List of works by Christian Happi

A high performance liquid chromatographic assay of mefloquine in saliva after a single oral dose in healthy adult Africans

scientific article published on 27 February 2012

A modified anthrax toxin-based enzyme-linked immunospot assay reveals robust T cell responses in symptomatic and asymptomatic Ebola virus exposed individuals.

scientific article published on 24 May 2018

A qualitative study of the feasibility and community perception on the effectiveness of artemether-lumefantrine use in the context of home management of malaria in south-west Nigeria

scientific article published on June 2008

A simple cost-effective high performance liquid chromatographic assay of sulphadoxine in whole blood spotted on filter paper for field studies

scientific article published on 24 October 2009

A simple dose regimen of artesunate and amodiaquine based on age or body weight range for uncomplicated falciparum malaria in children: comparison of therapeutic efficacy with standard dose regimen of artesunate and amodiaquine and artemether-lumef

scientific article published on July 2012

A simple dose regimen of artesunate and amodiaquine based on arm span- or age range for childhood falciparum malaria: a preliminary evaluation

scientific article published on 3 November 2011

Accelerating genomics-based surveillance for COVID-19 response in Africa

scientific article published on 18 August 2020

Activities of amodiaquine, artesunate, and artesunate-amodiaquine against asexual- and sexual-stage parasites in falciparum malaria in children

scientific article published on 26 February 2007

Activities of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine against sexual-stage parasites in falciparum malaria in children

scientific article published on 18 June 2008

Acute Kidney Injury and Mortality in Pediatric Lassa fever versus Question of Access to Dialysis

scientific article published on 08 November 2020

Acute Lassa Virus Encephalitis with Lassa Virus in the Cerebrospinal Fluid but Absent in the Blood: A Case Report with a Positive Outcome

African Resources and the Promise of Resilience against COVID-19

scientific article published on 03 June 2020

Amodiaquine-Ciprofloxacin: a potential combination therapy against drug resistant malaria

scientific article published on 4 March 2015

An Outbreak of Ebola Virus Disease in the Lassa Fever Zone

scientific article published on 11 July 2016

Anaemia following Artemisinin-Based Combination Treatments of Uncomplicated Plasmodium falciparum Malaria in Children: Temporal Patterns of Haematocrit and the Use of Uncomplicated Hyperparasitaemia as a Model for Evaluating Late-Appearing Anaemia

scientific article published on 28 April 2017

Antibodies from Sierra Leonean and Nigerian Lassa fever survivors cross-react with recombinant proteins representing Lassa viruses of divergent lineages

scientific article published on 29 September 2020

Assessment and characterization of Ca2+-ATPase expression in selected isolates and clones of Plasmodium falciparum.

scientific article published on 7 June 2012

Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria.

scientific article published on July 2006

Biosafety level-2 laboratory diagnosis of Zaire Ebola virus disease imported from Liberia to Nigeria

scientific article published on 17 October 2016

Capturing diverse microbial sequence with comprehensive and scalable probe design

scholarly article published 12 March 2018

Capturing sequence diversity in metagenomes with comprehensive and scalable probe design

scientific article published on 04 February 2019

Caseload and Case Fatality of Lassa Fever in Nigeria, 2001-2018: A Specialist Center's Experience and Its Implications

scientific article published on 25 June 2019

Characterization of Plasmodium falciparum structure in Nigeria with malaria SNPs barcode

scholarly article published by Pardis C. Sabeti in 2018

Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus

scientific article

Clinical and laboratory predictors of Lassa fever outcome in a dedicated treatment facility in Nigeria: a retrospective, observational cohort study.

scientific article

Clinical characteristics and disposition kinetics of the hepatomegaly associated with acute, uncomplicated, Plasmodium falciparum malaria in children.

scientific article

Clinical illness and outcomes in Nigerian children with persistent early-appearing anaemia following initiation of artemisinin-based combination treatments of uncomplicated falciparum malaria

scientific article published on 13 September 2019

Clinical illness and outcomes in patients with Ebola in Sierra Leone

scientific article

Community effectiveness of artemisinin-based combination therapy for malaria in rural southwestern Nigeria.

