List of works - Todd Washington

A lag-phase in the reduction of flavin dependent thymidylate synthase (FDTS) revealed a mechanistic missing link

scientific article published on 17 March 2006

Accuracy of lesion bypass by yeast and human DNA polymerase eta.

scientific article published on July 2001

Analyzing the Catalytic Activities and Interactions of Eukaryotic Translesion Synthesis Polymerases

scientific article published on 8 May 2017

Bridging the gap: a family of novel DNA polymerases that replicate faulty DNA.

scientific article

Conformational flexibility of fork-remodeling helicase Rad5 shown by full-ensemble hybrid methods

scientific article published on 18 October 2019

Crystal Structure of SUMO-Modified Proliferating Cell Nuclear Antigen

scientific article

Crystal structures of PCNA mutant proteins defective in gene silencing suggest a novel interaction site on the front face of the PCNA ring.

scientific article published on 2 March 2018

DNA Polymerase Fidelity: Beyond Right and Wrong.

scientific article published on November 2016

Dead-End Elimination with a Polarizable Force Field Repacks PCNA Structures

scientific article

Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase zeta.

scientific article published on August 2004

Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

scientific article (publication date: 31 August 2000)

Fidelity of human DNA polymerase eta

scientific article published on 01 March 2000

Human DNA polymerase iota utilizes different nucleotide incorporation mechanisms dependent upon the template base.

scientific article

Human DNA polymerase kappa forms nonproductive complexes with matched primer termini but not with mismatched primer termini.

scholarly article

Increased DNA unwinding efficiency of bacteriophage T7 DNA helicase mutant protein 4A'/E348K

scientific article published on 01 April 1998

Mechanism of efficient and accurate nucleotide incorporation opposite 7,8-dihydro-8-oxoguanine by Saccharomyces cerevisiae DNA polymerase eta.

scientific article published on March 2005

Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase eta.

scientific article

Mismatch extension ability of yeast and human DNA polymerase eta

scientific article published on 27 October 2000

PCNA Structure and Function: Insights from Structures of PCNA Complexes and Post-translationally Modified PCNA ⬇️

scientific article published on January 1, 2012

PCNA tool belts and polymerase bridges form during translesion synthesis

scientific article published on 20 June 2016

Pre-steady state kinetic studies of the fidelity of nucleotide incorporation by yeast DNA polymerase delta

scientific article

Pre-steady-state kinetic studies of protein-template-directed nucleotide incorporation by the yeast Rev1 protein

scientific article published on 26 October 2007

R.I.P. to the PIP: PCNA-binding motif no longer considered specific: PIP motifs and other related sequences are not distinct entities and can bind multiple proteins involved in genome maintenance.

scientific article

Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase eta.

scientific article

Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA

scientific article

Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response

scientific article

Structure of a Mutant Form of Proliferating Cell Nuclear Antigen That Blocks Translesion DNA Synthesis † ‡

scientific article

The C-terminal region of translesion synthesis DNA polymerase η is partially unstructured and has high conformational flexibility.

scientific article published on 29 January 2018

The Many Roles of PCNA in Eukaryotic DNA Replication

scientific article published on 19 April 2016

The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1

scientific article (publication date: 22 February 2016)

The mechanism of nucleotide incorporation by human DNA polymerase eta differs from that of the yeast enzyme.

scientific article

Variations on a theme: eukaryotic Y-family DNA polymerases

scientific article

Yeast DNA polymerase eta utilizes an induced-fit mechanism of nucleotide incorporation

scientific article published on 01 December 2001

Yeast DNA polymerase η makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate ⬇️

scientific article published on April 11, 2003

List of works by Todd Washington

A lag-phase in the reduction of flavin dependent thymidylate synthase (FDTS) revealed a mechanistic missing link

Accuracy of lesion bypass by yeast and human DNA polymerase eta.

Analyzing the Catalytic Activities and Interactions of Eukaryotic Translesion Synthesis Polymerases

Bridging the gap: a family of novel DNA polymerases that replicate faulty DNA.

Conformational flexibility of fork-remodeling helicase Rad5 shown by full-ensemble hybrid methods

Crystal Structure of SUMO-Modified Proliferating Cell Nuclear Antigen

Crystal structures of PCNA mutant proteins defective in gene silencing suggest a novel interaction site on the front face of the PCNA ring.

DNA Polymerase Fidelity: Beyond Right and Wrong.

Dead-End Elimination with a Polarizable Force Field Repacks PCNA Structures

Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase zeta.

Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

Fidelity of human DNA polymerase eta

Human DNA polymerase iota utilizes different nucleotide incorporation mechanisms dependent upon the template base.

Human DNA polymerase kappa forms nonproductive complexes with matched primer termini but not with mismatched primer termini.

Increased DNA unwinding efficiency of bacteriophage T7 DNA helicase mutant protein 4A'/E348K

Mechanism of efficient and accurate nucleotide incorporation opposite 7,8-dihydro-8-oxoguanine by Saccharomyces cerevisiae DNA polymerase eta.

Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase eta.

Mismatch extension ability of yeast and human DNA polymerase eta

PCNA Structure and Function: Insights from Structures of PCNA Complexes and Post-translationally Modified PCNA ⬇️

PCNA tool belts and polymerase bridges form during translesion synthesis

Pre-steady state kinetic studies of the fidelity of nucleotide incorporation by yeast DNA polymerase delta

Pre-steady-state kinetic studies of protein-template-directed nucleotide incorporation by the yeast Rev1 protein

R.I.P. to the PIP: PCNA-binding motif no longer considered specific: PIP motifs and other related sequences are not distinct entities and can bind multiple proteins involved in genome maintenance.

Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase eta.

Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA

Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response

Structure of a Mutant Form of Proliferating Cell Nuclear Antigen That Blocks Translesion DNA Synthesis † ‡

The C-terminal region of translesion synthesis DNA polymerase η is partially unstructured and has high conformational flexibility.

The Many Roles of PCNA in Eukaryotic DNA Replication

The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1

The mechanism of nucleotide incorporation by human DNA polymerase eta differs from that of the yeast enzyme.

Variations on a theme: eukaryotic Y-family DNA polymerases

Yeast DNA polymerase eta utilizes an induced-fit mechanism of nucleotide incorporation

Yeast DNA polymerase η makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate ⬇️