEAD box 1: a novel and independent prognostic marker for early recurrence in breast cancer

scientific article published on 25 May 2010

Darbepoetin alfa administered every 3 weeks alleviates anaemia in patients with solid tumours receiving chemotherapy; results of a double-blind, placebo-controlled, randomised study

scientific article published on 01 September 2003

Delayed resolution of jaundice in the arm of a patient with impaired lymphatic drainage: a case report

scientific article published on 01 December 2007

Deoxycytidine kinase and cN-II nucleotidase expression in blast cells predict survival in acute myeloid leukaemia patients treated with cytarabine.

scientific article

Development and evaluation of a theory-based physical activity guidebook for breast cancer survivors.

scientific article published on 21 July 2006

Does the theory of planned behavior mediate the effects of an oncologist's recommendation to exercise in newly diagnosed breast cancer survivors? Results from a randomized controlled trial.

scientific article published in March 2005

Early breast cancer therapy and cardiovascular injury.

scientific article published on 24 September 2007

Effect of acute exercise on upper-limb volume in breast cancer survivors: a pilot study.

scientific article

Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study.

scientific article published on 13 January 2015

Effect of capecitabine on mean corpuscular volume in patients with metastatic breast cancer.

scientific article

Effect of exercise training on C-reactive protein in postmenopausal breast cancer survivors: a randomized controlled trial.

scientific article

Effects of Aerobic Exercise Training in Anemic Cancer Patients Receiving Darbepoetin Alfa: A Randomized Controlled Trial

scientific article published on 08 September 2008

Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial.

scientific article published on 4 September 2007

Effects of aerobic exercise training on estrogen metabolism in premenopausal women: a randomized controlled trial

scientific article published on 01 April 2007

Effects of an oncologist's recommendation to exercise on self-reported exercise behavior in newly diagnosed breast cancer survivors: a single-blind, randomized controlled trial

scientific article published on 01 October 2004

Effects of exercise dose and type during breast cancer chemotherapy on longer-term patient-reported outcomes and health-related fitness: A randomized controlled trial

scientific article published on 27 June 2019

Effects of exercise dose and type during breast cancer chemotherapy: multicenter randomized trial.

scientific article published on 22 October 2013

Effects of exercise dose and type on sleep quality in breast cancer patients receiving chemotherapy: a multicenter randomized trial.

scientific article published on 20 February 2014

Effects of exercise during adjuvant chemotherapy on breast cancer outcomes.

scientific article

Effects of exercise training on antitumor efficacy of doxorubicin in MDA-MB-231 breast cancer xenografts.

scientific article published on September 2005

Effects of presurgical exercise training on cardiorespiratory fitness among patients undergoing thoracic surgery for malignant lung lesions

scientific article published on 01 August 2007

Estrogen receptor expression and docetaxel efficacy in patients with metastatic breast cancer: a pooled analysis of four randomized trials.

scientific article published on 26 April 2010

Estrogen receptor expression and efficacy of docetaxel-containing adjuvant chemotherapy in patients with node-positive breast cancer: results from a pooled analysis.

scientific article published in June 2008

Evaluation of tumor response, disease control, progression-free survival, and time to progression as potential surrogate end points in metastatic breast cancer.

scientific article published in April 2008

Evidence for copurification of micronuclei in sucrose density gradient-enriched plasma membranes from cell lines.

scientific article

Exercise beliefs of breast cancer survivors before and after participation in a randomized controlled trial.

scientific article published in January 2006

Exercise for breast cancer survivors: research evidence and clinical guidelines.

scientific article

Exercise intolerance in cancer and the role of exercise therapy to reverse dysfunction.

scientific article published on June 2009

Exploring the Feasibility of a Broad-Reach Physical Activity Behavior Change Intervention for Women Receiving Chemotherapy for Breast Cancer: A Randomized Trial.

scientific article published on 16 December 2015

Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine.

scientific article published on February 2002

Expression of nucleoside transporters and deoxycytidine kinase proteins in muscle invasive urothelial carcinoma of the bladder: correlation with pathological response to neoadjuvant platinum/gemcitabine combination chemotherapy.