scientific article

Comparative study of interactions between chloroquine and chlorpheniramine or promethazine in healthy volunteers: a potential combination-therapy phenomenon for resuscitating chloroquine for malaria treatment in Africa

scientific article published on January 2008

Comparison of SYBR Green I-, PicoGreen-, and [3H]-hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine

scientific article published on 18 February 2010

Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa

scientific article published on 04 October 2006

Corrigendum: Caseload and Case Fatality of Lassa Fever in Nigeria, 2001-2018: A Specialist Center's Experience and Its Implications

scientific article published on 13 September 2019

Cultural categorization of febrile illnesses in correlation with herbal remedies used for treatment in Southwestern Nigeria.

scientific article published on April 2003

Declining responsiveness of childhood Plasmodium falciparum infections to artemisinin-based combination treatments ten years following deployment as first-line antimalarials in Nigeria

scientific article published on 06 August 2019

Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time

scientific article published on 17 August 2020

Detection of Antibody and Antigen for Lassa Virus Nucleoprotein in Monkeys from Southern Nigeria

scientific article published on 01 June 2019

Development of a qualitative real-time RT-PCR assay for the detection of SARS-CoV-2: A guide and case study in setting up an emergency-use, laboratory-developed molecular assay

scientific article published on 01 September 2020

Different patterns of pfcrt and pfmdr1 polymorphisms in P. falciparum isolates from Nigeria and Brazil: the potential role of antimalarial drug selection pressure

scientific article

Dihydroartemisinin suppository in moderately severe malaria: comparative efficacy of dihydroartemisinin suppository versus intramuscular artemeter followed by oral sulfadoxine-pyrimethamine in the management of moderately severe malaria in Nigerian

scientific article published on 01 January 2007

Discovery of novel rhabdoviruses in the blood of healthy individuals from West Africa

scientific article

Early rising asexual parasitaemia in Nigerian children following a first dose of artemisinin-based combination treatments of falciparum malaria

scientific article

Early variations in plasmodium falciparum dynamics in Nigerian children after treatment with two artemisinin-based combinations: implications on delayed parasite clearance

scientific article

Ebola Virus Epidemiology and Evolution in Nigeria

scientific article published on 04 July 2016

Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone

scientific article

Effectiveness of artemisinin-based combination therapy used in the context of home management of malaria: a report from three study sites in sub-Saharan Africa

scientific article published on 27 September 2008

Effects of acute Plasmodium falciparum malaria on body weight in children in an endemic area

scientific article published on 25 February 2007

Effects of amodiaquine, artesunate, and artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia in children

scientific article

Effects of artesunate-cotrimoxazole and amodiaquine-artesunate against asexual and sexual stages of Plasmodium falciparum malaria in Nigerian children

scientific article

Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children

scientific article

Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children.

scientific article published on December 2006

Efficacy and safety of nitazoxanide plus atazanavir/ritonavir for the treatment of moderate to severe COVID-19 (NACOVID): A structured summary of a study protocol for a randomised controlled trial

scientific article published on 04 January 2021

Efficacy of Artemisinin-Based Combination Treatments of Uncomplicated Falciparum Malaria in Under-Five-Year-Old Nigerian Children Ten Years Following Adoption as First-Line Antimalarials

article

Empowering African genomics for infectious disease control

scientific article

Enhanced methods for unbiased deep sequencing of Lassa and Ebola RNA viruses from clinical and biological samples

scientific article

Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo

scientific article published on June 2007

Epidemiology. Emerging disease or diagnosis?

scientific article published on November 2012

Factors contributing to anaemia after uncomplicated Plasmodiumfalciparum malaria in children

scientific article published on 27 October 2009

Factors contributing to anaemia after uncomplicated falciparum malaria in under five year-old Nigerian children ten years following adoption of artemisinin-based combination therapies as first-line antimalarials

scientific article published on 19 December 2017

Factors contributing to delay in parasite clearance in uncomplicated falciparum malaria in children

scientific article

Feasibility, acceptability and use of artemisinin-based combination therapy

Field evaluation of a Pan-Lassa rapid diagnostic test during the 2018 Nigerian Lassa fever outbreak

scientific article published on 26 May 2020

Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever.

