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List of works by Roberta Frapolli

3D Mass Spectrometry Imaging Reveals a Very Heterogeneous Drug Distribution in Tumors

scientific article

A Nanostructured Matrices Assessment to Study Drug Distribution in Solid Tumor Tissues by Mass Spectrometry Imaging.

scientific article

A biodistribution study of PEGylated PCL-based nanoparticles in C57BL/6 mice bearing B16/F10 melanoma.

scientific article

Antiangiogenic activity of trabectedin in myxoid liposarcoma: Involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1

scientific article published on 19 June 2014

Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells.

scientific article

Application of 3D Mass Spectrometry Imaging to TKIs

scientific article

Assessing the anti-tumour properties of Iraqi propolis in vitro and in vivo

scientific article published on 28 January 2012

Base excision repair-mediated resistance to cisplatin in KRAS(G12C) mutant NSCLC cells.

scientific article published on 2 September 2015

Bevacizumab-Induced Inhibition of Angiogenesis Promotes a More Homogeneous Intratumoral Distribution of Paclitaxel, Improving the Antitumor Response.

scientific article published on 22 October 2015

Bioreducible Hydrophobin-Stabilized Supraparticles for Selective Intracellular Release.

scientific article published on 14 August 2017

Chemical characterization of Iraqi propolis samples and assessing their antioxidant potentials

article

Clinical pharmacokinetics of the new oral camptothecin gimatecan: the inter-patient variability is related to alpha1-acid glycoprotein plasma levels.

scientific article published on 16 December 2009

Combination of PPARγ Agonist Pioglitazone and Trabectedin Induce Adipocyte Differentiation to Overcome Trabectedin Resistance in Myxoid Liposarcomas

scientific article published on 03 September 2019

Comparison of in vitro and in vivo biological effects of trabectedin, lurbinectedin (PM01183) and Zalypsis® (PM00104).

scientific article

Determination of total and lactone form of a new camptothecin derivative gimatecan (ST1481) and its metabolite ST1698 in human plasma by high-performance liquid chromatography with fluorimetric detection.

scientific article published on 27 May 2009

Differences between in vivo and in vitro sensitivity to imatinib of Bcr/Abl+ cells obtained from leukemic patients.

scientific article published in May 2002

Establishment and characterisation of a new patient-derived model of myxoid liposarcoma with acquired resistance to trabectedin

scientific article published on 14 August 2019

Expression of thrombospondin-1 by tumor cells in patient-derived ovarian carcinoma xenografts.

scientific article published on 15 June 2015

G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.

scientific article

HMGA1/E2F1 axis and NFkB pathways regulate LPS progression and trabectedin resistance

scientific article published on 06 July 2018

HPLC-MS/MS method to measure trabectedin in tumors: preliminary PK study in a mesothelioma xenograft model

scientific article published on August 2015

Heterogeneity of paclitaxel distribution in different tumor models assessed by MALDI mass spectrometry imaging

scientific article published on 21 December 2016

High-performance liquid chromatographic assay for the determination of Aloe Emodin in mouse plasma.

scientific article published in October 2003

High-performance liquid chromatographic assay for the determination of the novel C-Seco-taxane derivative (IDN 5390) in mouse plasma

scientific article published on 01 November 2002

High-performance liquid chromatographic assay for the determination of the novel taxane derivative IDN5109 in mouse plasma

scientific article published on 01 December 1999

Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells.

scientific article

IDN 5390: an oral taxane candidate for protracted treatment schedules

scientific article published on March 2003

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth.

scientific article published on 29 November 2017

Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin

scientific article

Longitudinal tracking of triple labeled umbilical cord derived mesenchymal stromal cells in a mouse model of Amyotrophic Lateral Sclerosis

scientific article published on 27 June 2015

Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models

scientific article published on 6 July 2017

Mode of action of trabectedin in myxoid liposarcomas.

scientific article published on 11 November 2013

Novel models of myxoid liposarcoma xenografts mimicking the biological and pharmacologic features of human tumors.

scientific article published on 20 August 2010

OTX015 (MK-8628), a novel BET inhibitor, exhibits antitumor activity in non-small cell and small cell lung cancer models harboring different oncogenic mutations

scientific article

PEGylated Nanoparticles Obtained through Emulsion Polymerization as Paclitaxel Carriers

scientific article published in December 2015

Past-in-the-Future. Peak detection improves targeted mass spectrometry imaging

scientific article published on 28 June 2018

Patient-derived solitary fibrous tumour xenografts predict high sensitivity to doxorubicin/dacarbazine combination confirmed in the clinic and highlight the potential effectiveness of trabectedin or eribulin against this tumour.

scientific article published on 8 March 2017

Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib.

scientific article published on 24 August 2013

Pharmacokinetics and metabolism in mice of IDN 5390 (13-(N-Boc-3-i-butylisoserinoyl)-C-7,8-seco-10-deacetylbaccatin III), a new oral c-seco-taxane derivative with antiangiogenic property effective on paclitaxel-resistant tumors.

scientific article published on 8 September 2006

Promising in vivo efficacy of the BET bromodomain inhibitor OTX015/MK-8628 in malignant pleural mesothelioma xenografts

scientific article published on 4 September 2016

Readily prepared biodegradable nanoparticles to formulate poorly water soluble drugs improving their pharmacological properties: The example of trabectedin

scientific article published on 7 March 2018

Reduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells

scientific article

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

scientific article published on 01 February 2013

Self-Assembling PCL-Based Nanoparticles as PTX Solubility Enhancer Excipients

scientific article published on 25 July 2018

Sequence dependent antitumour efficacy of the vascular disrupting agent ZD6126 in combination with paclitaxel.

scientific article published on 11 September 2007

Snail levels control the migration mechanism of mesenchymal tumor cells.

scientific article published on 30 May 2016

The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus

scientific article published on 07 December 2016

The effects of vandetanib on paclitaxel tumor distribution and antitumor activity in a xenograft model of human ovarian carcinoma

scientific article

The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin

article

The isothiocyanate produced from glucomoringin inhibits NF-kB and reduces myeloma growth in nude mice in vivo.

scientific article

The neuroprotective effect of erythropoietin in docetaxel-induced peripheral neuropathy causes no reduction of antitumor activity in 13762 adenocarcinoma-bearing rats

scientific article published on 30 October 2009

Trabectedin efficacy in Ewing sarcoma is greatly increased by combination with anti-IGF signaling agents.

scientific article

Tumor-associated macrophages and anti-tumor therapies: complex links

scientific article published on 8 March 2016

Wee1 inhibitor MK1775 sensitizes KRAS mutated NSCLC cells to sorafenib.

scientific article published on 17 January 2018

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