List of works - Petra Kovaříková

A UHPLC-UV-QTOF study on the stability of carfilzomib, a novel proteasome inhibitor

scientific article

Are cardioprotective effects of NO-releasing drug molsidomine translatable to chronic anthracycline cardiotoxicity settings?

scientific article published on 2 November 2016

Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.

scientific article published on 7 May 2016

Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury

scientific article published on 12 October 2016

Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products.

scientific article published on April 2016

Chromatographic methods for the separation of biocompatible iron chelators from their synthetic precursors and iron chelates.

scientific article published in December 2004

Comparison of clinically used and experimental iron chelators for protection against oxidative stress-induced cellular injury.

scientific article

Comparison of various iron chelators used in clinical practice as protecting agents against catecholamine-induced oxidative injury and cardiotoxicity.

scientific article

Deferoxamine but not Dexrazoxane Alleviates Liver Injury Induced by Endotoxemia in Rats

scientific article published on 01 October 2014

Determination of lipophilicity of novel potential antituberculotic agents using HPLC on monolithic stationary phase and theoretical calculations

scientific article published on 04 January 2008

Development and validation of HPLC-DAD methods for the analysis of two novel iron chelators with potent anti-cancer activity

scientific article published on 12 December 2006

Development of LC-MS/MS method for the simultaneous analysis of the cardioprotective drug dexrazoxane and its metabolite ADR-925 in isolated cardiomyocytes and cell culture medium

scientific article published on 28 December 2012

Development of an LC-MS/MS method for analysis of interconvertible Z/E isomers of the novel anticancer agent, Bp4eT.

scientific article published on 2 February 2010

Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination.

scientific article published on 14 November 2008

Enhanced Topical and Transdermal Delivery of Antineoplastic and Antiviral Acyclic Nucleoside Phosphonate cPr-PMEDAP

scientific article published on 14 June 2011

HPLC study on stability of pyridoxal isonicotinoyl hydrazone.

scientific article published on 2 August 2005

Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites--the cardioprotectant dexrazoxane as a model case.

scientific article published on 27 November 2010

Identification of in vitro metabolites of the novel anti-tumor thiosemicarbazone, DpC, using ultra-high performance liquid chromatography–quadrupole-time-of-flight mass spectrometry

scientific article published on 22 November 2012

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

scientific article

Interface-free capillary electrophoresis-mass spectrometry system with nanospray ionization-Analysis of dexrazoxane in blood plasma

scientific article published on 23 August 2016

Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite.

scientific article published on 20 September 2017

Investigation of structure-activity relationships of dexrazoxane analogues reveals topoisomerase IIβ interaction as a prerequisite for effective protection against anthracycline cardiotoxicity

scientific article published on 06 April 2020

Investigation of the stability of aromatic hydrazones in plasma and related biological material.

scientific article

Iron chelation with salicylaldehyde isonicotinoyl hydrazone protects against catecholamine autoxidation and cardiotoxicity.

scientific article published on 13 December 2010

LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT.

scientific article published on 17 February 2012

LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH)

scientific article

Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: novel iron chelators with selective antiproliferative action.

scientific article

Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.

scientific article published on 25 November 2015

Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection.

scientific article published on 12 October 2012

Pharmacokinetics of the cardioprotective drug dexrazoxane and its active metabolite ADR-925 with focus on cardiomyocytes and the heart.

scientific article published on 22 December 2017

Photochemical stability of nimesulide.

scientific article

Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats

scientific article published on 20 November 2013

Structure-Activity Relationships of Nitro-Substituted Aroylhydrazone Iron Chelators with Antioxidant and Antiproliferative Activities

scientific article published on 23 May 2018

Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.

scientific article

The retention behaviour of polar compounds on zirconia based stationary phases under hydrophilic interaction liquid chromatography conditions

scientific article published on 06 August 2011

UHPLC-MS/MS method for analysis of sobuzoxane, its active form ICRF-154 and metabolite EDTA-diamide and its application to bioactivation study

scientific article published on 14 March 2019

Use of different stationary phases for separation of isoniazid, its metabolites and vitamin B6 forms

scientific article published on 13 May 2011

Zirconia--a stationary phase capable of the separation of polar markers of myocardial metabolism in hydrophilic interaction chromatography

scientific article published on 31 March 2014

List of works by Petra Kovaříková

A UHPLC-UV-QTOF study on the stability of carfilzomib, a novel proteasome inhibitor

Are cardioprotective effects of NO-releasing drug molsidomine translatable to chronic anthracycline cardiotoxicity settings?

Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.

Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury

Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products.

Chromatographic methods for the separation of biocompatible iron chelators from their synthetic precursors and iron chelates.

Comparison of clinically used and experimental iron chelators for protection against oxidative stress-induced cellular injury.

Comparison of various iron chelators used in clinical practice as protecting agents against catecholamine-induced oxidative injury and cardiotoxicity.

Deferoxamine but not Dexrazoxane Alleviates Liver Injury Induced by Endotoxemia in Rats

Determination of lipophilicity of novel potential antituberculotic agents using HPLC on monolithic stationary phase and theoretical calculations

Development and validation of HPLC-DAD methods for the analysis of two novel iron chelators with potent anti-cancer activity

Development of LC-MS/MS method for the simultaneous analysis of the cardioprotective drug dexrazoxane and its metabolite ADR-925 in isolated cardiomyocytes and cell culture medium

Development of an LC-MS/MS method for analysis of interconvertible Z/E isomers of the novel anticancer agent, Bp4eT.

Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination.

Enhanced Topical and Transdermal Delivery of Antineoplastic and Antiviral Acyclic Nucleoside Phosphonate cPr-PMEDAP

HPLC study on stability of pyridoxal isonicotinoyl hydrazone.

Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites--the cardioprotectant dexrazoxane as a model case.

Identification of in vitro metabolites of the novel anti-tumor thiosemicarbazone, DpC, using ultra-high performance liquid chromatography–quadrupole-time-of-flight mass spectrometry

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

Interface-free capillary electrophoresis-mass spectrometry system with nanospray ionization-Analysis of dexrazoxane in blood plasma

Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite.

Investigation of structure-activity relationships of dexrazoxane analogues reveals topoisomerase IIβ interaction as a prerequisite for effective protection against anthracycline cardiotoxicity

Investigation of the stability of aromatic hydrazones in plasma and related biological material.

Iron chelation with salicylaldehyde isonicotinoyl hydrazone protects against catecholamine autoxidation and cardiotoxicity.

LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT.

LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH)

Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: novel iron chelators with selective antiproliferative action.

Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.

Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection.

Pharmacokinetics of the cardioprotective drug dexrazoxane and its active metabolite ADR-925 with focus on cardiomyocytes and the heart.

Photochemical stability of nimesulide.

Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats

Structure-Activity Relationships of Nitro-Substituted Aroylhydrazone Iron Chelators with Antioxidant and Antiproliferative Activities

Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.

The retention behaviour of polar compounds on zirconia based stationary phases under hydrophilic interaction liquid chromatography conditions

UHPLC-MS/MS method for analysis of sobuzoxane, its active form ICRF-154 and metabolite EDTA-diamide and its application to bioactivation study

Use of different stationary phases for separation of isoniazid, its metabolites and vitamin B6 forms

Zirconia--a stationary phase capable of the separation of polar markers of myocardial metabolism in hydrophilic interaction chromatography