scientific article published on 12 April 2018

Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names

scientific article published on 26 September 2014

Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever

scientific article published on March 2012

Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018

article by Katherine J Siddle et al published 17 October 2018 in The New England Journal of Medicine

Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

scientific article

Herpes simplex labialis in children with acute falciparum malaria

scientific article

High crossreactivity of human T cell responses between Lassa virus lineages

scientific article published on 06 March 2020

Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum

scientific article

Identification of Common CD8+ T cell Epitopes from Lassa Fever Survivors in Nigeria and Sierra Leone

scientific article published on 08 April 2020

In Vitro and In Vivo Antimalarial Activity of Ficus thonningii Blume (Moraceae) and Lophira alata Banks (Ochnaceae), Identified from the Ethnomedicine of the Nigerian Middle Belt.

scientific article

In vitro amodiaquine resistance and its association with mutations in pfcrt and pfmdr1 genes of Plasmodium falciparum isolates from Nigeria

scientific article published on 6 September 2011

In vitro cytotoxicity studies of 20 plants used in Nigerian antimalarial ethnomedicine

scientific article published on 15 September 2005

In vitro-reduced susceptibility to artemether in P. falciparum and its association with polymorphisms on transporter genes

scientific article

In vitroantiplasmodial activity and toxicity assessment of some plants from Nigerian ethnomedicine ⬇️

scientific article published on August 26, 2010

Interaction between ciprofloxacin and chloroquine in mice infected with chloroquine resistant Plasmodium berghei: interaction between ciprofloxacin and chloroqune.

scientific article published on 9 August 2011

Interaction between rifampicin, amodiaquine and artemether in mice infected with chloroquine resistant Plasmodium berghei

scientific article published on 5 August 2014

Lassa Virus Genetics

scientific article published on 17 May 2020

Lassa fever diagnostics: past, present, and future

scientific article published on 01 August 2019

Lassa fever in post-conflict sierra leone

scientific article

Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria

scientific article published on 28 July 2006

Malaria diagnosis: false negative parasight-F tests in falciparum malaria patients in Nigeria.

scientific article published in March 2004

Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria

scientific article published on January 2004

Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation

scientific article published in 2012

Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits

scientific article

Nomenclature- and database-compatible names for the two Ebola virus variants that emerged in Guinea and the Democratic Republic of the Congo in 2014.

scientific article

Open randomized study of artesunate-amodiaquine vs. chloroquine-pyrimethamine-sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in Nigerian children.

scientific article

Oral artesunate-amodiaquine and artemether-lumefantrine in the treatment of uncomplicated hyperparasitaemic Plasmodium falciparum malaria in children

scientific article published on 26 May 2011

Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children

Pharmacokinetic disposition of sulfadoxine in children with acute uncomplicated falciparum malaria treated with sulfadoxine-pyrimethamine in South West Nigeria.

scientific article published in September 2012

Plasmodium berghei: efficacy and safety of combinations of chloroquine and promethazine in chloroquine resistant infections in gravid mice.

scientific article published on March 2004

Plasmodium falciparum gametocyte sex ratios in children with acute, symptomatic, uncomplicated infections treated with amodiaquine

scientific article published on 2 September 2008

Plasmodium falciparum gametocyte sex ratios in symptomatic children treated with antimalarial drugs

scientific article

Plasmodium falciparum hyperparasitaemia in Nigerian children: epidemiology, clinical characteristics, and therapeutic responses to oral artemisinin-based combination treatments

article

Plasmodium falciparum malaria in Nigerian children during high and low transmission seasons: gametocyte carriage and response to oral chloroquine.

scientific article published on 24 June 2005

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and multidrug-resistant gene 1 (Pfmdr-1) in Nigerian children 10 years post-adoption of artemisinin-based combination treatments

scientific article published on 23 December 2020

Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria

scientific article published in September 2005

Population structure of Plasmodium falciparum gametocyte sex ratios in malarious children in an endemic area

scientific article published on 31 August 2009

Potential contribution of prescription practices to the emergence and spread of chloroquine resistance in south-west Nigeria: caution in the use of artemisinin combination therapy

scientific article

Predictors of the failure of treatment with chloroquine in children with acute, uncomplicated, Plasmodium falciparum malaria, in an area with high and increasing incidences of chloroquine resistance.