scientific article published on 10 July 2013

Gefitinib or Placebo in Combination with Tamoxifen in Patients with Hormone Receptor–Positive Metastatic Breast Cancer: A Randomized Phase II Study ⬇️

scientific article published on January 10, 2011

Genotyping single nucleotide polymorphisms in human genomic DNA with an automated and self-contained PCR cassette.

scientific article published on 2 July 2014

Health-related quality of life with adjuvant docetaxel- and trastuzumab-based regimens in patients with node-positive and high-risk node-negative, HER2-positive early breast cancer: results from the BCIRG 006 Study

scientific article published on 28 June 2013

Hemoglobin and aerobic fitness changes with supervised exercise training in breast cancer patients receiving chemotherapy

scientific article published on 22 September 2010

High-dose mitoxantrone-vinblastine-cyclophosphamide and autologous stem cell transplantation for stage III breast cancer: final results of a prospective multicentre study.

scientific article published on 9 June 2005

Human Equilibrative Nucleoside Transporter 1 (hENT1) in Pancreatic Adenocarcinoma: Towards Individualized Treatment Decisions.

scientific article published on 02 December 2010

Human equilibrative nucleoside transporter 1 (hENT1) levels predict response to gemcitabine in patients with biliary tract cancer (BTC).

scientific article published on January 2011

Human equilibrative nucleoside transporter 1 (hENT1) protein is associated with short survival in resected ampullary cancer

scientific article

Human equilibrative nucleoside transporter 1 and carcinoma of the ampulla of Vater: expression differences in tumour histotypes.

scientific article

Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer.

scientific article

Human nucleoside transporters: biomarkers for response to nucleoside drugs.

scientific article published on May 2009

Imaging Radiation Doses and Associated Risks and Benefits in Subjects Participating in Breast Cancer Clinical Trials.

scientific article published on 29 May 2015

Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers.

scientific article published in January 2002

Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers.

scientific article published in August 2003

Immunohistochemistry for human concentrative nucleoside transporter 3 protein predicts fludarabine sensitivity in chronic lymphocytic leukemia.

scientific article published on 4 July 2008

Impact of clinical practice guidelines on the diagnostic strategy for carcinomas of unknown primary site: a controlled 'before-after' study

scientific article published on 21 July 2008

Impact of clinical practice guidelines on the management for carcinomas of unknown primary site: a controlled "before-after" study.

scientific article published on April 2009

Impact of providing audiotapes of primary adjuvant treatment consultations to women with breast cancer: a multisite, randomized, controlled trial.

scientific article published in November 2003

Impact of resistance and aerobic exercise on sarcopenia and dynapenia in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial

scientific article published on 9 July 2016

In the end what matters most? A review of clinical endpoints in advanced breast cancer.

scientific article published on 6 January 2011

Inherited polymorphisms in hyaluronan synthase 1 predict risk of systemic B-cell malignancies but not of breast cancer

scientific article

Intraoperative Saline and Gemcitabine Irrigation Improves Tumour Control in Human Squamous Cell Carcinoma-Contaminated Surgical Wounds

scientific article published on April 1, 2001

Large-volume air embolism as a complication of augmented computed tomography: case report

scientific article published on 01 October 2002

Learning to predict relapse in invasive ductal carcinomas based on the subcellular localization of junctional proteins.

scientific article

Letrozole in second-line therapy of advanced breast cancer: more questions than answers.

scientific article published in December 2001

Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma

scientific article published on 13 June 2012

Life-threatening complications from doxorubicin-docetaxel chemotherapy for breast cancer.

scientific article published in November 2005

Long-term outcomes after adjuvant treatment of sequential versus combination docetaxel with doxorubicin and cyclophosphamide in node-positive breast cancer: BCIRG-005 randomized trial.

scientific article published on 02 March 2016

Low serum albumin levels and liver metastasis are powerful prognostic markers for survival in patients with carcinomas of unknown primary site

scientific article published on 01 December 2006

Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines.

scientific article

Metabolic modulation of glioblastoma with dichloroacetate

scientific article

Moderators of the effects of exercise training in breast cancer patients receiving chemotherapy: a randomized controlled trial

scientific article published on 01 April 2008

Modulator of apoptosis 1 (MOAP-1) is a tumor suppressor protein linked to the RASSF1A protein.

