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List of works by Luisa Lanfrancone

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction ⬇️

scientific article published on July 10, 1992

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

scientific article

Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells

scientific article

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner.

scientific article published on 4 December 2014

Bombesin-induced pancreatic regeneration in pigs is mediated by p46Shc/p52Shc and p42/p44 mitogen-activated protein kinase upregulation.

scientific article

Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein

scientific article

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

scientific article published on 25 April 2019

Development of Personalized Therapeutic Strategies by Targeting Actionable Vulnerabilities in Metastatic and Chemotherapy-Resistant Breast Cancer PDXs

scientific article published on 18 June 2019

Early differential molecular response of a macrophage cell line to yeast and hyphal forms of Candida albicans ⬇️

scientific article published on March 1, 1992

Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells

scientific article

Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells ⬇️

scientific article published on October 1, 1992

Human lung carcinoma cells engineered to release IL2, IL7, GM-CSF and TNF alpha ⬇️

scientific article published on April 1, 1996

Human peritoneal mesothelial cells produce many cytokines (granulocyte colony-stimulating factor [CSF], granulocyte-monocyte-CSF, macrophage-CSF, interleukin-1 [IL-1], and IL-6) and are activated and stimulated to grow by IL-1 ⬇️

scientific article published on 01 December 1992

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

scientific article

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

scientific article published on 20 January 2017

Investigating the metastatic niche in melanoma: a new therapeutic opportunity?

scientific article published in April 2014

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.

scientific article published on 16 June 2016

Loss of amplification and appearance of a novel translocation site of the c-myc oncogene in HL-60 leukemia cells ⬇️

scientific article published on October 1, 1991

Melanoma: targeting signaling pathways and RaLP

scientific article published on 01 January 2009

Modeling cell proliferation in human acute myeloid leukemia xenografts

scientific article published on 01 September 2019

Modified phage peptide libraries as a tool to study specificity of phosphorylation and recognition of tyrosine containing peptides 1 1Edited by J. Karn ⬇️

scientific article published on June 27, 1997

Molecular networks in melanoma invasion and metastasis.

scientific article published on May 2013

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

scientific article published on February 1997

Pirin inhibits cellular senescence in melanocytic cells.

scientific article

RNAi screens identify CHD4 as an essential gene in breast cancer growth

scientific article

Retroviral gene transfer, rapid selection, and maintenance of the immature phenotype in mouse dendritic cells

scientific article published on 01 August 1999

Salicylates inhibit T cell adhesion on endothelium under nonstatic conditions: induction of L-selectin shedding by a tyrosine kinase-dependent mechanism

scientific article (publication date: 15 January 2001)

ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma

scientific article published on 13 November 2020

Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22

scientific article published on April 1, 1992

Suppressor macrophages in tumor-bearing mice. Inconsistency between in vivo and in vitro findings? ⬇️

scientific article published on June 15, 1982

Tbx3 represses E-cadherin expression and enhances melanoma invasiveness.

scientific article

The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor

scientific article

The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2 breast cancer cells

scientific article published on 18 April 2019

The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

scientific article published on 12 April 2004

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth

scientific article

Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation

scientific article

Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling

scientific article (publication date: April 2002)

WDR5 inhibition halts metastasis dissemination by repressing the mesenchymal phenotype of breast cancer cells

scientific article published on 21 November 2019

c-Cbl tyrosine phosphorylation and subcellular localization in human primary leukemic cells

scientific article published on 01 December 1998

p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells

scientific article published on 30 May 2007

p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value

scientific article published on 01 January 2019

p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.

scientific article published on February 2004

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