scientific article

Predictors of the failure of treatment with chloroquine plus chlorpheniramine, in children with acute, uncomplicated, Plasmodium falciparum malaria.

scientific article published on June 2005

Predictors of the failure of treatment with pyrimethamine-sulfadoxine in children with uncomplicated falciparum malaria.

scientific article

Preparing for the next Ebola outbreak: in-country genomic capacity in Africa

article

Prevalence of Lassa Virus Disease (LVD) in Nigerian children with fever or fever and convulsions in an endemic area

scientific article

Quadrivalent VesiculoVax vaccine protects nonhuman primates from viral-induced hemorrhagic fever and death

scientific article published on 01 January 2020

Rapid detection of lactate dehydrogenase and genotyping of Plasmodium falciparum in saliva of children with acute uncomplicated malaria

scientific article

Real-time Metagenomic Analysis of Undiagnosed Fever Cases Unveils a Yellow Fever Outbreak in Edo State, Nigeria

scientific article published on 21 February 2020

Recrudescent Plasmodium falciparum infections in children in an endemic area following artemisinin–based combination treatments: Implications for disease control

Reemergence of Human Monkeypox in Nigeria, 2017.

scientific article

Research capacity. Enabling the genomic revolution in Africa

scientific article published in June 2014

Retrospective Cohort Study of Lassa Fever in Pregnancy, Southern Nigeria

scientific article published on 01 August 2019

Risk factors for Plasmodium falciparum hyperparasitaemia in malarious children

scientific article

Risk factors for gametocyte carriage in uncomplicated falciparum malaria in children before and after artemisinin-based combination treatments

scientific article published in January 2011

Roots, Not Parachutes: Research Collaborations Combat Outbreaks

scientific article

Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria

scientific article published on 15 December 2008

Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children

scientific article published in December 2008

Streamlined inactivation, amplification, and Cas13-based detection of SARS-CoV-2

scientific article published on 20 November 2020

The Bacteria Genome Pipeline (BAGEP): an automated, scalable workflow for bacteria genomes with Snakemake

scientific article published on 27 October 2020

The effects of alpha1-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum

scientific article published on October 2006

The effects of artemether-lumefantrine vs amodiaquine-sulfalene-pyrimethamine on the hepatomegaly associated with Plasmodium falciparum malaria in children.

scientific article published on 30 September 2006

Therapeutic efficacies of artemisinin-based combination therapies in Nigerian children with uncomplicated falciparum malaria during five years of adoption as first-line treatments

scientific article

Therapeutic efficacy and effects of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine on gametocyte carriage in children with uncomplicated Plasmodium falciparum malaria in southwestern Nigeria.

scientific article

Therapeutic efficacy and effects of artemether-lumefantrine and artesunate-amodiaquine coformulated or copackaged on malaria-associated anemia in children with uncomplicated Plasmodium falciparum malaria in Southwest Nigeria

scientific article published on May 2011

Therapeutic efficacy and effects of artemisinin-based combination treatments on uncomplicated Plasmodium falciparum malaria -associated anaemia in Nigerian children during seven years of adoption as first-line treatments

scientific article published on 07 February 2017

Therapeutic efficacy and effects of artesunate-mefloquine and mefloquine alone on malaria-associated anemia in children with uncomplicated Plasmodium falciparum malaria in southwest Nigeria

scientific article published on December 2009

Therapeutic efficacy of artesunate-amodiaquine combinations and the plasma and saliva concentrations of desethylamodiaquine in children with acute uncomplicated Plasmodium falciparum malaria

scientific article published on January 2013

Use of Area Under the Curve to Evaluate the Effects of Antimalarial Drugs on Malaria-Associated Anemia After Treatment ⬇️

scientific article published on May 1, 2011

Virus genomes reveal factors that spread and sustained the Ebola epidemic

scientific article (publication date: 12 April 2017)

Virus genomes reveal the factors that spread and sustained the West African Ebola epidemic

article published in 2016

World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria

scientific article

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