scientific article

Motesanib, or open-label bevacizumab, in combination with paclitaxel, as first-line treatment for HER2-negative locally recurrent or metastatic breast cancer: a phase 2, randomised, double-blind, placebo-controlled study

scientific article

Motivation for Different Types and Doses of Exercise During Breast Cancer Chemotherapy: a Randomized Controlled Trial

scientific article published on 19 February 2016

Mouse mammary tumor virus in human breast cancer red herring or smoking gun?

scientific article

Multicenter phase III randomized trial comparing docetaxel and trastuzumab with docetaxel, carboplatin, and trastuzumab as first-line chemotherapy for patients with HER2-gene-amplified metastatic breast cancer (BCIRG 007 study): two highly active th

scientific article

N-myristoyltransferase proteins in breast cancer: prognostic relevance and validation as a new drug target

scientific article published on 04 January 2021

Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer.

scientific article published on 29 September 2015

Nucleoside analogues: mechanisms of drug resistance and reversal strategies.

scientific article

Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy ⬇️

scientific article published on October 20, 2003

Obesity and survival in operable breast cancer patients treated with adjuvant anthracyclines and taxanes according to pathological subtypes: a pooled analysis

scientific article

Oncologists’ opinions towards recommending exercise to patients with cancer: a Canadian national survey

article

Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance

scientific article published on 17 February 2016

PTEN Loss Is Associated with Worse Outcome in HER2-Amplified Breast Cancer Patients but Is Not Associated with Trastuzumab Resistance

scientific article published on 3 February 2015

Patterns and predictors of exercise behavior during 24 months of follow-up after a supervised exercise program during breast cancer chemotherapy

scientific article published on 14 February 2020

Phase III study of doxorubicin/cyclophosphamide with concomitant versus sequential docetaxel as adjuvant treatment in patients with human epidermal growth factor receptor 2-normal, node-positive breast cancer: BCIRG-005 trial

scientific article

Phase III trial comparing granulocyte colony-stimulating factor to leridistim in the prevention of neutropenic complications in breast cancer patients treated with docetaxel/doxorubicin/cyclophosphamide: results of the BCIRG 004 trial.

scientific article published in October 2002

Physical exercise and immune system function in cancer survivors: a comprehensive review and future directions.

scientific article

Plakoglobin interacts with and increases the protein levels of metastasis suppressor Nm23-H2 and regulates the expression of Nm23-H1.

scientific article

Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3σ ⬇️

scientific article published on May 17, 2013

Plasma and neutrophil fatty acid composition in advanced cancer patients and response to fish oil supplementation.

scientific article published on December 2002

Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility

scientific journal article

Predictive models for breast cancer susceptibility from multiple single nucleotide polymorphisms.

scientific article

Predictors of adherence to different types and doses of supervised exercise during breast cancer chemotherapy

scientific article

Predictors of follow-up exercise behavior 6 months after a randomized trial of exercise training during breast cancer chemotherapy

scientific article published on 04 April 2008

Predictors of supervised exercise adherence during breast cancer chemotherapy

scientific article published in June 2008

Presentation and management of docetaxel-related adverse effects in patients with breast cancer

scientific article

Presentation of a radiation-induced soft-tissue sarcoma interpreted as a breast prosthesis on computed tomographic scan: case report

scientific article published on 01 June 2000

Prevention of aromatase inhibitor-induced bone loss using risedronate: the SABRE trial.

scientific article published on 11 January 2010

Primary results of ROSE/TRIO-12, a randomized placebo-controlled phase III trial evaluating the addition of ramucirumab to first-line docetaxel chemotherapy in metastatic breast cancer.

scientific article

Prognostic role of human equilibrative transporter 1 (hENT1) in patients with resected gastric cancer.

scientific article published in May 2010

Prognostic significance of tissue inhibitor of metalloproteinase-1 in breast cancer.

scientific article

Prospective cohort study of lifetime physical activity and breast cancer survival

scientific article published in April 2009

Proteome profile of human breast cancer tissue generated by LC-ESI-MS/MS combined with sequential protein precipitation and solubilization.

scientific article published on 25 June 2008

Quantitative proteomic analysis of HER2 normal and overexpressing MCF-7 breast cancer cells revealed proteomic changes accompanied with HER2 gene amplification.

scientific article published on 11 July 2013

Ramucirumab (IMC-1121B): a novel attack on angiogenesis.

scientific article published on July 2010

Randomized Controlled Trial of Exercise Training in Postmenopausal Breast Cancer Survivors: Cardiopulmonary and Quality of Life Outcomes

article

Randomized controlled trial of exercise and blood immune function in postmenopausal breast cancer survivors.

scientific article

Randomized controlled trial of the effects of print materials and step pedometers on physical activity and quality of life in breast cancer survivors.

scientific article published on June 2007

Regulation of subcellular distribution and oncogenic potential of nucleophosmin by plakoglobin.

scientific article

Reply to H.J. Lee et al.

scientific article published on 20 July 2015

Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene

scientific article

STAT3 upregulates the protein expression and transcriptional activity of β-catenin in breast cancer ⬇️

scientific article published on July 25, 2010

Safety and feasibility of cardiopulmonary exercise testing in patients with advanced cancer.

scientific article published on 17 November 2006

Senescence evasion by MCF-7 human breast tumor-initiating cells.

scientific article

Sensitization of ara-C-resistant lymphoma cells by a pronucleotide analogue.

scientific article published in October 2003

Signal transducers and activators of transcription-3 up-regulates tissue inhibitor of metalloproteinase-1 expression and decreases invasiveness of breast cancer.

scientific article

Six-month follow-up of patient-rated outcomes in a randomized controlled trial of exercise training during breast cancer chemotherapy

scientific article published in December 2007

Skeletal health in postmenopausal survivors of early breast cancer.

scientific article

Subgroup effects in a randomised trial of different types and doses of exercise during breast cancer chemotherapy

scientific article published on 21 August 2014

Survival differences observed in metastatic breast cancer patients treated with capecitabine when compared with vinorelbine after pretreatment with anthracycline and taxane.

scientific article published on June 2007

Systemic inflammation, cardiorespiratory fitness, and quality of life in patients with advanced non-small cell lung cancer.

scientific article published in February 2008

Targeting lysyl oxidase for molecular imaging in breast cancer

scientific article

Targeting triple-negative breast cancer: optimising therapeutic outcomes

scientific article

Taxanes alone or in combination with anthracyclines as first-line therapy of patients with metastatic breast cancer.

scientific article published in April 2008

The Alberta Moving Beyond Breast Cancer (AMBER) Cohort Study: Recruitment, Baseline Assessment, and Description of the First 500 Participants

scientific article

The Alberta moving beyond breast cancer (AMBER) cohort study: a prospective study of physical activity and health-related fitness in breast cancer survivors.

scientific article

The BH3-only protein Bad confers breast cancer taxane sensitivity through a nonapoptotic mechanism

scientific article

The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma.

scientific article published in October 2004

The cancer patient with chronic pain due to herpes zoster.

scientific article

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

scientific article (publication date: 4 April 2012)

The influence of comorbidities, age, and performance status on the prognosis and treatment of patients with metastatic carcinomas of unknown primary site: a population-based study.

scientific article

The potential role of aerobic exercise to modulate cardiotoxicity of molecularly targeted cancer therapeutics.

scientific article published on 18 January 2013

The role of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography in disseminated carcinoma of unknown primary site.

scientific article published on January 2007

The role of membrane transporters in cellular resistance to anticancer nucleoside drugs.

scientific article

The role of neoadjuvant (HER)2-targeted therapies in (HER)2-overexpressing breast cancers.

scientific article published on September 2009

Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM

scientific article published on 28 September 2009

Tumor-induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast cancer progression

scientific article published on 12 June 2015

Unexpected immunohistochemical localization of deoxycytidine kinase

scientific article published on 01 November 2006

Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy.

scientific article published on 4 January 2014

Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: a phase III, double-blind, comparative trial

scientific article published on September 1, 2001

cN-II expression predicts survival in patients receiving gemcitabine for advanced non-small cell lung cancer.

scientific article

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